Aliases for EFCAB14 Gene
Aliases for EFCAB14 Gene
External Ids for EFCAB14 Gene
- HGNC: 29051
- Entrez Gene: 9813
- Ensembl: ENSG00000159658
- UniProtKB: O75071
Previous HGNC Symbols for EFCAB14 Gene
- KIAA0494
Previous GeneCards Identifiers for EFCAB14 Gene
- GC01M047125
Summaries for EFCAB14 Gene
GeneCards Summary for EFCAB14 Gene
EFCAB14 (EF-Hand Calcium Binding Domain 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding.
Additional gene information for EFCAB14 Gene
- Monarch Initiative
- Search for EFCAB14 at DataMed
- Search for EFCAB14 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFCAB14 Gene
Genomics for EFCAB14 Gene
GeneHancer (GH) Regulatory Elements for EFCAB14 Gene
Promoters and enhancers for EFCAB14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around EFCAB14 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for EFCAB14 Gene
Genomic Locations for EFCAB14 Gene
- chr1:46,675,159-46,719,064
- (GRCh38/hg38)
- Size:
- 43,906 bases
- Orientation:
- Minus strand
- chr1:47,124,366-47,184,824
- (GRCh37/hg19)
- Size:
- 60,459 bases
- Orientation:
- Minus strand
Genomic View for EFCAB14 Gene
Genes around EFCAB14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p33 by Entrez Gene
- 1p33 by HGNC
- 1p33 by Ensembl
EFCAB14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EFCAB14 Gene
Proteins for EFCAB14 Gene
-
Protein details for EFCAB14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75071-EFC14_HUMAN
- Recommended name:
- EF-hand calcium-binding domain-containing protein 14
- Protein Accession:
- O75071
- D3DQ23
- Q5SXB8
Protein attributes for EFCAB14 Gene
- Size:
- 495 amino acids
- Molecular mass:
- 55031 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA32328.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for EFCAB14 Gene
Post-translational modifications for EFCAB14 Gene
Other Protein References for EFCAB14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for EFCAB14
- Invitrogen Antibodies for EFCAB14
- GeneTex EFCAB14 Antibody for EFCAB14
-
Boster Bio Antibodies for EFCAB14
Protein Products
-
OriGene Purified Proteins for EFCAB14
- Search Origene for MassSpec and Protein Over-expression Lysates for EFCAB14
- Origene Custom Protein Services for EFCAB14
- Search GeneTex for Proteins for EFCAB14
-
Abcam proteins for EFCAB14
Assay Products
No data available for DME Specific Peptides for EFCAB14 Gene
Domains & Families for EFCAB14 Gene
Gene Families for EFCAB14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for EFCAB14 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for EFCAB14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for EFCAB14 Gene
Function for EFCAB14 Gene
Phenotypes From GWAS Catalog for EFCAB14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 27107014 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for EFCAB14 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EFCAB14
-
CRISPR Products
-
OriGene CRISPR knockouts for EFCAB14
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- genomics-online: gRNA clones - Search results for available KIAA0494 gene related products
- Applied Biological Materials CRISPR for EFCAB14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EFCAB14
- GenScript: Design CRISPR guide RNA sequences for EFCAB14
miRNA for EFCAB14 Gene
- miRTarBase miRNAs that target EFCAB14
-
- hsa-mir-374b-5p (MIRT016057)
- hsa-mir-590-3p (MIRT016201)
- hsa-mir-130b-3p (MIRT020278)
- hsa-mir-106b-5p (MIRT020481)
- hsa-mir-9-5p (MIRT021407)
- hsa-mir-93-5p (MIRT028181)
- hsa-mir-615-3p (MIRT039902)
- hsa-mir-149-5p (MIRT045631)
- hsa-let-7b-5p (MIRT051951)
- hsa-mir-3163 (MIRT071023)
- hsa-mir-32-3p (MIRT138871)
- hsa-mir-6826-3p (MIRT138920)
- hsa-mir-7856-5p (MIRT138926)
- hsa-mir-20a-5p (MIRT440391)
- hsa-mir-4477b (MIRT558208)
- hsa-mir-5047 (MIRT558209)
- hsa-mir-1301-3p (MIRT558210)
- hsa-mir-340-5p (MIRT558211)
- hsa-mir-3944-5p (MIRT558212)
- hsa-mir-4660 (MIRT558213)
- hsa-mir-4735-5p (MIRT558214)
- hsa-mir-519c-3p (MIRT558215)
- hsa-mir-519b-3p (MIRT558216)
- hsa-mir-519a-3p (MIRT558217)
- hsa-mir-3910 (MIRT558218)
- hsa-mir-3714 (MIRT558219)
- hsa-mir-4796-3p (MIRT558220)
- hsa-mir-548ah-5p (MIRT558221)
- hsa-mir-3609 (MIRT558222)
- hsa-mir-548t-5p (MIRT558223)
- hsa-mir-548az-5p (MIRT558224)
- hsa-mir-548n (MIRT558225)
- hsa-mir-5590-3p (MIRT558226)
- hsa-mir-142-5p (MIRT558227)
- hsa-mir-506-3p (MIRT558228)
- hsa-mir-124-3p (MIRT558229)
- hsa-mir-526b-3p (MIRT562424)
- hsa-mir-519d-3p (MIRT562425)
- hsa-mir-20b-5p (MIRT562426)
- hsa-mir-106a-5p (MIRT562427)
- hsa-mir-17-5p (MIRT562428)
- hsa-mir-4446-5p (MIRT628252)
- hsa-mir-3674 (MIRT628253)
- hsa-mir-3679-3p (MIRT628254)
- hsa-mir-498 (MIRT628255)
- hsa-mir-4465 (MIRT628256)
- hsa-mir-26b-5p (MIRT628257)
- hsa-mir-26a-5p (MIRT628258)
- hsa-mir-1297 (MIRT628259)
- hsa-mir-4703-3p (MIRT628260)
- hsa-mir-6756-3p (MIRT628261)
- hsa-mir-3127-3p (MIRT628262)
- hsa-mir-5001-3p (MIRT704004)
- hsa-mir-4711-3p (MIRT704005)
- hsa-mir-6740-3p (MIRT704006)
- hsa-mir-4424 (MIRT704007)
- hsa-mir-676-5p (MIRT704008)
- hsa-mir-520h (MIRT704009)
- hsa-mir-520g-3p (MIRT704010)
- hsa-mir-3973 (MIRT704011)
- hsa-mir-4735-3p (MIRT704012)
- hsa-mir-4686 (MIRT704013)
- hsa-mir-18b-5p (MIRT704014)
- hsa-mir-6507-5p (MIRT704015)
- hsa-mir-18a-5p (MIRT704016)
- hsa-mir-548l (MIRT704017)
- hsa-mir-181c-5p (MIRT727371)
- hsa-mir-181d-5p (MIRT727372)
- hsa-mir-181b-5p (MIRT727373)
- hsa-mir-181a-5p (MIRT727374)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EFCAB14
- Browse OriGene Inhibitory RNA Products For EFCAB14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EFCAB14
- genomics-online: shRNA clones - Search results for available KIAA0494 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EFCAB14
- VectorBuilder custom plasmid, inducible vectors for EFCAB14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EFCAB14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EFCAB14
- genomics-online: cdna clones - Search results for available KIAA0494 gene related products
- orf clones - Search results for available KIAA0494 gene related products
- Applied Biological Materials Clones for EFCAB14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EFCAB14
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EFCAB14 Gene
Localization for EFCAB14 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
- Golgi apparatus (2)
- Nucleoli (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EFCAB14 Gene
Pathways & Interactions for EFCAB14 Gene
No Data Available
Interacting Proteins for EFCAB14 Gene
GPS-Prot Interaction Network for EFCAB14
No data available for Pathways by source and SIGNOR curated interactions for EFCAB14 Gene
Transcripts for EFCAB14 Gene
mRNA/cDNA for EFCAB14 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (722) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000371933 5767 bps (uc001cqk.4)
- ENST00000479745 804 bps (uc057ggg.1)
- ENST00000487741 784 bps (uc057ggh.1)
- ENST00000481623 614 bps (uc057ggi.1)
- ENST00000459797 278 bps (uc057ggj.1)
Unigene Clusters for EFCAB14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EFCAB14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EFCAB14
- genomics-online: gRNA clones - Search results for available KIAA0494 gene related products
- Applied Biological Materials CRISPR for EFCAB14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EFCAB14
- GenScript: Design CRISPR guide RNA sequences for EFCAB14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EFCAB14
- Browse OriGene Inhibitory RNA Products For EFCAB14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EFCAB14
- genomics-online: shRNA clones - Search results for available KIAA0494 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EFCAB14
- VectorBuilder custom plasmid, inducible vectors for EFCAB14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EFCAB14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EFCAB14
- genomics-online: cdna clones - Search results for available KIAA0494 gene related products
- orf clones - Search results for available KIAA0494 gene related products
- Applied Biological Materials Clones for EFCAB14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - |
Expression for EFCAB14 Gene
This gene is overexpressed in Adipocyte (58.1) and Testis (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EFCAB14 Gene
NURSA nuclear receptor signaling pathways regulating expression of EFCAB14 Gene:
EFCAB14SOURCE GeneReport for Unigene cluster for EFCAB14 Gene:
Hs.707688Evidence on tissue expression from TISSUES for EFCAB14 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for EFCAB14
-
OriGene qPCR primer pairs for EFCAB14
- genomics-online: primer clones - Search results for available KIAA0494 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EFCAB14 Gene
Orthologs for EFCAB14 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EFCAB14 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EFCAB14 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EFCAB14 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Efcab14 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Efcab14 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EFCAB14 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | EFCAB14 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KIAA0494 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | EFCAB14 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | efcab14 33 |
|
||
| Str.5946 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.22643 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:77197 33 |
|
- Species where no ortholog for EFCAB14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for EFCAB14 Gene
- ENSEMBL:
- Gene Tree for EFCAB14 (if available)
- TreeFam:
- Gene Tree for EFCAB14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EFCAB14: view image
Paralogs for EFCAB14 Gene
Pseudogenes.org Pseudogenes for EFCAB14 Gene
No data available for Paralogs for EFCAB14 Gene
Variants for EFCAB14 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006868 | -- | 46,712,561(-) | T/C | intron_variant | |
| rs1000033855 | -- | 46,720,359(-) | C/T | upstream_transcript_variant | |
| rs1000113893 | -- | 46,713,240(-) | A/G | intron_variant | |
| rs1000267119 | -- | 46,676,706(-) | G/C | 3_prime_UTR_variant | |
| rs1000317861 | -- | 46,720,196(-) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.24;
52.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EFCAB14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EFCAB14
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EFCAB14 Gene
Disorders for EFCAB14 Gene
Additional Disease Information for EFCAB14
No disorders were found for EFCAB14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFCAB14 Gene
Publications for EFCAB14 Gene
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
- Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J … Colwill K (Science signaling 2015) 3 58
Products for EFCAB14 Gene
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- VectorBuilder custom plasmid, inducible vectors for EFCAB14
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- GeneTex EFCAB14 Antibody for EFCAB14
- Search GeneTex for Proteins for EFCAB14
- Horizon Cell Lines for EFCAB14
- genomics-online: cdna clones - Search results for available KIAA0494 gene related products
- orf clones - Search results for available KIAA0494 gene related products
- genomics-online: gRNA clones - Search results for available KIAA0494 gene related products
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- genomics-online: shRNA clones - Search results for available KIAA0494 gene related products
- Browse GeneCopoeia Cell Lines
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Sources for EFCAB14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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