Aliases for EFNA3 Gene
External Ids for EFNA3 Gene
Previous HGNC Symbols for EFNA3 Gene
Previous GeneCards Identifiers for EFNA3 Gene
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
GeneCards Summary for EFNA3 Gene
EFNA3 (Ephrin A3) is a Protein Coding gene. Diseases associated with EFNA3 include Breast Cancer and Androgenic Alopecia. Among its related pathways are Ras signaling pathway and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include ephrin receptor binding and transmembrane-ephrin receptor activity. An important paralog of this gene is ENSG00000251246.
UniProtKB/Swiss-Prot Summary for EFNA3 Gene
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).