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Aliases for EEF1AKMT1 Gene

Aliases for EEF1AKMT1 Gene

  • EEF1A Lysine Methyltransferase 1 2 3 5
  • Eukaryotic Translation Elongation Factor 1 Alpha Lysine Methyltransferase 1 2 3
  • N-6 Adenine-Specific DNA Methyltransferase 2 (Putative) 2 3
  • N(6)-Adenine-Specific DNA Methyltransferase 2 3 4
  • Protein-Lysine N-Methyltransferase N6AMT2 3 4
  • N6AMT2 3 4
  • EC 2.1.1.- 4
  • EC 2.1.1 56
  • ESP13 3

External Ids for EEF1AKMT1 Gene

Previous HGNC Symbols for EEF1AKMT1 Gene

  • N6AMT2

Summaries for EEF1AKMT1 Gene

GeneCards Summary for EEF1AKMT1 Gene

EEF1AKMT1 (EEF1A Lysine Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation.

UniProtKB/Swiss-Prot for EEF1AKMT1 Gene

  • Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at Lys-79.

Additional gene information for EEF1AKMT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1AKMT1 Gene

Genomics for EEF1AKMT1 Gene

GeneHancer (GH) Regulatory Elements for EEF1AKMT1 Gene

Promoters and enhancers for EEF1AKMT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I020772 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.8 +0.5 523 2.3 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B EEF1AKMT1 ZMYM5 SLC35E1P1 RNU2-7P RPS7P10 IFT88 ZMYM2 CRYL1 XPO4 ENSG00000275485
GH13I020812 Enhancer 1.3 Ensembl ENCODE dbSUPER 18.4 -40.5 -40506 3 FEZF1 ZNF2 FOS TSHZ1 ZNF488 GLIS1 MYNN STAT3 PRDM4 WT1 EEF1AKMT1 IFT88 GC13P020892 XPO4
GH13I021174 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -402.4 -402384 3.2 HDGF PKNOX1 CLOCK ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MRPL57 SKA3 EEF1AKMT1 SAP18
GH13I020702 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.4 +70.6 70556 2.8 PKNOX1 RB1 ARID4B SIN3A BMI1 ZNF48 RFX5 ZNF335 ZNF121 ELK1 ENSG00000278291 IL17D GC13M020702 IFT88 EEF1AKMT1 CRYL1
GH13I020822 Enhancer 0.7 FANTOM5 ENCODE 18.5 -50.7 -50680 3.4 JUND POLR2A HLF EEF1AKMT1 CRYL1 SLC35E1P1 IFT88 IL17D GC13P020892 XPO4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EEF1AKMT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EEF1AKMT1 Gene

Genomic Locations for EEF1AKMT1 Gene
45,228 bases
Minus strand

Genomic View for EEF1AKMT1 Gene

Genes around EEF1AKMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT1 Gene

Proteins for EEF1AKMT1 Gene

  • Protein details for EEF1AKMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EEF1A lysine methyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • B5G4V1

    Protein attributes for EEF1AKMT1 Gene

    214 amino acids
    Molecular mass:
    24506 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EEF1AKMT1 Gene

Selected DME Specific Peptides for EEF1AKMT1 Gene


Post-translational modifications for EEF1AKMT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT1 Gene

Domains & Families for EEF1AKMT1 Gene

Gene Families for EEF1AKMT1 Gene

Suggested Antigen Peptide Sequences for EEF1AKMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
genes like me logo Genes that share domains with EEF1AKMT1: view

Function for EEF1AKMT1 Gene

Molecular function for EEF1AKMT1 Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at Lys-79.

Enzyme Numbers (IUBMB) for EEF1AKMT1 Gene

Phenotypes From GWAS Catalog for EEF1AKMT1 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008168 methyltransferase activity IDA 26545399
GO:0016279 protein-lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with EEF1AKMT1: view
genes like me logo Genes that share phenotypes with EEF1AKMT1: view

Animal Models for EEF1AKMT1 Gene

MGI Knock Outs for EEF1AKMT1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EEF1AKMT1 Gene

Localization for EEF1AKMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1AKMT1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1AKMT1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EEF1AKMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with EEF1AKMT1: view

Pathways & Interactions for EEF1AKMT1 Gene

genes like me logo Genes that share pathways with EEF1AKMT1: view

Pathways by source for EEF1AKMT1 Gene

Interacting Proteins for EEF1AKMT1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8WVE0-EFMT1_HUMAN ENSP00000372202 for EEF1AKMT1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for EEF1AKMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation TAS --
GO:0018022 peptidyl-lysine methylation IDA 26545399
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with EEF1AKMT1: view

No data available for SIGNOR curated interactions for EEF1AKMT1 Gene

Drugs & Compounds for EEF1AKMT1 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT1 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT1 Gene

No ASD Table

Relevant External Links for EEF1AKMT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EEF1AKMT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EEF1AKMT1 Gene:


Evidence on tissue expression from TISSUES for EEF1AKMT1 Gene

  • Nervous system(4.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1AKMT1 Gene

Orthologs for EEF1AKMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1AKMT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia N6AMT2 34 33
  • 99.38 (n)
(Canis familiaris)
Mammalia N6AMT2 33 34
  • 86.41 (n)
(Rattus norvegicus)
Mammalia N6amt2 33
  • 80.97 (n)
(Mus musculus)
Mammalia N6amt2 33 34
  • 80.82 (n)
Eef1akmt1 16
(Bos Taurus)
Mammalia N6AMT2 33 34
  • 76.48 (n)
(Ornithorhynchus anatinus)
Mammalia N6AMT2 34
  • 76 (a)
(Monodelphis domestica)
Mammalia N6AMT2 34
  • 69 (a)
(Gallus gallus)
Aves N6AMT2 33 34
  • 74 (n)
(Anolis carolinensis)
Reptilia N6AMT2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia n6amt2 33
  • 69.35 (n)
Str.20519 33
(Danio rerio)
Actinopterygii n6amt2 33 34
  • 66.46 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5203 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010213 33
  • 52.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9154 33 34
  • 51.99 (n)
(Caenorhabditis elegans)
Secernentea CELE_M142.8 33
  • 54.58 (n)
M142.8 34
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGR001C 33
  • 51.89 (n)
-- 34
  • 36 (a)
EFM5 36
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL001W 33
  • 51.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08712g 33
  • 50.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58470 33
  • 53.11 (n)
(Oryza sativa)
Liliopsida Os03g0749900 33
  • 48.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02372 33
  • 50.25 (n)
Species where no ortholog for EEF1AKMT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1AKMT1 Gene

Gene Tree for EEF1AKMT1 (if available)
Gene Tree for EEF1AKMT1 (if available)

Paralogs for EEF1AKMT1 Gene

No data available for Paralogs for EEF1AKMT1 Gene

Variants for EEF1AKMT1 Gene

Sequence variations from dbSNP and Humsavar for EEF1AKMT1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000006396 -- 20,756,331(-) T/C intron_variant
rs1000118744 -- 20,751,621(-) G/C intron_variant
rs1000220928 -- 20,744,702(-) C/T intron_variant
rs1000239912 -- 20,759,675(-) G/A intron_variant
rs1000273263 -- 20,744,911(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1AKMT1 Gene

Variant ID Type Subtype PubMed ID
dgv6e24 CNV gain 17666407
nsv1078303 OTHER inversion 25765185
nsv1113545 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv832558 CNV loss 17160897
nsv951 CNV insertion 18451855

Variation tolerance for EEF1AKMT1 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EEF1AKMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1AKMT1 Gene

Disorders for EEF1AKMT1 Gene

No disorders were found for EEF1AKMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT1 Gene

Publications for EEF1AKMT1 Gene

  1. Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. (PMID: 26545399) Hamey JJ … Wilkins MR (Molecular & cellular proteomics : MCP 2016) 2 3 4 58
  2. Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li JY … Zhang YL (DNA research : an international journal for rapid publication of reports on genes and genomes 2008) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 58
  5. Genetic determinants of P wave duration and PR segment. (PMID: 24850809) Verweij N … van der Harst P (Circulation. Cardiovascular genetics 2014) 3 58

Products for EEF1AKMT1 Gene

Sources for EEF1AKMT1 Gene

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