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Aliases for EEF1AKMT4-ECE2 Gene

Aliases for EEF1AKMT4-ECE2 Gene

  • EEF1AKMT4-ECE2 Readthrough 2 3 5
  • EEF1AKMT4-ECE2 Readthrough Transcript Protein 3
  • EEF1AKMT4-ECE2 2
  • EC 3.4.24.71 4

External Ids for EEF1AKMT4-ECE2 Gene

Previous GeneCards Identifiers for EEF1AKMT4-ECE2 Gene

  • GC03P184250

Summaries for EEF1AKMT4-ECE2 Gene

Entrez Gene Summary for EEF1AKMT4-ECE2 Gene

  • This gene represents naturally occurring readthrough transcription between adjacent genes eukaryotic translation elongation factor 1 alpha lysine methyltransferase 4 (GeneID: 110599564) and endothelin converting enzyme 2 (GeneID:9718). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]

GeneCards Summary for EEF1AKMT4-ECE2 Gene

EEF1AKMT4-ECE2 (EEF1AKMT4-ECE2 Readthrough) is a Protein Coding gene. An important paralog of this gene is ECE2.

UniProtKB/Swiss-Prot for EEF1AKMT4-ECE2 Gene

  • Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid-beta processing (By similarity).

Additional gene information for EEF1AKMT4-ECE2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1AKMT4-ECE2 Gene

Genomics for EEF1AKMT4-ECE2 Gene

GeneHancer (GH) Regulatory Elements for EEF1AKMT4-ECE2 Gene

Promoters and enhancers for EEF1AKMT4-ECE2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J184247 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.4 -370 2.7 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CBX5 ZNF213 ALG3 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 POLR2H RPS3P3 PARL VWA5B2 DVL3 EIF2B5
GH03J184261 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 0.4 +12.5 12493 2.4 ARID4B FEZF1 ZNF48 YY1 GLIS2 SP3 GLIS1 SP7 ZIC2 HIC1 CAMK2N2 VWA5B2 DVL3 RPS3P3 POLR2H EIF2B5 ECE2 EEF1AKMT4-ECE2 PSMD2
GH03J184284 Enhancer 0.7 ENCODE 0.3 +35.2 35213 0.1 CTCF MXI1 PKNOX1 MAX SIN3A ZNF384 BMI1 RAD21 RFX5 ZNF324 PSMD2 CAMK2N2 ECE2 EEF1AKMT4-ECE2
GH03J184276 Promoter 0.6 EPDnew 0.3 +27.2 27249 0.1 NFE2 ECE2 CAMK2N2 PSMD2 EEF1AKMT4-ECE2
GH03J184275 Promoter 0.5 EPDnew 0.3 +26.3 26314 0.1 ECE2 CAMK2N2 PSMD2 EEF1AKMT4-ECE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EEF1AKMT4-ECE2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EEF1AKMT4-ECE2 Gene

Genomic Locations for EEF1AKMT4-ECE2 Gene
chr3:184,249,695-184,293,031
(GRCh38/hg38)
Size:
43,337 bases
Orientation:
Plus strand

Genomic View for EEF1AKMT4-ECE2 Gene

Genes around EEF1AKMT4-ECE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT4-ECE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT4-ECE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT4-ECE2 Gene

Proteins for EEF1AKMT4-ECE2 Gene

  • Protein details for EEF1AKMT4-ECE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DPD8-EFCE2_HUMAN
    Recommended name:
    EEF1AKMT4-ECE2 readthrough transcript protein
    Protein Accession:
    P0DPD8
    Secondary Accessions:
    • A5PLK8
    • O60344
    • Q6NTG7
    • Q6UW36
    • Q8NFD7
    • Q96NX3
    • Q96NX4
    • Q9BRZ8

    Protein attributes for EEF1AKMT4-ECE2 Gene

    Size:
    883 amino acids
    Molecular mass:
    99773 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL30386.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EEF1AKMT4-ECE2 Gene

neXtProt entry for EEF1AKMT4-ECE2 Gene

Post-translational modifications for EEF1AKMT4-ECE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT4-ECE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EEF1AKMT4-ECE2 Gene

Domains & Families for EEF1AKMT4-ECE2 Gene

Protein Domains for EEF1AKMT4-ECE2 Gene

Graphical View of Domain Structure for InterPro Entry

P0DPD8

UniProtKB/Swiss-Prot:

EFCE2_HUMAN :
  • In the N-terminal section; belongs to the methyltransferase superfamily.
Family:
  • In the N-terminal section; belongs to the methyltransferase superfamily.
  • In the C-terminal section; belongs to the peptidase M13 family.
genes like me logo Genes that share domains with EEF1AKMT4-ECE2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EEF1AKMT4-ECE2 Gene

Function for EEF1AKMT4-ECE2 Gene

Molecular function for EEF1AKMT4-ECE2 Gene

UniProtKB/Swiss-Prot Function:
Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid-beta processing (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the 21-Trp- -Val-22 bond in big endothelin to form endothelin 1.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by phosphoramidon.

Enzyme Numbers (IUBMB) for EEF1AKMT4-ECE2 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT4-ECE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008168 methyltransferase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with EEF1AKMT4-ECE2: view

Phenotypes for EEF1AKMT4-ECE2 Gene

genes like me logo Genes that share phenotypes with EEF1AKMT4-ECE2: view

Animal Model Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EEF1AKMT4-ECE2 Gene

Localization for EEF1AKMT4-ECE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1AKMT4-ECE2 Gene

Golgi apparatus membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane.

Gene Ontology (GO) - Cellular Components for EEF1AKMT4-ECE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0030658 transport vesicle membrane ISS --
genes like me logo Genes that share ontologies with EEF1AKMT4-ECE2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for EEF1AKMT4-ECE2 Gene

Pathways & Interactions for EEF1AKMT4-ECE2 Gene

SuperPathways for EEF1AKMT4-ECE2 Gene

No Data Available

Interacting Proteins for EEF1AKMT4-ECE2 Gene

Gene Ontology (GO) - Biological Process for EEF1AKMT4-ECE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016486 peptide hormone processing IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with EEF1AKMT4-ECE2: view

No data available for Pathways by source and SIGNOR curated interactions for EEF1AKMT4-ECE2 Gene

Drugs & Compounds for EEF1AKMT4-ECE2 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT4-ECE2 Gene

mRNA/cDNA for EEF1AKMT4-ECE2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT4-ECE2 Gene

No ASD Table

Relevant External Links for EEF1AKMT4-ECE2 Gene

GeneLoc Exon Structure for
EEF1AKMT4-ECE2
ECgene alternative splicing isoforms for
EEF1AKMT4-ECE2

Expression for EEF1AKMT4-ECE2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1AKMT4-ECE2 Gene

Orthologs for EEF1AKMT4-ECE2 Gene

Evolution for EEF1AKMT4-ECE2 Gene

ENSEMBL:
Gene Tree for EEF1AKMT4-ECE2 (if available)
TreeFam:
Gene Tree for EEF1AKMT4-ECE2 (if available)

No data available for Orthologs for EEF1AKMT4-ECE2 Gene

Paralogs for EEF1AKMT4-ECE2 Gene

Paralogs for EEF1AKMT4-ECE2 Gene

genes like me logo Genes that share paralogs with EEF1AKMT4-ECE2: view

Variants for EEF1AKMT4-ECE2 Gene

Additional Variant Information for EEF1AKMT4-ECE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1AKMT4-ECE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for EEF1AKMT4-ECE2 Gene

Disorders for EEF1AKMT4-ECE2 Gene

Additional Disease Information for EEF1AKMT4-ECE2

No disorders were found for EEF1AKMT4-ECE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT4-ECE2 Gene

Publications for EEF1AKMT4-ECE2 Gene

  1. Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. (PMID: 28520920) Jakobsson ME … Falnes PØ (Nucleic acids research 2017) 2 3 58
  2. Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. (PMID: 11718899) Lorenzo MN … Marsden PA (Biochimica et biophysica acta 2001) 3 4 58
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for EEF1AKMT4-ECE2 Gene

Sources for EEF1AKMT4-ECE2 Gene

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