Aliases for EEF2 Gene
External Ids for EEF2 Gene
Previous HGNC Symbols for EEF2 Gene
Previous GeneCards Identifiers for EEF2 Gene
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
GeneCards Summary for EEF2 Gene
EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria. Among its related pathways are Metabolism of proteins and Oxytocin signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is EFTUD2.
UniProtKB/Swiss-Prot Summary for EEF2 Gene
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.