Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EEF1AKMT4 Gene

Aliases for EEF1AKMT4 Gene

  • EEF1A Lysine Methyltransferase 4 2 3 3 5
  • Eukaryotic Translation Elongation Factor 1 Alpha Lysine Specific Methyltransferase 4 3
  • EC 2.1.1.- 4

External Ids for EEF1AKMT4 Gene

Previous GeneCards Identifiers for EEF1AKMT4 Gene

  • GC03P184251

Summaries for EEF1AKMT4 Gene

Entrez Gene Summary for EEF1AKMT4 Gene

  • This gene encodes a member of the lysine-specific methyltransferase (KMT) family. The encoded enzyme catalyzes the methylation of lysine-36 of the eukaryotic translation elongation factor 1 alpha. Methylation by this enzyme may affect endoplasmic reticulum-related processes. [provided by RefSeq, Jul 2017]

GeneCards Summary for EEF1AKMT4 Gene

EEF1AKMT4 (EEF1A Lysine Methyltransferase 4) is a Protein Coding gene. An important paralog of this gene is METTL13.

UniProtKB/Swiss-Prot for EEF1AKMT4 Gene

  • Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on Lys-36 in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).

Additional gene information for EEF1AKMT4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1AKMT4 Gene

Genomics for EEF1AKMT4 Gene

GeneHancer (GH) Regulatory Elements for EEF1AKMT4 Gene

Promoters and enhancers for EEF1AKMT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J184247 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.3 -325 2.7 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CBX5 ZNF213 ALG3 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 POLR2H RPS3P3 PARL VWA5B2 DVL3 EIF2B5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EEF1AKMT4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EEF1AKMT4 Gene

Genomic Locations for EEF1AKMT4 Gene
chr3:184,249,650-184,259,585
(GRCh38/hg38)
Size:
9,936 bases
Orientation:
Plus strand

Genomic View for EEF1AKMT4 Gene

Genes around EEF1AKMT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT4 Gene

Proteins for EEF1AKMT4 Gene

  • Protein details for EEF1AKMT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DPD7-EFMT4_HUMAN
    Recommended name:
    EEF1A lysine methyltransferase 4
    Protein Accession:
    P0DPD7
    Secondary Accessions:
    • A5PLK8
    • O60344
    • Q6NTG7
    • Q6UW36
    • Q8NFD7
    • Q96NX3
    • Q96NX4
    • Q9BRZ8

    Protein attributes for EEF1AKMT4 Gene

    Size:
    255 amino acids
    Molecular mass:
    28306 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for EEF1AKMT4 Gene

    Alternative splice isoforms for EEF1AKMT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1AKMT4 Gene

Post-translational modifications for EEF1AKMT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EEF1AKMT4 Gene

Domains & Families for EEF1AKMT4 Gene

Protein Domains for EEF1AKMT4 Gene

Graphical View of Domain Structure for InterPro Entry

P0DPD7

UniProtKB/Swiss-Prot:

EFMT4_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with EEF1AKMT4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EEF1AKMT4 Gene

Function for EEF1AKMT4 Gene

Molecular function for EEF1AKMT4 Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on Lys-36 in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + [protein]-L-lysine = S-adenosyl-L-homocysteine + [protein]-N(6)-methyl-L-lysine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + [protein]-N(6)-methyl-L-lysine = S-adenosyl-L-homocysteine + [protein]-N(6),N(6)-dimethyl-L-lysine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + [protein]-N(6),N(6)-dimethyl-L-lysine = S-adenosyl-L-homocysteine + [protein]-N(6),N(6),N(6)-trimethyl-L-lysine.

Enzyme Numbers (IUBMB) for EEF1AKMT4 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA,IMP 28520920
GO:0016279 protein-lysine N-methyltransferase activity IDA 28520920
genes like me logo Genes that share ontologies with EEF1AKMT4: view

Phenotypes for EEF1AKMT4 Gene

genes like me logo Genes that share phenotypes with EEF1AKMT4: view

Animal Model Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EEF1AKMT4 Gene

Localization for EEF1AKMT4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for EEF1AKMT4 Gene

Pathways & Interactions for EEF1AKMT4 Gene

SuperPathways for EEF1AKMT4 Gene

No Data Available

Interacting Proteins for EEF1AKMT4 Gene

Gene Ontology (GO) - Biological Process for EEF1AKMT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018022 peptidyl-lysine methylation IEA --
genes like me logo Genes that share ontologies with EEF1AKMT4: view

No data available for Pathways by source and SIGNOR curated interactions for EEF1AKMT4 Gene

Drugs & Compounds for EEF1AKMT4 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT4 Gene

mRNA/cDNA for EEF1AKMT4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT4 Gene

No ASD Table

Relevant External Links for EEF1AKMT4 Gene

GeneLoc Exon Structure for
EEF1AKMT4
ECgene alternative splicing isoforms for
EEF1AKMT4

Expression for EEF1AKMT4 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1AKMT4 Gene

Orthologs for EEF1AKMT4 Gene

Evolution for EEF1AKMT4 Gene

ENSEMBL:
Gene Tree for EEF1AKMT4 (if available)
TreeFam:
Gene Tree for EEF1AKMT4 (if available)

No data available for Orthologs for EEF1AKMT4 Gene

Paralogs for EEF1AKMT4 Gene

Paralogs for EEF1AKMT4 Gene

genes like me logo Genes that share paralogs with EEF1AKMT4: view

Variants for EEF1AKMT4 Gene

Sequence variations from dbSNP and Humsavar for EEF1AKMT4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs7633387 -- p.His101Tyr

Additional Variant Information for EEF1AKMT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1AKMT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for EEF1AKMT4 Gene

Disorders for EEF1AKMT4 Gene

Additional Disease Information for EEF1AKMT4

No disorders were found for EEF1AKMT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT4 Gene

Publications for EEF1AKMT4 Gene

  1. Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. (PMID: 28520920) Jakobsson ME … Falnes PØ (Nucleic acids research 2017) 2 3 4 58
  2. An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene. (PMID: 19089949) Tempel W … Bochkarev A (Proteins 2009) 4 58
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for EEF1AKMT4 Gene

Sources for EEF1AKMT4 Gene

Content
Loading form....