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Aliases for EBLN2 Gene

Aliases for EBLN2 Gene

  • Endogenous Bornavirus Like Nucleoprotein 2 2 3 5
  • Endogenous Borna-Like N Element-2 3 4
  • EBLN-2 3 4
  • Endogenous Bornavirus-Like Nucleoprotein 2 3
  • Endogenous Borna-Like N Element-1 3
  • Endogenous Borna-Like N Element 2 2
  • EBLN-1 3

External Ids for EBLN2 Gene

Previous GeneCards Identifiers for EBLN2 Gene

  • GC03P073111

Summaries for EBLN2 Gene

GeneCards Summary for EBLN2 Gene

EBLN2 (Endogenous Bornavirus Like Nucleoprotein 2) is a Protein Coding gene. An important paralog of this gene is EBLN1.

UniProtKB/Swiss-Prot for EBLN2 Gene

  • May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

Additional gene information for EBLN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBLN2 Gene

Genomics for EBLN2 Gene

GeneHancer (GH) Regulatory Elements for EBLN2 Gene

Promoters and enhancers for EBLN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I073060 Promoter/Enhancer 0.7 EPDnew ENCODE 550.8 -0.2 -238 0.9 EBLN2 SHQ1 GC03P073027 PPP4R2
GH03I073061 Enhancer 0.3 ENCODE 550.8 -1.0 -1024 0.2 ATF4 EBLN2 SHQ1 GC03P073027 PPP4R2
GH03I072273 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -787.1 -787146 2.7 HDAC1 FOXA2 RAD21 ZBTB40 YY1 SCRT2 ZNF548 ETV6 IKZF2 RUNX3 SHQ1 RYBP EBLN2 LINC00877 LOC105377158 ENSG00000242618
GH03I072738 Enhancer 1.1 Ensembl ENCODE 10.2 -322.2 -322160 2.6 HDAC1 PKNOX1 ZNF335 TCF12 SCRT2 ZNF548 FOS CREM USF2 ZNF592 GC03P072740 SHQ1 EBLN2 RYBP RNA5SP136
GH03I072278 Enhancer 0.7 dbSUPER 12.2 -782.4 -782354 2.1 BCOR ZMYM3 NFXL1 ZFHX2 PHF20 ZNF366 ADNP EGR2 SMARCA5 GATAD2B LINC00877 EBLN2 RYBP SHQ1 LOC105377158 ENSG00000242618
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EBLN2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EBLN2 Gene

Genomic Locations for EBLN2 Gene
chr3:73,061,659-73,063,337
(GRCh38/hg38)
Size:
1,679 bases
Orientation:
Plus strand
chr3:73,110,810-73,112,488
(GRCh37/hg19)

Genomic View for EBLN2 Gene

Genes around EBLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBLN2 Gene

Proteins for EBLN2 Gene

  • Protein details for EBLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2I7-EBLN2_HUMAN
    Recommended name:
    Endogenous Bornavirus-like nucleoprotein 2
    Protein Accession:
    Q6P2I7
    Secondary Accessions:
    • Q8WWH3
    • Q9NW89

    Protein attributes for EBLN2 Gene

    Size:
    272 amino acids
    Molecular mass:
    30450 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

neXtProt entry for EBLN2 Gene

Post-translational modifications for EBLN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EBLN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBLN2 Gene

Domains & Families for EBLN2 Gene

Gene Families for EBLN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EBLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EBLN2: view

No data available for UniProtKB/Swiss-Prot for EBLN2 Gene

Function for EBLN2 Gene

Molecular function for EBLN2 Gene

UniProtKB/Swiss-Prot Function:
May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

Phenotypes for EBLN2 Gene

genes like me logo Genes that share phenotypes with EBLN2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EBLN2 Gene

Localization for EBLN2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EBLN2 Gene

Pathways & Interactions for EBLN2 Gene

SuperPathways for EBLN2 Gene

No Data Available

Interacting Proteins for EBLN2 Gene

Gene Ontology (GO) - Biological Process for EBLN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EBLN2 Gene

Drugs & Compounds for EBLN2 Gene

No Compound Related Data Available

Transcripts for EBLN2 Gene

mRNA/cDNA for EBLN2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(231) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EBLN2 Gene

Endogenous Bornavirus-like nucleoprotein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBLN2 Gene

No ASD Table

Relevant External Links for EBLN2 Gene

GeneLoc Exon Structure for
EBLN2
ECgene alternative splicing isoforms for
EBLN2

Expression for EBLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EBLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EBLN2 Gene

This gene is overexpressed in Spinal cord (46.8) and Frontal cortex (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EBLN2 Gene



Protein tissue co-expression partners for EBLN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EBLN2 Gene:

EBLN2

SOURCE GeneReport for Unigene cluster for EBLN2 Gene:

Hs.658858
genes like me logo Genes that share expression patterns with EBLN2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EBLN2 Gene

Orthologs for EBLN2 Gene

Evolution for EBLN2 Gene

ENSEMBL:
Gene Tree for EBLN2 (if available)
TreeFam:
Gene Tree for EBLN2 (if available)

No data available for Orthologs for EBLN2 Gene

Paralogs for EBLN2 Gene

Paralogs for EBLN2 Gene

(1) SIMAP similar genes for EBLN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EBLN2: view

Variants for EBLN2 Gene

Sequence variations from dbSNP and Humsavar for EBLN2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000279281 -- 73,062,983(+) G/A/C 3_prime_UTR_variant
rs1000997069 -- 73,063,252(+) T/G 3_prime_UTR_variant
rs1001478432 -- 73,063,579(+) G/A downstream_transcript_variant
rs1001666226 -- 73,060,601(+) T/C upstream_transcript_variant
rs1002123984 -- 73,060,391(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EBLN2 Gene

Variant ID Type Subtype PubMed ID
nsv1005234 CNV gain 25217958
nsv460703 CNV loss 19166990
nsv528982 CNV gain 19592680
nsv590634 CNV loss 21841781

Variation tolerance for EBLN2 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EBLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EBLN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBLN2 Gene

Disorders for EBLN2 Gene

Additional Disease Information for EBLN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EBLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EBLN2 Gene

Publications for EBLN2 Gene

  1. Endogenous non-retroviral RNA virus elements in mammalian genomes. (PMID: 20054395) Horie M … Tomonaga K (Nature 2010) 2 3 4 58
  2. Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. (PMID: 20686665) Belyi VA … Skalka AM (PLoS pathogens 2010) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A … DeKAF Investigators (Transplantation 2010) 44 58
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J … Elledge SJ (Cell 2009) 3 58

Products for EBLN2 Gene

Sources for EBLN2 Gene

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