This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate ... See more...

Aliases for DYRK3 Gene

Aliases for DYRK3 Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3 2 3 5
  • Regulatory Erythroid Kinase 2 3 4
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 3 2 3
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 5 2 3
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 3 3 4
  • Protein Kinase Dyrk3 2 3
  • EC 2.7.12.1 4 54
  • REDK 3 4
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 3 2
  • EC 2.7.12 54
  • HYAK3-2 3
  • DYRK5 3
  • RED 3

External Ids for DYRK3 Gene

Previous GeneCards Identifiers for DYRK3 Gene

  • GC01P205468
  • GC01P202519
  • GC01P203452
  • GC01P203892
  • GC01P203197
  • GC01P204875
  • GC01P206800
  • GC01P177507

Summaries for DYRK3 Gene

Entrez Gene Summary for DYRK3 Gene

  • This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYRK3 Gene

DYRK3 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK2.

UniProtKB/Swiss-Prot Summary for DYRK3 Gene

  • Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603).

Gene Wiki entry for DYRK3 Gene

Additional gene information for DYRK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DYRK3 Gene

Genomics for DYRK3 Gene

GeneHancer (GH) Regulatory Elements for DYRK3 Gene

Promoters and enhancers for DYRK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYRK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYRK3 gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for DYRK3 Gene

Genomic Locations for DYRK3 Gene
chr1:206,635,534-206,684,419
(GRCh38/hg38)
Size:
48,886 bases
Orientation:
Plus strand
chr1:206,808,881-206,857,764
(GRCh37/hg19)
Size:
48,884 bases
Orientation:
Plus strand

Genomic View for DYRK3 Gene

Genes around DYRK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK3 Gene

Proteins for DYRK3 Gene

  • Protein details for DYRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43781-DYRK3_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 3
    Protein Accession:
    O43781
    Secondary Accessions:
    • D3DT79
    • Q7Z752
    • Q9HBY6
    • Q9HBY7

    Protein attributes for DYRK3 Gene

    Size:
    588 amino acids
    Molecular mass:
    65714 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with SIRT1.

    Three dimensional structures from OCA and Proteopedia for DYRK3 Gene

    Alternative splice isoforms for DYRK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK3 Gene

Selected DME Specific Peptides for DYRK3 Gene

O43781:
  • LYELIKKN
  • GAYIHVP
  • PGEDEGDQLACM
  • VRNEKRFHRQA
  • IGKGSFGQV
  • GGPNNGGYDD
  • KVIDFGSSC
  • MKVEQLFQEFG

Post-translational modifications for DYRK3 Gene

  • Ubiquitinated at anaphase by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome.
  • Protein kinase activity is activated following autophosphorylation at Tyr-369 (Probable). Autophosphorylation at Ser-350 stabilizes the protein and enhances the protein kinase activity (PubMed:9748265).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DYRK3 Gene

Gene Families for DYRK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DYRK3 Gene

Suggested Antigen Peptide Sequences for DYRK3 Gene

GenScript: Design optimal peptide antigens:
  • Regulatory erythroid kinase (DYRK3_HUMAN)
  • DYRK3 protein (Q4G0U0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43781

UniProtKB/Swiss-Prot:

DYRK3_HUMAN :
  • The N-terminal domain, which is intrinsically disordered, is required for stress granule localization.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Domain:
  • The N-terminal domain, which is intrinsically disordered, is required for stress granule localization.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK3: view

Function for DYRK3 Gene

Molecular function for DYRK3 Gene

UniProtKB/Swiss-Prot Function:
Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence={ECO:0000269 PubMed:23415227, ECO:0000269 PubMed:29634919, ECO:0000269 PubMed:29973724, ECO:0000269 PubMed:9748265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence={ECO:0000269 PubMed:23415227, ECO:0000269 PubMed:29634919, ECO:0000269 PubMed:29973724, ECO:0000269 PubMed:9748265};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Protein kinase activity is activated following autophosphorylation at Tyr-369 (PubMed:9748265). Inhibited by harmine, an ATP competitive inhibitor (PubMed:29634919). Inhibited by small-compound GSK-626616 (PubMed:29973724).
UniProtKB/Swiss-Prot Induction:
By EPO/erythropoietin.
GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3,expressed in fetal brain,phosphorylating histone H2B

Enzyme Numbers (IUBMB) for DYRK3 Gene

Phenotypes From GWAS Catalog for DYRK3 Gene

Gene Ontology (GO) - Molecular Function for DYRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10779429
GO:0004672 protein kinase activity TAS,IDA 10779429
GO:0004674 protein serine/threonine kinase activity IMP 23415227
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK3: view
genes like me logo Genes that share phenotypes with DYRK3: view

Animal Models for DYRK3 Gene

MGI Knock Outs for DYRK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK3

CRISPR Products

miRNA for DYRK3 Gene

miRTarBase miRNAs that target DYRK3

Clone Products

  • Addgene plasmids for DYRK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYRK3 Gene

Localization for DYRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK3 Gene

Nucleus. Cytoplasm. Nucleus speckle. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with membraneless organelles in the cytoplasm and nucleus (PubMed:29973724). Shuttles between cytoplasm and stress granules (PubMed:20167603). Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed:20167603). At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed:20167603). {ECO:0000269 PubMed:20167603, ECO:0000269 PubMed:29973724}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYRK3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DYRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IDA 29973724
GO:0005634 nucleus IDA,IEA 10779429
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 23415227
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with DYRK3: view

Pathways & Interactions for DYRK3 Gene

PathCards logo

SuperPathways for DYRK3 Gene

No Data Available

SIGNOR curated interactions for DYRK3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DYRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 10779429
GO:0007049 cell cycle IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0018107 peptidyl-threonine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with DYRK3: view

No data available for Pathways by source for DYRK3 Gene

Drugs & Compounds for DYRK3 Gene

(3) Drugs for DYRK3 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
ID-8 Pharma 0

(1) Additional Compounds for DYRK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(1) ApexBio Compounds for DYRK3 Gene

Compound Action Cas Number
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK3: view

Transcripts for DYRK3 Gene

mRNA/cDNA for DYRK3 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for DYRK3

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - - - - - -
SP6: - - - -

Relevant External Links for DYRK3 Gene

GeneLoc Exon Structure for
DYRK3
ECgene alternative splicing isoforms for
DYRK3

Expression for DYRK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYRK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYRK3 Gene

This gene is overexpressed in Testis (x8.5).

Protein differential expression in normal tissues from HIPED for DYRK3 Gene

This gene is overexpressed in Plasma (61.3) and Bone marrow mesenchymal stem cell (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DYRK3 Gene



Protein tissue co-expression partners for DYRK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYRK3 Gene:

DYRK3

SOURCE GeneReport for Unigene cluster for DYRK3 Gene:

Hs.164267

mRNA Expression by UniProt/SwissProt for DYRK3 Gene:

O43781-DYRK3_HUMAN
Tissue specificity: Isoform 1: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 1: Predominant form in fetal liver and bone marrow (PubMed:10779429). Isoform 1: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). Isoform 2: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 2: Predominant form in testis. Isoform 2: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429).

Evidence on tissue expression from TISSUES for DYRK3 Gene

  • Muscle(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DYRK3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK3 Gene

Orthologs for DYRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYRK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK3 33 32
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYRK3 33 32
  • 91.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DYRK3 33 32
  • 89.95 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYRK3 33
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dyrk3 32
  • 85.67 (n)
mouse
(Mus musculus)
Mammalia Dyrk3 17 33 32
  • 85.32 (n)
chicken
(Gallus gallus)
Aves DYRK3 33 32
  • 71.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYRK3 33
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk3 32
  • 67.02 (n)
zebrafish
(Danio rerio)
Actinopterygii DYRK3 33
  • 64 (a)
OneToOne
zgc:172180 32
  • 63.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta smi35A 34
  • 50 (a)
Dyrk3 33 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mbk-2 33 34
  • 35 (a)
OneToMany
C36B7.1 34
  • 32 (a)
C36B7.2 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 65 (a)
OneToMany
Species where no ortholog for DYRK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK3 Gene

ENSEMBL:
Gene Tree for DYRK3 (if available)
TreeFam:
Gene Tree for DYRK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYRK3: view image

Paralogs for DYRK3 Gene

(4) SIMAP similar genes for DYRK3 Gene using alignment to 3 proteins:

  • DYRK3_HUMAN
  • Q4G0U0_HUMAN
  • Q5SY34_HUMAN
genes like me logo Genes that share paralogs with DYRK3: view

Variants for DYRK3 Gene

Sequence variations from dbSNP and Humsavar for DYRK3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000775981 -- 206,649,305(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001050177 -- 206,637,124(+) A/G intron_variant
rs1001223845 -- 206,651,104(+) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001668757 -- 206,643,031(+) G/A/T intron_variant
rs1002000921 -- 206,644,631(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DYRK3 Gene

Variant ID Type Subtype PubMed ID
esv2675844 CNV deletion 23128226
esv3545578 CNV deletion 23714750
esv3588657 CNV loss 21293372

Variation tolerance for DYRK3 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYRK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK3 Gene

Disorders for DYRK3 Gene

Additional Disease Information for DYRK3

No disorders were found for DYRK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK3 Gene

Publications for DYRK3 Gene

  1. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. (PMID: 20167603) Guo X … Li X (The Journal of biological chemistry 2010) 3 4 23 56
  2. REDK, a novel human regulatory erythroid kinase. (PMID: 10779429) Lord KA … Dillon SB (Blood 2000) 3 4 23 56
  3. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W … Joost HG (The Journal of biological chemistry 1998) 2 3 4 56
  4. Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation. (PMID: 29634919) Kim K … Cho HS (Journal of molecular biology 2018) 3 4 56
  5. Kinase-controlled phase transition of membraneless organelles in mitosis. (PMID: 29973724) Rai AK … Pelkmans L (Nature 2018) 3 4 56

Products for DYRK3 Gene

Sources for DYRK3 Gene