Aliases for EDARADD Gene
Aliases for EDARADD Gene
External Ids for EDARADD Gene
- HGNC: 14341
- Entrez Gene: 128178
- Ensembl: ENSG00000186197
- OMIM: 606603
- UniProtKB: Q8WWZ3
Previous GeneCards Identifiers for EDARADD Gene
- GC01P234691
- GC01P232012
- GC01P232808
- GC01P233598
- GC01P232884
- GC01P232885
- GC01P236511
- GC01P207012
Summaries for EDARADD Gene
-
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for EDARADD Gene
EDARADD (EDAR Associated Death Domain) is a Protein Coding gene. Diseases associated with EDARADD include Ectodermal Dysplasia 11B, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive and Ectodermal Dysplasia 11A, Hypohidrotic/Hair/Tooth Type, Autosomal Dominant. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System.
UniProtKB/Swiss-Prot for EDARADD Gene
-
Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
Additional gene information for EDARADD Gene
- Monarch Initiative
- Search for EDARADD at DataMed
- Search for EDARADD at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDARADD Gene
Genomics for EDARADD Gene
GeneHancer (GH) Regulatory Elements for EDARADD Gene
Promoters and enhancers for EDARADD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around EDARADD on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for EDARADD Gene
Genomic Locations for EDARADD Gene
- chr1:236,348,257-236,484,914
- (GRCh38/hg38)
- Size:
- 136,658 bases
- Orientation:
- Plus strand
- chr1:236,511,562-236,648,214
- (GRCh37/hg19)
Genomic View for EDARADD Gene
Genes around EDARADD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.3 by Ensembl
- 1q42.3-q43 by Entrez Gene
- 1q42.3-q43 by HGNC
EDARADD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EDARADD Gene
Proteins for EDARADD Gene
-
Protein details for EDARADD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWZ3-EDAD_HUMAN
- Recommended name:
- Ectodysplasin-A receptor-associated adapter protein
- Protein Accession:
- Q8WWZ3
- A2VCK5
- A8K7B5
- B1AL54
- B9ZVW5
- Q5VYJ7
Protein attributes for EDARADD Gene
- Size:
- 215 amino acids
- Molecular mass:
- 24802 Da
- Quaternary structure:
-
- Self-associates and binds EDAR, TRAF1, TRAF2 and TRAF3.
Protein Expression for EDARADD Gene
Post-translational modifications for EDARADD Gene
Other Protein References for EDARADD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for EDARADD
- Invitrogen Antibodies for EDARADD
- antibodies-online: Search results for 7 available EDARADD Antibodies ranked by validation data
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Protein Products
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Assay Products
- antibodies-online: Search results for 2 available EDARADD Elisa Kits ranked by validation data
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Quality Products:
No data available for DME Specific Peptides for EDARADD Gene
Domains & Families for EDARADD Gene
Gene Families for EDARADD Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for EDARADD Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EDARADD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for EDARADD Gene
Function for EDARADD Gene
Molecular function for EDARADD Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
Phenotypes From GWAS Catalog for EDARADD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for EDARADD Gene
- MGI mutant phenotypes for EDARADD:
-
inferred from 5 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- mortality/aging
- behavior/neurological phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- pigmentation phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for EDARADD:
Animal Model Products
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-
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- Overview of 85 available EDARADD gene related products
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Vectors and viruses for KO, Activation, Repression, and more
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miRNA for EDARADD Gene
- miRTarBase miRNAs that target EDARADD
-
- hsa-mir-18a-3p (MIRT040816)
- hsa-mir-378a-3p (MIRT043891)
- hsa-mir-552-3p (MIRT186097)
- hsa-mir-764 (MIRT186098)
- hsa-mir-4436a (MIRT186099)
- hsa-mir-5000-3p (MIRT186100)
- hsa-mir-4674 (MIRT456952)
- hsa-mir-4639-5p (MIRT456953)
- hsa-mir-4437 (MIRT456954)
- hsa-mir-6838-3p (MIRT638787)
- hsa-mir-3686 (MIRT638788)
- hsa-mir-4284 (MIRT638789)
- hsa-mir-103a-2-5p (MIRT638790)
- hsa-mir-3182 (MIRT638791)
- hsa-mir-4772-3p (MIRT638792)
- hsa-mir-4638-5p (MIRT638793)
- hsa-mir-1307-3p (MIRT638794)
- hsa-mir-1304-3p (MIRT638795)
- hsa-mir-6741-3p (MIRT638796)
- hsa-mir-6890-3p (MIRT638797)
miRNA Products
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EDARADD Gene
Localization for EDARADD Gene
Subcellular locations from UniProtKB/Swiss-Prot for EDARADD Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
- Cytosol (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for EDARADD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytokine Signaling in Immune system | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 4 | TNFs bind their physiological receptors | ||
Pathways by source for EDARADD Gene
4 Reactome pathways for EDARADD Gene
Interacting Proteins for EDARADD Gene
Selected Interacting proteins:
Q8WWZ3-EDAD_HUMAN
ENSP00000335076
for EDARADD Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | TAS | -- |
No data available for SIGNOR curated interactions for EDARADD Gene
Transcripts for EDARADD Gene
mRNA/cDNA for EDARADD Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (37) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EDARADD Gene
CRISPR Products
-
OriGene CRISPR knockouts for EDARADD
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- Overview of 85 available EDARADD gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EDARADD
- GenScript: Design CRISPR guide RNA sequences for EDARADD
miRNA Products
- Search ViGene Biosciences for EDARADD
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EDARADD
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- genomics-online: shRNA clones - Search results for 85 available EDARADD gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for EDARADD gene
Clone Products
- Sino Biological Human cDNA Clone for EDARADD
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EDARADD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for EDARADD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Secondary Enamel Knot Cells Enamel Knot
- Primary Enamel Knot Cells Enamel Knot
-
Hair (Integumentary System)
- Primary Hair Placode Cells Hair Follicle
-
Epithelial Cells
- Primary Hair Placode Cells Hair Follicle
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for EDARADD Gene
This gene is overexpressed in Bladder (x6.7) and Stomach (x4.6).
This gene is overexpressed in Breast (51.9) and Fetal heart (17.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EDARADD Gene
NURSA nuclear receptor signaling pathways regulating expression of EDARADD Gene:
EDARADDSOURCE GeneReport for Unigene cluster for EDARADD Gene:
Hs.352224mRNA Expression by UniProt/SwissProt for EDARADD Gene:
Q8WWZ3-EDAD_HUMAN
Tissue specificity:
Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis.
Evidence on tissue expression from TISSUES for EDARADD Gene
- Skin(4.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EDARADD Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- integumentary
- nervous
- skeleton
Regions:
Head and neck:
- chin
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- scalp
- skull
- tooth
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- hair
- skin
- spinal column
- sweat gland
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for EDARADD
-
OriGene qPCR primer pairs and template standards for EDARADD
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Gene Expression Assay Products
Orthologs for EDARADD Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EDARADD 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EDARADD 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | EDARADD 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Edaradd 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Edaradd 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EDARADD 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EDARADD 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EDARADD 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490133 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | edaradd 33 34 |
|
- Species where no ortholog for EDARADD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for EDARADD Gene
(3) SIMAP similar genes for EDARADD Gene using alignment to 4 proteins:
No data available for Paralogs for EDARADD Gene
Variants for EDARADD Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1004330961 | uncertain-significance, Hypohidrotic Ectodermal Dysplasia, Recessive | 236,483,798(+) | G/A | 3_prime_UTR_variant | |
| rs114632254 | benign, not specified, Ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant, Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive | 236,482,309(+) | C/T | coding_sequence_variant, missense_variant | |
| rs114783553 | uncertain-significance, Hypohidrotic Ectodermal Dysplasia, Recessive | 236,484,536(+) | G/A | 3_prime_UTR_variant | |
| rs121908116 | pathogenic, Ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant, Autosomal dominant hypohidrotic ectodermal dysplasia, Ectodermal dysplasia 11A, hypohidrotic/hair/nail type, autosomal dominant (ECTD11A) [MIM:614940] | 236,482,366(+) | T/G | coding_sequence_variant, missense_variant | |
| rs142266831 | uncertain-significance, Hypohidrotic Ectodermal Dysplasia, Recessive | 236,482,934(+) | G/A | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.10;
38.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EDARADD Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EDARADD Gene
Disorders for EDARADD Gene
(13) MalaCards diseases for EDARADD Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive |
|
|
| ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant |
|
|
| ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant |
|
|
| hypohidrotic ectodermal dysplasia autosomal recessive |
|
|
| ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive |
|
Search EDARADD in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EDAD_HUMAN- Ectodermal dysplasia 11A, hypohidrotic/hair/nail type, autosomal dominant (ECTD11A) [MIM:614940]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands. {ECO:0000269 PubMed:17354266, ECO:0000269 PubMed:20979233}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD11B) [MIM:614941]: A disorder due to abnormal development of two or more ectodermal structures, and characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. {ECO:0000269 PubMed:11780064, ECO:0000269 PubMed:17354266, ECO:0000269 PubMed:20222921}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for EDARADD
No data available for Genatlas for EDARADD Gene
Publications for EDARADD Gene
- Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases. (PMID: 20222921) Chassaing N … Calvas P (The British journal of dermatology 2010) 3 4 22 58
- Gene defect in ectodermal dysplasia implicates a death domain adapter in development. (PMID: 11780064) Headon DJ … Overbeek PA (Nature 2001) 2 3 4 58
- Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. (PMID: 20979233) Cluzeau C … Smahi A (Human mutation 2011) 3 4 58
- Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus. (PMID: 17354266) Bal E … Smahi A (Human mutation 2007) 4 22 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 7 available EDARADD Antibodies ranked by validation data
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- Search GeneTex for Proteins for EDARADD
- ViGene Biosciences adenoviral particle packaged cDNA for EDARADD gene
- ViGene Biosciences lentiviral particle packaged cDNA for EDARADD gene
- ViGene Biosciences ready-to-package AAV shRNAs for EDARADD gene
- Search ViGene Biosciences for EDARADD
- Horizon Cell Lines for EDARADD
- genomics-online: cdna clones - Search results for 85 available EDARADD gene related products
- Overview of 85 available EDARADD gene related products
- orf clones - Search results for 85 available EDARADD gene related products
- Overview of 85 available EDARADD gene related products
- genomics-online: gRNA clones - Search results for 85 available EDARADD gene related products
- Overview of 85 available EDARADD gene related products
- genomics-online: primer clones - Search results for 85 available EDARADD gene related products
- Overview of 85 available EDARADD gene related products
- genomics-online: shRNA clones - Search results for 85 available EDARADD gene related products
- Overview of 85 available EDARADD gene related products
Sources for EDARADD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
