Aliases for EFCAB8 Gene

Aliases for EFCAB8 Gene

  • EF-Hand Calcium Binding Domain 8 2 3 5
  • EF-Hand Calcium-Binding Domain-Containing Protein 8 3 4
  • EF-Hand Domain-Containing Protein ENSP00000383366 3

External Ids for EFCAB8 Gene

Previous GeneCards Identifiers for EFCAB8 Gene

  • GC20P030908
  • GC20P031446
  • GC20P028234

Summaries for EFCAB8 Gene

GeneCards Summary for EFCAB8 Gene

EFCAB8 (EF-Hand Calcium Binding Domain 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is WDR64.

Additional gene information for EFCAB8 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EFCAB8 Gene

Genomics for EFCAB8 Gene

GeneHancer (GH) Regulatory Elements for EFCAB8 Gene

Promoters and enhancers for EFCAB8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EFCAB8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EFCAB8

Top Transcription factor binding sites by QIAGEN in the EFCAB8 gene promoter:
  • AML1a
  • c-Myc
  • c-Rel
  • C/EBPalpha
  • CUTL1
  • E2F
  • E2F-1
  • Max1
  • NF-AT
  • NF-AT1

Genomic Locations for EFCAB8 Gene

Genomic Locations for EFCAB8 Gene
chr20:32,858,923-32,961,845
(GRCh38/hg38)
Size:
102,923 bases
Orientation:
Plus strand
chr20:31,446,729-31,549,415
(GRCh37/hg19)
Size:
102,687 bases
Orientation:
Plus strand

Genomic View for EFCAB8 Gene

Genes around EFCAB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFCAB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFCAB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFCAB8 Gene

Proteins for EFCAB8 Gene

  • Protein details for EFCAB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MWE9-EFCB8_HUMAN
    Recommended name:
    EF-hand calcium-binding domain-containing protein 8
    Protein Accession:
    A8MWE9

    Protein attributes for EFCAB8 Gene

    Size:
    144 amino acids
    Molecular mass:
    16428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EFCAB8 Gene

Post-translational modifications for EFCAB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EFCAB8 Gene

Domains & Families for EFCAB8 Gene

Gene Families for EFCAB8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EFCAB8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EFCAB8 Gene

GenScript: Design optimal peptide antigens:
  • EF-hand calcium-binding domain-containing protein 8 (EFCB8_HUMAN)
genes like me logo Genes that share domains with EFCAB8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EFCAB8 Gene

Function for EFCAB8 Gene

Phenotypes From GWAS Catalog for EFCAB8 Gene

Gene Ontology (GO) - Molecular Function for EFCAB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with EFCAB8: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EFCAB8 Gene

Localization for EFCAB8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EFCAB8 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for EFCAB8 Gene

Pathways & Interactions for EFCAB8 Gene

PathCards logo

SuperPathways for EFCAB8 Gene

No Data Available

Interacting Proteins for EFCAB8 Gene

;

Gene Ontology (GO) - Biological Process for EFCAB8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EFCAB8 Gene

Drugs & Compounds for EFCAB8 Gene

No Compound Related Data Available

Transcripts for EFCAB8 Gene

mRNA/cDNA for EFCAB8 Gene

1 REFSEQ mRNAs :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for EFCAB8 Gene

No ASD Table

Relevant External Links for EFCAB8 Gene

GeneLoc Exon Structure for
EFCAB8

Expression for EFCAB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EFCAB8 Gene

mRNA differential expression in normal tissues according to GTEx for EFCAB8 Gene

This gene is overexpressed in Testis (x19.0) and Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for EFCAB8 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EFCAB8 Gene



Protein tissue co-expression partners for EFCAB8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EFCAB8

genes like me logo Genes that share expression patterns with EFCAB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EFCAB8 Gene

Orthologs for EFCAB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EFCAB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFCAB8 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC151671 31
  • 11 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Efcab8 31
  • 6 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 4 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 3 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EFCAB8 31
  • 1 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFCAB8 31
  • 10 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG40583 31
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 9 (a)
OneToMany
Species where no ortholog for EFCAB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EFCAB8 Gene

ENSEMBL:
Gene Tree for EFCAB8 (if available)
TreeFam:
Gene Tree for EFCAB8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EFCAB8: view image

Paralogs for EFCAB8 Gene

genes like me logo Genes that share paralogs with EFCAB8: view

Variants for EFCAB8 Gene

Additional dbSNP identifiers (rs#s) for EFCAB8 Gene

Variation tolerance for EFCAB8 Gene

Gene Damage Index Score: 7.81; 83.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EFCAB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EFCAB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for EFCAB8 Gene

Disorders for EFCAB8 Gene

Additional Disease Information for EFCAB8

No disorders were found for EFCAB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFCAB8 Gene

Publications for EFCAB8 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 54

Products for EFCAB8 Gene

Sources for EFCAB8 Gene