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This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an auto... See more...
Aliases for EEF1A1 Gene
Aliases for EEF1A1 Gene
- Eukaryotic Translation Elongation Factor 1 Alpha 1 2 3 5
- Leukocyte Receptor Cluster (LRC) Member 7 2 3
- Leukocyte Receptor Cluster Member 7 3 4
- Eukaryotic Elongation Factor 1 A-1 3 4
- Elongation Factor 1-Alpha 1 3 4
- Elongation Factor Tu 3 4
- EF-1-Alpha-1 3 4
- EEF1A-1 3 4
- EEF1A 3 4
- LENG7 3 4
- EF-Tu 3 4
- EF1A 3 4
- Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14 3
- Glucocorticoid Receptor AF-1 Specific Elongation Factor 3
- Translation Elongation Factor 1 Alpha 1-Like 14 3
- Epididymis Secretory Sperm Binding Protein 3
- Elongation Factor 1 Alpha Subunit 3
- Prostate Tumor-Inducing Protein 1 3
- Cervical Cancer Suppressor 3 3
- CTCL Tumor Antigen 3
- EF1a-Like Protein 3
- HNGC:16303 3
- GRAF-1EF 3
- CCS-3 3
- EE1A1 3
- EEF-1 3
- CCS3 3
- PTI1 3
External Ids for EEF1A1 Gene
- HGNC: 3189
- Entrez Gene: 1915
- Ensembl: ENSG00000156508
- OMIM: 130590
- UniProtKB: P68104
Previous HGNC Symbols for EEF1A1 Gene
- EF1A
- EEF1A
- LENG7
Previous GeneCards Identifiers for EEF1A1 Gene
- GC06M074183
- GC06M074221
- GC06M074222
- GC06M074282
- GC06M074225
Summaries for EEF1A1 Gene
-
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
GeneCards Summary for EEF1A1 Gene
EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) is a Protein Coding gene. Diseases associated with EEF1A1 include Eukaryotic Translation Elongation Factor 1 Alpha-1-Like 14 and Cervical Cancer. Among its related pathways are Cellular Senescence (REACTOME) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is EEF1A2.
UniProtKB/Swiss-Prot Summary for EEF1A1 Gene
-
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Additional gene information for EEF1A1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EEF1A1 Gene
Genomics for EEF1A1 Gene
GeneHancer (GH) Regulatory Elements for EEF1A1 Gene
Promoters and enhancers for EEF1A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EEF1A1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EEF1A1 gene promoter:
-
- HSF2
- ITF-2
- NF-1
- Pax-2
- Pax-2a
- Pax-4a
- SRF
- SRF (504 AA)
- Tal-1beta
Genomic Locations for EEF1A1 Gene
Genomic Locations for EEF1A1 Gene
- chr6:73,515,750-73,523,797
- (GRCh38/hg38)
- Size:
- 8,048 bases
- Orientation:
- Minus strand
- chr6:74,225,473-74,233,520
- (GRCh37/hg19)
- Size:
- 8,048 bases
- Orientation:
- Minus strand
Genomic View for EEF1A1 Gene
Genes around EEF1A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q13 by HGNC
- 6q13 by Entrez Gene
- 6q13 by Ensembl
EEF1A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EEF1A1 Gene
Proteins for EEF1A1 Gene
-
Protein details for EEF1A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68104-EF1A1_HUMAN
- Recommended name:
- Elongation factor 1-alpha 1
- Protein Accession:
- P68104
- P04719
- P04720
- Q6IQ15
Protein attributes for EEF1A1 Gene
- Size:
- 462 amino acids
- Molecular mass:
- 50141 Da
- Quaternary structure:
-
- Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts with PPP1R16B (PubMed:26497934). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (PubMed:18263879).
- SequenceCaution:
-
- Sequence=AAA52367.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for EEF1A1 Gene
Post-translational modifications for EEF1A1 Gene
- ISGylated.
- Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2 (PubMed:26497934).
