DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. ... See more...

Aliases for DYRK2 Gene

Aliases for DYRK2 Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 2 3 5
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2 2 3
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 3 4
  • EC 2.7.12.1 4 52
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2 2
  • EC 2.7.12 52

External Ids for DYRK2 Gene

Previous GeneCards Identifiers for DYRK2 Gene

  • GC12P067846
  • GC12P067759
  • GC12P066329
  • GC12P066328
  • GC12P068042
  • GC12P065093

Summaries for DYRK2 Gene

Entrez Gene Summary for DYRK2 Gene

  • DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYRK2 Gene

DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) is a Protein Coding gene. Diseases associated with DYRK2 include Mental Retardation, Autosomal Dominant 7. Among its related pathways are T-Cell Receptor and Co-stimulatory Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK3.

UniProtKB/Swiss-Prot Summary for DYRK2 Gene

  • Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).

Gene Wiki entry for DYRK2 Gene

Additional gene information for DYRK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DYRK2 Gene

Genomics for DYRK2 Gene

GeneHancer (GH) Regulatory Elements for DYRK2 Gene

Promoters and enhancers for DYRK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J067646 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.6 1561 5.8 EP300 CTCF NRF1 POLR2G NCOR1 PHF8 ZFX ZIC2 REST POLR2A DYRK2 LINC01479 ENSG00000235872
GH12J068556 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.7 +910.8 910836 4.9 USF1 JUND FOS ZNF263 ZNF623 CTBP1 MCM3 RBM25 NR2F2 GABPA NUP107 RPL10P12 RAP1B KRT8P39 LINC02384 SNORA70G MDM1 DYRK2 CPSF6 CPM
GH12J067680 Enhancer 0.8 Ensembl ENCODE dbSUPER 12.4 +33.3 33263 2 JUND FOS FOSL2 USF1 MAZ USF2 MYC STAT3 DYRK2 LINC01479 LOC105369816 lnc-DYRK2-6 lnc-IFNG-2
GH12J067678 Enhancer 0.8 Ensembl ENCODE dbSUPER 12.4 +29.5 29463 3.2 JUND FOS FOSL2 POLR2A LOC105369816 lnc-DYRK2-6 DYRK2 LINC01479 piR-32325-039
GH12J067628 Enhancer 0.9 FANTOM5 ENCODE 4.6 -18.3 -18341 3 SP1 CTCF BCL11A GABPA SPI1 NR2F2 ELF1 POU2F2 EBF1 IKZF1 ENSG00000235872 DYRK2 piR-50437-126
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYRK2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DYRK2

Top Transcription factor binding sites by QIAGEN in the DYRK2 gene promoter:
  • ATF6
  • FOXL1
  • GATA-2
  • p53
  • Pax-5
  • Roaz
  • RORalpha1
  • SREBP-1a
  • SREBP-1b

Genomic Locations for DYRK2 Gene

Genomic Locations for DYRK2 Gene
chr12:67,648,338-67,665,406
(GRCh38/hg38)
Size:
17,069 bases
Orientation:
Plus strand
chr12:68,042,118-68,059,186
(GRCh37/hg19)
Size:
17,069 bases
Orientation:
Plus strand

Genomic View for DYRK2 Gene

Genes around DYRK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK2 Gene

Proteins for DYRK2 Gene

  • Protein details for DYRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92630-DYRK2_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 2
    Protein Accession:
    Q92630
    Secondary Accessions:
    • B2R9V9
    • Q9BRB5

    Protein attributes for DYRK2 Gene

    Size:
    601 amino acids
    Molecular mass:
    66652 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and DCAF1. Interacts with SIAH2 and MDM2. Interacts with MAP3K10 and NFATC1. May also interact with CCNL2.
    SequenceCaution:
    • Sequence=CAA73885.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DYRK2 Gene

    Alternative splice isoforms for DYRK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK2 Gene

Selected DME Specific Peptides for DYRK2 Gene

Q92630:
  • PGEDEGDQLACM
  • VRNEKRFHRQA
  • GGPNNGGYDD
  • KVIDFGSSC
  • LYELIKKN
  • IGKGSFGQV
  • HPWLRRRLP
  • NAKKRQG
  • TFELLSMNLY

Post-translational modifications for DYRK2 Gene

  • Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.
  • Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYRK2 Gene

Domains & Families for DYRK2 Gene

Gene Families for DYRK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DYRK2 Gene

Suggested Antigen Peptide Sequences for DYRK2 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92630

UniProtKB/Swiss-Prot:

DYRK2_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK2: view

Function for DYRK2 Gene

Molecular function for DYRK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop. Inhibited by acridine analogs, purvalanol, and barely by harmine. Inhibited by leucettine and leucettine derivatives.
UniProtKB/Swiss-Prot Induction:
Accumulates in nucleus upon DNA damage. Induced in both esophageal and lung adenocarcinomas.
GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2,phosphorylating histone H2B

