Free for academic non-profit institutions. Other users need a Commercial license
Aliases for ECSIT Gene
Aliases for ECSIT Gene
External Ids for ECSIT Gene
- HGNC: 29548
- Entrez Gene: 51295
- Ensembl: ENSG00000130159
- OMIM: 608388
- UniProtKB: Q9BQ95
Previous GeneCards Identifiers for ECSIT Gene
- GC19M011478
- GC19M011616
- GC19M011191
Summaries for ECSIT Gene
GeneCards Summary for ECSIT Gene
ECSIT (ECSIT Signaling Integrator) is a Protein Coding gene. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and oxidoreductase activity, acting on NAD(P)H.
UniProtKB/Swiss-Prot Summary for ECSIT Gene
-
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).
-
Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Additional gene information for ECSIT Gene
- HGNC(29548)
- Entrez Gene(51295)
- Ensembl(ENSG00000130159)
- OMIM(608388)
- UniProtKB(Q9BQ95)
- Open Targets Platform(ENSG00000130159)
- Search for ECSIT at DataMed
- Search for ECSIT at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ECSIT Gene
Genomics for ECSIT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ECSIT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ECSIT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ECSIT
- Top Transcription factor binding sites by QIAGEN in the ECSIT gene promoter:
-
- ATF6
- FOXO4
- MAZR
- Pax-5
- Sox9
Genomic Locations for ECSIT Gene
Genomic Locations for ECSIT Gene
- chr19:11,505,916-11,529,172
- (GRCh38/hg38)
- Size:
- 23,257 bases
- Orientation:
- Minus strand
- chr19:11,616,731-11,639,989
- (GRCh37/hg19)
- Size:
- 23,259 bases
- Orientation:
- Minus strand
Genomic View for ECSIT Gene
Genes around ECSIT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
ECSIT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ECSIT Gene
Proteins for ECSIT Gene
-
Protein details for ECSIT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BQ95-ECSIT_HUMAN
- Recommended name:
- Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
- Protein Accession:
- Q9BQ95
- E9PAN9
- K7EMM0
- Q96HQ7
- Q9NYI1
Protein attributes for ECSIT Gene
- Size:
- 431 amino acids
- Molecular mass:
- 49148 Da
- Quaternary structure:
-
- Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with NDUFAF1 (PubMed:17344420). Interacts with ACAD9 (PubMed:20816094). Interacts with TRIM59 (By similarity).
Protein Expression for ECSIT Gene
Post-translational modifications for ECSIT Gene
Other Protein References for ECSIT Gene
Antibody Products
- Creative Diagnostics Anti-ECSIT monoclonal antibody
- Creative Biolabs Mouse Anti-ECSIT (AA 20-431) Recombinant Antibody (CBFYE-0416)
-
Custom Antibody ServicesOriGene Antibodies for ECSIT
- Novus Biologicals Antibodies for ECSIT
-
Abcam antibodies for ECSIT
- Invitrogen Antibodies for ECSIT (AFLGC-ECSIT)
-
Biorbyt antibodies for ECSIT
-
Boster Bio Antibodies for ECSIT
-
Custom Antibody ServicesProSci Antibodies for ECSIT
- Sino Biological Antibodies for ECSIT
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ECSIT
- Origene Custom Protein Services for ECSIT
- Novus Biologicals proteins for ECSIT
- Sino Biological Recombinant Proteins for ECSIT
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for ECSIT
-
Signalway Proteins for ECSIT
-
Abcam proteins for ECSIT
Assay Products
- antibodies-online: Show 7 available ECSIT Elisa Kits ranked by validation data
- Compare Top ECSIT Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ECSIT Gene
Domains & Families for ECSIT Gene
Gene Families for ECSIT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for ECSIT Gene
- GenScript: Design optimal peptide antigens:
-
- Protein SITPEC (ECSIT_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BQ95- Family:
-
- Belongs to the ECSIT family.
Function for ECSIT Gene
Molecular function for ECSIT Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).