- Trimethylated at Lys-79 by EEF1AKMT1 (PubMed:26545399). Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation (PubMed:28108655). Trimethylated at Lys-318 by EEF1AKMT2 (PubMed:25144183). Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs (PubMed:28520920). Trimethylated at Gly-2 by EEF1AKNMT (PubMed:30143613). Mono- and dimethylated at Lys-55 by EEF1AKNMT; dimethylated form is predominant (PubMed:30143613, PubMed:30612740).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for EEF1A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ EEF1A1 Antibody
- Atlas Antibodies Anti-EEF1A1 Antibody (HPA056990) and Anti-EEF1A1 Antibody (HPA051759)
-
Creative Diagnostics
- Anti-E. coli eEF1A1 Monoclonal antibody, Clone 002
- Rabbit anti-Human eEF1A1 polyclonal antibody (DPABH-11503)
- Rabbit anti-Human eEF1A1 polyclonal antibody (DPABH-03799)
- Rabbit anti-Human eEF1A1 polyclonal antibody (DPABH-26205)
- Mouse anti-Human EEF1A1 polyclonal antibody
- Anti-eEF1A polyclonal antibody
-
Creative Biolabs
- Recombinant Anti-Human EEF1A1 Antibody Fab Fragment
- Recombinant Anti-Human EEF1A1 Antibody
- Mouse Anti-EEF1A1 (AA 1-462) Recombinant Antibody (23C11)
- Rabbit Anti-EEF1A1 Recombinant Antibody (CBFYE-0457)
- Mouse Anti-EEF1A1 Recombinant Antibody (PAT23C11AT)
- Rabbit Anti-EEF1A1 Recombinant Antibody (EPR9470)
- Mouse Anti-EEF1A1 Recombinant Antibody (CBFYE-0456)
- Mouse Anti-EEF1A1 Recombinant Antibody (CBFYE-0458)
- Mouse Anti-EEF1A1 Recombinant Antibody (AT23C11)
-
Custom Antibody ServicesOriGene Antibodies for EEF1A1
- Novus Biologicals Antibodies for EEF1A1
- Invitrogen Antibodies for EEF1A1 (AFLGC-EEF1A1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for EEF1A1
- Sino Biological Antibodies for EEF1A1
Protein Products
- Atlas Antibodies PrEST Antigen EEF1A1 (APrEST83872) and PrEST Antigen EEF1A1 (APrEST83873)
-
OriGene Purified Proteins for EEF1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for EEF1A1
- Origene Custom Protein Services for EEF1A1
- ProSpec Recombinant Proteins for EEF1A1
-
Abcam proteins for EEF1A1
Assay Products
- Aviva Systems Biology EEF1A1 ELISA Kit (Human) : 96 Wells (OKEH02166) and EEF1A1 ELISA Kit (Human) (OKCD08740)
- antibodies-online: Show 14 available eEF1A1 Elisa Kits ranked by validation data
- Compare Top eEF1A1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for EEF1A1 Gene
Domains & Families for EEF1A1 Gene
Gene Families for EEF1A1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EEF1A1 Gene
Suggested Antigen Peptide Sequences for EEF1A1 Gene
- GenScript: Design optimal peptide antigens:
-
- Leukocyte receptor cluster member 7 (EF1A1_HUMAN)
- EEF1A protein (Q14222_HUMAN)
- EEF1A1 protein (Q504Z0_HUMAN)
- Elongation factor 1-alpha (Q6IPN6_HUMAN)
- Elongation factor 1-alpha (Q6IPS9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P68104UniProtKB/Swiss-Prot:
EF1A1_HUMAN :- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
- Family:
-
- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Function for EEF1A1 Gene
Molecular function for EEF1A1 Gene
- UniProtKB/Swiss-Prot Function:
- This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
- UniProtKB/Swiss-Prot Induction:
- By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.
