Aliases for EDNRA Gene
External Ids for EDNRA Gene
Previous GeneCards Identifiers for EDNRA Gene
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GeneCards Summary for EDNRA Gene
EDNRA (Endothelin Receptor Type A) is a Protein Coding gene. Diseases associated with EDNRA include Mandibulofacial Dysostosis With Alopecia and Migraine With Or Without Aura 1. Among its related pathways are Signaling by GPCR and Development Endothelin-1/EDNRA signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and endothelin receptor activity. An important paralog of this gene is EDNRB.
UniProtKB/Swiss-Prot Summary for EDNRA Gene
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
The endothelinA receptor (ETA receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETB. They are located primarily in the vascular smooth muscle where they play a role in vasoconstriction and cell proliferation.