The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the fa... See more...

Aliases for E2F5 Gene

Aliases for E2F5 Gene

  • E2F Transcription Factor 5 2 3 5
  • E2F Transcription Factor 5, P130-Binding 2 3
  • Transcription Factor E2F5 3 4
  • E2F-5 3 4
  • E2F5 5

External Ids for E2F5 Gene

Previous GeneCards Identifiers for E2F5 Gene

  • GC08P084913
  • GC08P086046
  • GC08P085869
  • GC08P086164
  • GC08P086276
  • GC08P081583
  • GC08P086089

Summaries for E2F5 Gene

Entrez Gene Summary for E2F5 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F5 Gene

E2F5 (E2F Transcription Factor 5) is a Protein Coding gene. Diseases associated with E2F5 include Retinoblastoma and Retinal Cancer. Among its related pathways are Cell cycle Cell cycle (generic schema) and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is E2F4.

UniProtKB/Swiss-Prot Summary for E2F5 Gene

  • Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Wiki entry for E2F5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for E2F5 Gene

Genomics for E2F5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for E2F5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J085174 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 259.7 +0.2 181 4.7 ZNF207 MYC ZNF600 ZNF592 KLF9 POLR2A ZNF223 ZSCAN16 ZIC2 YY1 E2F5 E2F5-DT ENSG00000254208 HSALNG0066695 LRRCC1 CA13
GH08J085958 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.8 +782.6 782605 2.9 MYC NCOR1 IKZF1 ZNF592 NFIC NONO REST HES1 MBD2 ZNF513 CA3-AS1 CA2 E2F5 piR-42694-162 HSALNG0066724 ATP6V0D2 LOC101929627
GH08J085147 Enhancer 0.8 Ensembl ENCODE 12.9 -29.4 -29436 1 ZNF654 NCOR1 TRIM22 CTCF RAD21 SMC3 TAL1 TCF12 TEAD4 TFAP4 HSALNG0066694 LRRCC1 E2F5 ENSG00000254208 CA13 piR-55194-402
GH08J085143 Enhancer 0.5 Ensembl 12.9 -33.1 -33053 1 NFE2 TAL1 SMARCA4 MAFK MAFF DPF2 ARID1B CBFA2T3 LRRCC1 E2F5 ENSG00000254208 CA13 HSALNG0066694 LOC105375933
GH08J085146 Enhancer 0.5 Ensembl 12.9 -30.4 -30353 0.8 MAFF ZNF316 MAFK MAFG CTCF EMSY HSALNG0066694 E2F5 ENSG00000254208 CA13 LRRCC1 LOC105375933
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around E2F5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for E2F5

Top Transcription factor binding sites by QIAGEN in the E2F5 gene promoter:
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Pax-4a
  • POU3F2

Genomic Locations for E2F5 Gene

Latest Assembly
chr8:85,177,154-85,217,158
(GRCh38/hg38)
Size:
40,005 bases
Orientation:
Plus strand

Previous Assembly
chr8:86,089,389-86,126,753
(GRCh37/hg19 by Entrez Gene)
Size:
37,365 bases
Orientation:
Plus strand

chr8:86,089,460-86,129,387
(GRCh37/hg19 by Ensembl)
Size:
39,928 bases
Orientation:
Plus strand

Genomic View for E2F5 Gene

Genes around E2F5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F5 Gene

Proteins for E2F5 Gene

  • Protein details for E2F5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15329-E2F5_HUMAN
    Recommended name:
    Transcription factor E2F5
    Protein Accession:
    Q15329
    Secondary Accessions:
    • E9PBN9
    • Q16601
    • Q92756

    Protein attributes for E2F5 Gene

    Size:
    346 amino acids
    Molecular mass:
    37610 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Three dimensional structures from OCA and Proteopedia for E2F5 Gene

    Alternative splice isoforms for E2F5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for E2F5 Gene

Post-translational modifications for E2F5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for E2F5

No data available for DME Specific Peptides for E2F5 Gene

Domains & Families for E2F5 Gene

Gene Families for E2F5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for E2F5 Gene

InterPro:
Blocks:
  • Transcription factor E2F/dimerisation partner (TDP)

Suggested Antigen Peptide Sequences for E2F5 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor E2F5 (E2F5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15329

UniProtKB/Swiss-Prot:

E2F5_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F5: view

Function for E2F5 Gene

Molecular function for E2F5 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Phenotypes From GWAS Catalog for E2F5 Gene

Gene Ontology (GO) - Molecular Function for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001216 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding IDA 17062573
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,NAS 7892279
genes like me logo Genes that share ontologies with E2F5: view
genes like me logo Genes that share phenotypes with E2F5: view

Animal Models for E2F5 Gene

MGI Knock Outs for E2F5:

Transcription Factor Targets for E2F5 Gene

Selected GeneGlobe predicted Target genes for E2F5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for E2F5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for E2F5 Gene

Localization for E2F5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for E2F5 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with E2F5: view

Pathways & Interactions for E2F5 Gene

PathCards logo

SuperPathways for E2F5 Gene

SuperPathway Contained pathways
1 Cyclins and Cell Cycle Regulation
.67
.67
.36
.31
2 Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer
3 Cell cycle
4 GPCR Pathway
.59
.58
5 Chks in Checkpoint Regulation
.59
.55
genes like me logo Genes that share pathways with E2F5: view

Pathways by source for E2F5 Gene

1 GeneGo (Thomson Reuters) pathway for E2F5 Gene
  • Cell cycle Cell cycle (generic schema)
14 Qiagen pathways for E2F5 Gene
  • BRCA1 Pathway
  • Breast Cancer Regulation by Stathmin1
  • Cell Cycle Control by BTG Proteins
  • Chks in Checkpoint Regulation
  • Cyclins and Cell Cycle Regulation

SIGNOR curated interactions for E2F5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0030030 cell projection organization IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II TAS --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with E2F5: view

Drugs & Compounds for E2F5 Gene

(1) Additional Compounds for E2F5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with E2F5: view

Transcripts for E2F5 Gene

mRNA/cDNA for E2F5 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for E2F5

Alternative Splicing Database (ASD) splice patterns (SP) for E2F5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1:
SP2:
SP3:

Relevant External Links for E2F5 Gene

GeneLoc Exon Structure for
E2F5

Expression for E2F5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for E2F5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for E2F5 Gene



Protein tissue co-expression partners for E2F5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for E2F5

SOURCE GeneReport for Unigene cluster for E2F5 Gene:

Hs.445758

Evidence on tissue expression from TISSUES for E2F5 Gene

  • Lung(4.4)
  • Intestine(2.3)
  • Lymph node(2.3)
  • Blood(2.2)
  • Nervous system(2.2)
  • Liver(2.1)
  • Kidney(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with E2F5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for E2F5 Gene

Orthologs for E2F5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for E2F5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia E2F5 29 30
  • 99.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia E2F5 29 30
  • 94.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia E2F5 29 30
  • 90.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia E2f5 29 16 30
  • 88.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia E2f5 29
  • 88.46 (n)
Oppossum
(Monodelphis domestica)
Mammalia E2F5 30
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia E2F5 30
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves E2F5 29 30
  • 75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia E2F5 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia e2f5 29
  • 72.48 (n)
Zebrafish
(Danio rerio)
Actinopterygii e2f5 29 30
  • 64.99 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta E2f2 29 30
  • 46.48 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea efl-1 30 31
  • 30 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons E2F1 29
  • 51.85 (n)
Species where no ortholog for E2F5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for E2F5 Gene

ENSEMBL:
Gene Tree for E2F5 (if available)
TreeFam:
Gene Tree for E2F5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for E2F5: view image
Alliance of Genome Resources:
Additional Orthologs for E2F5

Paralogs for E2F5 Gene

Paralogs for E2F5 Gene

(3) SIMAP similar genes for E2F5 Gene using alignment to 5 proteins:

  • E2F5_HUMAN
  • C9JYE9_HUMAN
  • E5RHD4_HUMAN
  • H0YBK0_HUMAN
  • H0YBW8_HUMAN
genes like me logo Genes that share paralogs with E2F5: view

Variants for E2F5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for E2F5 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs4150841 -- p.Gly18Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for E2F5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for E2F5 Gene

Variant ID Type Subtype PubMed ID
nsv483121 CNV loss 15286789
nsv483126 CNV gain+loss 15286789

Variation tolerance for E2F5 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for E2F5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
E2F5
Leiden Open Variation Database (LOVD)
E2F5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F5 Gene

Disorders for E2F5 Gene

MalaCards: The human disease database

(9) MalaCards diseases for E2F5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
retinal cancer
  • malignant neoplasm of retina
familial retinoblastoma
  • hereditary retinoblastoma
soft palate cancer
  • malignant tumor of soft palate
ocular cancer
  • eye neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search E2F5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for E2F5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with E2F5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F5 Gene

Publications for E2F5 Gene

  1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PMID: 7892279) Sardet C … Weinberg RA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22
  2. The molecular and functional characterization of E2F-5 transcription factor. (PMID: 9464260) Vaishnav YN … Pant V (Biochemical and biophysical research communications 1998) 3 4 22
  3. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. (PMID: 8589754) Itoh A … Mitsialis SA (Cellular & molecular biology research 1995) 3 4 22
  4. E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. (PMID: 20181230) Kothandaraman N … Choolani M (BMC cancer 2010) 3 22
  5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 40

Products for E2F5 Gene

Sources for E2F5 Gene