The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These ... See more...

Aliases for E2F2 Gene

Aliases for E2F2 Gene

  • E2F Transcription Factor 2 2 3 5
  • Transcription Factor E2F2 3 4
  • E2F-2 3 4

External Ids for E2F2 Gene

Previous GeneCards Identifiers for E2F2 Gene

  • GC01M023394
  • GC01M022908
  • GC01M023302
  • GC01M023578
  • GC01M023705
  • GC01M023832
  • GC01M022083
  • GC01M023506
  • GC01M023507

Summaries for E2F2 Gene

Entrez Gene Summary for E2F2 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F2 Gene

E2F2 (E2F Transcription Factor 2) is a Protein Coding gene. Diseases associated with E2F2 include Retinoblastoma and Encapsulated Thymoma. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and core promoter binding. An important paralog of this gene is E2F3.

UniProtKB/Swiss-Prot Summary for E2F2 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

Gene Wiki entry for E2F2 Gene

Additional gene information for E2F2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for E2F2 Gene

Genomics for E2F2 Gene

GeneHancer (GH) Regulatory Elements for E2F2 Gene

Promoters and enhancers for E2F2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around E2F2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for E2F2

Top Transcription factor binding sites by QIAGEN in the E2F2 gene promoter:
  • AML1a
  • c-Myb
  • c-Myc
  • Max1
  • Sox9
  • Tal-1beta
  • USF-1
  • USF1

Genomic Locations for E2F2 Gene

Genomic Locations for E2F2 Gene
chr1:23,505,974-23,531,250
(GRCh38/hg38)
Size:
25,277 bases
Orientation:
Minus strand
chr1:23,832,920-23,857,712
(GRCh37/hg19)
Size:
24,793 bases
Orientation:
Minus strand

Genomic View for E2F2 Gene

Genes around E2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F2 Gene

Proteins for E2F2 Gene

  • Protein details for E2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14209-E2F2_HUMAN
    Recommended name:
    Transcription factor E2F2
    Protein Accession:
    Q14209
    Secondary Accessions:
    • B2R9W1
    • Q7Z6H1

    Protein attributes for E2F2 Gene

    Size:
    437 amino acids
    Molecular mass:
    47506 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active complex. Binds EAPP.

    Three dimensional structures from OCA and Proteopedia for E2F2 Gene

neXtProt entry for E2F2 Gene

Post-translational modifications for E2F2 Gene

  • Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for E2F2 Gene

No data available for DME Specific Peptides for E2F2 Gene

Domains & Families for E2F2 Gene

Gene Families for E2F2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for E2F2 Gene

Blocks:
  • Transcription factor E2F/dimerisation partner (TDP)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for E2F2 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor E2F2 (E2F2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14209

UniProtKB/Swiss-Prot:

E2F2_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F2: view

Function for E2F2 Gene

Molecular function for E2F2 Gene

UniProtKB/Swiss-Prot Function:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
GENATLAS Biochemistry:
transcription factor E2F-like 2,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis

Phenotypes From GWAS Catalog for E2F2 Gene

Gene Ontology (GO) - Molecular Function for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IDA 7739537
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0000987 proximal promoter sequence-specific DNA binding IDA 15735762
GO:0001228 contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA 7739537
GO:0003677 DNA binding IBA,TAS 21873635
genes like me logo Genes that share ontologies with E2F2: view
genes like me logo Genes that share phenotypes with E2F2: view

Animal Models for E2F2 Gene

MGI Knock Outs for E2F2:
  • E2f2 E2f2<tm1Zubi>

Animal Model Products

CRISPR Products

miRNA for E2F2 Gene

miRTarBase miRNAs that target E2F2

Transcription Factor Targets for E2F2 Gene

Selected GeneGlobe predicted Target genes for E2F2

Clone Products

  • Addgene plasmids for E2F2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for E2F2 Gene

Localization for E2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for E2F2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0090575 RNA polymerase II transcription factor complex IDA 7739537
genes like me logo Genes that share ontologies with E2F2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for E2F2 Gene

Pathways & Interactions for E2F2 Gene

genes like me logo Genes that share pathways with E2F2: view

Pathways by source for E2F2 Gene

1 GeneGo (Thomson Reuters) pathway for E2F2 Gene
  • Cell cycle Cell cycle (generic schema)
14 Qiagen pathways for E2F2 Gene
  • BRCA1 Pathway
  • Breast Cancer Regulation by Stathmin1
  • Cell Cycle Control by BTG Proteins
  • Chks in Checkpoint Regulation
  • Cyclins and Cell Cycle Regulation

SIGNOR curated interactions for E2F2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS 8246996
GO:0007049 cell cycle IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 7739537
genes like me logo Genes that share ontologies with E2F2: view

Drugs & Compounds for E2F2 Gene

(1) Drugs for E2F2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HLM006474 Pharma E2F inhibitor 0

(2) Additional Compounds for E2F2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for E2F2 Gene

Compound Action Cas Number
HLM006474 E2F inhibitor 353519-63-8
genes like me logo Genes that share compounds with E2F2: view

Drug Products

Transcripts for E2F2 Gene

mRNA/cDNA for E2F2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for E2F2

Alternative Splicing Database (ASD) splice patterns (SP) for E2F2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1:
SP2: -
SP3: -

Relevant External Links for E2F2 Gene

GeneLoc Exon Structure for
E2F2

Expression for E2F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for E2F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for E2F2 Gene

This gene is overexpressed in Whole Blood (x14.8), Esophagus - Mucosa (x7.1), and Colon - Transverse (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for E2F2

SOURCE GeneReport for Unigene cluster for E2F2 Gene:

Hs.194333

mRNA Expression by UniProt/SwissProt for E2F2 Gene:

Q14209-E2F2_HUMAN
Tissue specificity: Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.

Evidence on tissue expression from TISSUES for E2F2 Gene

  • Eye(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with E2F2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for E2F2 Gene

Orthologs for E2F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F2 31 30
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia E2F2 31 30
  • 88.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia E2F2 31 30
  • 88.01 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f2 30
  • 84.36 (n)
mouse
(Mus musculus)
Mammalia E2f2 17 31 30
  • 84.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia E2F2 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F2 31
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F2 31
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC568846 30
  • 59.01 (n)
E2F2 31
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta E2f 31 32
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-2 31
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToMany
Species where no ortholog for E2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for E2F2 Gene

ENSEMBL:
Gene Tree for E2F2 (if available)
TreeFam:
Gene Tree for E2F2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for E2F2: view image

Paralogs for E2F2 Gene

Paralogs for E2F2 Gene

(3) SIMAP similar genes for E2F2 Gene using alignment to 1 proteins:

  • E2F2_HUMAN
genes like me logo Genes that share paralogs with E2F2: view

Variants for E2F2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for E2F2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
713748 Likely Benign: not provided 23,521,045(-) G/A MISSENSE_VARIANT
715330 Benign: not provided 23,516,451(-) G/A MISSENSE_VARIANT
744420 Likely Benign: not provided 23,516,486(-) G/A SYNONYMOUS_VARIANT
744421 Likely Benign: not provided 23,519,073(-) T/C SYNONYMOUS_VARIANT
rs2075995 - p.Gln226His

Additional dbSNP identifiers (rs#s) for E2F2 Gene

Structural Variations from Database of Genomic Variants (DGV) for E2F2 Gene

Variant ID Type Subtype PubMed ID
esv3417141 CNV insertion 20981092
nsv834435 CNV loss 17160897

Variation tolerance for E2F2 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.98; 93.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for E2F2 Gene

Human Gene Mutation Database (HGMD)
E2F2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
E2F2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F2 Gene

Disorders for E2F2 Gene

MalaCards: The human disease database

(18) MalaCards diseases for E2F2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
encapsulated thymoma
maxillary sinus adenocarcinoma
  • adenocarcinoma of maxillary sinus
exocervical carcinoma
  • carcinoma of exocervix
retinal cancer
  • malignant neoplasm of retina
- elite association - COSMIC cancer census association via MalaCards
Search E2F2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for E2F2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with E2F2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F2 Gene

Publications for E2F2 Gene

  1. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 23 41 54
  2. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. (PMID: 8246995) Ivey-Hoyle M … Heimbrook DC (Molecular and cellular biology 1993) 2 3 4 54
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 41 54
  4. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. (PMID: 19690970) Chen J … Frazier ML (Cancer causes & control : CCC 2009) 3 41 54
  5. Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors. (PMID: 19142864) Justenhoven C … Brauch H (International journal of cancer 2009) 3 41 54

Products for E2F2 Gene

Sources for E2F2 Gene