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Aliases for EEF1G Gene

Aliases for EEF1G Gene

  • Eukaryotic Translation Elongation Factor 1 Gamma 2 3 5
  • EEF-1B Gamma 3 4
  • EF-1-Gamma 3 4
  • EF1G 3 4
  • Translation Elongation Factor EEF-1 Gamma Chain 3
  • Pancreatic Tumor-Related Protein 3
  • Elongation Factor 1-Gamma 3
  • PRO1608 3
  • GIG35 3

External Ids for EEF1G Gene

Previous GeneCards Identifiers for EEF1G Gene

  • GC11M064840
  • GC11M063902
  • GC11M062577
  • GC11M062102
  • GC11M062083
  • GC11M062328
  • GC11M062332

Summaries for EEF1G Gene

Entrez Gene Summary for EEF1G Gene

  • This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1G Gene

EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a Protein Coding gene. Diseases associated with EEF1G include Gastrointestinal Carcinoma. Among its related pathways are Translation Factors and Legionellosis. Gene Ontology (GO) annotations related to this gene include translation elongation factor activity.

UniProtKB/Swiss-Prot for EEF1G Gene

  • Probably plays a role in anchoring the complex to other cellular components.

Gene Wiki entry for EEF1G Gene

Additional gene information for EEF1G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1G Gene

Genomics for EEF1G Gene

GeneHancer (GH) Regulatory Elements for EEF1G Gene

Promoters and enhancers for EEF1G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062572 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.4 -1400 7.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 TUT1 EEF1G NXF1 EML3 GANAB CSKMT MTA2 INTS5 STX5 LOC105369332
GH11J062571 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +2.4 2443 0.1 EEF1G MIR6747 ENSG00000255508
GH11J062838 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 38.8 -266.8 -266760 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WDR74 RNU2-2P GC11M062842 NXF1 CSKMT INTS5 SNHG1 UBXN1 MTA2 GANAB
GH11J062852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.4 -281.8 -281751 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NXF1 SNHG1 SLC3A2 SNORD29 SNORD28 SNORD27 SNORD26 SNORD25 GC11M062942 GC11M062939
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EEF1G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EEF1G gene promoter:
  • p53
  • Meis-1b
  • Meis-1a
  • Meis-1
  • STAT3
  • MEF-2A
  • aMEF-2
  • YY1
  • MyoD
  • CUTL1

Genomic Locations for EEF1G Gene

Genomic Locations for EEF1G Gene
14,486 bases
Minus strand
15,329 bases
Minus strand

Genomic View for EEF1G Gene

Genes around EEF1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1G Gene

Proteins for EEF1G Gene

  • Protein details for EEF1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Elongation factor 1-gamma
    Protein Accession:
    Secondary Accessions:
    • B4DTG2
    • Q6PJ62
    • Q6PK31
    • Q96CU2
    • Q9P196

    Protein attributes for EEF1G Gene

    437 amino acids
    Molecular mass:
    50119 Da
    Quaternary structure:
    • EF-1 is composed of four subunits: alpha, beta, delta, and gamma.

    Three dimensional structures from OCA and Proteopedia for EEF1G Gene

    Alternative splice isoforms for EEF1G Gene


neXtProt entry for EEF1G Gene

Post-translational modifications for EEF1G Gene

  • Ubiquitination at Lys294 and Lys17
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF1G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EEF1G Gene

Domains & Families for EEF1G Gene

Gene Families for EEF1G Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EEF1G Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EEF1G: view

No data available for UniProtKB/Swiss-Prot for EEF1G Gene

Function for EEF1G Gene

Molecular function for EEF1G Gene

UniProtKB/Swiss-Prot Function:
Probably plays a role in anchoring the complex to other cellular components.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Phenotypes From GWAS Catalog for EEF1G Gene

Gene Ontology (GO) - Molecular Function for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IBA --
GO:0004364 glutathione transferase activity IBA --
GO:0005515 protein binding IPI 10908348
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with EEF1G: view
genes like me logo Genes that share phenotypes with EEF1G: view

Animal Model Products

miRNA for EEF1G Gene

miRTarBase miRNAs that target EEF1G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1G Gene

Localization for EEF1G Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1G gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA,IBA --
GO:0005737 cytoplasm IDA 8743958
GO:0005783 colocalizes_with endoplasmic reticulum IDA 8743958
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with EEF1G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1G Gene

Pathways & Interactions for EEF1G Gene

genes like me logo Genes that share pathways with EEF1G: view

Pathways by source for EEF1G Gene

1 BioSystems pathway for EEF1G Gene
1 KEGG pathway for EEF1G Gene

Gene Ontology (GO) - Biological Process for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006414 translational elongation TAS --
GO:0006749 glutathione metabolic process IBA --
GO:0009615 response to virus IEP 16548883
genes like me logo Genes that share ontologies with EEF1G: view

No data available for SIGNOR curated interactions for EEF1G Gene

Drugs & Compounds for EEF1G Gene

(1) Additional Compounds for EEF1G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1G: view

Transcripts for EEF1G Gene

mRNA/cDNA for EEF1G Gene

(1) REFSEQ mRNAs :
(31) Additional mRNA sequences :
(548) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EEF1G Gene

Eukaryotic translation elongation factor 1 gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1G Gene

No ASD Table

Relevant External Links for EEF1G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EEF1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EEF1G Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EEF1G Gene

Protein tissue co-expression partners for EEF1G Gene

NURSA nuclear receptor signaling pathways regulating expression of EEF1G Gene:


SOURCE GeneReport for Unigene cluster for EEF1G Gene:


mRNA Expression by UniProt/SwissProt for EEF1G Gene:

Tissue specificity: Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.

Evidence on tissue expression from TISSUES for EEF1G Gene

  • Blood(4)
  • Bone marrow(4)
  • Eye(4)
  • Liver(4)
  • Lung(4)
  • Muscle(4)
genes like me logo Genes that share expression patterns with EEF1G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1G Gene

Orthologs for EEF1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EEF1G 34 33
  • 99.77 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
-- 34
  • 96 (a)
EEF1G 33
  • 94.81 (n)
-- 34
  • 94 (a)
-- 34
  • 92 (a)
-- 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia EEF1G 34
  • 93 (a)
(Bos Taurus)
Mammalia EEF1G 34 33
  • 92.75 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
-- 34
  • 92 (a)
-- 34
  • 68 (a)
-- 34
  • 55 (a)
(Mus musculus)
Mammalia Eef1g 16 34 33
  • 91.46 (n)
(Rattus norvegicus)
Mammalia Eef1g 33
  • 89.7 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 86 (a)
-- 34
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397861 33
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76278 33
(Danio rerio)
Actinopterygii eef1g 34 33 33
  • 75.54 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12147 33
fruit fly
(Drosophila melanogaster)
Insecta Ef1gamma 34 35 33
  • 63.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000883 33
  • 60.47 (n)
(Caenorhabditis elegans)
Secernentea eef-1G 34 33
  • 55.89 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR147C 33
  • 49.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAM1 36 34
  • 34 (a)
TEF4 34
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09640 33
  • 49.88 (n)
(Oryza sativa)
Liliopsida Os02g0220600 33
  • 48.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2821 34
  • 50 (a)
Species where no ortholog for EEF1G was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1G Gene

Gene Tree for EEF1G (if available)
Gene Tree for EEF1G (if available)
Evolutionary constrained regions (ECRs) for EEF1G: view image

Paralogs for EEF1G Gene

(1) SIMAP similar genes for EEF1G Gene using alignment to 3 proteins:

  • Q53YD7_HUMAN
genes like me logo Genes that share paralogs with EEF1G: view

No data available for Paralogs for EEF1G Gene

Variants for EEF1G Gene

Sequence variations from dbSNP and Humsavar for EEF1G Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000018459 -- 62,575,950(-) C/T upstream_transcript_variant
rs1000147208 -- 62,568,791(-) G/A intron_variant
rs1000451807 -- 62,567,325(-) G/A intron_variant
rs1000630294 -- 62,571,239(-) C/T intron_variant
rs1000736984 -- 62,562,295(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1G Gene

Variant ID Type Subtype PubMed ID
esv3584599 CNV gain 24956385
nsv347 CNV deletion 18451855
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832180 CNV loss 17160897
nsv832182 CNV gain+loss 17160897
nsv975193 CNV duplication 23825009

Variation tolerance for EEF1G Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EEF1G Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1G Gene

Disorders for EEF1G Gene

MalaCards: The human disease database

(1) MalaCards diseases for EEF1G Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastrointestinal carcinoma
  • gastrointestinal neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search EEF1G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EEF1G

genes like me logo Genes that share disorders with EEF1G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EEF1G Gene

Publications for EEF1G Gene

  1. Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation. (PMID: 1461723) Sanders J … Möller W (Nucleic acids research 1992) 2 3 4 22 58
  2. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. (PMID: 1598220) Kumabe T … Yamamoto T (Nucleic acids research 1992) 2 3 4 22 58
  3. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. (PMID: 1372736) Lew Y … Frazier ML (Pancreas 1992) 3 4 22 58
  4. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong WF … Chow VT (Cellular microbiology 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for EEF1G Gene

Sources for EEF1G Gene

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