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This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is EFTUD2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0002039 | p53 binding | IEA | -- |
GO:0003723 | RNA binding | IEA,HDA | 22658674 |
GO:0003746 | translation elongation factor activity | IBA | 21873635 |
GO:0003924 | GTPase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IEA,HDA | 21630459 |
GO:0005737 | cytoplasm | IEA,IDA | 25064856 |
GO:0005829 | cytosol | TAS | -- |
GO:0005844 | polysome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
2 | Viral mRNA Translation |
.77
|
|
3 | Innate Immune System |
.61
|
|
4 | HIV Life Cycle |
.45
|
|
5 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
GO:0002931 | response to ischemia | IEA | -- |
GO:0003009 | skeletal muscle contraction | IEA | -- |
GO:0006412 | translation | IEA | -- |
GO:0006414 | translational elongation | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Esketamine | Approved, Investigational | Pharma | Target, inhibitor | 65 | ||
Moxetumomab Pasudotox | Approved, Investigational | Pharma | Target, inactivator | 0 | ||
Water | Approved | Pharma | 0 | |||
Guanosine diphosphate | Experimental | Pharma | Target | 0 | ||
Diphthamide | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | |||||||||||
SP3: | |||||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: | |||||||||||
SP7: | - | - | - | - | - | ||||||
SP8: | - | - | |||||||||
SP9: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EEF2 31 |
|
OneToOne | |
LOC100614367 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | EEF2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EEF2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EEF2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Eef2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Eef2 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | EEF2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EEF2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eef2.1 30 |
|
||
MGC76191 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | eef2-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | eef2l2 31 |
|
OneToOne | |
eef2b 30 |
|
||||
zgc63584 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9660 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009441 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ef2b 30 31 32 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | eft-2 32 |
|
|
|
eef-2 30 31 |
|
ManyToMany | |||
K10C3.5 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EFT2 31 33 |
|
OneToMany | |
EFT1 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | LOS1 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6678 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.10782 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0742200 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.5736 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11302 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712228 | Benign/Likely Benign: not provided | 3,976,635(-) | G/A | SYNONYMOUS_VARIANT | |
715322 | Likely Benign: not provided | 3,978,017(-) | G/A | SYNONYMOUS_VARIANT | |
715638 | Benign: not provided | 3,976,671(-) | C/G | SYNONYMOUS_VARIANT | |
717754 | Benign/Likely Benign: not provided | 3,982,975(-) | G/A | SYNONYMOUS_VARIANT | |
718576 | Benign: not provided | 3,979,871(-) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia 26 |
|
|
diphtheria |
|
|
myotonic dystrophy 2 |
|
|
subacute glomerulonephritis |
|
|
refractory hematologic cancer |
|
|