The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells u... See more...

Aliases for ECT2 Gene

Aliases for ECT2 Gene

  • Epithelial Cell Transforming 2 2 3 5
  • Epithelial Cell-Transforming Sequence 2 Oncogene 3 4
  • Protein ECT2 3 4
  • ARHGEF31 2 3
  • Epithelial Cell Transforming Sequence 2 Oncogene 2
  • ECT2 5

External Ids for ECT2 Gene

Previous GeneCards Identifiers for ECT2 Gene

  • GC03P169518
  • GC03P173499
  • GC03P173870
  • GC03P173793
  • GC03P173773
  • GC03P173951
  • GC03P172468
  • GC03P169843

Summaries for ECT2 Gene

Entrez Gene Summary for ECT2 Gene

  • The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

GeneCards Summary for ECT2 Gene

ECT2 (Epithelial Cell Transforming 2) is a Protein Coding gene. Diseases associated with ECT2 include Breast Cancer and Lung Cancer. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GTPase activator activity.

UniProtKB/Swiss-Prot Summary for ECT2 Gene

  • Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

Gene Wiki entry for ECT2 Gene

Additional gene information for ECT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ECT2 Gene

Genomics for ECT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ECT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J172747 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 605.4 -0.4 -390 5 SP1 CREB1 GATAD2A CTCF ZNF629 RFX1 SOX13 IKZF1 ZNF692 RCOR2 ECT2 HSALNG0030755 lnc-NCEH1-3 NCEH1 RNU6-547P piR-31433-009
GH03J171804 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 -942.0 -941995 9.3 CEBPG HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 ZNF512 RFX1 PLD1 RPL22L1 FNDC3B TMEM212 ECT2 TNIK lnc-PLD1-1 RF00017-4168
GH03J172690 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 10.2 -58.6 -58612 2.3 GATAD2A RCOR2 FOXA1 RXRB CEBPA SOX13 CTBP1 FOXA2 MAFF MAFK NCEH1 ECT2 lnc-TNFSF10-5 LOC100420939 lnc-ECT2-2 TNFSF10
GH03J171787 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.5 -959.8 -959844 6.7 GATAD2A PRDM10 ZNF629 SOX13 ZNF692 RCOR2 ZNF7 FOXA1 POLR2A PATZ1 PLD1 TMEM212 FNDC3B ECT2 RF00017-4168 lnc-PLD1-1 TNIK
GH03J172725 Enhancer 0.4 Ensembl 11 -24.0 -23981 2.2 CEBPA CEBPB CREB1 NCEH1 RNU6-547P ECT2 piR-31433-009 ENSG00000287012 lnc-NCEH1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ECT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ECT2

Top Transcription factor binding sites by QIAGEN in the ECT2 gene promoter:
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXO1
  • FOXO1a
  • HOXA3

Genomic Locations for ECT2 Gene

Genomic Locations for ECT2 Gene
chr3:172,750,682-172,829,273
(GRCh38/hg38)
Size:
78,592 bases
Orientation:
Plus strand
chr3:172,468,472-172,539,264
(GRCh37/hg19)
Size:
70,793 bases
Orientation:
Plus strand

Genomic View for ECT2 Gene

Genes around ECT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ECT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ECT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECT2 Gene

Proteins for ECT2 Gene

  • Protein details for ECT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8V3-ECT2_HUMAN
    Recommended name:
    Protein ECT2
    Protein Accession:
    Q9H8V3
    Secondary Accessions:
    • Q0MT80
    • Q2M269
    • Q6U836
    • Q9NSV8
    • Q9NVW9

    Protein attributes for ECT2 Gene

    Size:
    914 amino acids
    Molecular mass:
    103505 Da
    Quaternary structure:
    • Homodimer (PubMed:15545273, PubMed:14645260, PubMed:16170345). Homooligomer (PubMed:15545273). Found in the centralspindlin complex (PubMed:16236794). Interacts with NR1I3 (By similarity). Interacts (Thr-359 phosphorylated form) with PARD6A; the interaction is observed in cancer cells (PubMed:15254234, PubMed:19617897). Interacts (Thr-359 phosphorylated form) with PRKCI; the interaction is observed in cancer cells (PubMed:19617897). Interacts with PKP4; the interaction is observed at the midbody (PubMed:22814378). Interacts with RACGAP1/CYK4; the interaction is direct, occurs in a microtubule-dependent manner, occurs at anaphase and during cytokinesis, is inhibited in metaphase by phosphorylation of ECT2 on Thr-373 and is stimulated in early anaphase by dephosphorylation of ECT2 probably on Thr-373 through CDK1 activity (PubMed:16103226, PubMed:16129829, PubMed:16236794, PubMed:19468300, PubMed:19468302, PubMed:25068414). Interacts with PLK1; the interaction is stimulated upon its phosphorylation on Thr-444 (PubMed:16247472). Interacts with RHOA; the interaction results in allosteric activation of ECT2 (PubMed:31888991). Interacts with KIF23, PARD3, PARD6B and PRKCQ (PubMed:15254234, PubMed:16236794).
    SequenceCaution:
    • Sequence=BAA91624.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for ECT2 Gene

    Alternative splice isoforms for ECT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ECT2 Gene

Post-translational modifications for ECT2 Gene

  • Phosphorylated by PLK1 in vitro. Hyperphosphorylated during the G2 phase of the cell cycle. Phosphorylation at Thr-373 occurs during the G2/M phase, relieves its auto-inhibition status and stimulates its GEF activity. Phosphorylation at Thr-444 in G2/M phase is required for subsequent binding with PLK1 and Rho exchange activation. Dephosphorylated at the time of cytokinesis. Phosphorylation at Thr-359 is required for its transformation activity in cancer cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ECT2 Gene

Domains & Families for ECT2 Gene

Gene Families for ECT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ECT2 Gene

InterPro:
Blocks:
  • Pleckstrin-like
  • DH domain
  • BRCT domain
ProtoNet:

Suggested Antigen Peptide Sequences for ECT2 Gene

GenScript: Design optimal peptide antigens:
  • Epithelial cell-transforming sequence 2 oncogene (ECT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H8V3

UniProtKB/Swiss-Prot:

ECT2_HUMAN :
  • The BRCT domains 1 and 2 are required for intramolecular interaction, but not for intermolecular oligomerization (PubMed:15545273). The BRCT domains negatively inhibit its GEF activity in interphase cells (PubMed:15545273, PubMed:31888991). The same BRCT domains may act as a positive regulatory motif for the completion of cytokinesis after the breakdown of nuclear membrane during mitosis (PubMed:15545273).
Domain:
  • The BRCT domains 1 and 2 are required for intramolecular interaction, but not for intermolecular oligomerization (PubMed:15545273). The BRCT domains negatively inhibit its GEF activity in interphase cells (PubMed:15545273, PubMed:31888991). The same BRCT domains may act as a positive regulatory motif for the completion of cytokinesis after the breakdown of nuclear membrane during mitosis (PubMed:15545273).
genes like me logo Genes that share domains with ECT2: view

Function for ECT2 Gene

Molecular function for ECT2 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
UniProtKB/Swiss-Prot Induction:
Up-regulated by calcium in cells forming cell-cell contact sites. Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited by the C-terminal PH domain which folds back and binds to the surface of the DH domain, blocking binding of RHOA to the catalytic center of the DH domain (PubMed:31888991). The 2nd BRCT domain is also involved in inhibition, probably by helping to impede RHOA binding (PubMed:31888991). Allosterically activated by binding of activated GTP-bound RHOA to the PH domain which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the catalytic center (PubMed:31888991). Binding of phosphorylated RACGAP1 to the N-terminal BRCT domain-containing region also releases autoinhibition (PubMed:25068414).
GENATLAS Biochemistry:
mouse Ect2 related proto-oncogene 2

Phenotypes From GWAS Catalog for ECT2 Gene

Gene Ontology (GO) - Molecular Function for ECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IDA 15254234
GO:0005096 GTPase activator activity IMP 15642749
GO:0005515 protein binding IPI 15254234
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with ECT2: view
genes like me logo Genes that share phenotypes with ECT2: view

Animal Models for ECT2 Gene

MGI Knock Outs for ECT2:
  • Ect2 Ect2<tm1b(EUCOMM)Wtsi>
  • Ect2 Ect2<tm1.2Cjd>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ECT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ECT2 Gene

Localization for ECT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ECT2 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cell junction. Cell junction, tight junction. Note=Sequestered within the nucleus during interphase. Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis. Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalized with RhoA at the midbody. Its subcellular localization to tight junction is increased by calcium. Localized predominantly in the cytoplasm of numerous carcinoma cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ECT2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15254234
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 19617897
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ECT2: view

Pathways & Interactions for ECT2 Gene

genes like me logo Genes that share pathways with ECT2: view

Pathways by source for ECT2 Gene

3 GeneGo (Thomson Reuters) pathways for ECT2 Gene
  • G-protein signaling_Regulation of CDC42 activity
  • G-protein signaling_Regulation of RAC1 activity
  • G-protein signaling_RhoA regulation pathway

SIGNOR curated interactions for ECT2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 16236794
GO:0000902 cell morphogenesis IEA --
GO:0007049 cell cycle IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007399 nervous system development IEA,IBA 21873635
genes like me logo Genes that share ontologies with ECT2: view

Drugs & Compounds for ECT2 Gene

No Compound Related Data Available

Transcripts for ECT2 Gene

mRNA/cDNA for ECT2 Gene

14 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ECT2

Alternative Splicing Database (ASD) splice patterns (SP) for ECT2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3: - - -
SP4:
SP5: - -
SP6:
SP7: - - -
SP8: - -
SP9: - -
SP10: -
SP11:
SP12:
SP13:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b
SP1: - -
SP2: - - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for ECT2 Gene

GeneLoc Exon Structure for
ECT2

Expression for ECT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ECT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ECT2 Gene

This gene is overexpressed in Lung (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ECT2 Gene



Protein tissue co-expression partners for ECT2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ECT2

SOURCE GeneReport for Unigene cluster for ECT2 Gene:

Hs.518299

mRNA Expression by UniProt/SwissProt for ECT2 Gene:

Q9H8V3-ECT2_HUMAN
Tissue specificity: Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma.

Evidence on tissue expression from TISSUES for ECT2 Gene

  • Lung(4.4)
  • Nervous system(2.7)
  • Intestine(2.6)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with ECT2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ECT2 Gene

Orthologs for ECT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ECT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ECT2 30 31
  • 99.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ECT2 30 31
  • 93.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ECT2 30 31
  • 92.89 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 90 (a)
OneToMany
-- 31
  • 81 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ECT2 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ect2 30 17 31
  • 87.15 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ect2 30
  • 86.67 (n)
Chicken
(Gallus gallus)
Aves ECT2 30 31
  • 78.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ECT2 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ect2 30
  • 74.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii ect2 30 31
  • 65.64 (n)
OneToOne
Dr.12679 30
Fruit Fly
(Drosophila melanogaster)
Insecta pbl 30 31
  • 47.41 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005796 30
  • 47.1 (n)
Worm
(Caenorhabditis elegans)
Secernentea ect-2 31
  • 18 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToOne
Species where no ortholog for ECT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ECT2 Gene

ENSEMBL:
Gene Tree for ECT2 (if available)
TreeFam:
Gene Tree for ECT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ECT2: view image

Paralogs for ECT2 Gene

(1) SIMAP similar genes for ECT2 Gene using alignment to 10 proteins:

  • ECT2_HUMAN
  • C9J0L6_HUMAN
  • C9J1C4_HUMAN
  • C9JB41_HUMAN
  • C9JDB4_HUMAN
  • C9JDV9_HUMAN
  • C9JTI2_HUMAN
  • G5E9L8_HUMAN
  • H7C103_HUMAN
  • H7C3G1_HUMAN

Pseudogenes.org Pseudogenes for ECT2 Gene

genes like me logo Genes that share paralogs with ECT2: view

No data available for Paralogs for ECT2 Gene

Variants for ECT2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ECT2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
775928 Benign: not provided 172,773,917(+) A/G SYNONYMOUS_VARIANT
VAR_035975 A breast cancer sample p.Thr833Pro
rs34703432 - p.Ser15Thr

Additional dbSNP identifiers (rs#s) for ECT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ECT2 Gene

Variant ID Type Subtype PubMed ID
dgv4983n100 CNV loss 25217958
dgv8731n54 CNV loss 21841781
nsv472498 CNV novel sequence insertion 20440878
nsv7356 OTHER inversion 18451855

Variation tolerance for ECT2 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ECT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ECT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECT2 Gene

Disorders for ECT2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ECT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
lung cancer
  • adenocarcinoma of lung
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search ECT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ECT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ECT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ECT2 Gene

Publications for ECT2 Gene

  1. Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. (PMID: 19468300) Wolfe BA … Glotzer M (PLoS biology 2009) 3 4 23
  2. The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PMID: 17115030) Wolf A … Hatzfeld M (Nature cell biology 2006) 3 4 23
  3. Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. (PMID: 16247472) Niiya F … Miki T (Oncogene 2006) 3 4 23
  4. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. (PMID: 15545273) Kim JE … Chen J (The Journal of biological chemistry 2005) 3 4 23
  5. Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. (PMID: 14587037) Saito S … Miki T (Journal of cellular biochemistry 2003) 3 4 23

Products for ECT2 Gene

Sources for ECT2 Gene