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Aliases for ECM2 Gene

Aliases for ECM2 Gene

  • Extracellular Matrix Protein 2 2 3 3 5
  • Matrix Glycoprotein SC1/ECM2 2 3 4
  • Extracellular Matrix Protein 2, Female Organ And Adipocyte Specific 2 3

External Ids for ECM2 Gene

Previous GeneCards Identifiers for ECM2 Gene

  • GC09M086084
  • GC09M086985
  • GC09M088556
  • GC09M090599
  • GC09M090597
  • GC09M092335
  • GC09M094297
  • GC09M095257
  • GC09M064935

Summaries for ECM2 Gene

Entrez Gene Summary for ECM2 Gene

  • ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for ECM2 Gene

ECM2 (Extracellular Matrix Protein 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include heparin binding and collagen binding. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot for ECM2 Gene

  • Promotes matrix assembly and cell adhesiveness.

Gene Wiki entry for ECM2 Gene

Additional gene information for ECM2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ECM2 Gene

Genomics for ECM2 Gene

GeneHancer (GH) Regulatory Elements for ECM2 Gene

Promoters and enhancers for ECM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J092533 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 693 4.3 PKNOX1 FOXA2 TAF1 HLF EBF1 MEF2B YY1 SP1 JUND GATA3 ECM2 CENPP ASPN OMD OGN IPPK BICD2 MIR4670
GH09J092761 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.2 -227.6 -227550 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 BICD2 PHF2 NOL8 CENPP ZNF484 LINC00475 IPPK ECM2 GC09P092689
GH09J092668 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.6 -133.5 -133523 3.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 CBX5 IPPK CENPP NOL8 PHF2 ECM2 PIR41553
GH09J092715 Enhancer 0.9 ENCODE dbSUPER 10 -179.8 -179832 2.9 CTCF KLF1 RB1 ARID4B SIN3A EBF1 ZIC2 RAD21 ARID2 SMC3 CENPP ECM2 GC09P092689 BICD2
GH09J092769 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.1 -234.1 -234050 2.5 HDAC1 TFAP4 SAP130 EBF1 E4F1 ZNF766 POLR2A FOXK2 PHF20 VEZF1 CENPP PHF2 ECM2 BICD2 LOC101929748
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ECM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ECM2 gene promoter:

Genomic Locations for ECM2 Gene

Genomic Locations for ECM2 Gene
43,109 bases
Minus strand

Genomic View for ECM2 Gene

Genes around ECM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ECM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ECM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECM2 Gene

Proteins for ECM2 Gene

  • Protein details for ECM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Extracellular matrix protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R730
    • E2PU11
    • Q5T9F2
    • Q7Z3D0

    Protein attributes for ECM2 Gene

    699 amino acids
    Molecular mass:
    79789 Da
    Quaternary structure:
    • Interacts with numerous extracellular matrix proteins.
    • Sequence=CAD97940.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ECM2 Gene


neXtProt entry for ECM2 Gene

Post-translational modifications for ECM2 Gene

  • Glycosylation at Asn506, Asn449, and Asn378
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ECM2 Gene

Domains & Families for ECM2 Gene

Gene Families for ECM2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for ECM2 Gene

Suggested Antigen Peptide Sequences for ECM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
genes like me logo Genes that share domains with ECM2: view

Function for ECM2 Gene

Molecular function for ECM2 Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly and cell adhesiveness.
GENATLAS Biochemistry:
extracellular matrix 2,predominantly expressed in adipose tissue,mammary gland,ovary and uterus

Gene Ontology (GO) - Molecular Function for ECM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 9790758
GO:0005515 protein binding IEA --
GO:0005518 collagen binding IEA --
GO:0008201 heparin binding IBA --
GO:0070052 collagen V binding IBA --
genes like me logo Genes that share ontologies with ECM2: view
genes like me logo Genes that share phenotypes with ECM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ECM2

CRISPR Products

miRNA for ECM2 Gene

miRTarBase miRNAs that target ECM2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ECM2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ECM2 Gene

Localization for ECM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ECM2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ECM2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for ECM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with ECM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ECM2 Gene

Pathways & Interactions for ECM2 Gene

genes like me logo Genes that share pathways with ECM2: view

Pathways by source for ECM2 Gene

Gene Ontology (GO) - Biological Process for ECM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion TAS 9790758
GO:0007409 NOT axonogenesis IBA --
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with ECM2: view

No data available for SIGNOR curated interactions for ECM2 Gene

Drugs & Compounds for ECM2 Gene

No Compound Related Data Available

Transcripts for ECM2 Gene

Unigene Clusters for ECM2 Gene

Extracellular matrix protein 2, female organ and adipocyte specific:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ECM2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ECM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12
SP1: - - - -
SP2: - - -
SP3: - - -
SP5: -

Relevant External Links for ECM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ECM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ECM2 Gene

mRNA differential expression in normal tissues according to GTEx for ECM2 Gene

This gene is overexpressed in Artery - Coronary (x5.4), Artery - Tibial (x4.9), and Artery - Aorta (x4.8).

Protein differential expression in normal tissues from HIPED for ECM2 Gene

This gene is overexpressed in Ovary (21.3), Breast (18.4), Heart (12.9), and Adipocyte (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ECM2 Gene

Protein tissue co-expression partners for ECM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ECM2 Gene:


SOURCE GeneReport for Unigene cluster for ECM2 Gene:


mRNA Expression by UniProt/SwissProt for ECM2 Gene:

Tissue specificity: Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus.

Evidence on tissue expression from TISSUES for ECM2 Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with ECM2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ECM2 Gene

Orthologs for ECM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ECM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ECM2 34 33
  • 99.14 (n)
(Bos Taurus)
Mammalia ECM2 34 33
  • 85.33 (n)
(Canis familiaris)
Mammalia ECM2 34 33
  • 82.06 (n)
(Rattus norvegicus)
Mammalia LOC100361383 33
  • 82.02 (n)
(Mus musculus)
Mammalia Ecm2 16 34 33
  • 81.05 (n)
(Ornithorhynchus anatinus)
Mammalia ECM2 34
  • 68 (a)
(Monodelphis domestica)
Mammalia ECM2 34
  • 44 (a)
(Gallus gallus)
Aves ECM2 34 33
  • 65.98 (n)
(Anolis carolinensis)
Reptilia ECM2 34
  • 55 (a)
(Danio rerio)
Actinopterygii ecm2 34 33
  • 56.5 (n)
Species where no ortholog for ECM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ECM2 Gene

Gene Tree for ECM2 (if available)
Gene Tree for ECM2 (if available)
Evolutionary constrained regions (ECRs) for ECM2: view image

Paralogs for ECM2 Gene

Paralogs for ECM2 Gene

(7) SIMAP similar genes for ECM2 Gene using alignment to 5 proteins:

  • Q3KR19_HUMAN
  • Q5T9F3_HUMAN
  • Q5T9F4_HUMAN
  • Q6PID0_HUMAN Pseudogenes for ECM2 Gene

genes like me logo Genes that share paralogs with ECM2: view

Variants for ECM2 Gene

Sequence variations from dbSNP and Humsavar for ECM2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000094805 -- 92,501,363(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000156409 -- 92,528,134(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000265708 -- 92,521,125(-) A/G intron_variant
rs1000278237 -- 92,501,819(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000513761 -- 92,523,503(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ECM2 Gene

Variant ID Type Subtype PubMed ID
esv1019101 CNV insertion 17803354
esv3621081 CNV loss 21293372
esv3891693 CNV gain 25118596
nsv1047337 CNV loss 25217958
nsv1049599 CNV loss 25217958
nsv1052846 CNV loss 25217958
nsv1115209 CNV deletion 24896259
nsv527206 CNV loss 19592680

Variation tolerance for ECM2 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ECM2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECM2 Gene

Disorders for ECM2 Gene

Additional Disease Information for ECM2

No disorders were found for ECM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ECM2 Gene

Publications for ECM2 Gene

  1. Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3. (PMID: 9790758) Nishiu J … Nakamura Y (Genomics 1998) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. (PMID: 9345023) Oritani K … Kincade PW (Blood 1997) 3 22 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ECM2 Gene

Sources for ECM2 Gene

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