Aliases for EBI3 Gene
External Ids for EBI3 Gene
Previous GeneCards Identifiers for EBI3 Gene
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
GeneCards Summary for EBI3 Gene
EBI3 (Epstein-Barr Virus Induced 3) is a Protein Coding gene. Diseases associated with EBI3 include Autoimmune Glomerulonephritis and Inflammatory Bowel Disease. Among its related pathways are Innate Immune System and Th1 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-27 receptor binding. An important paralog of this gene is LIFR.
UniProtKB/Swiss-Prot for EBI3 Gene
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.