Aliases for EFNA4 Gene
External Ids for EFNA4 Gene
Previous HGNC Symbols for EFNA4 Gene
Previous GeneCards Identifiers for EFNA4 Gene
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for EFNA4 Gene
EFNA4 (Ephrin A4) is a Protein Coding gene. Diseases associated with EFNA4 include Craniofrontonasal Syndrome and Craniosynostosis. Among its related pathways are Ras signaling pathway and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include ephrin receptor binding and transmembrane-ephrin receptor activity. An important paralog of this gene is EFNA2.
UniProtKB/Swiss-Prot Summary for EFNA4 Gene
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.