Free for academic non-profit institutions. Other users need a Commercial license

Aliases for E2F8 Gene

Aliases for E2F8 Gene

  • E2F Transcription Factor 8 2 3 5
  • E2F-8 3 4
  • Transcription Factor E2F8 3
  • E2F Family Member 8 3

External Ids for E2F8 Gene

Previous GeneCards Identifiers for E2F8 Gene

  • GC11M018929

Summaries for E2F8 Gene

Entrez Gene Summary for E2F8 Gene

  • This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

GeneCards Summary for E2F8 Gene

E2F8 (E2F Transcription Factor 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is E2F7.

UniProtKB/Swiss-Prot for E2F8 Gene

  • Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5-TTTC[CG]CGC-3. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

Additional gene information for E2F8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F8 Gene

Genomics for E2F8 Gene

GeneHancer (GH) Regulatory Elements for E2F8 Gene

Promoters and enhancers for E2F8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I019236 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 935 9.1 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 YY1 E2F8 FOS SP3 E2F8 SPTY2D1 ENSG00000256361 ENSG00000256588 TSG101 ZDHHC13 LOC105376580 CSRP3 ENSG00000255308
GH11I019216 Enhancer 1 VISTA ENCODE dbSUPER 19.2 +23.0 23027 3.6 CEBPB CEBPG ATF2 GATA3 ATF4 NFYB ATF7 ZNF600 E2F8 ENSG00000255308 ZDHHC13 CSRP3
GH11I019198 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 6.9 +41.3 41252 4.9 ZNF148 FOSL1 ZNF366 NR2F1 EBF1 MNT NR2F2 CSRP3 E2F8 ENSG00000255308
GH11I019206 Enhancer 0.7 VISTA dbSUPER 7 +33.4 33414 3.7 USF1 E2F8 CSRP3 ENSG00000255308
GH11I019224 Enhancer 0.4 dbSUPER 6.3 +16.2 16207 1.8 ATF2 ZBTB40 ENSG00000255308 ZDHHC13 E2F8 CSRP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around E2F8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the E2F8 gene promoter:

Genomic Locations for E2F8 Gene

Genomic Locations for E2F8 Gene
chr11:19,224,063-19,241,655
(GRCh38/hg38)
Size:
17,593 bases
Orientation:
Minus strand
chr11:19,245,610-19,263,167
(GRCh37/hg19)

Genomic View for E2F8 Gene

Genes around E2F8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F8 Gene

Proteins for E2F8 Gene

  • Protein details for E2F8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVK6-E2F8_HUMAN
    Recommended name:
    Transcription factor E2F8
    Protein Accession:
    A0AVK6
    Secondary Accessions:
    • A8K9H3
    • Q2VPJ3
    • Q3C1U6
    • Q5BKY4
    • Q8N340
    • Q9H5M0

    Protein attributes for E2F8 Gene

    Size:
    867 amino acids
    Molecular mass:
    94166 Da
    Quaternary structure:
    • Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Interacts with HIF1A.
    SequenceCaution:
    • Sequence=AAH28244.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for E2F8 Gene

neXtProt entry for E2F8 Gene

Post-translational modifications for E2F8 Gene

No Post-translational modifications

Other Protein References for E2F8 Gene

No data available for DME Specific Peptides for E2F8 Gene

Domains & Families for E2F8 Gene

Gene Families for E2F8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for E2F8 Gene

Suggested Antigen Peptide Sequences for E2F8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0AVK6

UniProtKB/Swiss-Prot:

E2F8_HUMAN :
  • In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
  • Belongs to the E2F/DP family.
Domain:
  • In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F8: view

Function for E2F8 Gene

Molecular function for E2F8 Gene

UniProtKB/Swiss-Prot Function:
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5-TTTC[CG]CGC-3. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
UniProtKB/Swiss-Prot Induction:
Following DNA damage (PubMed:18202719). Up-regulation in response to DNA damage is not confirmed by PubMed:22802528.

Phenotypes From GWAS Catalog for E2F8 Gene

Gene Ontology (GO) - Molecular Function for E2F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 16179649
GO:0001047 core promoter binding IDA 22903062
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 16179649
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IMP 22903062
genes like me logo Genes that share ontologies with E2F8: view
genes like me logo Genes that share phenotypes with E2F8: view

Animal Models for E2F8 Gene

MGI Knock Outs for E2F8:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for E2F8 Gene

Localization for E2F8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for E2F8 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for E2F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with E2F8: view

Pathways & Interactions for E2F8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for E2F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001890 placenta development ISS,IEA --
GO:0002040 sprouting angiogenesis IEA,IMP 22903062
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with E2F8: view

No data available for Pathways by source and SIGNOR curated interactions for E2F8 Gene

Drugs & Compounds for E2F8 Gene

No Compound Related Data Available

Transcripts for E2F8 Gene

Unigene Clusters for E2F8 Gene

E2F transcription factor 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - - -
SP2:
SP3: - -
SP4: -

Relevant External Links for E2F8 Gene

GeneLoc Exon Structure for
E2F8
ECgene alternative splicing isoforms for
E2F8

Expression for E2F8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for E2F8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for E2F8 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4) and Esophagus - Mucosa (x5.6).

Protein differential expression in normal tissues from HIPED for E2F8 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for E2F8 Gene



Protein tissue co-expression partners for E2F8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of E2F8 Gene:

E2F8

SOURCE GeneReport for Unigene cluster for E2F8 Gene:

Hs.523526

Evidence on tissue expression from TISSUES for E2F8 Gene

  • Skin(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with E2F8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for E2F8 Gene

Orthologs for E2F8 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F8 33 34
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia E2F8 33 34
  • 90.01 (n)
cow
(Bos Taurus)
Mammalia E2F8 33 34
  • 88.49 (n)
rat
(Rattus norvegicus)
Mammalia E2f8 33
  • 83.37 (n)
mouse
(Mus musculus)
Mammalia E2f8 33 16 34
  • 82.79 (n)
oppossum
(Monodelphis domestica)
Mammalia E2F8 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F8 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F8 34 33
  • 60.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F8 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f8 33
  • 59.46 (n)
Str.19889 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16178 33
zebrafish
(Danio rerio)
Actinopterygii e2f8 34 33
  • 56.03 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea efl-3 34
  • 25 (a)
OneToMany
Species where no ortholog for E2F8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F8 Gene

ENSEMBL:
Gene Tree for E2F8 (if available)
TreeFam:
Gene Tree for E2F8 (if available)

Paralogs for E2F8 Gene

Paralogs for E2F8 Gene

(1) SIMAP similar genes for E2F8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with E2F8: view

Variants for E2F8 Gene

Sequence variations from dbSNP and Humsavar for E2F8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000063120 -- 19,232,586(-) A/G intron_variant
rs1000130319 -- 19,226,342(-) T/C/G intron_variant
rs1000199620 -- 19,235,781(-) C/T intron_variant
rs1000280640 -- 19,229,327(-) T/C intron_variant
rs1000388560 -- 19,242,369(-) CCC/CCCC upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for E2F8 Gene

Variant ID Type Subtype PubMed ID
nsv1041249 CNV gain 25217958

Variation tolerance for E2F8 Gene

Residual Variation Intolerance Score: 6.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 54.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for E2F8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
E2F8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F8 Gene

Disorders for E2F8 Gene

Additional Disease Information for E2F8

No disorders were found for E2F8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for E2F8 Gene

Publications for E2F8 Gene

  1. E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. (PMID: 22903062) Weijts BG … de Bruin A (The EMBO journal 2012) 3 4 58
  2. DNA-damage response control of E2F7 and E2F8. (PMID: 18202719) Zalmas LP … La Thangue NB (EMBO reports 2008) 3 4 58
  3. E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. (PMID: 15897886) Logan N … La Thangue NB (Oncogene 2005) 3 4 58
  4. Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. (PMID: 15722552) Maiti B … Leone G (The Journal of biological chemistry 2005) 2 3 58
  5. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. (PMID: 16179649) Christensen J … Helin K (Nucleic acids research 2005) 3 4 58

Products for E2F8 Gene

Sources for E2F8 Gene

Content
Loading form....