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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These ... See more...
Aliases for E2F1 Gene
Aliases for E2F1 Gene
External Ids for E2F1 Gene
- HGNC: 3113
- Entrez Gene: 1869
- Ensembl: ENSG00000101412
- OMIM: 189971
- UniProtKB: Q01094
Previous HGNC Symbols for E2F1 Gene
- RBBP3
Previous GeneCards Identifiers for E2F1 Gene
- GC20M032022
- GC20M031981
- GC20M032931
- GC20M032979
- GC20M031727
- GC20M032263
- GC20M029049
Summaries for E2F1 Gene
-
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for E2F1 Gene
E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Glioblastoma Multiforme. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is E2F3.
UniProtKB/Swiss-Prot Summary for E2F1 Gene
-
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).
Additional gene information for E2F1 Gene
- HGNC(3113)
- Entrez Gene(1869)
- Ensembl(ENSG00000101412)
- OMIM(189971)
- UniProtKB(Q01094)
- Open Targets Platform(ENSG00000101412)
- Search for E2F1 at DataMed
- Search for E2F1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for E2F1 Gene
Genomics for E2F1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for E2F1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around E2F1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for E2F1
- Top Transcription factor binding sites by QIAGEN in the E2F1 gene promoter:
-
- GCNF
- GCNF-1
- GCNF-2
- Sp1
Genomic Locations for E2F1 Gene
Genomic Locations for E2F1 Gene
- chr20:33,675,477-33,686,385
- (GRCh38/hg38)
- Size:
- 10,909 bases
- Orientation:
- Minus strand
- chr20:32,263,292-32,274,210
- (GRCh37/hg19)
- Size:
- 10,919 bases
- Orientation:
- Minus strand
Genomic View for E2F1 Gene
Genes around E2F1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.22 by HGNC
- 20q11.22 by Entrez Gene
- 20q11.22 by Ensembl
E2F1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for E2F1 Gene
Proteins for E2F1 Gene
-
Protein details for E2F1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01094-E2F1_HUMAN
- Recommended name:
- Transcription factor E2F1
- Protein Accession:
- Q01094
- Q13143
- Q92768
Protein attributes for E2F1 Gene
- Size:
- 437 amino acids
- Molecular mass:
- 46920 Da
- Quaternary structure:
-
- Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1 (PubMed:8336704). During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional activity. Interacts with BIRC2/c-IAP1 (via BIR domains). The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target genes promoters and represses its transcriptional activity (PubMed:20176812). Interacts with RRP1B (PubMed:20040599). Interacts with HCFC1 (PubMed:23629655). Interacts with KMT2E; the interaction is probably indirect and is mediated via HCFC1 (PubMed:23629655).
- (Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123.
- SequenceCaution:
-
- Sequence=AAB24289.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for E2F1 Gene
Post-translational modifications for E2F1 Gene
- Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.
- Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for E2F1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences E2F1 Antibody (LS-B52) and E2F1 Antibody (LS-B6744)
- GeneTex Anti-E2F1 antibody [N1N3] and Anti-E2F1 antibody [16G7]
- Novus Biologicals Antibodies for E2F1
-
Abcam antibodies for E2F1
- Invitrogen Antibodies for E2F1 (AFLGC-E2F1)
- antibodies-online: Show 154 available E2F1 Antibodies ranked by validation data
- Compare Top E2F1 Antibodies
-
Recommended
- 345 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 8 DB Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 109 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 52 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for E2F1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for E2F1
- Origene Custom Protein Services for E2F1
-
Abcam proteins for E2F1
Assay Products
No data available for DME Specific Peptides for E2F1 Gene
Domains & Families for E2F1 Gene
Gene Families for E2F1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for E2F1 Gene
- InterPro:
- Blocks:
-
- Transcription factor E2F/dimerisation partner (TDP)
- ProtoNet:
Suggested Antigen Peptide Sequences for E2F1 Gene
- GenScript: Design optimal peptide antigens:
-
- Retinoblastoma-binding protein 3 (E2F1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01094- Family:
-
- Belongs to the E2F/DP family.
Function for E2F1 Gene
Molecular function for E2F1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- BIRC2/c-IAP1 stimulates its transcriptional activity.
