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This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) is a Protein Coding gene. Diseases associated with EEF1A1 include Eukaryotic Translation Elongation Factor 1 Alpha-1-Like 14 and Felty Syndrome. Among its related pathways are Viral mRNA Translation and Protein methylation. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is EEF1A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000049 | tRNA binding | IDA | 12426392 |
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003746 | translation elongation factor activity | IEA,TAS | 17595531 |
GO:0003924 | GTPase activity | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | HDA | 23580065 |
GO:0005634 | nucleus | IEA,IDA | 8743958 |
GO:0005730 | nucleolus | IEA,IDA | 9852145 |
GO:0005737 | cytoplasm | TAS | 3512269 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
|
|
2 | Innate Immune System |
.61
|
|
3 | Cellular response to heat stress |
.01
|
|
4 | Metabolism of proteins | ||
5 | Translational Control |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IBA | 21873635 |
GO:0006414 | translational elongation | IEA,TAS | 8812466 |
GO:0043312 | neutrophil degranulation | TAS | -- |
GO:0071364 | cellular response to epidermal growth factor stimulus | IDA | 9852145 |
GO:1900022 | regulation of D-erythro-sphingosine kinase activity | IDA | 18263879 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 249 | ||
Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
Zinc chloride | Approved, Investigational | Pharma | Target, binder | 0 | ||
Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, binder | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
Compound | Action | Cas Number |
---|---|---|
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species] | Elongation factor-1 subunit |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||
SP2: | |||||||||||||
SP3: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | EEF1A1 31 |
|
OneToOne | |
LOC102151992 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chimpanzee (Pan troglodytes) |
Mammalia | EEF1A1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | EEF1A1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Eef1a1 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EEF1A1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Eef1a1 30 |
|
||
Chicken (Gallus gallus) |
Aves | EEF1A 31 |
|
OneToOne | |
EEF1A1 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | EEF1A1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eef1a1o 30 |
|
||
MGC75658 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | eef1a1b 31 |
|
OneToMany | |
eef1a1a 30 31 |
|
OneToMany | |||
-- 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1771 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ef1alpha100E 31 32 |
|
ManyToMany | |
Ef1alpha48D 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | eef-1A.2 31 |
|
ManyToMany | |
eef-1A.1 31 |
|
ManyToMany | |||
eft-3 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TEF2 31 33 33 33 |
|
OneToMany | |
TEF1 33 33 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G07940 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.10761 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0177500 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11100 31 |
|
ManyToMany | |
CSA.4537 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
CSA.11147 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2675873 | CNV | deletion | 23128226 |
esv2763576 | CNV | gain | 21179565 |
esv3609512 | CNV | loss | 21293372 |
nsv463153 | CNV | loss | 19166990 |
nsv5350 | CNV | deletion | 18451855 |
nsv603693 | CNV | loss | 21841781 |
nsv981157 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
eukaryotic translation elongation factor 1 alpha-1-like 14 |
|
|
felty syndrome |
|
|
myotonic dystrophy 2 |
|
|
epileptic encephalopathy, early infantile, 33 |
|
|
legionellosis |
|
|