Aliases for EBLN1 Gene

Aliases for EBLN1 Gene

  • Endogenous Bornavirus Like Nucleoprotein 1 2 3 5
  • Endogenous Bornavirus-Like Nucleoprotein 1 3 4
  • Endogenous Borna-Like N Element-1 3 4
  • EBLN-1 3 4
  • Endogenous Borna-Like N Element-Containing Protein 1 3
  • Endogenous Borna-Like N Element 1 2
  • EBLN1 5

External Ids for EBLN1 Gene

Previous GeneCards Identifiers for EBLN1 Gene

  • GC10M022499

Summaries for EBLN1 Gene

GeneCards Summary for EBLN1 Gene

EBLN1 (Endogenous Bornavirus Like Nucleoprotein 1) is a Protein Coding gene. An important paralog of this gene is EBLN2.

UniProtKB/Swiss-Prot Summary for EBLN1 Gene

  • May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EBLN1 Gene

Genomics for EBLN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EBLN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EBLN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EBLN1

Genomic Locations for EBLN1 Gene

Latest Assembly
1,208 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,170 bases
Minus strand

(GRCh37/hg19 by Ensembl)
1,208 bases
Minus strand

Genomic View for EBLN1 Gene

Genes around EBLN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBLN1 Gene

Proteins for EBLN1 Gene

  • Protein details for EBLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endogenous Bornavirus-like nucleoprotein 1
    Protein Accession:
    Secondary Accessions:
    • S4R316

    Protein attributes for EBLN1 Gene

    366 amino acids
    Molecular mass:
    40313 Da
    Quaternary structure:
    No Data Available
    • Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-1 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

neXtProt entry for EBLN1 Gene

Post-translational modifications for EBLN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EBLN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBLN1 Gene

Domains & Families for EBLN1 Gene

Gene Families for EBLN1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for EBLN1 Gene

GenScript: Design optimal peptide antigens:
  • Endogenous Borna-like N element-1 (EBLN1_HUMAN)
genes like me logo Genes that share domains with EBLN1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EBLN1 Gene

Function for EBLN1 Gene

Molecular function for EBLN1 Gene

UniProtKB/Swiss-Prot Function:
May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).

Phenotypes From GWAS Catalog for EBLN1 Gene

Phenotypes for EBLN1 Gene

genes like me logo Genes that share phenotypes with EBLN1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EBLN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EBLN1 Gene

Localization for EBLN1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EBLN1 gene
Compartment Confidence
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for EBLN1 Gene

Pathways & Interactions for EBLN1 Gene

PathCards logo

SuperPathways for EBLN1 Gene

No Data Available

Interacting Proteins for EBLN1 Gene

Gene Ontology (GO) - Biological Process for EBLN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for EBLN1 Gene

Drugs & Compounds for EBLN1 Gene

No Compound Related Data Available

Transcripts for EBLN1 Gene

mRNA/cDNA for EBLN1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EBLN1

Alternative Splicing Database (ASD) splice patterns (SP) for EBLN1 Gene

No ASD Table

Relevant External Links for EBLN1 Gene

GeneLoc Exon Structure for

Expression for EBLN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EBLN1 Gene

mRNA differential expression in normal tissues according to GTEx for EBLN1 Gene

This gene is overexpressed in Testis (x33.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EBLN1

SOURCE GeneReport for Unigene cluster for EBLN1 Gene:


mRNA Expression by UniProt/SwissProt for EBLN1 Gene:

Tissue specificity: Expression detected by RT-PCR in a few cell lines, including OL, HEK293T and MOLT-4. Not observed in HeLa cells (PubMed:20054395).
genes like me logo Genes that share expression patterns with EBLN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EBLN1 Gene

Orthologs for EBLN1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for EBLN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EBLN1 29
  • 98.54 (n)
(Mus musculus)
Mammalia LOC102636291 29
  • 52.8 (n)
Species where no ortholog for EBLN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for EBLN1 Gene

Gene Tree for EBLN1 (if available)
Gene Tree for EBLN1 (if available)
Alliance of Genome Resources:
Additional Orthologs for EBLN1

Paralogs for EBLN1 Gene

Paralogs for EBLN1 Gene

(1) SIMAP similar genes for EBLN1 Gene using alignment to 1 proteins:

  • EBLN1_HUMAN Pseudogenes for EBLN1 Gene

genes like me logo Genes that share paralogs with EBLN1: view

Variants for EBLN1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EBLN1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for EBLN1 Gene

Gene Damage Index Score: 19.77; 98.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EBLN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for EBLN1 Gene

Disorders for EBLN1 Gene

Additional Disease Information for EBLN1

No disorders were found for EBLN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EBLN1 Gene

Publications for EBLN1 Gene

  1. Endogenous non-retroviral RNA virus elements in mammalian genomes. (PMID: 20054395) Horie M … Tomonaga K (Nature 2010) 2 3 4
  2. Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. (PMID: 20686665) Belyi VA … Skalka AM (PLoS pathogens 2010) 2 3
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability. (PMID: 27739501) Myers KN … Collis SJ (Scientific reports 2016) 3

Products for EBLN1 Gene

Sources for EBLN1 Gene