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Aliases for DYRK4 Gene

Aliases for DYRK4 Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4 2 3 5
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4 2 3
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4 2
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 3
  • EC 2.7.12.1 4

External Ids for DYRK4 Gene

Previous GeneCards Identifiers for DYRK4 Gene

  • GC12P004436
  • GC12P004591
  • GC12P004569
  • GC12P004699
  • GC12P004671
  • GC12P004571
  • GC12P004708
  • GC12P004859
  • GC12P005015
  • GC12P005178
  • GC12P005329
  • GC12P005492

Summaries for DYRK4 Gene

Entrez Gene Summary for DYRK4 Gene

  • This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

GeneCards Summary for DYRK4 Gene

DYRK4 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK3.

UniProtKB/Swiss-Prot for DYRK4 Gene

  • Possible non-essential role in spermiogenesis.

Additional gene information for DYRK4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK4 Gene

Genomics for DYRK4 Gene

GeneHancer (GH) Regulatory Elements for DYRK4 Gene

Promoters and enhancers for DYRK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J004604 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 658.8 +42.8 42824 1.5 HDGF ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ETS1 GLIS2 ZNF207 DYRK4 LOC103568124 PIR36901 ENSG00000272921 LOC100420673 GC12M004620
GH12J004561 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 0.0 -17 1.2 ARID4B KLF17 ZNF48 ZNF614 GLIS2 SP5 MXD4 REST ZNF592 KAT8 DYRK4 RAD51AP1 C12orf4 AKAP3 GC12M004550
GH12J004590 Promoter 0.5 EPDnew 650.3 +27.9 27855 0.1 DYRK4 AKAP3 LOC103568124
GH12J004613 Promoter 0.5 EPDnew 650.2 +51.4 51370 0.1 DYRK4 AKAP3 NDUFA9 GC12M004620 ENSG00000272921
GH12J004614 Promoter 0.5 EPDnew 650.2 +51.5 51543 0.1 DYRK4 AKAP3 NDUFA9 GC12M004620 ENSG00000272921
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYRK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYRK4 gene promoter:
  • AREB6
  • Sox5
  • Cart-1
  • Nkx2-2
  • AML1a
  • C/EBPalpha
  • Nkx6-1
  • FAC1
  • TBP
  • SEF-1 (1)

Genomic Locations for DYRK4 Gene

Genomic Locations for DYRK4 Gene
chr12:4,562,204-4,615,302
(GRCh38/hg38)
Size:
53,099 bases
Orientation:
Plus strand
chr12:4,671,370-4,723,325
(GRCh37/hg19)
Size:
51,956 bases
Orientation:
Plus strand

Genomic View for DYRK4 Gene

Genes around DYRK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK4 Gene

Proteins for DYRK4 Gene

  • Protein details for DYRK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR20-DYRK4_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 4
    Protein Accession:
    Q9NR20
    Secondary Accessions:
    • A8K8F7
    • Q8NEF2
    • Q92631

    Protein attributes for DYRK4 Gene

    Size:
    520 amino acids
    Molecular mass:
    59608 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF91393.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK308260; Type=Frameshift; Positions=470; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK4 Gene

Post-translational modifications for DYRK4 Gene

  • Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYRK4 Gene

Domains & Families for DYRK4 Gene

Gene Families for DYRK4 Gene

Protein Domains for DYRK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR20

UniProtKB/Swiss-Prot:

DYRK4_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK4: view

Function for DYRK4 Gene

Molecular function for DYRK4 Gene

UniProtKB/Swiss-Prot Function:
Possible non-essential role in spermiogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for DYRK4 Gene

Phenotypes From GWAS Catalog for DYRK4 Gene

Gene Ontology (GO) - Molecular Function for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 23602568
genes like me logo Genes that share ontologies with DYRK4: view
genes like me logo Genes that share phenotypes with DYRK4: view

Animal Models for DYRK4 Gene

MGI Knock Outs for DYRK4:

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK4

Clone Products

  • Addgene plasmids for DYRK4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYRK4 Gene

Localization for DYRK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK4 Gene

Isoform 1: Cytoplasm.
Isoform 4: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYRK4 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with DYRK4: view

Pathways & Interactions for DYRK4 Gene

SuperPathways for DYRK4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with DYRK4: view

No data available for Pathways by source and SIGNOR curated interactions for DYRK4 Gene

Drugs & Compounds for DYRK4 Gene

(2) Drugs for DYRK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DYRK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DYRK4: view

Transcripts for DYRK4 Gene

mRNA/cDNA for DYRK4 Gene

(3) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DYRK4 Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for DYRK4

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - -
SP9: - -
SP10: - - - - -
SP11:
SP12:
SP13: - - -

ExUns: 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for DYRK4 Gene

GeneLoc Exon Structure for
DYRK4
ECgene alternative splicing isoforms for
DYRK4

Expression for DYRK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYRK4 Gene

mRNA differential expression in normal tissues according to GTEx for DYRK4 Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for DYRK4 Gene

This gene is overexpressed in Liver (11.4), Adrenal (9.4), Lung (9.3), Kidney (6.3), and Platelet (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DYRK4 Gene



Protein tissue co-expression partners for DYRK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DYRK4 Gene:

DYRK4

SOURCE GeneReport for Unigene cluster for DYRK4 Gene:

Hs.439530

Evidence on tissue expression from TISSUES for DYRK4 Gene

  • Nervous system(4.4)
  • Kidney(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DYRK4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK4 Gene

Orthologs for DYRK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYRK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK4 34 33
  • 98.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYRK4 34 33
  • 87.08 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DYRK4 34 33
  • 84.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dyrk4 33
  • 82.88 (n)
mouse
(Mus musculus)
Mammalia Dyrk4 16 34 33
  • 82.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK4 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYRK4 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dyrk4 34 33
  • 68.48 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007847 33
  • 67.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta smi35A 34 35 33
  • 60.56 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C36B7.1 35
  • 29 (a)
C36B7.2 35
  • 28 (a)
rice
(Oryza sativa)
Liliopsida Os.12653 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 65 (a)
OneToMany
Cin.916 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.916 33
Species where no ortholog for DYRK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DYRK4 Gene

ENSEMBL:
Gene Tree for DYRK4 (if available)
TreeFam:
Gene Tree for DYRK4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYRK4: view image

Paralogs for DYRK4 Gene

(43) SIMAP similar genes for DYRK4 Gene using alignment to 12 proteins:

  • DYRK4_HUMAN
  • B4DQW1_HUMAN
  • D3JEN0_HUMAN
  • D3JEN1_HUMAN
  • D3JEN2_HUMAN
  • D3JEN3_HUMAN
  • D3JEN4_HUMAN
  • F5GWS4_HUMAN
  • F5H3D3_HUMAN
  • F5H4X6_HUMAN
  • F5H6L9_HUMAN
  • H0YFI4_HUMAN
genes like me logo Genes that share paralogs with DYRK4: view

Variants for DYRK4 Gene

Sequence variations from dbSNP and Humsavar for DYRK4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000015514 -- 4,614,372(+) A/G downstream_transcript_variant
rs1000129014 -- 4,610,735(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000535195 -- 4,609,305(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000550455 -- 4,603,340(+) A/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000580186 -- 4,603,676(+) A/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DYRK4 Gene

Variant ID Type Subtype PubMed ID
nsv1040098 CNV gain 25217958
nsv483060 CNV loss 15286789
nsv557123 CNV gain 21841781
nsv7226 OTHER inversion 18451855
nsv832318 CNV gain 17160897

Variation tolerance for DYRK4 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYRK4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK4 Gene

Disorders for DYRK4 Gene

Additional Disease Information for DYRK4

No disorders were found for DYRK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK4 Gene

Publications for DYRK4 Gene

  1. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W … Joost HG (The Journal of biological chemistry 1998) 2 3 4 58
  2. Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. (PMID: 21127067) Papadopoulos C … de la Luna S (The Journal of biological chemistry 2011) 3 4 58
  3. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. (PMID: 17292540) Sacher F … Fritsch M (Molecular and cellular endocrinology 2007) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DYRK4 Gene

Sources for DYRK4 Gene

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