- GENATLAS Biochemistry:
- transcription factor E2F1,involved in cell proliferation and apoptosis,controlling genes regulating S phase entry and DNA synthesis,downregulated in post-mitotic neurons by interaction with NDN and proteolysis through the ubiquitin-proteasome pathway
Phenotypes From GWAS Catalog for E2F1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IMP,ISM | 19274049 |
| GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 15735762 |
| GO:0001216 | bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding | IDA | 17062573 |
| GO:0003677 | DNA binding | IBA,IMP | 11418595 |
| GO:0003700 | DNA-binding transcription factor activity | IBA,TAS | 11418595 |
Phenotypes for E2F1 Gene
- MGI mutant phenotypes for E2F1:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for E2F1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- shRNA abundance <= 50%
- Decreased viability of wild-type and TP53 knockout cells
- Increased G1 DNA content
- shRNA abundance <= 25%
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased influenza A/WSN/33 replication
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased homologous recombination repair frequency
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for E2F1 - Select products 50% OFF >
- * E2F1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for E2F1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for E2F1
-
Santa Cruz Biotechnology (SCBT) CRISPR for E2F1
miRNA for E2F1 Gene
- miRTarBase miRNAs that target E2F1
-
- hsa-miR-20a-5p (MIRT000180)
- hsa-miR-106a-5p (MIRT000374)
- hsa-miR-223-3p (MIRT000632)
- hsa-miR-330-3p (MIRT000718)
- hsa-miR-98-5p (MIRT001124)
- hsa-miR-21-5p (MIRT001191)
- hsa-miR-93-5p (MIRT002472)
- hsa-miR-17-5p (MIRT002935)
- hsa-miR-106b-5p (MIRT003045)
- hsa-miR-205-5p (MIRT003322)
- hsa-miR-23b-3p (MIRT003424)
- hsa-let-7a-5p (MIRT003904)
- hsa-miR-34a-5p (MIRT004821)
- hsa-miR-126-3p (MIRT005020)
- hsa-miR-149-3p (MIRT005356)
- hsa-miR-203a-3p (MIRT006039)
- hsa-miR-331-3p (MIRT006506)
- hsa-miR-362-3p (MIRT007349)
- mmu-miR-124-3p (MIRT015789)
- hsa-miR-193b-3p (MIRT016529)
- hsa-miR-130b-3p (MIRT020292)
- hsa-miR-24-3p (MIRT030626)
- hsa-miR-181b-5p (MIRT035553)
- hsa-miR-10a-5p (MIRT047521)
- mmu-miR-122-5p (MIRT054340)
- mmu-miR-320-3p (MIRT054739)
- hsa-miR-4283 (MIRT083347)
- hsa-miR-6846-5p (MIRT083357)
- hsa-miR-6848-5p (MIRT083358)
- hsa-miR-4685-5p (MIRT083373)
- hsa-miR-6837-5p (MIRT083385)
- hsa-miR-7113-5p (MIRT083388)
- hsa-miR-3158-5p (MIRT153017)
- hsa-miR-329-3p (MIRT438107)
- hsa-miR-3678-3p (MIRT511990)
- hsa-miR-6829-5p (MIRT511991)
- hsa-miR-2467-3p (MIRT511992)
- hsa-miR-6798-5p (MIRT511993)
- hsa-miR-6805-5p (MIRT511994)
- hsa-miR-211-3p (MIRT511995)
- hsa-miR-4446-3p (MIRT511996)
- hsa-miR-7845-5p (MIRT511997)
- mmu-miR-342-3p (MIRT583864)
- mmu-miR-377-3p (MIRT583865)
- mmu-miR-717 (MIRT583866)
- mmu-miR-467g (MIRT591367)
- mmu-miR-466e-3p (MIRT591368)
- mmu-miR-466a-3p (MIRT591369)
- mmu-miR-297b-3p (MIRT591370)
- mmu-miR-466d-3p (MIRT591371)
- mmu-miR-466c-3p (MIRT591372)
- mmu-miR-466p-3p (MIRT591373)
- mmu-miR-1b-5p (MIRT591374)
- mmu-miR-466b-3p (MIRT591375)
- mmu-miR-466m-3p (MIRT591376)
- mmu-miR-466o-3p (MIRT591377)
- mmu-miR-466f-3p (MIRT591378)
- mmu-miR-329-3p (MIRT591379)
- mmu-miR-362-3p (MIRT591380)
- mmu-miR-466i-3p (MIRT591381)
- mmu-miR-128-3p (MIRT593167)
- hsa-miR-519d-3p (MIRT727823)
- hsa-miR-20b-5p (MIRT727824)
- hsa-miR-135a-5p (MIRT733538)
- hsa-miR-302b-3p (MIRT733642)
- hsa-miR-193a-3p (MIRT733932)
- hsa-miR-342-3p (MIRT734732)
- hsa-miR-9-3p (MIRT735212)
- hsa-miR-1324 (MIRT737389)
- hsa-miR-1343-5p (MIRT737459)
- hsa-miR-1827 (MIRT738098)
- hsa-miR-3150a-3p (MIRT740260)
- hsa-miR-3175 (MIRT740654)
- hsa-miR-3612 (MIRT741561)
- hsa-miR-650 (MIRT753009)
- hsa-miR-6763-5p (MIRT755002)
- hsa-miR-6808-5p (MIRT756560)
- hsa-miR-6825-5p (MIRT756971)
- hsa-miR-6893-5p (MIRT758704)
- hsa-miR-939-5p (MIRT760750)
- hsa-miR-940 (MIRT760801)
Transcription Factor Targets for E2F1 Gene
Targeted motifs for E2F1 Gene
HOMER Transcription Factor Regulatory Elements motif E2F1
- Consensus sequence: CWGGCGGGAA Submotif: canonical Cell Type: Hela GEO ID: GSE22478
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for E2F1
- Browse OriGene Inhibitory RNA Products For E2F1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for E2F1
Clone Products
- Applied Biological Materials (abm): Clones for E2F1 - Select products 50% OFF >
- * E2F1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for E2F1
- Addgene plasmids for E2F1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for E2F1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for E2F1 Gene
