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This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008] See more...
Aliases for EEF2 Gene
Aliases for EEF2 Gene
External Ids for EEF2 Gene
- HGNC: 3214
- Entrez Gene: 1938
- Ensembl: ENSG00000167658
- OMIM: 130610
- UniProtKB: P13639
Previous HGNC Symbols for EEF2 Gene
- EF2
Previous GeneCards Identifiers for EEF2 Gene
- GC19M004066
- GC19M003916
- GC19M003927
- GC19M003738
Summaries for EEF2 Gene
-
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
GeneCards Summary for EEF2 Gene
EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is EFTUD2.
UniProtKB/Swiss-Prot Summary for EEF2 Gene
-
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Additional gene information for EEF2 Gene
- HGNC(3214)
- Entrez Gene(1938)
- Ensembl(ENSG00000167658)
- OMIM(130610)
- UniProtKB(P13639)
- Open Targets Platform(ENSG00000167658)
- Monarch Initiative
- Search for EEF2 at DataMed
- Search for EEF2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EEF2 Gene
Genomics for EEF2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EEF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EEF2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EEF2
- Top Transcription factor binding sites by QIAGEN in the EEF2 gene promoter:
-
- c-Myb
- C/EBPalpha
- p53
- Sp1
- STAT5A
- TBP
- YY1
Genomic Locations for EEF2 Gene
Genomic Locations for EEF2 Gene
- chr19:3,976,056-3,985,463
- (GRCh38/hg38)
- Size:
- 9,408 bases
- Orientation:
- Minus strand
- chr19:3,976,054-3,985,467
- (GRCh37/hg19)
- Size:
- 9,414 bases
- Orientation:
- Minus strand
Genomic View for EEF2 Gene
Genes around EEF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by HGNC
- 19p13.3 by Entrez Gene
- 19p13.3 by Ensembl
EEF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EEF2 Gene
Proteins for EEF2 Gene
-
Protein details for EEF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13639-EF2_HUMAN
- Recommended name:
- Elongation factor 2
- Protein Accession:
- P13639
- B2RMP5
- D6W618
- Q58J86
Protein attributes for EEF2 Gene
- Size:
- 858 amino acids
- Molecular mass:
- 95338 Da
- Quaternary structure:
-
- Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9 (PubMed:19417104). Interacts with RBPMS2 (PubMed:25064856).
Protein Expression for EEF2 Gene
Post-translational modifications for EEF2 Gene
- Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
- Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).
- (Microbial infection) Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis.
- ISGylated.
- Proteolytically processed at two sites following phosphorylation by CSK.
- SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.
-
Ubiquitination at Lys32, Lys42, Lys152, Lys159, Lys235, Lys239, Lys272, Lys275, Lys318, Lys333, Lys366, Lys386, Lys426, Lys481, Lys498, Lys512, Lys594, Lys638, Lys648, Lys688, and Lys845
- NX_P13639 (NX_P13639-1)
- Modification sites at PhosphoSitePlus
Other Protein References for EEF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ EEF2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for EEF2
- Novus Biologicals Antibodies for EEF2
-
Abcam antibodies for EEF2
- Invitrogen Antibodies for EEF2 (AFLGC-EEF2)
- antibodies-online: Show 82 available EEF2 Antibodies ranked by validation data
- Compare Top EEF2 Antibodies
-
Recommended
- 115 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 57 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Boster Bio Antibodies for EEF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for EEF2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for EEF2
- Origene Custom Protein Services for EEF2
- ProSpec Recombinant Proteins for EEF2
-
Abcam proteins for EEF2
No data available for DME Specific Peptides for EEF2 Gene
Domains & Families for EEF2 Gene
Gene Families for EEF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EEF2 Gene
- InterPro:
- Blocks:
-
- Elongation factor G, C-terminal
- Elongation factor G, domain IV
- ProtoNet:
Suggested Antigen Peptide Sequences for EEF2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60696, highly similar to Elongation factor 2 (B4DMC6_HUMAN)
- cDNA FLJ56548, highly similar to Elongation factor 2 (B4DPU3_HUMAN)
- Elongation factor 2 (EF2_HUMAN)
- EEF2 protein (Q6PK56_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13639UniProtKB/Swiss-Prot:
EF2_HUMAN :- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
- Family:
-
- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Function for EEF2 Gene
Molecular function for EEF2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
- GENATLAS Biochemistry:
- eukaryotic translation elongation factor 2
Phenotypes From GWAS Catalog for EEF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0002039 | p53 binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0003746 | translation elongation factor activity | IBA | 21873635 |
| GO:0003924 | GTPase activity | IBA | 21873635 |
Phenotypes for EEF2 Gene
- MGI mutant phenotypes for EEF2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for EEF2:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Increased shRNA abundance
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability in colon lineage
- Increased cell number in S
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EEF2 - Select products 50% OFF >
- * EEF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EEF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EEF2
miRNA for EEF2 Gene
- miRTarBase miRNAs that target EEF2
-
- hsa-miR-16-5p (MIRT031753)
- hsa-miR-1229-3p (MIRT036266)
- hsa-miR-296-3p (MIRT038365)
- hsa-miR-99b-3p (MIRT038532)
- hsa-miR-92a-1-5p (MIRT038923)
- hsa-miR-769-3p (MIRT039112)
- hsa-miR-615-3p (MIRT039659)
- hsa-miR-589-3p (MIRT040505)
- hsa-miR-193b-3p (MIRT041593)
- hsa-miR-484 (MIRT041660)
- hsa-miR-324-3p (MIRT042856)
- hsa-miR-342-3p (MIRT043730)
- hsa-miR-99b-5p (MIRT044210)
- hsa-miR-320a (MIRT044535)
- hsa-miR-186-5p (MIRT045161)
- hsa-miR-185-5p (MIRT045338)
- hsa-miR-222-3p (MIRT046806)
- hsa-miR-10a-5p (MIRT047726)
- hsa-miR-196a-5p (MIRT048271)
- hsa-miR-92a-3p (MIRT049005)
- hsa-miR-30a-5p (MIRT049963)
- hsa-miR-18a-5p (MIRT050660)
- hsa-let-7b-5p (MIRT051895)
- hsa-let-7a-5p (MIRT052441)
- hsa-miR-4433b-5p (MIRT502532)
- hsa-miR-6741-5p (MIRT502533)
- hsa-miR-4701-3p (MIRT502534)
- hsa-miR-6736-5p (MIRT502535)
- hsa-miR-1262 (MIRT502536)
- hsa-miR-642a-5p (MIRT502537)
- hsa-miR-3147 (MIRT502538)
- hsa-miR-4425 (MIRT502539)
- hsa-miR-3657 (MIRT502540)
- hsa-miR-4433a-5p (MIRT502541)
- hsa-miR-609 (MIRT502542)
- hsa-miR-4455 (MIRT502543)
- hsa-miR-6772-5p (MIRT502544)
- hsa-miR-6124 (MIRT502545)
- hsa-miR-3148 (MIRT502546)
- hsa-miR-3185 (MIRT502547)
- hsa-miR-146a-3p (MIRT502548)
- hsa-miR-2276-5p (MIRT502549)
- hsa-miR-6892-3p (MIRT502550)
- hsa-miR-3688-3p (MIRT502551)
- hsa-miR-5680 (MIRT502552)
- hsa-miR-4694-3p (MIRT502553)
- hsa-miR-548t-5p (MIRT502554)
- hsa-miR-548az-5p (MIRT502555)
- hsa-miR-4446-5p (MIRT511986)
- hsa-miR-5006-3p (MIRT511987)
- hsa-miR-4755-5p (MIRT511988)
- hsa-miR-488-3p (MIRT548480)
- hsa-miR-5093 (MIRT548481)
- hsa-miR-1299 (MIRT548482)
- hsa-miR-4522 (MIRT548483)
- hsa-miR-6128 (MIRT548484)
- hsa-miR-875-3p (MIRT548485)
- hsa-miR-518c-5p (MIRT548486)
- hsa-miR-514a-5p (MIRT548487)
- hsa-miR-7850-5p (MIRT562429)
- hsa-miR-4529-3p (MIRT562430)
- hsa-miR-4520-2-3p (MIRT562431)
- hsa-miR-2053 (MIRT562432)
- hsa-miR-4520-3p (MIRT562433)
- hsa-miR-8068 (MIRT562434)
- hsa-miR-6854-3p (MIRT562435)
- hsa-miR-4682 (MIRT562436)
- hsa-miR-3200-5p (MIRT562437)
- hsa-miR-4282 (MIRT562438)
- hsa-miR-155-5p (MIRT562439)
- hsa-miR-1266-5p (MIRT736702)
- hsa-miR-1343-5p (MIRT737460)
- hsa-miR-3664-3p (MIRT742021)
- hsa-miR-3925-3p (MIRT742991)
- hsa-miR-4518 (MIRT745775)
- hsa-miR-6090 (MIRT752034)
- hsa-miR-6798-5p (MIRT756256)
- hsa-miR-6800-3p (MIRT756355)
- hsa-miR-766-3p (MIRT759606)
- hsa-miR-939-5p (MIRT760751)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EEF2
- Browse OriGene Inhibitory RNA Products For EEF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF2
Clone Products
- Applied Biological Materials (abm): Clones for EEF2 - Select products 50% OFF >
- * EEF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for EEF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF2
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF2 Gene
Localization for EEF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EEF2 Gene
- Cytoplasm. Nucleus. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269 PubMed:24648518}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| golgi apparatus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
- Cytosol (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IEA,HDA | 21630459 |
| GO:0005737 | cytoplasm | IEA,IDA | 25064856 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005844 | polysome | IEA | -- |
Pathways & Interactions for EEF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 2 | Viral mRNA Translation |
.77
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
Pathways by source for EEF2 Gene
1 Sino Biological pathway for EEF2 Gene
4 BioSystems pathways for EEF2 Gene
16 Reactome pathways for EEF2 Gene
2 KEGG pathways for EEF2 Gene
3 GeneGo (Thomson Reuters) pathways for EEF2 Gene
- Regulation of lipid metabolism Insulin signaling-generic cascades
- Translation Insulin regulation of translation
- Translation Translation regulation by Alpha-1 adrenergic receptors
1 R&D Systems pathway for EEF2 Gene
2 Qiagen pathways for EEF2 Gene
- Insulin Receptor Pathway
- p70S6K Signaling
1 Cell Signaling Technology pathway for EEF2 Gene
Interacting Proteins for EEF2 Gene
Selected Interacting proteins:
P13639-EF2_HUMAN
ENSP00000307940
for EEF2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EEF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
| GO:0002931 | response to ischemia | IEA | -- |
| GO:0003009 | skeletal muscle contraction | IEA | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006414 | translational elongation | TAS | -- |
Drugs & Compounds for EEF2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Esketamine | Approved, Investigational | Pharma | Target, inhibitor | 65 | ||
| Moxetumomab Pasudotox | Approved, Investigational | Pharma | Target, inactivator | 0 | ||
| Water | Approved | Pharma | 0 | |||
| Guanosine diphosphate | Experimental | Pharma | Target | 0 | ||
| Diphthamide | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Transcripts for EEF2 Gene
mRNA/cDNA for EEF2 Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000600794 352 nts (view in UCSC)
- ENST00000309311 3158 nts (view in UCSC)
- ENST00000596417 218 nts (view in UCSC)
- ENST00000598182 581 nts (view in UCSC)
- ENST00000598436 549 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EEF2 - Select products 50% OFF >
- * EEF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EEF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EEF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EEF2
- Browse OriGene Inhibitory RNA Products For EEF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF2
Clone Products
- Applied Biological Materials (abm): Clones for EEF2 - Select products 50% OFF >
- * EEF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for EEF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | - | - | - | - | - | ||||||
| SP8: | - | - | |||||||||
| SP9: |
Relevant External Links for EEF2 Gene
- GeneLoc Exon Structure for
- EEF2
Expression for EEF2 Gene
This gene is overexpressed in Lymph node (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EEF2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EEF2
SOURCE GeneReport for Unigene cluster for EEF2 Gene:
Hs.515070Evidence on tissue expression from TISSUES for EEF2 Gene
- Nervous system(5)
- Liver(4.8)
- Intestine(4.8)
- Blood(4.7)
- Lung(4.5)
- Muscle(4.4)
- Heart(4.3)
- Stomach(4.2)
- Kidney(4.1)
- Skin(4.1)
- Thyroid gland(3.8)
- Eye(3.6)
- Pancreas(3.5)
- Spleen(3.3)
- Lymph node(3.3)
- Bone marrow(3.2)
- Adrenal gland(3.1)
- Gall bladder(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- head
Limb:
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for EEF2
-
OriGene qPCR primer pairs and template standards for EEF2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEF2 Gene
Orthologs for EEF2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | EEF2 31 |
|
OneToOne | |
| LOC100614367 30 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | EEF2 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | EEF2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | EEF2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Eef2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Eef2 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | EEF2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | EEF2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eef2.1 30 |
|
||
| MGC76191 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | eef2-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | eef2l2 31 |
|
OneToOne | |
| eef2b 30 |
|
||||
| zgc63584 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9660 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009441 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ef2b 30 31 32 |
|
ManyToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | eft-2 32 |
|
|
|
| eef-2 30 31 |
|
ManyToMany | |||
| K10C3.5 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EFT2 31 33 |
|
OneToMany | |
| EFT1 33 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | LOS1 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6678 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.10782 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0742200 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.5736 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11302 31 |
|
ManyToMany |
- Species where no ortholog for EEF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for EEF2 Gene
- ENSEMBL:
- Gene Tree for EEF2 (if available)
- TreeFam:
- Gene Tree for EEF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EEF2: view image
Paralogs for EEF2 Gene
Paralogs for EEF2 Gene
(3) SIMAP similar genes for EEF2 Gene using alignment to 3 proteins:
- EF2_HUMAN
- M0R0I6_HUMAN
- Q6PK56_HUMAN
Variants for EEF2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EEF2 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 712228 | Benign/Likely Benign: not provided | 3,976,635(-) | G/A | SYNONYMOUS_VARIANT | |
| 715322 | Likely Benign: not provided | 3,978,017(-) | G/A | SYNONYMOUS_VARIANT | |
| 715638 | Benign: not provided | 3,976,671(-) | C/G | SYNONYMOUS_VARIANT | |
| 717754 | Benign/Likely Benign: not provided | 3,982,975(-) | G/A | SYNONYMOUS_VARIANT | |
| 718576 | Benign: not provided | 3,979,871(-) | C/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
0.879% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.37;
8.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EEF2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF2 Gene
Disorders for EEF2 Gene
(13) MalaCards diseases for EEF2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia 26 |
|
|
| diphtheria |
|
|
| myotonic dystrophy 2 |
|
|
| subacute glomerulonephritis |
|
|
| refractory hematologic cancer |
|
|
Search EEF2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EF2_HUMAN- Spinocerebellar ataxia 26 (SCA26) [MIM:609306]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. {ECO:0000269 PubMed:23001565}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for EEF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for EEF2 Gene
Publications for EEF2 Gene
- Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. (PMID: 2610926) Rapp G … Scheit KH (Biological chemistry Hoppe-Seyler 1989) 2 3 4
- Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). (PMID: 25231979) Davydova E … Falnes PØ (The Journal of biological chemistry 2014) 3 4
- Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. (PMID: 25064856) Sagnol S … de Santa Barbara P (Nucleic acids research 2014) 3 4
- C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2. (PMID: 24648518) Yao Q … Guo L (The Journal of biological chemistry 2014) 3 4
- Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. (PMID: 23184662) Hizli AA … Clurman BE (Molecular and cellular biology 2013) 3 4
ExternalLinks
Products for EEF2 Gene
- Custom Antibody ServicesOriGene Antibodies for EEF2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for EEF2
- Origene Custom Protein Services for EEF2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EEF2
- Browse OriGene Inhibitory RNA Products For EEF2
- OriGene qPCR primer pairs for EEF2
- OriGene qPCR primer pairs and template standards for EEF2
- OriGene CRISPR knockouts for EEF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EEF2
- Sino Biological Human cDNA Clone for EEF2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for EEF2
- Novus Biologicals proteins and lysates for EEF2
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for EEF2
- Abcam proteins for EEF2
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for EEF2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for EEF2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for EEF2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for EEF2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for EEF2
- antibodies-online: Show 82 available EEF2 Antibodies ranked by validation data
- Compare Top EEF2 Antibodies
- Recommended
- 115 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 57 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 16 available EEF2 Elisa Kits ranked by validation data
- Compare Top EEF2 Elisa Kits
- antibodies-online: Show 10 available EEF2 Proteins ranked by validation data
- Compare Top EEF2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for EEF2
- Search Santa Cruz Biotechnology (SCBT) for EEF2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EEF2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for EEF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF2
Sources for EEF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB