Aliases for EEF2K Gene
External Ids for EEF2K Gene
Previous GeneCards Identifiers for EEF2K Gene
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
GeneCards Summary for EEF2K Gene
EEF2K (Eukaryotic Elongation Factor 2 Kinase) is a Protein Coding gene. Diseases associated with EEF2K include Anoxia and Chief Cell Adenoma. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is HSPA12B.
UniProtKB/Swiss-Prot Summary for EEF2K Gene
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.