Localization for E2F1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for E2F1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| mitochondrion | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Centrosome (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IEA,ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 12717439 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for E2F1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
|
.80
|
| 2 | Glioma |
.49
.46
|
|
| 3 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
G1-S Phase Transition
.67
Cell Cycle Control by BTG Proteins
.36
|
.31
|
| 4 | Activation of BH3-only proteins | ||
| 5 | E2F mediated regulation of DNA replication |
Cell cycle Start of DNA replication in early S phase
.53
|
|
Pathways by source for E2F1 Gene
23 BioSystems pathways for E2F1 Gene
38 Reactome pathways for E2F1 Gene
25 KEGG pathways for E2F1 Gene
8 GeneGo (Thomson Reuters) pathways for E2F1 Gene
- Cell cycle Cell cycle (generic schema)
- Cell cycle ESR1 regulation of G1/S transition
- Cell cycle Regulation of G1/S transition (part 2)
- Cell cycle Role of SCF complex in cell cycle regulation
- Cell cycle Start of DNA replication in early S phase
2 R&D Systems pathways for E2F1 Gene
15 Qiagen pathways for E2F1 Gene
- BRCA1 Pathway
- Breast Cancer Regulation by Stathmin1
- Cell Cycle Control by BTG Proteins
- Chks in Checkpoint Regulation
- Cyclins and Cell Cycle Regulation
1 Cell Signaling Technology pathway for E2F1 Gene
Interacting Proteins for E2F1 Gene
Selected Interacting proteins:
Q01094-E2F1_HUMAN
ENSP00000345571
for E2F1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for E2F1
SIGNOR curated interactions for E2F1 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IMP | 12717439 |
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 20224733 |
| GO:0006351 | transcription, DNA-templated | IEA,ISS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 12717439 |
Transcripts for E2F1 Gene
mRNA/cDNA for E2F1 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343380 2690 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for E2F1 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for E2F1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for E2F1
-
Santa Cruz Biotechnology (SCBT) CRISPR for E2F1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for E2F1
- Browse OriGene Inhibitory RNA Products For E2F1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for E2F1
Clone Products
- Applied Biological Materials (abm): Clones for E2F1 - Select products 50% OFF >
- * E2F1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for E2F1
- Addgene plasmids for E2F1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for E2F1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | - |
Relevant External Links for E2F1 Gene
- GeneLoc Exon Structure for
- E2F1
Expression for E2F1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for E2F1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for E2F1
SOURCE GeneReport for Unigene cluster for E2F1 Gene:
Hs.654393Evidence on tissue expression from TISSUES for E2F1 Gene
- Skin(4.5)
- Pancreas(4.4)
- Nervous system(2.9)
- Intestine(2.7)
- Blood(2.5)
- Bone marrow(2.4)
- Kidney(2.4)
- Liver(2.3)
- Muscle(2.3)
- Lymph node(2.3)
- Heart(2.2)
- Lung(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for E2F1
-
OriGene qPCR primer pairs and template standards for E2F1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for E2F1 Gene
Orthologs for E2F1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | E2F1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | E2F1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | E2F1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | E2f1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | E2f1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | E2F1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | E2F1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | E2F1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | e2f1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101885420 30 |
|
||
| E2F1 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | E2f 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | efl-2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for E2F1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for E2F1 Gene
- ENSEMBL:
- Gene Tree for E2F1 (if available)
- TreeFam:
- Gene Tree for E2F1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for E2F1: view image
Paralogs for E2F1 Gene
