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Aliases for EBAG9 Gene

Aliases for EBAG9 Gene

  • Estrogen Receptor Binding Site Associated, Antigen, 9 2 3 5
  • Estrogen Receptor-Binding Fragment-Associated Gene 9 Protein 3 4
  • Cancer-Associated Surface Antigen RCAS1 3 4
  • Receptor-Binding Cancer Antigen Expressed On SiSo Cells 3
  • RCAS1 4
  • PDAF 3
  • EB9 3

External Ids for EBAG9 Gene

Previous GeneCards Identifiers for EBAG9 Gene

  • GC08P110619
  • GC08P110220
  • GC08P110508
  • GC08P110621
  • GC08P105873

Summaries for EBAG9 Gene

Entrez Gene Summary for EBAG9 Gene

  • This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. [provided by RefSeq, Jul 2013]

GeneCards Summary for EBAG9 Gene

EBAG9 (Estrogen Receptor Binding Site Associated, Antigen, 9) is a Protein Coding gene. Diseases associated with EBAG9 include Placental Abruption and Cervical Adenocarcinoma. Among its related pathways are Translational Control and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include peptidase activator activity involved in apoptotic process.

UniProtKB/Swiss-Prot for EBAG9 Gene

  • May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

Gene Wiki entry for EBAG9 Gene

Additional gene information for EBAG9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBAG9 Gene

Genomics for EBAG9 Gene

GeneHancer (GH) Regulatory Elements for EBAG9 Gene

Promoters and enhancers for EBAG9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J109538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.9 926 3.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 EBAG9 NUDCD1 PKHD1L1 MAPK6PS5 GC08P109564
GH08J109550 Promoter 0.5 EPDnew 650.4 +11.1 11088 0.1 EBAG9 SYBU NUDCD1 ENY2 LOC100132813 GC08P109564
GH08J109611 Enhancer 1 ENCODE 10.1 +72.1 72089 1.5 PKNOX1 ARNT FEZF1 GLI4 ZNF2 YY1 TCF12 ZNF121 GLIS2 ZNF213 SYBU LOC100132813 NUDCD1 EBAG9 GC08P109564
GH08J109584 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 6 +47.7 47747 5.7 JUN MAX YY1 ZNF664 CTBP1 GATA3 ZNF316 SCRT2 RCOR1 FOSL2 SYBU PKHD1L1 EBAG9 KCNV1 GC08P109564 LOC100132813
GH08J109591 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.7 +54.5 54534 4.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ETS1 YY1 GATA2 ATF7 EBAG9 MAPK6PS5 GC08P109564 LOC100132813 SYBU
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EBAG9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EBAG9 gene promoter:
  • GR
  • HOXA5
  • AP-1
  • Max
  • GR-alpha
  • c-Myc

Genomic Locations for EBAG9 Gene

Genomic Locations for EBAG9 Gene
chr8:109,539,700-109,565,996
(GRCh38/hg38)
Size:
26,297 bases
Orientation:
Plus strand
chr8:110,551,929-110,578,225
(GRCh37/hg19)
Size:
26,297 bases
Orientation:
Plus strand

Genomic View for EBAG9 Gene

Genes around EBAG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBAG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBAG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBAG9 Gene

Proteins for EBAG9 Gene

  • Protein details for EBAG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00559-RCAS1_HUMAN
    Recommended name:
    Receptor-binding cancer antigen expressed on SiSo cells
    Protein Accession:
    O00559
    Secondary Accessions:
    • A8K3N6
    • Q5Y8C7
    • Q6IB20
    • Q9BS76

    Protein attributes for EBAG9 Gene

    Size:
    213 amino acids
    Molecular mass:
    24377 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • May serve as a prognostic marker for cancers such as adenocarcinomas of the lung and breast cancers. It is present and overexpressed in many patients suffering from breast carcinomas, its level of expression correlates with tumor grade, suggesting that it may be involved in cancer immune escape. According to PubMed:12672804, it is however not directly a tumor-associated antigen, but it rather modulates surface expression of tumor-associated O-linked glycan Tn when it is overexpressed, suggesting that it contributes indirectly to the antigenicity of tumor cells.

    Alternative splice isoforms for EBAG9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EBAG9 Gene

Post-translational modifications for EBAG9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EBAG9 Gene

Domains & Families for EBAG9 Gene

Gene Families for EBAG9 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for EBAG9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EBAG9 Gene

Graphical View of Domain Structure for InterPro Entry

O00559

UniProtKB/Swiss-Prot:

RCAS1_HUMAN :
  • The coiled coil domain is necessary for the homodimerization.
Domain:
  • The coiled coil domain is necessary for the homodimerization.
genes like me logo Genes that share domains with EBAG9: view

Function for EBAG9 Gene

Molecular function for EBAG9 Gene

UniProtKB/Swiss-Prot Function:
May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
UniProtKB/Swiss-Prot Induction:
By estrogen.

Gene Ontology (GO) - Molecular Function for EBAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016505 peptidase activator activity involved in apoptotic process NAS 10426319
genes like me logo Genes that share ontologies with EBAG9: view
genes like me logo Genes that share phenotypes with EBAG9: view

Animal Models for EBAG9 Gene

MGI Knock Outs for EBAG9:

Animal Model Products

  • Taconic Biosciences Mouse Models for EBAG9

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EBAG9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EBAG9 Gene

Localization for EBAG9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBAG9 Gene

Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EBAG9 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
mitochondrion 3
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EBAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with EBAG9: view

Pathways & Interactions for EBAG9 Gene

genes like me logo Genes that share pathways with EBAG9: view

Pathways by source for EBAG9 Gene

1 KEGG pathway for EBAG9 Gene
1 Cell Signaling Technology pathway for EBAG9 Gene

Interacting Proteins for EBAG9 Gene

Gene Ontology (GO) - Biological Process for EBAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10426319
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with EBAG9: view

No data available for SIGNOR curated interactions for EBAG9 Gene

Drugs & Compounds for EBAG9 Gene

(1) Drugs for EBAG9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EBAG9: view

Transcripts for EBAG9 Gene

Unigene Clusters for EBAG9 Gene

Estrogen receptor binding site associated, antigen, 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EBAG9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBAG9 Gene

No ASD Table

Relevant External Links for EBAG9 Gene

GeneLoc Exon Structure for
EBAG9
ECgene alternative splicing isoforms for
EBAG9

Expression for EBAG9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EBAG9 Gene

Protein differential expression in normal tissues from HIPED for EBAG9 Gene

This gene is overexpressed in Plasma (17.2), Pancreas (14.1), Testis (9.8), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EBAG9 Gene



Protein tissue co-expression partners for EBAG9 Gene

NURSA nuclear receptor signaling pathways regulating expression of EBAG9 Gene:

EBAG9

SOURCE GeneReport for Unigene cluster for EBAG9 Gene:

Hs.409368

mRNA Expression by UniProt/SwissProt for EBAG9 Gene:

O00559-RCAS1_HUMAN
Tissue specificity: Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.

Evidence on tissue expression from TISSUES for EBAG9 Gene

  • Blood(4.4)
  • Lung(4.4)
  • Liver(4.3)
  • Nervous system(4.2)
  • Lymph node(2.4)
genes like me logo Genes that share expression patterns with EBAG9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EBAG9 Gene

Orthologs for EBAG9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EBAG9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EBAG9 34 33
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EBAG9 34 33
  • 94.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EBAG9 34 33
  • 93.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ebag9 16 34 33
  • 91.08 (n)
rat
(Rattus norvegicus)
Mammalia Ebag9 33
  • 91.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves EBAG9 34 33
  • 82.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EBAG9 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ebag9 33
  • 76.51 (n)
Str.2052 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24520 33
zebrafish
(Danio rerio)
Actinopterygii ebag9 34 33
  • 70.91 (n)
OneToOne
zgc56608 33
Species where no ortholog for EBAG9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EBAG9 Gene

ENSEMBL:
Gene Tree for EBAG9 (if available)
TreeFam:
Gene Tree for EBAG9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EBAG9: view image

Paralogs for EBAG9 Gene

(2) SIMAP similar genes for EBAG9 Gene using alignment to 5 proteins:

  • RCAS1_HUMAN
  • E9PJ38_HUMAN
  • E9PJ40_HUMAN
  • E9PN10_HUMAN
  • E9PND3_HUMAN

Pseudogenes.org Pseudogenes for EBAG9 Gene

genes like me logo Genes that share paralogs with EBAG9: view

No data available for Paralogs for EBAG9 Gene

Variants for EBAG9 Gene

Sequence variations from dbSNP and Humsavar for EBAG9 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000151421 -- 109,559,283(+) CCCCCC/CCCCCCC intron_variant
rs1000193470 -- 109,538,791(+) C/A upstream_transcript_variant
rs1000417105 -- 109,559,690(+) C/T intron_variant
rs1000490939 -- 109,563,639(+) C/T intron_variant
rs1000492902 -- 109,551,337(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EBAG9 Gene

Variant ID Type Subtype PubMed ID
nsv1075574 CNV deletion 25765185

Variation tolerance for EBAG9 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EBAG9 Gene

Human Gene Mutation Database (HGMD)
EBAG9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EBAG9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBAG9 Gene

Disorders for EBAG9 Gene

MalaCards: The human disease database

(6) MalaCards diseases for EBAG9 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
placental abruption
  • abruptio placenta
cervical adenocarcinoma
  • adenocarcinoma cervix uteri
bile duct carcinoma
  • bile duct cancer
paget disease, extramammary
  • cutaneous paget's disease
endometrial cancer
  • endometrial cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search EBAG9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EBAG9

genes like me logo Genes that share disorders with EBAG9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EBAG9 Gene

Publications for EBAG9 Gene

  1. Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers. (PMID: 11705872) Tsuneizumi M … Nakamura Y (Clinical cancer research : an official journal of the American Association for Cancer Research 2001) 3 22 44 58
  2. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1. (PMID: 10426319) Nakashima M … Watanabe T (Nature medicine 1999) 3 4 22 58
  3. Isolation of estrogen-responsive genes with a CpG island library. (PMID: 9418891) Watanabe T … Muramatsu M (Molecular and cellular biology 1998) 3 4 22 58
  4. Analysis of the expression of human tumor antigens in ovarian cancer tissues. (PMID: 20164540) Ali-Fehmi R … Tainsky MA (Cancer biomarkers : section A of Disease markers 2010) 3 22 58
  5. [Evaluation of RCAS1 as serum tumor marker for pancreatic cancer]. (PMID: 19957811) Yang YC … Dai MH (Zhonghua wai ke za zhi [Chinese journal of surgery] 2009) 3 22 58

Products for EBAG9 Gene

Sources for EBAG9 Gene

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