- GENATLAS Biochemistry:
- eukaryotic translation elongation factor 1,alpha 1,ubiquitously expressed
Phenotypes From GWAS Catalog for EEF1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000049 | tRNA binding | IDA | 12426392 |
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003746 | translation elongation factor activity | IEA,TAS | 17595531 |
| GO:0003924 | GTPase activity | IEA,IBA | 21873635 |
Phenotypes for EEF1A1 Gene
- MGI mutant phenotypes for EEF1A1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for EEF1A1:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased cell number
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death HMECs cells
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased melanin production
- Decreased NF-kappaB reporter expression
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A/WSN/33 replication
- shRNA abundance <= 50%
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for EEF1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF1A1
- genomics-online: gRNA clones - Search for available eEF1A1 gRNA products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
- Applied Biological Materials (abm): CRISPR Clones for EEF1A1 - Select products 50% OFF >
- * EEF1A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * EEF1A1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for EEF1A1
miRNA for EEF1A1 Gene
- miRTarBase miRNAs that target EEF1A1
-
- hsa-mir-16-5p (MIRT031618)
- hsa-mir-1226-3p (MIRT036484)
- hsa-mir-877-5p (MIRT037373)
- hsa-mir-455-3p (MIRT037887)
- hsa-mir-361-3p (MIRT038270)
- hsa-mir-296-3p (MIRT038433)
- hsa-mir-93-3p (MIRT038724)
- hsa-mir-421 (MIRT039430)
- hsa-mir-652-3p (MIRT039465)
- hsa-mir-615-3p (MIRT040041)
- hsa-mir-505-3p (MIRT041069)
- hsa-mir-501-5p (MIRT041144)
- hsa-mir-497-5p (MIRT041183)
- hsa-mir-484 (MIRT041803)
- hsa-mir-423-3p (MIRT042476)
- hsa-mir-339-5p (MIRT042754)
- hsa-mir-324-3p (MIRT042916)
- hsa-mir-340-3p (MIRT043857)
- hsa-mir-30e-5p (MIRT044159)
- hsa-mir-106b-5p (MIRT044291)
- hsa-mir-186-5p (MIRT044909)
- hsa-mir-185-5p (MIRT045351)
- hsa-mir-125a-5p (MIRT045725)
- hsa-mir-125b-5p (MIRT045935)
- hsa-mir-23b-3p (MIRT046331)
- hsa-mir-15b-5p (MIRT046401)
- hsa-let-7g-5p (MIRT046556)
- hsa-mir-221-3p (MIRT046863)
- hsa-mir-30c-5p (MIRT047870)
- hsa-mir-197-3p (MIRT048051)
- hsa-mir-100-5p (MIRT048484)
- hsa-mir-96-5p (MIRT048716)
- hsa-mir-93-5p (MIRT048759)
- hsa-mir-92a-3p (MIRT049131)
- hsa-mir-30a-5p (MIRT049950)
- hsa-mir-26b-5p (MIRT050042)
- hsa-mir-25-3p (MIRT050247)
- hsa-mir-24-3p (MIRT050378)
- hsa-mir-18a-5p (MIRT050679)
- hsa-mir-17-5p (MIRT050841)
- hsa-let-7b-5p (MIRT051968)
- hsa-mir-1260b (MIRT052768)
- hsa-mir-4441 (MIRT477715)
- hsa-mir-4776-3p (MIRT477716)
- hsa-mir-6516-5p (MIRT477717)
- hsa-mir-4659b-5p (MIRT477718)
- hsa-mir-4659a-5p (MIRT477719)
- hsa-mir-5590-5p (MIRT477720)
- hsa-mir-765 (MIRT477721)
- hsa-mir-6499-3p (MIRT477722)
- hsa-mir-4784 (MIRT477723)
- hsa-mir-3150b-3p (MIRT477724)
- hsa-mir-5186 (MIRT477725)
- hsa-mir-6840-3p (MIRT477726)
- hsa-mir-665 (MIRT477727)
- hsa-mir-6888-5p (MIRT477728)
- hsa-mir-4459 (MIRT477729)
- hsa-mir-6732-5p (MIRT477730)
- hsa-mir-7150 (MIRT477731)
- hsa-mir-4736 (MIRT477732)
- hsa-mir-4763-3p (MIRT477733)
- hsa-mir-1207-5p (MIRT477734)
- hsa-mir-4328 (MIRT768697)
- hsa-mir-4457 (MIRT769208)
- hsa-mir-4482-3p (MIRT769586)
- hsa-mir-4731-3p (MIRT771775)
- hsa-mir-4801 (MIRT772546)
- hsa-mir-7159-3p (MIRT781573)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for EEF1A1
- Browse OriGene Inhibitory RNA Products For EEF1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF1A1
- genomics-online: shRNA clones - Search for available eEF1A1 shRNA products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for EEF1A1
- Addgene plasmids for EEF1A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF1A1
- genomics-online: cdna clones - Search for available eEF1A1 CDNA products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
