Aliases for EEF2K Gene
External Ids for EEF2K Gene
Previous GeneCards Identifiers for EEF2K Gene
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
GeneCards Summary for EEF2K Gene
EEF2K (Eukaryotic Elongation Factor 2 Kinase) is a Protein Coding gene. Diseases associated with EEF2K include Chief Cell Adenoma. Among its related pathways are Oxytocin signaling pathway and BDNF-TrkB Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is ALPK2.
UniProtKB/Swiss-Prot Summary for EEF2K Gene
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.