Enzyme Numbers (IUBMB) for DYRK2 Gene

Phenotypes From GWAS Catalog for DYRK2 Gene

Gene Ontology (GO) - Molecular Function for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 9748265
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK2: view
genes like me logo Genes that share phenotypes with DYRK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK2

CRISPR Products

miRNA for DYRK2 Gene

miRTarBase miRNAs that target DYRK2

Clone Products

  • Addgene plasmids for DYRK2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYRK2 Gene

Localization for DYRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK2 Gene

Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYRK2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 19287380
GO:0005634 nucleus IBA,IDA 17349958
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,TAS 17349958
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DYRK2: view

Pathways & Interactions for DYRK2 Gene

genes like me logo Genes that share pathways with DYRK2: view

Pathways by source for DYRK2 Gene

1 GeneGo (Thomson Reuters) pathway for DYRK2 Gene
  • Translation Regulation of EIF2 activity
1 Cell Signaling Technology pathway for DYRK2 Gene

SIGNOR curated interactions for DYRK2 Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11311121
GO:0006915 apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEP 19965871
GO:0007224 smoothened signaling pathway IMP 18455992
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DYRK2: view

Drugs & Compounds for DYRK2 Gene

(4) Drugs for DYRK2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 51
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
ID-8 Pharma 0

(1) Additional Compounds for DYRK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(1) ApexBio Compounds for DYRK2 Gene

Compound Action Cas Number
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK2: view

Drug Products

Transcripts for DYRK2 Gene

mRNA/cDNA for DYRK2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for DYRK2

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for DYRK2 Gene

GeneLoc Exon Structure for
DYRK2

Expression for DYRK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYRK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DYRK2 Gene

This gene is overexpressed in Adipocyte (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DYRK2 Gene



Protein tissue co-expression partners for DYRK2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DYRK2

SOURCE GeneReport for Unigene cluster for DYRK2 Gene:

Hs.173135

mRNA Expression by UniProt/SwissProt for DYRK2 Gene:

Q92630-DYRK2_HUMAN
Tissue specificity: Testis, after the onset of spermatogenesis.

Evidence on tissue expression from TISSUES for DYRK2 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DYRK2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK2 Gene

Orthologs for DYRK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK2 31 30
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYRK2 31 30
  • 93.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DYRK2 31 30
  • 92.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dyrk2 17 31 30
  • 90.76 (n)
rat
(Rattus norvegicus)
Mammalia Dyrk2 30
  • 90.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK2 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYRK2 31 30
  • 82.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYRK2 31
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk2 30
  • 77.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4918 30
zebrafish
(Danio rerio)
Actinopterygii dyrk2 31 30
  • 74.73 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008241 30
  • 64.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dyrk3 31 32 30
  • 64.15 (n)
OneToMany
smi35A 32
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea mbk-2 31 32 30
  • 66.07 (n)
OneToMany
C36B7.2 32
  • 31 (a)
C36B7.1 32
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 77 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06638 30
  • 51.39 (n)
Species where no ortholog for DYRK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK2 Gene

ENSEMBL:
Gene Tree for DYRK2 (if available)
TreeFam:
Gene Tree for DYRK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYRK2: view image

Paralogs for DYRK2 Gene

(7) SIMAP similar genes for DYRK2 Gene using alignment to 5 proteins:

  • DYRK2_HUMAN
  • F5GXG1_HUMAN
  • F5H5L5_HUMAN
  • G8JLB4_HUMAN
  • L8ECA4_HUMAN
genes like me logo Genes that share paralogs with DYRK2: view

Variants for DYRK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DYRK2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
790666 Benign: not provided 67,649,166(+) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
rs1384093596 A glioblastoma multiforme sample p.Pro198Leu
rs34166200 - p.His245Asn
rs35139851 - p.Ser98Gly
rs35688869 - p.Arg451Gln

Additional dbSNP identifiers (rs#s) for DYRK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DYRK2 Gene

Variant ID Type Subtype PubMed ID
nsv1143702 CNV deletion 24896259

Variation tolerance for DYRK2 Gene

Residual Variation Intolerance Score: 8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYRK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK2 Gene

Disorders for DYRK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DYRK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 7
  • mrd7
- elite association - COSMIC cancer census association via MalaCards
Search DYRK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DYRK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DYRK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYRK2 Gene

Publications for DYRK2 Gene

  1. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (PMID: 17349958) Taira N … Yoshida K (Molecular cell 2007) 3 4 23 54
  2. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W … Joost HG (The Journal of biological chemistry 1998) 2 3 4 54
  3. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. (PMID: 23362280) Jung HY … Park JI (The Journal of biological chemistry 2013) 3 4 54
  4. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PMID: 22307329) Taira N … Yoshida K (The Journal of clinical investigation 2012) 3 4 54
  5. Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. (PMID: 22878263) Pérez M … Calzado MA (Journal of molecular cell biology 2012) 3 4 54

Products for DYRK2 Gene

Sources for DYRK2 Gene