- orf clones - Search for available eEF1A1 ORF products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
- Applied Biological Materials (abm): Clones for EEF1A1 - Select products 50% OFF >
- * EEF1A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * EEF1A1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1A1 Gene
Localization for EEF1A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EEF1A1 Gene
- Cytoplasm. Nucleus. Nucleus, nucleolus. Cell membrane. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340). Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580). Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934). {ECO:0000269 PubMed:19158340, ECO:0000269 PubMed:26497934, ECO:0000269 PubMed:8650580}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| lysosome | 4 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | HDA | 23580065 |
| GO:0005634 | nucleus | IDA,IEA | 8743958 |
| GO:0005730 | nucleolus | IEA,IDA | 9852145 |
| GO:0005737 | cytoplasm | TAS | 3512269 |
Pathways & Interactions for EEF1A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Cellular response to heat stress |
.01
|
|
| 4 | Metabolism of proteins | ||
| 5 | Translational Control | ||
Pathways by source for EEF1A1 Gene
1 BioSystems pathway for EEF1A1 Gene
13 Reactome pathways for EEF1A1 Gene
3 KEGG pathways for EEF1A1 Gene
1 Cell Signaling Technology pathway for EEF1A1 Gene
Interacting Proteins for EEF1A1 Gene
Selected Interacting proteins:
P68104-EF1A1_HUMAN
ENSP00000339063
for EEF1A1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EEF1A1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IBA | 21873635 |
| GO:0006414 | translational elongation | TAS,IEA | 8812466 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0071364 | cellular response to epidermal growth factor stimulus | IDA | 9852145 |
| GO:1900022 | regulation of D-erythro-sphingosine kinase activity | IDA | 18263879 |
Drugs & Compounds for EEF1A1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 227 | ||
| Zinc | Approved, Investigational | Pharma | Target | 2741 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target | 0 | ||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
(1) ApexBio Compounds for EEF1A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species] | Elongation factor-1 subunit |
Drug Products
- Atlas Antibodies PrEST Antigen EEF1A1 (APrEST83872) and PrEST Antigen EEF1A1 (APrEST83873)
- ApexBio compounds for EEF1A1
Transcripts for EEF1A1 Gene
mRNA/cDNA for EEF1A1 Gene
- (2) REFSEQ mRNAs :
- (82) Additional mRNA sequences :
- (2606) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000316292 4441 bps (ENST00000316292.13)
- ENST00000491404 633 bps (ENST00000491404.1)
- ENST00000309268 3512 bps (ENST00000309268.10)
- ENST00000490569 1802 bps (ENST00000490569.5)
- ENST00000331523 1923 bps (ENST00000331523.6)
CRISPR Products
-
OriGene CRISPR knockouts for EEF1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF1A1
- genomics-online: gRNA clones - Search for available eEF1A1 gRNA products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
- Applied Biological Materials (abm): CRISPR Clones for EEF1A1 - Select products 50% OFF >
- * EEF1A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * EEF1A1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for EEF1A1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for EEF1A1
- Browse OriGene Inhibitory RNA Products For EEF1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF1A1
- genomics-online: shRNA clones - Search for available eEF1A1 shRNA products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for EEF1A1
- Addgene plasmids for EEF1A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF1A1
- genomics-online: cdna clones - Search for available eEF1A1 CDNA products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
- orf clones - Search for available eEF1A1 ORF products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
- Applied Biological Materials (abm): Clones for EEF1A1 - Select products 50% OFF >
- * EEF1A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * EEF1A1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: |
Expression for EEF1A1 Gene
This gene is overexpressed in Breast (23.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EEF1A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of EEF1A1 Gene:
EEF1A1SOURCE GeneReport for Unigene cluster for EEF1A1 Gene:
Hs.535192mRNA Expression by UniProt/SwissProt for EEF1A1 Gene:
P68104-EF1A1_HUMAN
Tissue specificity:
Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for EEF1A1 Gene
- Blood(5)
- Eye(5)
- Heart(5)
- Intestine(5)
- Kidney(5)
- Liver(5)
- Lung(5)
- Pancreas(5)
- Skin(5)
- Spleen(5)
- Stomach(5)
- Nervous system(5)
- Bone(4.9)
- Muscle(4.9)
- Thyroid gland(4.6)
- Lymph node(3.1)
- Adrenal gland(3)
- Bone marrow(3)
- Gall bladder(2.8)
Primer Products
-
OriGene qPCR primer pairs for EEF1A1
-
OriGene qPCR primer pairs and template standards for EEF1A1
- genomics-online: primer clones - Search for available eEF1A1 Primer products
- Overview of 263 available eEF1A1 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1A1 Gene
Orthologs for EEF1A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | EEF1A1 33 |
|
OneToOne | |
| LOC102151992 32 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | EEF1A1 33 32 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | EEF1A1 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Eef1a1 17 33 32 |
|
||
| cow (Bos Taurus) |
Mammalia | EEF1A1 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Eef1a1 32 |
|
||
| chicken (Gallus gallus) |
Aves | EEF1A 33 |
|
OneToOne | |
| EEF1A1 32 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | EEF1A1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eef1a1o 32 |
|
||
| MGC75658 32 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | eef1a1b 33 |
|
OneToMany | |
| eef1a1a 33 32 |
|
OneToMany | |||
| -- 32 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1771 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ef1alpha100E 33 34 |
|
ManyToMany | |
| Ef1alpha48D 34 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | eef-1A.2 33 |
|
ManyToMany | |
| eef-1A.1 33 |
|
ManyToMany | |||
| eft-3 34 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TEF2 35 33 |
|
||
| TEF1 35 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G07940 32 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.10761 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0177500 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11100 33 |
|
ManyToMany | |
| CSA.4537 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| CSA.11147 33 |
|
ManyToMany |
- Species where no ortholog for EEF1A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for EEF1A1 Gene
- ENSEMBL:
- Gene Tree for EEF1A1 (if available)
- TreeFam:
- Gene Tree for EEF1A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EEF1A1: view image
Paralogs for EEF1A1 Gene
Paralogs for EEF1A1 Gene
(11) SIMAP similar genes for EEF1A1 Gene using alignment to 13 proteins:
- EF1A1_HUMAN
- A6PW80_HUMAN
- Q504Z0_HUMAN
- Q5JR01_HUMAN
- Q6IPN6_HUMAN
- Q6IPS9_HUMAN
- Q6IPT9_HUMAN
- Q6IQ15_HUMAN
- Q6NS35_HUMAN
- Q6NSH7_HUMAN
- Q6P082_HUMAN
- Q6P4C9_HUMAN
- Q96EB3_HUMAN
Pseudogenes.org Pseudogenes for EEF1A1 Gene
- PGOHUM00000290556
- PGOHUM00000291437
- PGOHUM00000291569
- PGOHUM00000291633
- PGOHUM00000292739
- PGOHUM00000292949
- PGOHUM00000293481
- PGOHUM00000296410
- PGOHUM00000296705
- PGOHUM00000296712
- PGOHUM00000296913
- PGOHUM00000298054
- PGOHUM00000299300
- PGOHUM00000299311
- PGOHUM00000299407
- PGOHUM00000299612
- PGOHUM00000300174
- PGOHUM00000300312
- PGOHUM00000300382
- PGOHUM00000300575
- PGOHUM00000301076
- PGOHUM00000301947
- PGOHUM00000302065
- PGOHUM00000302473
- PGOHUM00000302529
- PGOHUM00000302538
- PGOHUM00000302545
- PGOHUM00000302841
- PGOHUM00000303662
- PGOHUM00000304735
- PGOHUM00000304807
- PGOHUM00000304823
- PGOHUM00000304920
- PGOHUM00000305205
- PGOHUM00000305241
- PGOHUM00000289777
Variants for EEF1A1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000235376 | -- | 73,520,422(-) | G/A | intron_variant | |
| rs1000315082 | -- | 73,517,341(-) | T/C | 3_prime_UTR_variant | |
| rs1000407491 | -- | 73,521,641(-) | C/T | upstream_transcript_variant | |
| rs1000790827 | -- | 73,517,217(-) | A/G | 3_prime_UTR_variant | |
| rs1001396441 | -- | 73,518,540(-) | A/G | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2675873 | CNV | deletion | 23128226 |
| esv2763576 | CNV | gain | 21179565 |
| esv3609512 | CNV | loss | 21293372 |
| nsv463153 | CNV | loss | 19166990 |
| nsv5350 | CNV | deletion | 18451855 |
| nsv603693 | CNV | loss | 21841781 |
| nsv981157 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.40;
8.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EEF1A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EEF1A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1A1 Gene
Disorders for EEF1A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| eukaryotic translation elongation factor 1 alpha-1-like 14 |
|
|
| cervical cancer |
|
|
| retinitis pigmentosa 40 |
|
|
| cutaneous anthrax |
|
|
| retinitis pigmentosa |
|
|
Search EEF1A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EEF1A1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for EEF1A1 Gene
Publications for EEF1A1 Gene
- Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. (PMID: 17177976) Maruyama T … Suzuki N (Clinical and experimental immunology 2007) 3 4 23 56
- Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack MT … Görlich D (The EMBO journal 2002) 3 4 23 56
- The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). (PMID: 28108655) Malecki J … Falnes PØ (Nucleic acids research 2017) 3 4 56
- Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. (PMID: 28520920) Jakobsson ME … Falnes PØ (Nucleic acids research 2017) 3 4 56
- Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. (PMID: 26545399) Hamey JJ … Wilkins MR (Molecular & cellular proteomics : MCP 2016) 3 4 56
ExternalLinks
Products for EEF1A1 Gene
- Custom Antibody ServicesOriGene Antibodies for EEF1A1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EEF1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for EEF1A1
- Origene Custom Protein Services for EEF1A1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for EEF1A1
- Browse OriGene Inhibitory RNA Products For EEF1A1
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- OriGene qPCR primer pairs and template standards for EEF1A1
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- Browse OriGene miRNA Products For EEF1A1
- Sino Biological Human cDNA Clone for EEF1A1
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for EEF1A1
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- ApexBio compounds for EEF1A1
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- antibodies-online: Show 37 available eEF1A1 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for EEF1A1
- Search Santa Cruz Biotechnology (SCBT) for EEF1A1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EEF1A1
- genomics-online: cdna clones - Search for available eEF1A1 CDNA products
- Overview of 263 available eEF1A1 gene related products
- Recommended
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- Overview of 263 available eEF1A1 gene related products
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- Overview of 263 available eEF1A1 gene related products
- Recommended
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- Overview of 263 available eEF1A1 gene related products
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- Overview of 263 available eEF1A1 gene related products
- Recommended
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EEF1A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EEF1A1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for EEF1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EEF1A1
Sources for EEF1A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158)