Variants for E2F1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for E2F1 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713735 | Benign: not provided | 33,676,909(-) | C/T | SYNONYMOUS_VARIANT | |
| 719834 | Benign: not provided | 33,677,440(-) | C/T | MISSENSE_VARIANT | |
| 729545 | Benign: not provided | 33,686,231(-) | A/T | MISSENSE_VARIANT | |
| 734667 | Benign: not provided | 33,686,031(-) | C/G | SYNONYMOUS_VARIANT | |
| 741802 | Likely Benign: not provided | 33,677,441(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1065189 | CNV | loss | 25217958 |
| nsv1072113 | CNV | deletion | 25765185 |
| nsv1143983 | CNV | deletion | 24896259 |
| nsv833960 | CNV | loss | 17160897 |
| nsv833961 | CNV | loss | 17160897 |
| nsv954024 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.63;
45.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for E2F1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F1 Gene
Disorders for E2F1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
|
| glioblastoma multiforme |
|
|
| pediatric systemic lupus erythematosus |
|
|
| lung cancer |
|
|
| bladder cancer |
|
Search E2F1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for E2F1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for E2F1 Gene
Publications for E2F1 Gene
- Structure and partial genomic sequence of the human E2F1 gene. (PMID: 8964493) Neuman E … Kaelin WG (Gene 1996) 2 3 4 23
- Chk2 activates E2F-1 in response to DNA damage. (PMID: 12717439) Stevens C … La Thangue NB (Nature cell biology 2003) 3 4 23
- Regulation of E2F1 by BRCT domain-containing protein TopBP1. (PMID: 12697828) Liu K … Lin WC (Molecular and cellular biology 2003) 3 4 23
- Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A. (PMID: 12501191) Lowe ED … Johnson LN (Biochemistry 2002) 3 4 23
- E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PMID: 11418595) Lang SE … Hearing P (The Journal of biological chemistry 2001) 3 4 23
ExternalLinks
Products for E2F1 Gene
- Custom Antibody ServicesOriGene Antibodies for E2F1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for E2F1
- Origene Custom Protein Services for E2F1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for E2F1
- Browse OriGene Inhibitory RNA Products For E2F1
- OriGene qPCR primer pairs for E2F1
- OriGene qPCR primer pairs and template standards for E2F1
- OriGene CRISPR knockouts for E2F1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For E2F1
- Sino Biological Human cDNA Clone for E2F1
- Browse Sino Biological Recombinant Proteins
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for E2F1
- Novus Biologicals proteins and lysates for E2F1
- Browse Antibodies
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- Abcam antibodies for E2F1
- Abcam proteins for E2F1
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- Browse Primary Antibodies
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- Invitrogen Antibodies for E2F1 (AFLGC-E2F1)
- VectorBuilder Custom and pre-made DNA vectors for E2F1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for E2F1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for E2F1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for E2F1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for E2F1
- Addgene plasmids for E2F1
- antibodies-online: Show 154 available E2F1 Antibodies ranked by validation data
- Compare Top E2F1 Antibodies
- Recommended
- 345 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 8 DB Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 109 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 52 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 15 available E2F1 Elisa Kits ranked by validation data
- Compare Top E2F1 Elisa Kits
- antibodies-online: Show 8 available E2F1 Proteins ranked by validation data
- Compare Top E2F1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for E2F1
- Search Santa Cruz Biotechnology (SCBT) for E2F1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for E2F1
- Horizon Cell Lines for E2F1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for E2F1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for E2F1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for E2F1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for E2F1
Sources for E2F1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
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- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (169) SILVA
- (170) snOPY
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- (172) GENCODE
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB