EEF1G Gene (Protein Coding)

Eukaryotic Translation Elongation Factor 1 Gamma

GC11M063873
GIFtS:
42
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Ju... See more...

Aliases for EEF1G Gene

Aliases for EEF1G Gene

  • Eukaryotic Translation Elongation Factor 1 Gamma 2 3 5
  • EF1G 2 3 4
  • Elongation Factor 1-Gamma 3 4
  • EEF-1B Gamma 3 4
  • EF-1-Gamma 3 4
  • Translation Elongation Factor EEF-1 Gamma Chain 3
  • Pancreatic Tumor-Related Protein 3
  • PRO1608 3
  • GIG35 3
  • EEF1G 5

External Ids for EEF1G Gene

Previous GeneCards Identifiers for EEF1G Gene

  • GC11M064840
  • GC11M063902
  • GC11M062577
  • GC11M062102
  • GC11M062083
  • GC11M062328
  • GC11M062332
  • GC11M062560
  • GC11M063396

Summaries for EEF1G Gene

Entrez Gene Summary for EEF1G Gene

  • This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1G Gene

EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a Protein Coding gene. Diseases associated with EEF1G include Legionellosis and Lynch Syndrome. Among its related pathways are Viral mRNA Translation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include translation elongation factor activity. An important paralog of this gene is CLIC6.

UniProtKB/Swiss-Prot Summary for EEF1G Gene

  • Probably plays a role in anchoring the complex to other cellular components.

Gene Wiki entry for EEF1G Gene

Additional gene information for EEF1G Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EEF1G Gene

Genomics for EEF1G Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for EEF1G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EEF1G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EEF1G

Top Transcription factor binding sites by QIAGEN in the EEF1G gene promoter:
  • aMEF-2
  • CUTL1
  • MEF-2A
  • Meis-1
  • Meis-1a
  • Meis-1b
  • MyoD
  • p53
  • STAT3
  • YY1

Genomic Locations for EEF1G Gene

Latest Assembly
chr11:62,559,596-62,574,086
(GRCh38/hg38)
Size:
14,491 bases
Orientation:
Minus strand

Previous Assembly
chr11:62,327,068-62,341,363
(GRCh37/hg19 by Entrez Gene)
Size:
14,296 bases
Orientation:
Minus strand

chr11:62,327,073-62,342,401
(GRCh37/hg19 by Ensembl)
Size:
15,329 bases
Orientation:
Minus strand

Genomic View for EEF1G Gene

Genes around EEF1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1G Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EEF1G Gene

Proteins for EEF1G Gene

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  • Protein details for EEF1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26641-EF1G_HUMAN
    Recommended name:
    Elongation factor 1-gamma
    Protein Accession:
    P26641
    Secondary Accessions:
    • B4DTG2
    • Q6PJ62
    • Q6PK31
    • Q96CU2
    • Q9P196

    Protein attributes for EEF1G Gene

    Size:
    437 amino acids
    Molecular mass:
    50119 Da
    Quaternary structure:
    • EF-1 is composed of four subunits: alpha, beta, delta, and gamma.

    Three dimensional structures from OCA and Proteopedia for EEF1G Gene

    Alternative splice isoforms for EEF1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1G Gene

Protein Expression for EEF1G Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for EEF1G Gene

  • Ubiquitination at Lys17, Lys147, Lys212, Lys285, and Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF1G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EEF1G Gene

Domains & Families for EEF1G Gene

Gene Families for EEF1G Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EEF1G Gene

InterPro:
Blocks:
  • Glutathione S-transferase, N-terminal
  • Elongation factor 1, gamma chain
ProtoNet:

Suggested Antigen Peptide Sequences for EEF1G Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59433, highly similar to Elongation factor 1-gamma (B4DUP0_HUMAN)
  • eEF-1B gamma (EF1G_HUMAN)
  • GIG35 (Q53YD7_HUMAN)
genes like me logo Genes that share domains with EEF1G: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EEF1G Gene

Function for EEF1G Gene

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  6. Cell Lines for research

Molecular function for EEF1G Gene

UniProtKB/Swiss-Prot Function:
Probably plays a role in anchoring the complex to other cellular components.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Phenotypes From GWAS Catalog for EEF1G Gene

Gene Ontology (GO) - Molecular Function for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 10908348
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with EEF1G: view
genes like me logo Genes that share phenotypes with EEF1G: view

Animal Models for research

miRNA for EEF1G Gene

miRTarBase miRNAs that target EEF1G

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF1G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1G Gene

Localization for EEF1G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1G gene
Compartment Confidence
extracellular 4
nucleus 4
cytosol 4
cytoskeleton 2
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,IDA 8743958
GO:0005783 colocalizes_with endoplasmic reticulum IDA 8743958
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with EEF1G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1G Gene

Pathways & Interactions for EEF1G Gene

genes like me logo Genes that share pathways with EEF1G: view

Pathways by source for EEF1G Gene

1 BioSystems pathway for EEF1G Gene
1 KEGG pathway for EEF1G Gene

Gene Ontology (GO) - Biological Process for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006414 translational elongation TAS --
GO:0006749 glutathione metabolic process IEA --
GO:0009615 response to virus IEP 16548883
genes like me logo Genes that share ontologies with EEF1G: view

No data available for SIGNOR curated interactions for EEF1G Gene

Drugs & Compounds for EEF1G Gene

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  1. Drug products for research

(1) Additional Compounds for EEF1G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1G: view

Transcripts for EEF1G Gene

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mRNA/cDNA for EEF1G Gene

1 REFSEQ mRNAs :
35 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF1G

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1G Gene

No ASD Table

Relevant External Links for EEF1G Gene

GeneLoc Exon Structure for
EEF1G

Expression for EEF1G Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EEF1G Gene

mRNA expression in normal human tissues for EEF1G Gene
mRNA expression by BioGPS for EEF1G Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EEF1G Gene



Protein tissue co-expression partners for EEF1G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EEF1G

SOURCE GeneReport for Unigene cluster for EEF1G Gene:

Hs.144835

mRNA Expression by UniProt/SwissProt for EEF1G Gene:

P26641-EF1G_HUMAN
Tissue specificity: Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.

Evidence on tissue expression from TISSUES for EEF1G Gene

  • Blood(4.3)
  • Muscle(4.2)
  • Liver(4.2)
  • Lung(4.1)
  • Eye(4.1)
  • Bone marrow(4.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with EEF1G: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1G Gene

Orthologs for EEF1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia EEF1G 30 31
  • 99.77 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia -- 31
  • 98 (a)
 OneToMany
-- 31
  • 96 (a)
 OneToMany
EEF1G 30
  • 94.81 (n)
-- 31
  • 94 (a)
 OneToMany
-- 31
  • 92 (a)
 OneToMany
-- 31
  • 70 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia EEF1G 31
  • 93 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia EEF1G 30 31
  • 92.75 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 92 (a)
 OneToMany
-- 31
  • 92 (a)
 OneToMany
-- 31
  • 68 (a)
 OneToMany
-- 31
  • 55 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Eef1g 30 17 31
  • 91.46 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Eef1g 30
  • 89.7 (n)
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 86 (a)
 OneToMany
-- 31
  • 84 (a)
 OneToMany
African clawed frog
(Xenopus laevis)
 Amphibia LOC397861 30
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia MGC76278 30
Zebrafish
(Danio rerio)
 Actinopterygii eef1g 30 31
  • 75.54 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12147 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Ef1gamma 30 31 32
  • 63.16 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000883 30
  • 60.47 (n)
Worm
(Caenorhabditis elegans)
 Secernentea eef-1G 30 31
  • 55.89 (n)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ADR147C 30
  • 49.17 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TEF4 31
  • 34 (a)
 OneToMany
CAM1 31 33
  • 34 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT1G09640 30
  • 49.88 (n)
Rice
(Oryza sativa)
 Liliopsida Os02g0220600 30
  • 48.18 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.2821 31
  • 50 (a)
 OneToOne
Species where no ortholog for EEF1G was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EEF1G Gene

ENSEMBL:
Gene Tree for EEF1G (if available)
TreeFam:
Gene Tree for EEF1G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EEF1G: view image

Paralogs for EEF1G Gene

Paralogs for EEF1G Gene

(1) SIMAP similar genes for EEF1G Gene using alignment to 3 proteins:

  • EF1G_HUMAN
  • B4DTG2_HUMAN
  • Q53YD7_HUMAN

Pseudogenes.org Pseudogenes for EEF1G Gene

genes like me logo Genes that share paralogs with EEF1G: view

Variants for EEF1G Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EEF1G Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EEF1G Gene

Variant ID Type Subtype PubMed ID
esv3584599 CNV gain 24956385
nsv347 CNV deletion 18451855
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832180 CNV loss 17160897
nsv832182 CNV gain+loss 17160897
nsv975193 CNV duplication 23825009

Variation tolerance for EEF1G Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EEF1G Gene

Human Gene Mutation Database (HGMD)
EEF1G
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1G

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EEF1G Gene

Disorders for EEF1G Gene

MalaCards: The human disease database

(2) MalaCards diseases for EEF1G Gene - From: COP and GCD

Disorder Aliases PubMed IDs
legionellosis
  • legionella infection
lynch syndrome
  • coca 1
- elite association - COSMIC cancer census association via MalaCards
Search EEF1G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EEF1G

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with EEF1G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EEF1G Gene

Publications for EEF1G Gene

  1. Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation. (PMID: 1461723) Sanders J … Möller W (Nucleic acids research 1992) 2 3 4 23
  2. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. (PMID: 1598220) Kumabe T … Yamamoto T (Nucleic acids research 1992) 2 3 4 23
  3. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. (PMID: 1372736) Lew Y … Frazier ML (Pancreas 1992) 3 4 23
  4. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong WF … Chow VT (Cellular microbiology 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

ExternalLinks

View latest publications for EEF1G gene in Mastermind

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