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This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) clas... See more...
Aliases for EFNA1 Gene
Aliases for EFNA1 Gene
External Ids for EFNA1 Gene
- HGNC: 3221
- NCBI Entrez Gene: 1942
- Ensembl: ENSG00000169242
- OMIM®: 191164
- UniProtKB/Swiss-Prot: P20827
Previous HGNC Symbols for EFNA1 Gene
- TNFAIP4
- EPLG1
Previous GeneCards Identifiers for EFNA1 Gene
- GC01P152980
- GC01P150840
- GC01P151875
- GC01P152317
- GC01P152318
- GC01P151913
- GC01P153367
- GC01P155099
- GC01P126462
Summaries for EFNA1 Gene
-
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
GeneCards Summary for EFNA1 Gene
EFNA1 (Ephrin A1) is a Protein Coding gene. Diseases associated with EFNA1 include Cortical Senile Cataract and Gastric Cancer. Among its related pathways are Ras signaling pathway and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and ephrin receptor binding. An important paralog of this gene is EFNA5.
UniProtKB/Swiss-Prot Summary for EFNA1 Gene
-
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Additional gene information for EFNA1 Gene
- HGNC (3221)
- NCBI Entrez Gene (1942)
- Ensembl (ENSG00000169242)
- OMIM® (191164)
- UniProtKB/Swiss-Prot (P20827)
- Open Targets Platform(ENSG00000169242)
- Alliance of Genome Resources
- Search for EFNA1 at DataMed
- Search for EFNA1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EFNA1 Gene
Genomics for EFNA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EFNA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EFNA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EFNA1
- Top Transcription factor binding sites by QIAGEN in the EFNA1 gene promoter:
-
- C/EBPalpha
- CHOP-10
- Lmo2
- MRF-2
- Pax-3
- PPAR-gamma1
- STAT3
Genomic Locations for EFNA1 Gene
Latest Assembly
- chr1:155,127,876-155,134,899
- (GRCh38/hg38)
- Size:
- 7,024 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:155,100,352-155,107,375
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 7,024 bases
- Orientation:
- Plus strand
Genomic View for EFNA1 Gene
Genes around EFNA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q22 by HGNC
- 1q22 by Entrez Gene
- 1q22 by Ensembl
EFNA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EFNA1 Gene
Proteins for EFNA1 Gene
-
Protein details for EFNA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20827-EFNA1_HUMAN
- Recommended name:
- Ephrin-A1
- Protein Accession:
- P20827
- D3DV86
- Q5SR60
- Q5SR61
- Q6I9T9
- Q8N578
Protein attributes for EFNA1 Gene
- Size:
- 205 amino acids
- Molecular mass:
- 23787 Da
- Quaternary structure:
-
- Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.
Protein Expression for EFNA1 Gene
Post-translational modifications for EFNA1 Gene
- Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
- N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
-
Glycosylation at Asn26 and Thr152
- NX_P20827 (NX_P20827-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- EFNA1_HUMAN (1209)
Other Protein References for EFNA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences EFNA1 / Ephrin A1 Antibody
- Novus Biologicals Antibodies for EFNA1
-
Abcam antibodies for EFNA1
- Invitrogen Antibodies for EFNA1 (AFLGC-EFNA1)
- antibodies-online: Show 76 available Ephrin A1 Antibodies ranked by validation data
- Compare Top Ephrin A1 Antibodies
-
Recommended
- 46 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 33 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 51 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
-
Boster Bio Antibodies for EFNA1
-
Custom Antibody ServicesProSci Antibodies for EFNA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for EFNA1
- Sino Biological Antibodies for EFNA1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for EFNA1
- Origene Custom Protein Services for EFNA1
- Sino Biological Recombinant Proteins for EFNA1
- Sino Biological Cell Lysates for EFNA1
- ProSpec Recombinant Proteins for EFNA1
-
ProSci Proteins for EFNA1
-
Abcam proteins for EFNA1
Assay products for research
- G Biosciences Immunotag™ Human EFNA1 (Ephrin-A1) ELISA and Immunotag™ Ephrin-A1 ELISA Kit
- Sino Biological Assays for EFNA1
No data available for DME Specific Peptides for EFNA1 Gene
Domains & Families for EFNA1 Gene
Gene Families for EFNA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted secreted proteins
Protein Domains for EFNA1 Gene
- InterPro:
- Blocks:
-
- Ephrin signature
Suggested Antigen Peptide Sequences for EFNA1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ75959, highly similar to Homo sapiens ephrin-A1 (EFNA1), transcript variant 2, mRNA (A8K0M4_HUMAN)
- Tumor necrosis factor alpha-induced protein 4 (EFNA1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P20827- Family:
-
- Belongs to the ephrin family.
Function for EFNA1 Gene
Molecular function for EFNA1 Gene
- UniProtKB/Swiss-Prot Function:
- Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
- UniProtKB/Swiss-Prot Induction:
- By TNF and IL1B/interleukin-1 beta.
- GENATLAS Biochemistry:
- ephrin A-1,eph-related receptor tyrosine kinase,class A,ligand,high affinity,involved in short-range contact-mediated axonal guidance
Phenotypes From GWAS Catalog for EFNA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 8660976 |
| GO:0005515 | protein binding | IPI | 19525919 |
| GO:0046875 | ephrin receptor binding | IPI | 11519828 |
Phenotypes for EFNA1 Gene
- MGI mutant phenotypes for EFNA1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for EFNA1:
Animal Models for EFNA1 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for EFNA1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for EFNA1 - Starting at $85 >
- * EFNA1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for EFNA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EFNA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EFNA1
miRNA for EFNA1 Gene
- miRTarBase miRNAs that target EFNA1
-
- hsa-miR-218-5p (MIRT001058)
- hsa-miR-335-5p (MIRT016724)
- hsa-miR-9-5p (MIRT021322)
- hsa-miR-124-3p (MIRT022145)
- hsa-miR-200c-3p (MIRT053497)
- hsa-miR-30c-2-3p (MIRT059808)
- hsa-miR-187-5p (MIRT059809)
- hsa-miR-185-5p (MIRT059811)
- hsa-miR-30c-1-3p (MIRT059812)
- hsa-miR-1283 (MIRT059814)
- hsa-miR-664a-5p (MIRT059815)
- hsa-miR-3123 (MIRT059816)
- hsa-miR-4306 (MIRT059817)
- hsa-miR-2392 (MIRT059819)
- hsa-miR-4644 (MIRT059820)
- hsa-miR-4794 (MIRT059821)
- hsa-miR-6788-5p (MIRT059823)
- hsa-miR-6871-5p (MIRT059824)
- hsa-miR-6763-5p (MIRT477619)
- hsa-miR-3150a-3p (MIRT477620)
- hsa-miR-6825-5p (MIRT477621)
- hsa-miR-939-5p (MIRT477622)
- hsa-miR-1343-5p (MIRT477623)
- hsa-miR-3175 (MIRT477624)
- hsa-miR-504-3p (MIRT477625)
- hsa-miR-6882-3p (MIRT477626)
- hsa-miR-3189-5p (MIRT477627)
- hsa-miR-4758-3p (MIRT477628)
- hsa-miR-5699-5p (MIRT477629)
- hsa-miR-7155-5p (MIRT477630)
- hsa-miR-637 (MIRT477631)
- hsa-miR-8089 (MIRT477632)
- hsa-miR-4700-5p (MIRT477633)
- hsa-miR-4667-5p (MIRT477634)
- hsa-miR-324-3p (MIRT477635)
- hsa-miR-1913 (MIRT477636)
- hsa-miR-6840-3p (MIRT477637)
- hsa-miR-512-3p (MIRT477638)
- hsa-miR-7851-3p (MIRT477639)
- hsa-miR-6769b-5p (MIRT477640)
- hsa-miR-619-3p (MIRT477641)
- hsa-miR-6769a-5p (MIRT477642)
- hsa-miR-92a-2-5p (MIRT477643)
- hsa-miR-654-5p (MIRT477644)
- hsa-miR-541-3p (MIRT477645)
- hsa-miR-6739-5p (MIRT477646)
- hsa-miR-6733-5p (MIRT477647)
- hsa-miR-3153 (MIRT477648)
- hsa-miR-4668-5p (MIRT477649)
- hsa-miR-873-5p (MIRT477650)
- hsa-miR-4790-3p (MIRT477651)
- hsa-miR-6893-5p (MIRT477652)
- hsa-miR-940 (MIRT477653)
- hsa-miR-6808-5p (MIRT477654)
- hsa-miR-3169 (MIRT477655)
- hsa-miR-3714 (MIRT477656)
- hsa-miR-4484 (MIRT477657)
- hsa-miR-6768-3p (MIRT477658)
- hsa-miR-548an (MIRT477659)
- hsa-miR-6731-5p (MIRT753999)
- hsa-miR-6878-5p (MIRT758202)
- hsa-miR-8085 (MIRT760202)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EFNA1
- Browse OriGene Inhibitory RNA Products For EFNA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EFNA1
Clone products for research
- Applied Biological Materials (abm): Clones for EFNA1 - Starting at $45 >
- * EFNA1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202142
- MG226172
- MR202142
- MR202142L3
- MR202142L4
- MR226172
- MR226172L3
- MR226172L4
- RC210635
- RC210635L1
- RC210635L2
- RC210635L3
- RC210635L4
- RC212122
- RC212122L3
- RC212122L4
- RG210635
- RG212122
- RR202325
- RR202325L3
- RR202325L4
- MR202142L3V
- MR202142L4V
- MR226172L3V
- MR226172L4V
- RC210635L1V
- RC210635L2V
- RC210635L3V
- RC210635L4V
- RC212122L3V
- RC212122L4V
- RR202325L3V
- RR202325L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EFNA1
- Addgene plasmids for EFNA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EFNA1
