Aliases for ECH1 Gene
External Ids for ECH1 Gene
Previous GeneCards Identifiers for ECH1 Gene
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
GeneCards Summary for ECH1 Gene
ECH1 (Enoyl-CoA Hydratase 1) is a Protein Coding gene. Among its related pathways are Fatty Acid Biosynthesis (WikiPathways) and Peroxisome. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and isomerase activity. An important paralog of this gene is AUH.
UniProtKB/Swiss-Prot Summary for ECH1 Gene
Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.