- UniProtKB/Swiss-Prot Function:
- Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Phenotypes From GWAS Catalog for ECSIT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17344420 |
Phenotypes for ECSIT Gene
- MGI mutant phenotypes for ECSIT:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ECSIT:
Animal Models for ECSIT Gene
- MGI Knock Outs for ECSIT:
-
- Ecsit Ecsit<tm1Gho>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ECSIT - Select products 50% OFF >
- * ECSIT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ECSIT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ECSIT
-
Santa Cruz Biotechnology (SCBT) CRISPR for ECSIT
miRNA for ECSIT Gene
- miRTarBase miRNAs that target ECSIT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ECSIT
- Browse OriGene Inhibitory RNA Products For ECSIT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ECSIT
Clone Products
- Applied Biological Materials (abm): Clones for ECSIT - Select products 50% OFF >
- * ECSIT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206934
- MR206934
- MR206934L3
- MR206934L4
- MR229892
- MR229893
- RC201343
- RC201343L1
- RC201343L2
- RC201343L3
- RC201343L4
- RC227591
- RC227591L3
- RC227591L4
- RC227595
- RC227595L3
- RC227595L4
- RC232397
- RG201343
- RG227591
- RG227595
- RG232397
- RR209134
- RR209134L3
- RR209134L4
- MR206934L3V
- MR206934L4V
- RC201343L1V
- RC201343L2V
- RC201343L3V
- RC201343L4V
- RC227591L3V
- RC227591L4V
- RC227595L3V
- RC227595L4V
- RR209134L3V
- RR209134L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ECSIT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ECSIT
Cell Line Products
-
Horizon Cell Lines for ECSIT
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ECSIT Gene
Localization for ECSIT Gene
Subcellular locations from UniProtKB/Swiss-Prot for ECSIT Gene
- Cytoplasm. Nucleus. Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 17344420 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17344420 |
| GO:0005739 | mitochondrion | IBA,IDA | 17344420 |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
Pathways & Interactions for ECSIT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
| 3 | Toll Comparative Pathway |
Toll Comparative Pathway
.61
Immune response MIF in innate immunity response
.46
|
IL-1 Pathway
.39
|
| 4 | MAPK signaling pathway | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for ECSIT Gene
1 Sino Biological pathway for ECSIT Gene
3 BioSystems pathways for ECSIT Gene
21 Reactome pathways for ECSIT Gene
1 KEGG pathway for ECSIT Gene
3 GeneGo (Thomson Reuters) pathways for ECSIT Gene
- Immune response IL-1 signaling pathway
- Immune response MIF in innate immunity response
- Transcription_NF-kB signaling pathway
4 Qiagen pathways for ECSIT Gene
- IL-1 Pathway
- NF-KappaB (p50-p65) Pathway
- Toll Comparative Pathway
- Toll-Like Receptors Pathway
Interacting Proteins for ECSIT Gene
Selected Interacting proteins:
Q9BQ95-ECSIT_HUMAN
ENSP00000270517
for ECSIT Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ECSIT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | TAS | -- |
| GO:0045087 | innate immune response | IEA | -- |
| GO:0051341 | regulation of oxidoreductase activity | IDA | 17344420 |
| GO:0061635 | regulation of protein complex stability | IDA | 17344420 |
Drugs & Compounds for ECSIT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| NADH | Approved | Nutra | 0 |
Transcripts for ECSIT Gene
mRNA/cDNA for ECSIT Gene
- 4 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000270517 1647 nts (view in UCSC)
- ENST00000588998 818 nts (view in UCSC)
- ENST00000252440 1501 nts (view in UCSC)
- ENST00000592571 941 nts (view in UCSC)
- ENST00000417981 970 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ECSIT - Select products 50% OFF >
- * ECSIT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ECSIT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ECSIT
-
Santa Cruz Biotechnology (SCBT) CRISPR for ECSIT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ECSIT
- Browse OriGene Inhibitory RNA Products For ECSIT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ECSIT
Clone Products
- Applied Biological Materials (abm): Clones for ECSIT - Select products 50% OFF >
- * ECSIT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206934
- MR206934
- MR206934L3
- MR206934L4
- MR229892
- MR229893
- RC201343
- RC201343L1
- RC201343L2
- RC201343L3
- RC201343L4
- RC227591
- RC227591L3
- RC227591L4
- RC227595
- RC227595L3
- RC227595L4
- RC232397
- RG201343
- RG227591
- RG227595
- RG232397
- RR209134
- RR209134L3
- RR209134L4
- MR206934L3V
- MR206934L4V
- RC201343L1V
- RC201343L2V
- RC201343L3V
- RC201343L4V
- RC227591L3V
- RC227591L4V
- RC227595L3V
- RC227595L4V
- RR209134L3V
- RR209134L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ECSIT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ECSIT
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - |
Relevant External Links for ECSIT Gene
- GeneLoc Exon Structure for
- ECSIT
Expression for ECSIT Gene
mRNA differential expression in normal tissues according to GTEx for ECSIT Gene
This gene is overexpressed in Heart - Left Ventricle (x4.1).
