Aliases for EEF1D Gene
External Ids for EEF1D Gene
Previous GeneCards Identifiers for EEF1D Gene
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
GeneCards Summary for EEF1D Gene
EEF1D (Eukaryotic Translation Elongation Factor 1 Delta) is a Protein Coding gene. Diseases associated with EEF1D include Autosomal Recessive Non-Syndromic Intellectual Disability and Cystic Echinococcosis. Among its related pathways are Viral mRNA Translation and Gene Expression. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and translation factor activity, RNA binding. An important paralog of this gene is EEF1B2.
UniProtKB/Swiss-Prot Summary for EEF1D Gene
[Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.
[Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).