Cell Lines for research
-
Horizon Cell Lines for EFNA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EFNA1 Gene
Localization for EFNA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EFNA1 Gene
- Cell membrane. Lipid-anchor, GPI-anchor.
- [Ephrin-A1, secreted form]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031225 | anchored component of membrane | IEA | -- |
| GO:0046658 | anchored component of plasma membrane | IEA,IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for EFNA1 Gene
Pathways & Interactions for EFNA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | EPHA forward signaling |
EphrinA-EphR Signaling
.30
|
|
| 2 | EPH-Ephrin signaling |
Cell adhesion Ephrins signaling
.35
|
|
| 3 | Ras signaling pathway | ||
| 4 | Developmental Biology |
.51
|
|
| 5 | Axon guidance | ||
Pathways by source for EFNA1 Gene
5 BioSystems pathways for EFNA1 Gene
5 Reactome pathways for EFNA1 Gene
6 KEGG pathways for EFNA1 Gene
3 GeneGo (Thomson Reuters) pathways for EFNA1 Gene
- Cell adhesion Ephrins signaling
- G-protein signaling_RhoA regulation pathway
- Neurophysiological process Receptor-mediated axon growth repulsion
3 Qiagen pathways for EFNA1 Gene
- EphrinA-EphR Signaling
- Ephrin-Eph Signaling
- Guidance Cues and Growth Cone Motility
Interacting Proteins for EFNA1 Gene
Selected Interacting proteins:
P20827-EFNA1_HUMAN
ENSP00000357392
for EFNA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EFNA1
SIGNOR curated interactions for EFNA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,ISS | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IGI | 24217950 |
| GO:0003180 | aortic valve morphogenesis | IEA,ISS | -- |
| GO:0003183 | mitral valve morphogenesis | IEA,ISS | -- |
Transcripts for EFNA1 Gene
mRNA/cDNA for EFNA1 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368406 1444 nts (view in UCSC)
- ENST00000368407 1552 nts (view in UCSC)
- ENST00000469878 1288 nts (view in UCSC)
- ENST00000474413 1083 nts (view in UCSC)
- ENST00000497282 719 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for EFNA1 - Starting at $85 >
- * EFNA1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for EFNA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EFNA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EFNA1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EFNA1
- Browse OriGene Inhibitory RNA Products For EFNA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EFNA1
Clone products for research
- Applied Biological Materials (abm): Clones for EFNA1 - Starting at $45 >
- * EFNA1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202142
- MG226172
- MR202142
- MR202142L3
- MR202142L4
- MR226172
- MR226172L3
- MR226172L4
- RC210635
- RC210635L1
- RC210635L2
- RC210635L3
- RC210635L4
- RC212122
- RC212122L3
- RC212122L4
- RG210635
- RG212122
- RR202325
- RR202325L3
- RR202325L4
- MR202142L3V
- MR202142L4V
- MR226172L3V
- MR226172L4V
- RC210635L1V
- RC210635L2V
- RC210635L3V
- RC210635L4V
- RC212122L3V
- RC212122L4V
- RR202325L3V
- RR202325L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EFNA1
- Addgene plasmids for EFNA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EFNA1
Relevant External Links for EFNA1 Gene
- GeneLoc Exon Structure for
- EFNA1
Expression for EFNA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Gonad
- Eye (Sensory Organs)
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
-
Somite (Muscoskeletal System)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Pancreas (Endocrine System)
- Mature Beta Cells Islets of Langerhans
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Lung (Respiratory System)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
- Germ Cells (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for EFNA1 Gene
This gene is overexpressed in Liver (x12.7).
This gene is overexpressed in Vitreous humor (21.4), Testis (12.6), Gallbladder (10.3), and Thyroid (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EFNA1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EFNA1
SOURCE GeneReport for Unigene cluster for EFNA1 Gene:
Hs.516664mRNA Expression by UniProt/SwissProt for EFNA1 Gene:
P20827-EFNA1_HUMAN
Tissue specificity:
Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Evidence on tissue expression from TISSUES for EFNA1 Gene
- Liver(4.5)
- Nervous system(3.5)
- Lung(2.9)
- Heart(2.8)
- Intestine(2.8)
- Skin(2.7)
- Kidney(2.6)
- Muscle(2.4)
- Lymph node(2.2)
- Stomach(2.2)
Primer products for research
-
OriGene qPCR primer pairs for EFNA1
-
OriGene qPCR primer pairs and template standards for EFNA1
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EFNA1 Gene
Orthologs for EFNA1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | EFNA1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | EFNA1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | EFNA1 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Efna1 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Efna1 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | EFNA1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | EFNA1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | efna1 29 |
|
||
| Str.196 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | elfa-A-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | efna1a 29 30 |
|
OneToMany | |
| efna1b 30 |
|
OneToMany |
- Species where no ortholog for EFNA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for EFNA1 Gene
- ENSEMBL:
- Gene Tree for EFNA1 (if available)
- TreeFam:
- Gene Tree for EFNA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EFNA1: view image
- Alliance of Genome Resources:
- Additional Orthologs for EFNA1
Paralogs for EFNA1 Gene
Variants for EFNA1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EFNA1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs4745 | -- |
p.Asp159Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.67;
86.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EFNA1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFNA1 Gene
Disorders for EFNA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cortical senile cataract |
|
|
| gastric cancer |
|
|
| breast cancer |
|
|
Search EFNA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EFNA1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for EFNA1 Gene
Publications for EFNA1 Gene
- Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. (PMID: 19525919) Himanen JP … Nikolov DB (EMBO reports 2009) 3 4 22
- Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. (PMID: 17332925) Liu DP … Xie D (International journal of oncology 2007) 3 4 22
- The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. (PMID: 8660976) Cerretti DP … Morris SW (Genomics 1996) 2 3 22
- A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. (PMID: 2233719) Holzman LB … Dixit VM (Molecular and cellular biology 1990) 2 3 4
- Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase. (PMID: 23661698) Ferluga S … Debinski W (The Journal of biological chemistry 2013) 3 4
ExternalLinks
Products for EFNA1 Gene
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- OriGene qPCR primer pairs and template standards for EFNA1
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- MG202142
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- antibodies-online: Show 76 available Ephrin A1 Antibodies ranked by validation data
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- 3 IHC (p) Antibodies (anti-rat)
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- 51 WB Antibodies (anti-human)
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- 3 IHC Antibodies (anti-human)
- antibodies-online: Show 38 available Ephrin A1 Elisa Kits ranked by validation data
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- antibodies-online: Show 30 available Ephrin A1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for EFNA1
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Sources for EFNA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources