Aliases for EBF1 Gene
External Ids for EBF1 Gene
Previous HGNC Symbols for EBF1 Gene
Previous GeneCards Identifiers for EBF1 Gene
GeneCards Summary for EBF1 Gene
EBF1 (EBF Transcription Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include Plasmacytoma and B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1. Among its related pathways are Developmental Biology and Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and C2H2 zinc finger domain binding. An important paralog of this gene is EBF3.
UniProtKB/Swiss-Prot Summary for EBF1 Gene
Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity).
(Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314).