Aliases for EDN2 Gene
External Ids for EDN2 Gene
Previous GeneCards Identifiers for EDN2 Gene
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
GeneCards Summary for EDN2 Gene
EDN2 (Endothelin 2) is a Protein Coding gene. Diseases associated with EDN2 include Mandibulofacial Dysostosis With Alopecia and Hypertension, Essential. Among its related pathways are Signaling by GPCR and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is EDN1.
UniProtKB/Swiss-Prot Summary for EDN2 Gene
Endothelins are endothelium-derived vasoconstrictor peptides.
The endothelin family consists of highly potent vasoconstrictive peptides. Three endogenous isoforms are known to exist - ET-1, ET-2 and ET-3. Due to their physiological role as vasoactive peptides, endothelins have been linked to certain cardiac, vascular and renal diseases; endothelin antagonists may therefore play an important role in the treatment of these conditions. Two distinct endothelin receptors have so far been cloned in mammals, classified as ETA and ETB receptors.