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Aliases for ECSCR Gene

Aliases for ECSCR Gene

  • Endothelial Cell Surface Expressed Chemotaxis And Apoptosis Regulator 2 3 5
  • Apoptosis Regulator Through Modulating IAP Expression 2 3 4
  • Endothelial Cell-Specific Molecule 2 2 3 4
  • Endothelial Cell-Specific Chemotaxis Regulator 2 3
  • ECSM2 3 4
  • ARIA 3 4

External Ids for ECSCR Gene

Previous GeneCards Identifiers for ECSCR Gene

  • GC05M138818
  • GC05M133974

Summaries for ECSCR Gene

Entrez Gene Summary for ECSCR Gene

  • The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

CIViC summary for ECSCR Gene

GeneCards Summary for ECSCR Gene

ECSCR (Endothelial Cell Surface Expressed Chemotaxis And Apoptosis Regulator) is a Protein Coding gene. An important paralog of this gene is ENSG00000279686.

UniProtKB/Swiss-Prot for ECSCR Gene

  • Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.

Additional gene information for ECSCR Gene

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ECSCR Gene

Genomics for ECSCR Gene

GeneHancer (GH) Regulatory Elements for ECSCR Gene

Promoters and enhancers for ECSCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I139457 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.1 +2.3 2290 5.6 HDGF FOXA2 BATF IRF4 ZNF121 ATF7 IKZF2 RUNX3 SMARCA5 CBFB ECSCR DNAJC18 PURA TMEM173 ENSG00000279686 RNU5B-4P GC05P138946
GH05I139413 Enhancer 0.9 Ensembl ENCODE 13.1 +45.7 45693 6.6 CTCF FEZF1 RAD21 IKZF2 EZH2 SMARCA5 ZNF362 HLF REST EP300 DNAJC18 RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 SIL1 MATR3 GC05P139410
GH05I139503 Enhancer 0.9 ENCODE 12.8 -41.3 -41250 1.5 PKNOX1 ARNT ARID4B ZNF48 POLR2B ATF7 RXRA NCOA1 NFYC PPARG ECSCR RNU5B-4P DNAJC18 PIR33843 UBE2D2 GC05M139466 GC05P138946
GH05I139422 Enhancer 0.8 ENCODE 13.2 +40.3 40256 0.2 RB1 ARID4B KLF17 SIN3A ZNF2 ZSCAN9 RAD21 RFX5 ZNF213 ARID2 DNAJC18 RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 SIL1 MATR3 GC05P139410
GH05I139426 Enhancer 0.5 ENCODE 13.3 +36.1 36114 1.2 CTBP1 TEAD4 CBFA2T3 ZMYM3 DNAJC18 RNU5B-4P ECSCR GC05P139409 GC05P139410 GC05P138946
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ECSCR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ECSCR gene promoter:

Genomic Locations for ECSCR Gene

Genomic Locations for ECSCR Gene
chr5:139,448,554-139,462,743
(GRCh38/hg38)
Size:
14,190 bases
Orientation:
Minus strand
chr5:138,784,245-138,842,328
(GRCh37/hg19)

Genomic View for ECSCR Gene

Genes around ECSCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ECSCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ECSCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECSCR Gene

Proteins for ECSCR Gene

  • Protein details for ECSCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q19T08-ECSCR_HUMAN
    Recommended name:
    Endothelial cell-specific chemotaxis regulator
    Protein Accession:
    Q19T08
    Secondary Accessions:
    • B4E3H7
    • C3RSF2

    Protein attributes for ECSCR Gene

    Size:
    205 amino acids
    Molecular mass:
    21295 Da
    Quaternary structure:
    • Interacts with FLNA. Interacts with the 20S proteasome subunit PSMA7.

neXtProt entry for ECSCR Gene

Post-translational modifications for ECSCR Gene

Other Protein References for ECSCR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ECSCR Gene

Domains & Families for ECSCR Gene

Gene Families for ECSCR Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ECSCR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ECSCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q19T08

UniProtKB/Swiss-Prot:

ECSCR_HUMAN :
  • Belongs to the ECSCR family.
Family:
  • Belongs to the ECSCR family.
genes like me logo Genes that share domains with ECSCR: view

Function for ECSCR Gene

Molecular function for ECSCR Gene

UniProtKB/Swiss-Prot Function:
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.

Phenotypes From GWAS Catalog for ECSCR Gene

Gene Ontology (GO) - Molecular Function for ECSCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19416853
genes like me logo Genes that share ontologies with ECSCR: view
genes like me logo Genes that share phenotypes with ECSCR: view

Animal Models for ECSCR Gene

MGI Knock Outs for ECSCR:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ECSCR Gene

Localization for ECSCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ECSCR Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ECSCR gene
Compartment Confidence
plasma membrane 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
  • Vesicles (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ECSCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 19416853
GO:0005886 plasma membrane IDA 19416853
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ECSCR: view

Pathways & Interactions for ECSCR Gene

SuperPathways for ECSCR Gene

No Data Available

Interacting Proteins for ECSCR Gene

Gene Ontology (GO) - Biological Process for ECSCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA --
GO:0006935 chemotaxis IEA --
GO:0007275 multicellular organism development IEA --
GO:0016525 negative regulation of angiogenesis IMP 19416853
genes like me logo Genes that share ontologies with ECSCR: view

No data available for Pathways by source and SIGNOR curated interactions for ECSCR Gene

Drugs & Compounds for ECSCR Gene

No Compound Related Data Available

Transcripts for ECSCR Gene

mRNA/cDNA for ECSCR Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ECSCR Gene

Endothelial cell surface expressed chemotaxis and apoptosis regulator:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ECSCR Gene

No ASD Table

Relevant External Links for ECSCR Gene

GeneLoc Exon Structure for
ECSCR
ECgene alternative splicing isoforms for
ECSCR

Expression for ECSCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ECSCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ECSCR Gene:

ECSCR

SOURCE GeneReport for Unigene cluster for ECSCR Gene:

Hs.483538

mRNA Expression by UniProt/SwissProt for ECSCR Gene:

Q19T08-ECSCR_HUMAN
Tissue specificity: Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells.

Evidence on tissue expression from TISSUES for ECSCR Gene

  • Heart(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with ECSCR: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ECSCR Gene

Orthologs for ECSCR Gene

This gene was present in the common ancestor of chordates.

Orthologs for ECSCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ECSCR 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ECSCR 34 33
  • 84.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ECSCR 34 33
  • 77.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ecscr 33
  • 70.33 (n)
mouse
(Mus musculus)
Mammalia Ecscr 16 34 33
  • 69.98 (n)
oppossum
(Monodelphis domestica)
Mammalia ECSCR 34
  • 8 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ECSCR 34
  • 5 (a)
OneToOne
chicken
(Gallus gallus)
Aves ECSCR 34
  • 7 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ecscr 34
  • 3 (a)
OneToOne
Species where no ortholog for ECSCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ECSCR Gene

ENSEMBL:
Gene Tree for ECSCR (if available)
TreeFam:
Gene Tree for ECSCR (if available)

Paralogs for ECSCR Gene

Paralogs for ECSCR Gene

genes like me logo Genes that share paralogs with ECSCR: view

Variants for ECSCR Gene

Sequence variations from dbSNP and Humsavar for ECSCR Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000344935 -- 139,457,176(-) C/A intron_variant
rs1000366322 -- 139,457,870(-) G/T intron_variant
rs1001205036 -- 139,451,064(-) C/G/T intron_variant
rs1001278213 -- 139,463,331(-) C/T upstream_transcript_variant
rs1001310819 -- 139,463,023(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ECSCR Gene

Variant ID Type Subtype PubMed ID
esv3404017 CNV duplication 20981092
nsv519808 CNV loss 19592680

Variation tolerance for ECSCR Gene

Gene Damage Index Score: 0.11; 2.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ECSCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ECSCR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECSCR Gene

Disorders for ECSCR Gene

Additional Disease Information for ECSCR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ECSCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ECSCR Gene

Publications for ECSCR Gene

  1. ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis. (PMID: 18556573) Armstrong LJ … Bicknell R (Arteriosclerosis, thrombosis, and vascular biology 2008) 2 3 4 58
  2. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert TA … Walter MJ (PloS one 2009) 3 44 58
  3. Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. (PMID: 19416853) Ikeda K … Matsubara H (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 58
  4. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. (PMID: 23393131) Kilari S … Wilkinson GA (The Journal of biological chemistry 2013) 3 58
  5. Favorable prognosis of operable non-small cell lung cancer (NSCLC) patients harboring an increased expression of tumor endothelial markers (TEMs). (PMID: 23664449) Pircher A … Hilbe W (Lung cancer (Amsterdam, Netherlands) 2013) 3 58

Products for ECSCR Gene

Sources for ECSCR Gene

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