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Aliases for E2F5 Gene

Aliases for E2F5 Gene

  • E2F Transcription Factor 5 2 3 5
  • E2F Transcription Factor 5, P130-Binding 2 3
  • E2F-5 3 4
  • Transcription Factor E2F5 3

External Ids for E2F5 Gene

Previous GeneCards Identifiers for E2F5 Gene

  • GC08P084913
  • GC08P086046
  • GC08P085869
  • GC08P086164
  • GC08P086276
  • GC08P081583
  • GC08P086089

Summaries for E2F5 Gene

Entrez Gene Summary for E2F5 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F5 Gene

E2F5 (E2F Transcription Factor 5) is a Protein Coding gene. Diseases associated with E2F5 include Retinal Cancer and Sensory System Cancer. Among its related pathways are Cyclins and Cell Cycle Regulation and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is E2F4.

UniProtKB/Swiss-Prot for E2F5 Gene

  • Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Wiki entry for E2F5 Gene

Additional gene information for E2F5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F5 Gene

Genomics for E2F5 Gene

GeneHancer (GH) Regulatory Elements for E2F5 Gene

Promoters and enhancers for E2F5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I085174 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.8 +0.3 279 4.7 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 E2F5 ENSG00000254208 LOC102723322 LRRCC1
GH08I085199 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 550.3 +24.0 23974 3.8 SMAD1 ZNF133 BACH1 PAX8 EBF1 BMI1 POLR2A ATF7 ETV6 BCLAF1 E2F5 LRRCC1 GC08P085189 GC08P085214
GH08I085186 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 550.4 +13.0 12966 6.2 HDGF FOXA2 PKNOX1 RAD21 YY1 ATF7 BCLAF1 RUNX3 RXRA CEBPB GC08P085189 E2F5 LRRCC1 GC08P085214
GH08I085147 Enhancer 0.7 ENCODE 12.9 -29.4 -29425 0.2 CTCF TFAP4 ZNF654 TEAD4 TAL1 TRIM22 CBFA2T3 RAD21 CC2D1A TCF12 E2F5 ENSG00000254208 CA13 LOC105375933
GH08I085153 Enhancer 0.5 Ensembl ENCODE 13.1 -23.1 -23146 0.6 NFYC E2F5 ENSG00000254208 LRRCC1 CA13 LOC105375933
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around E2F5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the E2F5 gene promoter:

Genomic Locations for E2F5 Gene

Genomic Locations for E2F5 Gene
chr8:85,177,056-85,217,158
(GRCh38/hg38)
Size:
40,103 bases
Orientation:
Plus strand
chr8:86,089,460-86,129,387
(GRCh37/hg19)

Genomic View for E2F5 Gene

Genes around E2F5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F5 Gene

Proteins for E2F5 Gene

  • Protein details for E2F5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15329-E2F5_HUMAN
    Recommended name:
    Transcription factor E2F5
    Protein Accession:
    Q15329
    Secondary Accessions:
    • E9PBN9
    • Q16601
    • Q92756

    Protein attributes for E2F5 Gene

    Size:
    346 amino acids
    Molecular mass:
    37610 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Three dimensional structures from OCA and Proteopedia for E2F5 Gene

    Alternative splice isoforms for E2F5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for E2F5 Gene

Post-translational modifications for E2F5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for E2F5 Gene

Domains & Families for E2F5 Gene

Gene Families for E2F5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for E2F5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15329

UniProtKB/Swiss-Prot:

E2F5_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F5: view

Function for E2F5 Gene

Molecular function for E2F5 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Phenotypes From GWAS Catalog for E2F5 Gene

Gene Ontology (GO) - Molecular Function for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16360038
GO:0008134 transcription factor binding IPI 16360038
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with E2F5: view
genes like me logo Genes that share phenotypes with E2F5: view

Animal Models for E2F5 Gene

MGI Knock Outs for E2F5:

Animal Model Products

CRISPR Products

Transcription Factor Targets for E2F5 Gene

Selected GeneGlobe predicted Target genes for E2F5

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for E2F5 Gene

Localization for E2F5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for E2F5 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with E2F5: view

Pathways & Interactions for E2F5 Gene

genes like me logo Genes that share pathways with E2F5: view

Gene Ontology (GO) - Biological Process for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009887 animal organ morphogenesis IEA --
GO:0030030 cell projection organization IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with E2F5: view

No data available for SIGNOR curated interactions for E2F5 Gene

Drugs & Compounds for E2F5 Gene

(1) Additional Compounds for E2F5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with E2F5: view

Transcripts for E2F5 Gene

Unigene Clusters for E2F5 Gene

E2F transcription factor 5, p130-binding:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1:
SP2:
SP3:

Relevant External Links for E2F5 Gene

GeneLoc Exon Structure for
E2F5
ECgene alternative splicing isoforms for
E2F5

Expression for E2F5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for E2F5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for E2F5 Gene



Protein tissue co-expression partners for E2F5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of E2F5 Gene:

E2F5

SOURCE GeneReport for Unigene cluster for E2F5 Gene:

Hs.445758

Evidence on tissue expression from TISSUES for E2F5 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with E2F5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for E2F5 Gene

Orthologs for E2F5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for E2F5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F5 34 33
  • 99.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia E2F5 33 34
  • 94.05 (n)
cow
(Bos Taurus)
Mammalia E2F5 33 34
  • 90.68 (n)
mouse
(Mus musculus)
Mammalia E2f5 16 34 33
  • 88.56 (n)
rat
(Rattus norvegicus)
Mammalia E2f5 33
  • 88.46 (n)
oppossum
(Monodelphis domestica)
Mammalia E2F5 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F5 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F5 33 34
  • 75 (n)
lizard
(Anolis carolinensis)
Reptilia E2F5 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f5 33
  • 72.48 (n)
zebrafish
(Danio rerio)
Actinopterygii e2f5 33 34
  • 64.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta E2f2 33 34
  • 46.48 (n)
worm
(Caenorhabditis elegans)
Secernentea efl-1 35 34
  • 41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons E2F1 33
  • 51.85 (n)
Species where no ortholog for E2F5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F5 Gene

ENSEMBL:
Gene Tree for E2F5 (if available)
TreeFam:
Gene Tree for E2F5 (if available)

Paralogs for E2F5 Gene

Paralogs for E2F5 Gene

(3) SIMAP similar genes for E2F5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with E2F5: view

Variants for E2F5 Gene

Sequence variations from dbSNP and Humsavar for E2F5 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000042933 -- 85,196,430(+) C/G intron_variant
rs1000210403 -- 85,177,482(+) A/C coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000272070 -- 85,211,031(+) G/A intron_variant
rs1000312074 -- 85,188,865(+) A/T intron_variant
rs1000330864 -- 85,183,063(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for E2F5 Gene

Variant ID Type Subtype PubMed ID
nsv483121 CNV loss 15286789
nsv483126 CNV gain+loss 15286789

Variation tolerance for E2F5 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for E2F5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
E2F5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F5 Gene

Disorders for E2F5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for E2F5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinal cancer
  • malignant neoplasm of retina
sensory system cancer
- elite association - COSMIC cancer census association via MalaCards
Search E2F5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for E2F5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with E2F5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F5 Gene

Publications for E2F5 Gene

  1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PMID: 7892279) Sardet C … Weinberg RA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
  2. The molecular and functional characterization of E2F-5 transcription factor. (PMID: 9464260) Vaishnav YN … Pant V (Biochemical and biophysical research communications 1998) 3 4 22 58
  3. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. (PMID: 8589754) Itoh A … Mitsialis SA (Cellular & molecular biology research 1995) 3 4 22 58
  4. E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. (PMID: 20181230) Kothandaraman N … Choolani M (BMC cancer 2010) 3 22 58
  5. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N … Pharoah PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 44 58

Products for E2F5 Gene

  • Addgene plasmids for E2F5

Sources for E2F5 Gene

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