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ECSIT (ECSIT Signaling Integrator) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Toll Comparative Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and oxidoreductase activity, acting on NAD(P)H.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17344420 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 17344420 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 17344420 |
GO:0005739 | mitochondrion | IEA,IDA | 17344420 |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
3 | Toll Comparative Pathway |
Toll Comparative Pathway
.61
Immune response MIF in innate immunity response
.46
|
IL-1 Pathway
.39
|
4 | MAPK signaling pathway | ||
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0032981 | mitochondrial respiratory chain complex I assembly | TAS | -- |
GO:0045087 | innate immune response | IEA | -- |
GO:0051341 | regulation of oxidoreductase activity | IDA | 17344420 |
GO:0061635 | regulation of protein complex stability | IDA | 17344420 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
NADH | Approved | Nutra | 0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ECSIT 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ECSIT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ECSIT 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ecsit 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ecsit 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ECSIT 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ECSIT 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ECSIT 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | ECSIT 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ecsit 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ecsit 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005295 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ECSIT 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y17G9B.5 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2302971 | - |
p.Gly406Arg |
|||
rs34803265 | - |
p.Arg278Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3643673 | CNV | loss | 21293372 |
nsv1123221 | CNV | deletion | 24896259 |
nsv509721 | CNV | insertion | 20534489 |
nsv519802 | CNV | loss | 19592680 |
nsv960784 | CNV | duplication | 23825009 |
No disorders were found for ECSIT Gene.