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Aliases for EEF1B2 Gene

Aliases for EEF1B2 Gene

  • Eukaryotic Translation Elongation Factor 1 Beta 2 2 3 5
  • EF-1-Beta 3 4
  • EEF1B 3 4
  • EF1B 3 4
  • Eukaryotic Translation Elongation Factor 1 Beta 1 3
  • Elongation Factor 1-Beta 3
  • EEF1B1 3

External Ids for EEF1B2 Gene

Previous GeneCards Identifiers for EEF1B2 Gene

  • GC02P205241
  • GC02P205748
  • GC02P206988
  • GC02P207227
  • GC02P207228
  • GC02P206849
  • GC02P206732
  • GC02P207024

Summaries for EEF1B2 Gene

Entrez Gene Summary for EEF1B2 Gene

  • This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1B2 Gene

EEF1B2 (Eukaryotic Translation Elongation Factor 1 Beta 2) is a Protein Coding gene. Among its related pathways are Translation Factors and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include translation elongation factor activity. An important paralog of this gene is EEF1D.

UniProtKB/Swiss-Prot for EEF1B2 Gene

  • EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

Gene Wiki entry for EEF1B2 Gene

Additional gene information for EEF1B2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1B2 Gene

Genomics for EEF1B2 Gene

GeneHancer (GH) Regulatory Elements for EEF1B2 Gene

Promoters and enhancers for EEF1B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J206157 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 64 3.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 NDUFS1 EEF1B2 GC02P206178 GC02P206176 ENSG00000277502 INO80D ENSG00000231955 GCSHP3 ENSG00000227946 KLF7-IT1
GH02J206081 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.7 -75.1 -75147 6.7 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 ZNF143 ENSG00000227946 INO80D ZDBF2 NDUFS1 GCSHP3 ENSG00000231955 SNORD51 EEF1B2 SNORA41 GPR1
GH02J206078 Enhancer 0.7 ENCODE dbSUPER 11.2 -79.9 -79935 1.7 SP1 SOX13 SP5 POLR2A KAT7 TEAD3 NDUFS1 ENSG00000231955 GCSHP3 EEF1B2 SNORD51 SNORA41 ENSG00000225610 GPR1 ENSG00000227946 INO80D
GH02J206077 Enhancer 0.7 ENCODE dbSUPER 11.2 -81.6 -81604 0.7 FOXA2 NFIA TEAD1 FOXA3 CEBPA ZNF384 ENSG00000231955 GCSHP3 NDUFS1 EEF1B2 SNORD51 SNORA41 ENSG00000225610 INO80D ENSG00000227946 RPL27P8
GH02J206250 Enhancer 0.6 Ensembl ENCODE 11 +90.9 90913 0.6 CTCF POLR2A RAD21 ZDBF2 RN7SKP200 GPR1 SNORA41 EEF1B2 SNORD51 NDUFS1 HMGN1P6 LOC100132849 GPR1-AS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EEF1B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EEF1B2 gene promoter:
  • AREB6
  • Nkx2-5
  • Brachyury
  • POU2F1a
  • POU2F1
  • Tal-1beta
  • ITF-2
  • deltaCREB
  • CREB
  • NF-Y

Genomic Locations for EEF1B2 Gene

Genomic Locations for EEF1B2 Gene
3,345 bases
Plus strand
3,345 bases
Plus strand

Genomic View for EEF1B2 Gene

Genes around EEF1B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1B2 Gene

Proteins for EEF1B2 Gene

  • Protein details for EEF1B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Elongation factor 1-beta
    Protein Accession:
    Secondary Accessions:
    • A8K795
    • Q6IBH9

    Protein attributes for EEF1B2 Gene

    225 amino acids
    Molecular mass:
    24764 Da
    Quaternary structure:
    • EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.

    Three dimensional structures from OCA and Proteopedia for EEF1B2 Gene

neXtProt entry for EEF1B2 Gene

Post-translational modifications for EEF1B2 Gene

  • Phosphorylation affects the GDP/GTP exchange rate.
  • Ubiquitination at isoforms=147 and isoforms=78
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for EEF1B2
  • Santa Cruz Biotechnology (SCBT) Antibodies for EEF1B2

No data available for DME Specific Peptides for EEF1B2 Gene

Domains & Families for EEF1B2 Gene

Gene Families for EEF1B2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EEF1B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EF-1-beta/EF-1-delta family.
  • Belongs to the EF-1-beta/EF-1-delta family.
genes like me logo Genes that share domains with EEF1B2: view

Function for EEF1B2 Gene

Molecular function for EEF1B2 Gene

UniProtKB/Swiss-Prot Function:
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
UniProtKB/Swiss-Prot Induction:
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.
GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,beta 2,specifically transcribed in fetal brain and in skeletal muscle (multigene family)

Phenotypes From GWAS Catalog for EEF1B2 Gene

Gene Ontology (GO) - Molecular Function for EEF1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity NAS 1886777
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with EEF1B2: view
genes like me logo Genes that share phenotypes with EEF1B2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1B2 Gene

Localization for EEF1B2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1B2 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EEF1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 8743958
GO:0005783 colocalizes_with endoplasmic reticulum IDA 8743958
GO:0005829 cytosol TAS --
GO:0005853 eukaryotic translation elongation factor 1 complex NAS 1886777
genes like me logo Genes that share ontologies with EEF1B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1B2 Gene

Pathways & Interactions for EEF1B2 Gene

genes like me logo Genes that share pathways with EEF1B2: view

Pathways by source for EEF1B2 Gene

1 BioSystems pathway for EEF1B2 Gene

Gene Ontology (GO) - Biological Process for EEF1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006414 translational elongation TAS --
GO:0045471 response to ethanol IEA --
genes like me logo Genes that share ontologies with EEF1B2: view

No data available for SIGNOR curated interactions for EEF1B2 Gene

Drugs & Compounds for EEF1B2 Gene

(1) Drugs for EEF1B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for EEF1B2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1B2: view

Transcripts for EEF1B2 Gene

mRNA/cDNA for EEF1B2 Gene

Unigene Clusters for EEF1B2 Gene

Eukaryotic translation elongation factor 1 beta 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1B2 Gene

No ASD Table

Relevant External Links for EEF1B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EEF1B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EEF1B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EEF1B2 Gene

Protein tissue co-expression partners for EEF1B2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EEF1B2 Gene:


SOURCE GeneReport for Unigene cluster for EEF1B2 Gene:


Evidence on tissue expression from TISSUES for EEF1B2 Gene

  • Pancreas(4.9)
  • Nervous system(4.9)
  • Skin(4.8)
  • Eye(4.7)
  • Liver(4.7)
  • Intestine(4.3)
  • Lung(4.3)
  • Blood(3.1)
  • Muscle(2.9)
  • Heart(2.5)
  • Spleen(2.5)
  • Kidney(2.4)
  • Lymph node(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with EEF1B2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1B2 Gene

Orthologs for EEF1B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EEF1B2 34 33
  • 99.85 (n)
(Bos Taurus)
Mammalia EEF1B 34
  • 98 (a)
EEF1B2 33
  • 91.11 (n)
(Canis familiaris)
Mammalia EEF1B2 33
  • 93.04 (n)
-- 34
  • 92 (a)
-- 34
  • 76 (a)
-- 34
  • 74 (a)
(Monodelphis domestica)
Mammalia EEF1B2 34
  • 91 (a)
(Mus musculus)
Mammalia Eef1b2 16 34 33
  • 89.19 (n)
(Rattus norvegicus)
Mammalia Eef1b2 33
  • 89.19 (n)
(Ornithorhynchus anatinus)
Mammalia EEF1B2 34
  • 88 (a)
(Gallus gallus)
Aves EEF1B2 34 33
  • 81.99 (n)
(Anolis carolinensis)
Reptilia EEF1B2 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1b2 33
  • 78.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20382 33
(Danio rerio)
Actinopterygii eef1b2 34 33
  • 73.81 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010613 33
  • 60.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ef1beta 34 33
  • 58.67 (n)
Ef1&bgr; 35
  • 57 (a)
(Caenorhabditis elegans)
Secernentea Y41E3.10 35
  • 65 (a)
eef-1B.1 34 33
  • 55.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C18469g 33
  • 53.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFB1 34 33
  • 52.36 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR003C 33
  • 50.16 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19510 33
  • 52.7 (n)
(Oryza sativa)
Liliopsida Os07g0662500 33
  • 53.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11115 34
  • 67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tef5 33
  • 58.53 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06035 33
  • 57.59 (n)
Species where no ortholog for EEF1B2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1B2 Gene

Gene Tree for EEF1B2 (if available)
Gene Tree for EEF1B2 (if available)
Evolutionary constrained regions (ECRs) for EEF1B2: view image

Paralogs for EEF1B2 Gene

Paralogs for EEF1B2 Gene

(3) SIMAP similar genes for EEF1B2 Gene using alignment to 5 proteins:

  • F2Z2G2_HUMAN
  • F8WF65_HUMAN
genes like me logo Genes that share paralogs with EEF1B2: view

Variants for EEF1B2 Gene

Sequence variations from dbSNP and Humsavar for EEF1B2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs4147707 likely-benign, Mitochondrial complex I deficiency, Leigh syndrome 206,159,383(+) G/C/T upstream_transcript_variant
rs1000178857 -- 206,159,395(+) C/A/G upstream_transcript_variant
rs1000965132 -- 206,158,425(+) T/C upstream_transcript_variant
rs1001271223 -- 206,158,208(+) C/T upstream_transcript_variant
rs1001638994 -- 206,163,072(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1B2 Gene

Variant ID Type Subtype PubMed ID
nsv821885 CNV gain 20364138
nsv963768 CNV duplication 23825009

Variation tolerance for EEF1B2 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EEF1B2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1B2 Gene

Disorders for EEF1B2 Gene

Additional Disease Information for EEF1B2

No disorders were found for EEF1B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1B2 Gene

Publications for EEF1B2 Gene

  1. Nucleotide sequence of human elongation factor-1 beta cDNA. (PMID: 1886777) Sanders J … Möller W (Nucleic acids research 1991) 3 4 22 58
  2. Human elongation factor 1 beta: cDNA and derived amino acid sequence. (PMID: 1710449) von der Kammer H … Scheit KH (Biochemical and biophysical research communications 1991) 3 4 22 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for EEF1B2 Gene

Sources for EEF1B2 Gene

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