Aliases for EEF2 Gene
Aliases for EEF2 Gene
External Ids for EEF2 Gene
- HGNC: 3214
- Entrez Gene: 1938
- Ensembl: ENSG00000167658
- OMIM: 130610
- UniProtKB: P13639
Previous HGNC Symbols for EEF2 Gene
- EF2
Previous GeneCards Identifiers for EEF2 Gene
- GC19M004066
- GC19M003916
- GC19M003927
- GC19M003738
Summaries for EEF2 Gene
-
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
GeneCards Summary for EEF2 Gene
EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria. Among its related pathways are Translation Factors and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding.
UniProtKB/Swiss-Prot for EEF2 Gene
-
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Additional gene information for EEF2 Gene
- Monarch Initiative
- Search for EEF2 at DataMed
- Search for EEF2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF2 Gene
Genomics for EEF2 Gene
GeneHancer (GH) Regulatory Elements for EEF2 Gene
Promoters and enhancers for EEF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around EEF2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EEF2 gene promoter:
-
- TBP
- STAT5A
- p53
- c-Myb
- Sp1
- YY1
- C/EBPalpha
Regulatory Element Products
Genomic Locations for EEF2 Gene
Genomic Locations for EEF2 Gene
- chr19:3,976,056-3,985,469
- (GRCh38/hg38)
- Size:
- 9,414 bases
- Orientation:
- Minus strand
- chr19:3,976,054-3,985,467
- (GRCh37/hg19)
- Size:
- 9,414 bases
- Orientation:
- Minus strand
Genomic View for EEF2 Gene
Genes around EEF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
- 19p13.3 by Ensembl
EEF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EEF2 Gene
Proteins for EEF2 Gene
-
Protein details for EEF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13639-EF2_HUMAN
- Recommended name:
- Elongation factor 2
- Protein Accession:
- P13639
- B2RMP5
- D6W618
- Q58J86
Protein attributes for EEF2 Gene
- Size:
- 858 amino acids
- Molecular mass:
- 95338 Da
- Quaternary structure:
-
- Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9 (PubMed:19417104). Interacts with RBPMS2 (PubMed:25064856).
Protein Expression for EEF2 Gene
Post-translational modifications for EEF2 Gene
- Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
- Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis (By similarity).
- ISGylated.
- Proteolytically processed at two sites following phosphorylation by CSK.
- SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.
- Ubiquitination at isoforms=845, isoforms=688, Lys648, Lys594, isoforms=498, isoforms=481, isoforms=426, Lys386, Lys366, isoforms=333, Lys318, isoforms=275, isoforms=272, Lys239, isoforms=235, isoforms=152, isoforms=42, and isoforms=32
- Modification sites at PhosphoSitePlus
Other Protein References for EEF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for EEF2 (eEF-2)
-
Custom Antibody ServicesOriGene Antibodies for EEF2
- Novus Biologicals Antibodies for EEF2
- Invitrogen Antibodies for EEF2
- antibodies-online: Search results for 123 available EEF2 Antibodies ranked by validation data
- Compare Top EEF2 Antibodies
-
Recommended
- 87 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 45 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 42 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex EEF2 Antibody for EEF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for EEF2
Protein Products
-
OriGene Purified Proteins for EEF2
- Search Origene for MassSpec and Protein Over-expression Lysates for EEF2
- Origene Custom Protein Services for EEF2
- ProSpec Recombinant Proteins for EEF2
- Search GeneTex for Proteins for EEF2
Assay Products
No data available for DME Specific Peptides for EEF2 Gene
Domains & Families for EEF2 Gene
Gene Families for EEF2 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EEF2 Gene
Suggested Antigen Peptide Sequences for EEF2 Gene
Graphical View of Domain Structure for InterPro Entry
P13639UniProtKB/Swiss-Prot:
EF2_HUMAN :- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
- Family:
-
- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Function for EEF2 Gene
Molecular function for EEF2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
- GENATLAS Biochemistry:
- eukaryotic translation elongation factor 2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002039 | p53 binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0003746 | translation elongation factor activity | IEA | -- |
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 19417104 |
Phenotypes for EEF2 Gene
- MGI mutant phenotypes for EEF2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for EEF2:
-
- Decreased shRNA abundance (Z-score < -2)
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Increased gamma-H2AX phosphorylation
- Increased cell number in S
- shRNA abundance <= 50%
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EEF2
-
CRISPR Products
-
OriGene CRISPR knockouts for EEF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF2
- genomics-online: gRNA clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
- Applied Biological Materials CRISPR for EEF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EEF2
- GenScript: Design CRISPR guide RNA sequences for EEF2
miRNA for EEF2 Gene
- miRTarBase miRNAs that target EEF2
-
- hsa-mir-16-5p (MIRT031753)
- hsa-mir-1229-3p (MIRT036266)
- hsa-mir-296-3p (MIRT038365)
- hsa-mir-99b-3p (MIRT038532)
- hsa-mir-92a-1-5p (MIRT038923)
- hsa-mir-769-3p (MIRT039112)
- hsa-mir-615-3p (MIRT039659)
- hsa-mir-589-3p (MIRT040505)
- hsa-mir-193b-3p (MIRT041593)
- hsa-mir-484 (MIRT041660)
- hsa-mir-324-3p (MIRT042856)
- hsa-mir-342-3p (MIRT043730)
- hsa-mir-99b-5p (MIRT044210)
- hsa-mir-320a (MIRT044535)
- hsa-mir-186-5p (MIRT045161)
- hsa-mir-185-5p (MIRT045338)
- hsa-mir-222-3p (MIRT046806)
- hsa-mir-10a-5p (MIRT047726)
- hsa-mir-196a-5p (MIRT048271)
- hsa-mir-92a-3p (MIRT049005)
- hsa-mir-30a-5p (MIRT049963)
- hsa-mir-18a-5p (MIRT050660)
- hsa-let-7b-5p (MIRT051895)
- hsa-let-7a-5p (MIRT052441)
- hsa-mir-4433b-5p (MIRT502532)
- hsa-mir-6741-5p (MIRT502533)
- hsa-mir-4701-3p (MIRT502534)
- hsa-mir-6736-5p (MIRT502535)
- hsa-mir-1262 (MIRT502536)
- hsa-mir-642a-5p (MIRT502537)
- hsa-mir-3147 (MIRT502538)
- hsa-mir-4425 (MIRT502539)
- hsa-mir-3657 (MIRT502540)
- hsa-mir-4433a-5p (MIRT502541)
- hsa-mir-609 (MIRT502542)
- hsa-mir-4455 (MIRT502543)
- hsa-mir-6772-5p (MIRT502544)
- hsa-mir-6124 (MIRT502545)
- hsa-mir-3148 (MIRT502546)
- hsa-mir-3185 (MIRT502547)
- hsa-mir-146a-3p (MIRT502548)
- hsa-mir-2276-5p (MIRT502549)
- hsa-mir-6892-3p (MIRT502550)
- hsa-mir-3688-3p (MIRT502551)
- hsa-mir-5680 (MIRT502552)
- hsa-mir-4694-3p (MIRT502553)
- hsa-mir-548t-5p (MIRT502554)
- hsa-mir-548az-5p (MIRT502555)
- hsa-mir-4446-5p (MIRT511986)
- hsa-mir-5006-3p (MIRT511987)
- hsa-mir-4755-5p (MIRT511988)
- hsa-mir-488-3p (MIRT548480)
- hsa-mir-5093 (MIRT548481)
- hsa-mir-1299 (MIRT548482)
- hsa-mir-4522 (MIRT548483)
- hsa-mir-6128 (MIRT548484)
- hsa-mir-875-3p (MIRT548485)
- hsa-mir-518c-5p (MIRT548486)
- hsa-mir-514a-5p (MIRT548487)
- hsa-mir-7850-5p (MIRT562429)
- hsa-mir-4529-3p (MIRT562430)
- hsa-mir-4520-2-3p (MIRT562431)
- hsa-mir-2053 (MIRT562432)
- hsa-mir-4520-3p (MIRT562433)
- hsa-mir-8068 (MIRT562434)
- hsa-mir-6854-3p (MIRT562435)
- hsa-mir-4682 (MIRT562436)
- hsa-mir-3200-5p (MIRT562437)
- hsa-mir-4282 (MIRT562438)
- hsa-mir-155-5p (MIRT562439)
- hsa-mir-1266-5p (MIRT736702)
- hsa-mir-1343-5p (MIRT737460)
- hsa-mir-3664-3p (MIRT742021)
- hsa-mir-3925-3p (MIRT742991)
- hsa-mir-4518 (MIRT745775)
- hsa-mir-6090 (MIRT752034)
- hsa-mir-6798-5p (MIRT756256)
- hsa-mir-6800-3p (MIRT756355)
- hsa-mir-766-3p (MIRT759606)
- hsa-mir-939-5p (MIRT760751)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for EEF2
- Browse OriGene Inhibitory RNA Products For EEF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF2
- genomics-online: shRNA clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EEF2
- VectorBuilder custom plasmid, inducible vectors for EEF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EEF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF2
- Applied Biological Materials Clones for EEF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF2 Gene
Localization for EEF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EEF2 Gene
- Cytoplasm. Nucleus. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269 PubMed:24648518}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Cytosol (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | HDA,IEA | 21630459 |
| GO:0005737 | cytoplasm | IEA,IDA | 25064856 |
| GO:0005829 | cytosol | TAS,IEA | -- |
| GO:0005844 | polysome | IEA | -- |
Pathways & Interactions for EEF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 2 | Viral mRNA Translation |
.77
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
Pathways by source for EEF2 Gene
1 Sino Biological pathway for EEF2 Gene
4 BioSystems pathways for EEF2 Gene
16 Reactome pathways for EEF2 Gene
2 KEGG pathways for EEF2 Gene
3 GeneGo (Thomson Reuters) pathways for EEF2 Gene
1 R&D Systems pathway for EEF2 Gene
2 Qiagen pathways for EEF2 Gene
1 Cell Signaling Technology pathway for EEF2 Gene
Interacting Proteins for EEF2 Gene
Selected Interacting proteins:
P13639-EF2_HUMAN
ENSP00000307940
for EEF2 Gene via
IID
MINT
STRING
UniProtKB
GPS-Prot Interaction Network for EEF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
| GO:0002931 | response to ischemia | IEA | -- |
| GO:0003009 | skeletal muscle contraction | IEA | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006414 | translational elongation | TAS | -- |
Drugs & Compounds for EEF2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Water | Approved | Pharma | 0 | |||
| Guanosine diphosphate | Experimental | Pharma | Target | 0 | ||
| Diphthamide | Experimental | Pharma | Target | 0 | ||
| Adenosine-5-Diphosphoribose | Experimental | Pharma | Target | 0 | ||
| N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Transcripts for EEF2 Gene
mRNA/cDNA for EEF2 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (1223) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000309311 3164 bps (uc002lze.4)
- ENST00000594885 580 bps (uc060rtr.1)
- ENST00000596417 218 bps (uc060rtn.1)
- ENST00000598182 581 bps (uc060rto.1)
- ENST00000598436 549 bps (uc060rtp.1)
Unigene Clusters for EEF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EEF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF2
- genomics-online: gRNA clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
- Applied Biological Materials CRISPR for EEF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EEF2
- GenScript: Design CRISPR guide RNA sequences for EEF2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for EEF2
- Browse OriGene Inhibitory RNA Products For EEF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF2
- genomics-online: shRNA clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EEF2
- VectorBuilder custom plasmid, inducible vectors for EEF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EEF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF2
- Applied Biological Materials Clones for EEF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | - | - | - | - | - | ||||||
| SP8: | - | - | |||||||||
| SP9: |
Expression for EEF2 Gene
This gene is overexpressed in Lymph node (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EEF2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EEF2 Gene:
EEF2SOURCE GeneReport for Unigene cluster for EEF2 Gene:
Hs.515070Evidence on tissue expression from TISSUES for EEF2 Gene
- Nervous system(5)
- Liver(4.8)
- Intestine(4.7)
- Blood(4.6)
- Lung(4.4)
- Muscle(4.3)
- Heart(4.1)
- Kidney(3.9)
- Stomach(3.8)
- Skin(3.6)
- Thyroid gland(3.4)
- Eye(3.2)
- Pancreas(3.1)
- Bone marrow(2.5)
- Gall bladder(2.5)
- Lymph node(2.5)
- Spleen(2.5)
- Adrenal gland(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- head
Limb:
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for EEF2
-
OriGene qPCR primer pairs and template standards for EEF2
- genomics-online: primer clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEF2 Gene
Orthologs for EEF2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EEF2 34 |
|
OneToOne | |
| LOC100614367 33 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EEF2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EEF2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EEF2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Eef2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Eef2 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | EEF2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | EEF2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eef2.1 33 |
|
||
| MGC76191 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | eef2-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | eef2l2 34 |
|
OneToOne | |
| eef2b 33 |
|
||||
| zgc63584 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9660 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009441 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ef2b 34 35 33 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | eft-2 35 |
|
|
|
| eef-2 34 33 |
|
ManyToMany | |||
| K10C3.5 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EFT2 34 |
|
OneToMany | |
| EFT1 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | LOS1 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6678 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.10782 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0742200 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.5736 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11302 34 |
|
ManyToMany |
- Species where no ortholog for EEF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for EEF2 Gene
- ENSEMBL:
- Gene Tree for EEF2 (if available)
- TreeFam:
- Gene Tree for EEF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EEF2: view image
Paralogs for EEF2 Gene
(3) SIMAP similar genes for EEF2 Gene using alignment to 3 proteins:
- EF2_HUMAN
- M0R0I6_HUMAN
- Q6PK56_HUMAN
No data available for Paralogs for EEF2 Gene
Variants for EEF2 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs587777052 | pathogenic, Spinocerebellar ataxia 26, Spinocerebellar ataxia 26 (SCA26) [MIM:609306] | 3,978,099(-) | G/T | coding_sequence_variant, missense_variant | |
| rs145155508 | likely-benign, not specified | 3,982,410(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs200480185 | likely-benign, not specified | 3,982,033(-) | C/T | coding_sequence_variant, missense_variant | |
| rs36526 | likely-benign, not specified | 3,979,410(-) | A/G | coding_sequence_variant, synonymous_variant | |
| rs36527 | likely-benign, not specified | 3,977,488(-) | A/G | coding_sequence_variant, synonymous_variant |
Residual Variation Intolerance Score:
0.879% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.37;
8.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EEF2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF2 Gene
Disorders for EEF2 Gene
(6) MalaCards diseases for EEF2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia 26 |
|
|
| diphtheria |
|
|
| fusariosis |
|
|
| myotonic dystrophy 2 |
|
|
| primary bacterial infectious disease |
|
|
Search EEF2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EF2_HUMAN- Spinocerebellar ataxia 26 (SCA26) [MIM:609306]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. {ECO:0000269 PubMed:23001565}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for EEF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for EEF2 Gene
Publications for EEF2 Gene
- Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. (PMID: 2610926) Rapp G … Scheit KH (Biological chemistry Hoppe-Seyler 1989) 2 3 4 58
- C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2. (PMID: 24648518) Yao Q … Guo L (The Journal of biological chemistry 2014) 3 4 58
- Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. (PMID: 25064856) Sagnol S … de Santa Barbara P (Nucleic acids research 2014) 3 4 58
- Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). (PMID: 25231979) Davydova E … Falnes PØ (The Journal of biological chemistry 2014) 3 4 58
- Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. (PMID: 23184662) Hizli AA … Clurman BE (Molecular and cellular biology 2013) 3 4 58
Products for EEF2 Gene
- R&D Systems Antibodies for EEF2 (eEF-2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EEF2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EEF2
- Search Origene for MassSpec and Protein Over-expression Lysates for EEF2
- Origene Custom Protein Services for EEF2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for EEF2
- Browse OriGene Inhibitory RNA Products For EEF2
- OriGene qPCR primer pairs for EEF2
- OriGene qPCR primer pairs and template standards for EEF2
- OriGene CRISPR knockouts for EEF2
- OriGene ORF clones in human for EEF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EEF2
- GenScript: Next-day shipping of latest version cDNA ORF clones for EEF2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EEF2
- GenScript Custom Assay Services for EEF2
- GenScript Custom overexpressing Cell Line Services for EEF2
- GenScript: Design CRISPR guide RNA sequences for EEF2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EEF2
- Sino Biological Human cDNA Clone for EEF2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for EEF2
- Novus Biologicals proteins and lysates for EEF2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for EEF2
- VectorBuilder custom plasmid, inducible vectors for EEF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EEF2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 123 available EEF2 Antibodies ranked by validation data
- Compare Top EEF2 Antibodies
- Recommended
- 87 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 45 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 42 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 16 available EEF2 Elisa Kits ranked by validation data
- Compare Top EEF2 Elisa Kits
- antibodies-online: Search results for 14 available EEF2 Proteins ranked by validation data
- Compare Top EEF2 Proteins
- GeneTex EEF2 Antibody for EEF2
- Search GeneTex for Proteins for EEF2
- Santa Cruz Biotechnology (SCBT) Antibodies for EEF2
- Search Santa Cruz Biotechnology (SCBT) for EEF2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EEF2
- genomics-online: cdna clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
- orf clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
- genomics-online: gRNA clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
- genomics-online: primer clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
- genomics-online: shRNA clones - Search results for 131 available EEF2 gene related products
- Overview of 131 available EEF2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF2
- GeneCopoeia miRNA 3'UTR Target clone products for EEF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF2
Sources for EEF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt