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Aliases for EEF1AKMT2 Gene

Aliases for EEF1AKMT2 Gene

  • EEF1A Lysine Methyltransferase 2 2 3 5
  • Eukaryotic Translation Elongation Factor 1 Alpha Lysine Methyltransferase 2 2 3
  • Protein-Lysine N-Methyltransferase METTL10 3 4
  • Methyltransferase-Like Protein 10 3 4
  • Methyltransferase Like 10 2 3
  • C10orf138 3 4
  • METTL10 3 4
  • Chromosome 10 Open Reading Frame 138 2
  • EC 2.1.1.- 4
  • EC 2.1.1 56
  • Efm4 3

External Ids for EEF1AKMT2 Gene

Previous HGNC Symbols for EEF1AKMT2 Gene

  • C10orf138
  • METTL10

Summaries for EEF1AKMT2 Gene

GeneCards Summary for EEF1AKMT2 Gene

EEF1AKMT2 (EEF1A Lysine Methyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation. An important paralog of this gene is ENSG00000258539.

UniProtKB/Swiss-Prot for EEF1AKMT2 Gene

  • Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at Lys-318.

Additional gene information for EEF1AKMT2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1AKMT2 Gene

Genomics for EEF1AKMT2 Gene

GeneHancer (GH) Regulatory Elements for EEF1AKMT2 Gene

Promoters and enhancers for EEF1AKMT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I124790 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 588.2 +0.1 68 2.6 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B EEF1AKMT2 ENSG00000258539 EDRF1-AS1 EDRF1 CTBP2 ENSG00000234134 MMP21
GH10I124731 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 66.6 +51.5 51508 18.4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FAM53B EEF1AKMT2 ENSG00000234134 EDRF1 ABRAXAS2 GC10P124736 ENSG00000258539
GH10I124714 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 46.4 +69.1 69143 16.1 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT SIN3A IRF4 ZNF766 ZNF207 EEF1AKMT2 FAM53B ABRAXAS2 ZRANB1 GC10P124736 GC10P124712 FAM53B-AS1 ENSG00000258539
GH10I124691 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 40.6 +90.5 90534 19.6 HDGF CLOCK SMAD1 FOXA2 ARNT ARID4B IRF4 ZNF766 REST ZNF592 EEF1AKMT2 FAM53B LHPP ZRANB1 FAM53B-AS1 PIR45733 PIR48648 GC10M124645 ENSG00000258539
GH10I124091 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.1 +698.4 698399 4.3 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ETS1 GLIS2 ZNF213 KLF7 SP3 CHST15 EEF1AKMT2 GC10M124074
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EEF1AKMT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EEF1AKMT2 Gene

Genomic Locations for EEF1AKMT2 Gene
chr10:124,748,149-124,791,941
(GRCh38/hg38)
Size:
43,793 bases
Orientation:
Minus strand
chr10:126,436,718-126,480,439
(GRCh37/hg19)

Genomic View for EEF1AKMT2 Gene

Genes around EEF1AKMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT2 Gene

Proteins for EEF1AKMT2 Gene

  • Protein details for EEF1AKMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JPI9-EFMT2_HUMAN
    Recommended name:
    EEF1A lysine methyltransferase 2
    Protein Accession:
    Q5JPI9
    Secondary Accessions:
    • A8MPY7

    Protein attributes for EEF1AKMT2 Gene

    Size:
    291 amino acids
    Molecular mass:
    31830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EEF1AKMT2 Gene

Selected DME Specific Peptides for EEF1AKMT2 Gene

Q5JPI9:
  • EFVKRII
  • QGRTMRWALAWSFY
  • IHDSLQLKKRLRWYSCMLGKKCSLAPLK
  • FLATEVDD
  • DLMNQLCT
  • ILTDLKV
  • RNRYKDKPPDF
  • LIKVVKVPQKTLLMDALKEES
  • RKLEKPRKP
  • FCMCNPPFF
  • TEIMAEGGELEFVKR

Post-translational modifications for EEF1AKMT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT2 Gene

Domains & Families for EEF1AKMT2 Gene

Gene Families for EEF1AKMT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EEF1AKMT2 Gene

Suggested Antigen Peptide Sequences for EEF1AKMT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JPI9

UniProtKB/Swiss-Prot:

EFMT2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
genes like me logo Genes that share domains with EEF1AKMT2: view

Function for EEF1AKMT2 Gene

Molecular function for EEF1AKMT2 Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at Lys-318.

Enzyme Numbers (IUBMB) for EEF1AKMT2 Gene

Phenotypes From GWAS Catalog for EEF1AKMT2 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IDA 25144183
GO:0016279 protein-lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with EEF1AKMT2: view
genes like me logo Genes that share phenotypes with EEF1AKMT2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1AKMT2 Gene

Localization for EEF1AKMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1AKMT2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1AKMT2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EEF1AKMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25144183
GO:0005737 cytoplasm IDA,IEA 25144183
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EEF1AKMT2: view

Pathways & Interactions for EEF1AKMT2 Gene

genes like me logo Genes that share pathways with EEF1AKMT2: view

Pathways by source for EEF1AKMT2 Gene

Interacting Proteins for EEF1AKMT2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357829%0d%0a9606.ENSP00000298910%0d%0a9606.ENSP00000373600%0d%0a9606.ENSP00000357040%0d%0a9606.ENSP00000310800%0d%0a9606.ENSP00000330054%0d%0a
Selected Interacting proteins: Q5JPI9-EFMT2_HUMAN ENSP00000357829 for EEF1AKMT2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for EEF1AKMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation TAS --
GO:0018022 peptidyl-lysine methylation IDA 25144183
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with EEF1AKMT2: view

No data available for SIGNOR curated interactions for EEF1AKMT2 Gene

Drugs & Compounds for EEF1AKMT2 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT2 Gene

No ASD Table

Relevant External Links for EEF1AKMT2 Gene

GeneLoc Exon Structure for
EEF1AKMT2
ECgene alternative splicing isoforms for
EEF1AKMT2

Expression for EEF1AKMT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EEF1AKMT2 Gene:

EEF1AKMT2

Evidence on tissue expression from TISSUES for EEF1AKMT2 Gene

  • Lymph node(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1AKMT2 Gene

Orthologs for EEF1AKMT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1AKMT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL10 33 34
  • 99.77 (n)
rat
(Rattus norvegicus)
Mammalia Mettl10 33
  • 89.58 (n)
mouse
(Mus musculus)
Mammalia Mettl10 33
  • 88.89 (n)
Eef1akmt2 16
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves METTL10 33
  • 75.89 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498530 33
  • 62.27 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl10 34 33
  • 62.19 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005673 33
  • 53.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9643 33 34
  • 52.57 (n)
worm
(Caenorhabditis elegans)
Secernentea F29B9.1 33 34
  • 49.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEE1 33 34
  • 50.29 (n)
EFM4 36
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07931g 33
  • 49.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AR401 33
  • 52.54 (n)
rice
(Oryza sativa)
Liliopsida Os01g0121100 33
  • 53.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC839.14c 33
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for EEF1AKMT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1AKMT2 Gene

ENSEMBL:
Gene Tree for EEF1AKMT2 (if available)
TreeFam:
Gene Tree for EEF1AKMT2 (if available)

Paralogs for EEF1AKMT2 Gene

Paralogs for EEF1AKMT2 Gene

genes like me logo Genes that share paralogs with EEF1AKMT2: view

Variants for EEF1AKMT2 Gene

Sequence variations from dbSNP and Humsavar for EEF1AKMT2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000076263 -- 124,779,541(-) T/A intron_variant
rs1000125071 -- 124,779,285(-) C/T intron_variant
rs1000140343 -- 124,787,341(-) G/A intron_variant
rs1000150604 -- 124,778,197(-) T/C intron_variant
rs1000203396 -- 124,778,492(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1AKMT2 Gene

Variant ID Type Subtype PubMed ID
esv3624817 CNV loss 21293372
nsv1050837 CNV gain 25217958
nsv1051396 CNV loss 25217958
nsv825604 CNV gain 20364138
nsv832013 CNV loss 17160897
nsv832014 CNV loss 17160897

Variation tolerance for EEF1AKMT2 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EEF1AKMT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1AKMT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1AKMT2 Gene

Disorders for EEF1AKMT2 Gene

No disorders were found for EEF1AKMT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT2 Gene

Publications for EEF1AKMT2 Gene

  1. Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. (PMID: 25144183) Shimazu T … Shinkai Y (PloS one 2014) 2 3 4 58
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 58

Products for EEF1AKMT2 Gene

Sources for EEF1AKMT2 Gene

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