Aliases for EEF1AKMT3 Gene

Aliases for EEF1AKMT3 Gene

  • EEF1A Lysine Methyltransferase 3 2 3 4 5
  • Hepatocellular Carcinoma-Associated Antigen 557a 3 4
  • Family With Sequence Similarity 119, Member B 2 3
  • Protein-Lysine Methyltransferase METTL21B 3 4
  • Methyltransferase-Like Protein 21B 3 4
  • Methyltransferase Like 21B 2 3
  • METTL21B 3 4
  • FAM119B 3 4
  • Hepatocellularcarcinoma-Associated Antigen HCA557a 3
  • DKFZP586D0919 2
  • EC 2.1.1.- 4
  • EEF1AKMT3 5
  • HCA557A 4

External Ids for EEF1AKMT3 Gene

Previous HGNC Symbols for EEF1AKMT3 Gene

  • FAM119B
  • METTL21B

Summaries for EEF1AKMT3 Gene

GeneCards Summary for EEF1AKMT3 Gene

EEF1AKMT3 (EEF1A Lysine Methyltransferase 3) is a Protein Coding gene. An important paralog of this gene is METTL21A.

UniProtKB/Swiss-Prot Summary for EEF1AKMT3 Gene

  • Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EEF1AKMT3 Gene

Genomics for EEF1AKMT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EEF1AKMT3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057770 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 301.2 +1.2 1211 4.2 TBP ZBTB10 SP1 MXD4 MNT IKZF1 SMAD5 ETS1 ZFP64 MBD2 TSFM EEF1AKMT3 ENSG00000257921 HSALNG0091660 METTL1 NEMP1 MBD6 ZBTB39 HSALNG0091662 HSALNG0091661
GH12J057109 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 110.2 -660.3 -660291 4 ZSCAN16 CHD2 TBP ZBTB10 FEZF1 CEBPA MNT DEK IKZF1 SMAD5 STAT6 HSALNG0091591 lnc-LRP1-4 NEMP1 BAZ2A PAN2 EEF1AKMT3 CDK4 SMARCC2 ENSG00000257740
GH12J057780 Promoter/Enhancer 0.6 EPDnew ENCODE 299.8 +9.6 9627 1.4 GTF2E2 TSFM EEF1AKMT3 HSALNG0091661 ENSG00000257921 RF00017-1166
GH12J057830 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 44.7 +68.1 68098 17.2 TBP SP1 ZBTB10 FEZF1 CEBPA MNT SMAD5 HES1 MBD2 ZNF217 CTDSP2 EEF1AKMT3 TSFM ATP23 NEMP1 ZBTB39 MBD6 METTL1 TSPAN31 CDK4
GH12J057750 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 49.8 -17.6 -17591 6.6 TBP ZBTB10 MXD4 SP1 FEZF1 CEBPA NR2C1 MNT DEK IKZF1 CDK4 MARCHF9 lnc-AGAP2-3 NEMP1 EEF1AKMT3 TSFM MBD6 CTDSP2 ZBTB39 TSPAN31
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EEF1AKMT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EEF1AKMT3

Genomic Locations for EEF1AKMT3 Gene

Latest Assembly
11,050 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
9,928 bases
Plus strand

(GRCh37/hg19 by Ensembl)
11,050 bases
Plus strand

Genomic View for EEF1AKMT3 Gene

Genes around EEF1AKMT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT3 Gene

Proteins for EEF1AKMT3 Gene

  • Protein details for EEF1AKMT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EEF1A lysine methyltransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q9H749
    • Q9Y3W2

    Protein attributes for EEF1AKMT3 Gene

    226 amino acids
    Molecular mass:
    24911 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 70 and 90 families and of the TCP-1 chaperonin family, as well as with HSPD1, STIP1 and tubulin; at least some of these proteins may be methylation substrates.

    Three dimensional structures from OCA and Proteopedia for EEF1AKMT3 Gene

    Alternative splice isoforms for EEF1AKMT3 Gene


neXtProt entry for EEF1AKMT3 Gene

Post-translational modifications for EEF1AKMT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT3 Gene

No data available for DME Specific Peptides for EEF1AKMT3 Gene

Domains & Families for EEF1AKMT3 Gene

Gene Families for EEF1AKMT3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EEF1AKMT3 Gene

Suggested Antigen Peptide Sequences for EEF1AKMT3 Gene

GenScript: Design optimal peptide antigens:
  • Hepatocellular carcinoma-associated antigen 557a (MT21B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL21 family.
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with EEF1AKMT3: view

Function for EEF1AKMT3 Gene

Molecular function for EEF1AKMT3 Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.

Enzyme Numbers (IUBMB) for EEF1AKMT3 Gene

Phenotypes From GWAS Catalog for EEF1AKMT3 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23349634
GO:0008168 methyltransferase activity IEA,IDA 28108655
GO:0016279 protein-lysine N-methyltransferase activity IBA,IDA 28108655
GO:0016740 transferase activity IEA --
GO:0031072 heat shock protein binding IPI 23349634
genes like me logo Genes that share ontologies with EEF1AKMT3: view
genes like me logo Genes that share phenotypes with EEF1AKMT3: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EEF1AKMT3 Gene

Localization for EEF1AKMT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1AKMT3 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1AKMT3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Mitotic chromosome (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EEF1AKMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IDA --
GO:0005737 cytoplasm IBA,IDA 23349634
GO:0005813 centrosome IDA 28108655
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with EEF1AKMT3: view

Pathways & Interactions for EEF1AKMT3 Gene

PathCards logo

SuperPathways for EEF1AKMT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EEF1AKMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018022 peptidyl-lysine methylation IBA,IDA 28108655
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with EEF1AKMT3: view

No data available for Pathways by source and SIGNOR curated interactions for EEF1AKMT3 Gene

Drugs & Compounds for EEF1AKMT3 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT3 Gene

mRNA/cDNA for EEF1AKMT3 Gene

7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT3 Gene

No ASD Table

Relevant External Links for EEF1AKMT3 Gene

GeneLoc Exon Structure for

Expression for EEF1AKMT3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EEF1AKMT3

Evidence on tissue expression from TISSUES for EEF1AKMT3 Gene

  • Intestine(4.2)
  • Lung(4.2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1AKMT3 Gene

Orthologs for EEF1AKMT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EEF1AKMT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL21B 30 31
  • 99.41 (n)
(Canis familiaris)
Mammalia METTL21B 30 31
  • 93 (n)
(Bos Taurus)
Mammalia METTL21B 30 31
  • 92.04 (n)
(Rattus norvegicus)
Mammalia LOC679247 30
  • 86.64 (n)
(Mus musculus)
Mammalia LOC100504608 30
  • 86.28 (n)
Mettl21b 31
  • 83 (a)
Eef1akmt3 17
(Monodelphis domestica)
Mammalia METTL21B 31
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia METTL21B 31
  • 62 (a)
(Gallus gallus)
Aves -- 31
  • 30 (a)
(Anolis carolinensis)
Reptilia METTL21B 31
  • 58 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mettl21b 30
  • 61.62 (n)
(Danio rerio)
Actinopterygii zgc:92518 31
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C42C1.13 31
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 28 (a)
EFM2 33
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
Species where no ortholog for EEF1AKMT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EEF1AKMT3 Gene

Gene Tree for EEF1AKMT3 (if available)
Gene Tree for EEF1AKMT3 (if available)
Evolutionary constrained regions (ECRs) for EEF1AKMT3: view image

Paralogs for EEF1AKMT3 Gene

Paralogs for EEF1AKMT3 Gene

genes like me logo Genes that share paralogs with EEF1AKMT3: view

Variants for EEF1AKMT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EEF1AKMT3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs34913183 - p.Ser28Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EEF1AKMT3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EEF1AKMT3 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559046 CNV gain 21841781

Variation tolerance for EEF1AKMT3 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EEF1AKMT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1AKMT3 Gene

Disorders for EEF1AKMT3 Gene

Additional Disease Information for EEF1AKMT3

No disorders were found for EEF1AKMT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT3 Gene

Publications for EEF1AKMT3 Gene

  1. The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). (PMID: 28108655) Malecki J … Falnes PØ (Nucleic acids research 2017) 2 3 4
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout. (PMID: 28663172) Hamey JJ … Wilkins MR (Molecular & cellular proteomics : MCP 2017) 3
  5. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S … Falnes PØ (Nature communications 2012) 3

Products for EEF1AKMT3 Gene

Sources for EEF1AKMT3 Gene