This gene is overexpressed in Heart (12.3), Peripheral blood mononuclear cells (11.8), and Retina (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ECSIT Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ECSIT
SOURCE GeneReport for Unigene cluster for ECSIT Gene:
Hs.515146Evidence on tissue expression from TISSUES for ECSIT Gene
- Lung(4.4)
- Eye(4.2)
- Pancreas(4.2)
- Nervous system(3.9)
- Muscle(2.7)
- Heart(2.4)
- Blood(2.2)
- Spleen(2.2)
- Kidney(2.1)
- Lymph node(2.1)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for ECSIT
-
OriGene qPCR primer pairs and template standards for ECSIT
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ECSIT Gene
Orthologs for ECSIT Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ECSIT 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ECSIT 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ECSIT 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ecsit 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ecsit 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ECSIT 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ECSIT 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ECSIT 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | ECSIT 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ecsit 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ecsit 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005295 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | ECSIT 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y17G9B.5 30 31 |
|
OneToOne |
- Species where no ortholog for ECSIT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ECSIT Gene
- ENSEMBL:
- Gene Tree for ECSIT (if available)
- TreeFam:
- Gene Tree for ECSIT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ECSIT: view image
Paralogs for ECSIT Gene
No data available for Paralogs for ECSIT Gene
Variants for ECSIT Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ECSIT Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2302971 | - | p.Gly406Arg | |||
| rs34803265 | - | p.Arg278Cys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3643673 | CNV | loss | 21293372 |
| nsv1123221 | CNV | deletion | 24896259 |
| nsv509721 | CNV | insertion | 20534489 |
| nsv519802 | CNV | loss | 19592680 |
| nsv960784 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.13;
61.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ECSIT Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECSIT Gene
Disorders for ECSIT Gene
Additional Disease Information for ECSIT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for ECSIT Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ECSIT Gene
Publications for ECSIT Gene
- Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex. (PMID: 22982022) Heide H … Brandt U (Cell metabolism 2012) 2 3
- Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I. (PMID: 20816094) Nouws J … Vogel RO (Cell metabolism 2010) 3 4
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
- Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. (PMID: 17344420) Vogel RO … Nijtmans LG (Genes & development 2007) 3 4
- ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. (PMID: 10465784) Kopp E … Ghosh S (Genes & development 1999) 2 3
ExternalLinks
Products for ECSIT Gene
- Custom Antibody ServicesOriGene Antibodies for ECSIT
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ECSIT
- Origene Custom Protein Services for ECSIT
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ECSIT
- Browse OriGene Inhibitory RNA Products For ECSIT
- OriGene qPCR primer pairs for ECSIT
- OriGene qPCR primer pairs and template standards for ECSIT
- OriGene CRISPR knockouts for ECSIT
- MG206934
- MR206934
- MR206934L3
- MR206934L4
- MR229892
- MR229893
- RC201343
- RC201343L1
- RC201343L2
- RC201343L3
- RC201343L4
- RC227591
- RC227591L3
- RC227591L4
- RC227595
- RC227595L3
- RC227595L4
- RC232397
- RG201343
- RG227591
- RG227595
- RG232397
- RR209134
- RR209134L3
- RR209134L4
- MR206934L3V
- MR206934L4V
- RC201343L1V
- RC201343L2V
- RC201343L3V
- RC201343L4V
- RC227591L3V
- RC227591L4V
- RC227595L3V
- RC227595L4V
- RR209134L3V
- RR209134L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ECSIT
- Sino Biological Human cDNA Clone for ECSIT
- Sino Biological Recombinant Proteins for ECSIT
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ECSIT
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ECSIT
- Novus Biologicals proteins for ECSIT
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ECSIT
- Abcam proteins for ECSIT
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for ECSIT (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ECSIT (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ECSIT (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ECSIT CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ECSIT
- antibodies-online: Show 16 available ECSIT Antibodies ranked by validation data
- Compare Top ECSIT Antibodies
- antibodies-online: Show 7 available ECSIT Elisa Kits ranked by validation data
- Compare Top ECSIT Elisa Kits
- Quality Products:
- antibodies-online: Show 13 available ECSIT Proteins ranked by validation data
- Compare Top ECSIT Proteins
- Custom Antibody ServicesProSci Antibodies for ECSIT
- Search for ECSIT Proteins at ProSci
- Horizon Cell Lines for ECSIT
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ECSIT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ECSIT
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ECSIT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ECSIT
- Boster Bio Antibodies for ECSIT
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ECSIT
- Signalway Proteins for ECSIT
Sources for ECSIT Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB