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This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a Protein Coding gene. Diseases associated with EEF1G include Legionellosis and Lynch Syndrome. Among its related pathways are Viral mRNA Translation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include translation elongation factor activity. An important paralog of this gene is CLIC6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003746 | translation elongation factor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 10908348 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA,IDA | 8743958 |
GO:0005783 | colocalizes_with endoplasmic reticulum | IDA | 8743958 |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | HDA | 19946888 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
|
|
2 | Legionellosis | ||
3 | Gene Expression |
.48
|
|
4 | Metabolism of proteins | ||
5 | Translation Factors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IEA | -- |
GO:0006414 | translational elongation | TAS | -- |
GO:0006749 | glutathione metabolic process | IEA | -- |
GO:0009615 | response to virus | IEP | 16548883 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EEF1G 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
EEF1G 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | EEF1G 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EEF1G 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Eef1g 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Eef1g 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
African clawed frog (Xenopus laevis) |
Amphibia | LOC397861 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | MGC76278 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | eef1g 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12147 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ef1gamma 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000883 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | eef-1G 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR147C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TEF4 31 |
|
OneToMany | |
CAM1 31 33 |
|
OneToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G09640 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0220600 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2821 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
legionellosis |
|
|
lynch syndrome |
|
|