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Aliases for EFCAB10 Gene

Aliases for EFCAB10 Gene

  • EF-Hand Calcium Binding Domain 10 2 3 5
  • EF-Hand Calcium-Binding Domain-Containing Protein 10 3
  • EF-Hand Domain-Containing Protein 3

External Ids for EFCAB10 Gene

Previous GeneCards Identifiers for EFCAB10 Gene

  • GC07M104997
  • GC07M105205
  • GC07M099563

Summaries for EFCAB10 Gene

GeneCards Summary for EFCAB10 Gene

EFCAB10 (EF-Hand Calcium Binding Domain 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

Additional gene information for EFCAB10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFCAB10 Gene

Genomics for EFCAB10 Gene

GeneHancer (GH) Regulatory Elements for EFCAB10 Gene

Promoters and enhancers for EFCAB10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J105580 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.4 +19.5 19493 0.9 ARID4B NEUROD1 SIN3A ZNF2 YY1 GLIS2 ZNF207 RXRA MXD4 REST EFCAB10 ENSG00000272604 YBX1P2
GH07J105600 Promoter 1 EPDnew 650.7 0.0 -37 0.1 NFATC3 NFRKB TAL1 IRF9 TCF12 ZNF766 POLR2A VEZF1 ZSCAN5C TRIM24 EFCAB10 PIR36718
GH07J105601 Enhancer 0.7 ENCODE 650.7 -0.3 -334 0.2 NFATC3 TAL1 IRF9 TCF12 CTBP1 ZNF766 ELK1 VEZF1 TRIM24 L3MBTL2 EFCAB10 PIR36718
GH07J105602 Enhancer 0.5 ENCODE 650.7 -0.5 -492 0.2 MEF2D CTBP1 ZNF766 ELK1 MNT ZNF395 EFCAB10 PIR36718
GH07J105643 Enhancer 1 ENCODE dbSUPER 11 -43.2 -43163 1.5 HDAC1 PKNOX1 ATF1 SIN3A TCF12 ZNF143 ATF7 CREM ZBTB11 REST EFCAB10 PIR36718 ATXN7L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EFCAB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EFCAB10 gene promoter:
  • POU2F1a
  • POU2F1
  • Nkx2-2
  • FOXD3
  • MIF-1
  • AML1a
  • ATF-2
  • Elk-1
  • Evi-1
  • ATF6

Genomic Locations for EFCAB10 Gene

Genomic Locations for EFCAB10 Gene
chr7:105,565,120-105,600,875
(GRCh38/hg38)
Size:
35,756 bases
Orientation:
Minus strand
chr7:105,205,567-105,241,322
(GRCh37/hg19)
Size:
35,756 bases
Orientation:
Minus strand

Genomic View for EFCAB10 Gene

Genes around EFCAB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFCAB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFCAB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFCAB10 Gene

Proteins for EFCAB10 Gene

  • Protein details for EFCAB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFE3-EFC10_HUMAN
    Recommended name:
    EF-hand calcium-binding domain-containing protein 10
    Protein Accession:
    A6NFE3

    Protein attributes for EFCAB10 Gene

    Size:
    127 amino acids
    Molecular mass:
    14721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EFCAB10 Gene

Post-translational modifications for EFCAB10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for EFCAB10 Gene

Domains & Families for EFCAB10 Gene

Gene Families for EFCAB10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EFCAB10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EFCAB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EFCAB10: view

No data available for UniProtKB/Swiss-Prot for EFCAB10 Gene

Function for EFCAB10 Gene

Phenotypes From GWAS Catalog for EFCAB10 Gene

Gene Ontology (GO) - Molecular Function for EFCAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with EFCAB10: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EFCAB10 Gene

Localization for EFCAB10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EFCAB10 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for EFCAB10 Gene

Pathways & Interactions for EFCAB10 Gene

SuperPathways for EFCAB10 Gene

No Data Available

Interacting Proteins for EFCAB10 Gene

Gene Ontology (GO) - Biological Process for EFCAB10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EFCAB10 Gene

Drugs & Compounds for EFCAB10 Gene

No Compound Related Data Available

Transcripts for EFCAB10 Gene

mRNA/cDNA for EFCAB10 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFCAB10 Gene

EF-hand calcium binding domain 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EFCAB10 Gene

No ASD Table

Relevant External Links for EFCAB10 Gene

GeneLoc Exon Structure for
EFCAB10
ECgene alternative splicing isoforms for
EFCAB10

Expression for EFCAB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EFCAB10 Gene

mRNA differential expression in normal tissues according to GTEx for EFCAB10 Gene

This gene is overexpressed in Testis (x25.1).

NURSA nuclear receptor signaling pathways regulating expression of EFCAB10 Gene:

EFCAB10

SOURCE GeneReport for Unigene cluster for EFCAB10 Gene:

Hs.719432
genes like me logo Genes that share expression patterns with EFCAB10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EFCAB10 Gene

Orthologs for EFCAB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFCAB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFCAB10 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFCAB10 34
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efcab10 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFCAB10 34
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EFCAB10 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves EFCAB10 34
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFCAB10 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii EFCAB10 34
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for EFCAB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFCAB10 Gene

ENSEMBL:
Gene Tree for EFCAB10 (if available)
TreeFam:
Gene Tree for EFCAB10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EFCAB10: view image

Paralogs for EFCAB10 Gene

No data available for Paralogs for EFCAB10 Gene

Variants for EFCAB10 Gene

Sequence variations from dbSNP and Humsavar for EFCAB10 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs144371182 likely-benign, not specified 105,565,638(-) T/C intron_variant
rs758183598 likely-benign, not specified 105,567,125(-) A/G intron_variant
rs765770922 likely-benign, not specified 105,565,598(-) T/C intron_variant
rs1060503044 uncertain-significance, not specified 105,565,314(-) A/T non_coding_transcript_variant
rs1060503046 uncertain-significance, not specified 105,567,294(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EFCAB10 Gene

Variant ID Type Subtype PubMed ID
esv2759549 CNV gain 17122850
nsv464668 CNV gain 19166990
nsv608069 CNV gain 21841781

Variation tolerance for EFCAB10 Gene

Gene Damage Index Score: 0.62; 13.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EFCAB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EFCAB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFCAB10 Gene

Disorders for EFCAB10 Gene

Additional Disease Information for EFCAB10

No disorders were found for EFCAB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFCAB10 Gene

Publications for EFCAB10 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  2. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. (PMID: 24322204) Winham SJ … Biernacka JM (Molecular psychiatry 2014) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for EFCAB10 Gene

Sources for EFCAB10 Gene

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