This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014... See more...

Aliases for DYRK1B Gene

Aliases for DYRK1B Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B 2 3 5
  • Minibrain-Related Kinase 2 3 4
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2 3
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B 3 4
  • Mirk Protein Kinase 3 4
  • MIRK 3 4
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2
  • EC 2.7.12.1 4
  • EC 2.7.12 52
  • AOMS3 3

External Ids for DYRK1B Gene

Previous GeneCards Identifiers for DYRK1B Gene

  • GC19M040957
  • GC19M040707
  • GC19M044992
  • GC19M045007
  • GC19M040316
  • GC19M036763

Summaries for DYRK1B Gene

Entrez Gene Summary for DYRK1B Gene

  • This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DYRK1B Gene

DYRK1B (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B) is a Protein Coding gene. Diseases associated with DYRK1B include Abdominal Obesity-Metabolic Syndrome 3 and Mental Retardation, Autosomal Dominant 7. Among its related pathways are Glucose / Energy Metabolism and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot Summary for DYRK1B Gene

  • Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Tocris Summary for DYRK1B Gene

  • Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.

Gene Wiki entry for DYRK1B Gene

Additional gene information for DYRK1B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DYRK1B Gene

Genomics for DYRK1B Gene

GeneHancer (GH) Regulatory Elements for DYRK1B Gene

Promoters and enhancers for DYRK1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039831 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.8 783 3.6 HNRNPK ZBTB40 ZNF217 EP300 SIN3A TCF12 NRF1 MYC ZNF300 USF1 DYRK1B HNRNPL FBL SNRPA COQ8B ZNF780B RN7SL566P ZNF780A AKT2 ENSG00000269688
GH19J040579 Enhancer 0.8 ENCODE dbSUPER 7.6 -746.0 -746029 0.8 ZNF316 MAX PBX2 NFE2 TAL1 MAFK BHLHE40 MAFG EGR1 DPF2 DYRK1B HSALNG0126122 SHKBP1 LTBP4 HSALNG0126126
GH19J039843 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -11.5 -11548 4.4 ZBTB40 ZNF217 CTCF NRF1 TCF12 POLR2G SP1 PHF8 PHB2 ZNF639 FBL lnc-FBL-1 lnc-LEUTX-3 SNRPA ENSG00000269843 HNRNPL ZNF780B EID2B ITPKC SUPT5H
GH19J039823 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 0.4 +9.3 9317 2.7 ZNF217 POLR2G SP1 ZFX ZNF10 ZIC2 ZBTB26 RFX1 KLF7 POLR2A lnc-DYRK1B-1 HNRNPL SNRPA ZNF780B AKT2 FBL COQ8B ZNF780A ITPKC PAK4
GH19J039841 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -7.7 -7697 1.7 CTCF TRIM28 REST MYC RAD21 TRIM22 ATF2 FOXA2 ZBTB17 SMC3 SNRPA ENSG00000269843 HNRNPL FBL RPS16 ITPKC lnc-FBL-1 DYRK1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYRK1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DYRK1B

Top Transcription factor binding sites by QIAGEN in the DYRK1B gene promoter:
  • MyoD

Genomic Locations for DYRK1B Gene

Genomic Locations for DYRK1B Gene
chr19:39,825,347-39,834,233
(GRCh38/hg38)
Size:
8,887 bases
Orientation:
Minus strand
chr19:40,315,990-40,324,841
(GRCh37/hg19)
Size:
8,852 bases
Orientation:
Minus strand

Genomic View for DYRK1B Gene

Genes around DYRK1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK1B Gene

Proteins for DYRK1B Gene

  • Protein details for DYRK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y463-DYR1B_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Protein Accession:
    Q9Y463
    Secondary Accessions:
    • O75258
    • O75788
    • O75789

    Protein attributes for DYRK1B Gene

    Size:
    629 amino acids
    Molecular mass:
    69198 Da
    Quaternary structure:
    • Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7.
    SequenceCaution:
    • Sequence=AAC28914.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK1B Gene

Selected DME Specific Peptides for DYRK1B Gene

Q9Y463:
  • HDTEMKYYIVHLK
  • YDLAIDMWSLGCILVEMHTGEPLFSG
  • FRGVSLNLTRK
  • IVEVLGIPPA
  • LSYNLYDLLRNT
  • IGKGSFGQV
  • DLIKTYKHIN
  • NPKRSAIKI
  • QAPKARK

Post-translational modifications for DYRK1B Gene

  • Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DYRK1B Gene

Gene Families for DYRK1B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DYRK1B Gene

GenScript: Design optimal peptide antigens:
  • Mirk protein kinase (DYR1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y463

UniProtKB/Swiss-Prot:

DYR1B_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK1B: view

Function for DYRK1B Gene

Molecular function for DYRK1B Gene

UniProtKB/Swiss-Prot Function:
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by RANBP9.
GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse homolog,expressed in muscle and testis,involved in the regulation of nuclear functions

Enzyme Numbers (IUBMB) for DYRK1B Gene

Phenotypes From GWAS Catalog for DYRK1B Gene

Gene Ontology (GO) - Molecular Function for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA,IDA 11980910
GO:0004672 protein kinase activity IDA,TAS 11980910
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK1B: view
genes like me logo Genes that share phenotypes with DYRK1B: view

Human Phenotype Ontology for DYRK1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DYRK1B Gene

MGI Knock Outs for DYRK1B:
  • Dyrk1b Dyrk1b<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK1B

CRISPR Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for DYRK1B Gene

Localization for DYRK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYRK1B gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with DYRK1B: view

Pathways & Interactions for DYRK1B Gene

genes like me logo Genes that share pathways with DYRK1B: view

Pathways by source for DYRK1B Gene

3 Cell Signaling Technology pathways for DYRK1B Gene

SIGNOR curated interactions for DYRK1B Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11980910
GO:0007520 myoblast fusion IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0018107 peptidyl-threonine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with DYRK1B: view

Drugs & Compounds for DYRK1B Gene

(10) Drugs for DYRK1B Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
AZ191 Pharma DYRK1B inhibitor,potent and selective 0
ID-8 Pharma 0
Harmine Pharma Potent and selective DYRK1A inhibitor 1

(2) Additional Compounds for DYRK1B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(3) Tocris Compounds for DYRK1B Gene

Compound Action Cas Number
Harmine Potent and selective DYRK1A inhibitor 442-51-3
INDY DYRK1A/B inhibitor 1169755-45-6
ProINDY DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997) 719277-30-2

(2) ApexBio Compounds for DYRK1B Gene

Compound Action Cas Number
AZ191 DYRK1B inhibitor,potent and selective
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK1B: view

Drug Products

Transcripts for DYRK1B Gene

mRNA/cDNA for DYRK1B Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1B Gene

No ASD Table

Relevant External Links for DYRK1B Gene

GeneLoc Exon Structure for
DYRK1B

Expression for DYRK1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYRK1B Gene

mRNA differential expression in normal tissues according to GTEx for DYRK1B Gene

This gene is overexpressed in Muscle - Skeletal (x6.6) and Testis (x5.6).

Protein differential expression in normal tissues from HIPED for DYRK1B Gene

This gene is overexpressed in Blymphocyte (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DYRK1B Gene



Protein tissue co-expression partners for DYRK1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DYRK1B

SOURCE GeneReport for Unigene cluster for DYRK1B Gene:

Hs.130988

mRNA Expression by UniProt/SwissProt for DYRK1B Gene:

Q9Y463-DYR1B_HUMAN
Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.

Evidence on tissue expression from TISSUES for DYRK1B Gene

  • Muscle(4.6)
  • Pancreas(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK1B Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
Regions:
Head and neck:
  • ear
Thorax:
  • heart
Abdomen:
  • duodenum
  • intestine
  • liver
  • small intestine
General:
  • blood vessel
genes like me logo Genes that share expression patterns with DYRK1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DYRK1B Gene

Orthologs for DYRK1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK1B 31 30
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYRK1B 31 30
  • 95.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DYRK1B 31 30
  • 94.01 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dyrk1b 30
  • 92.76 (n)
mouse
(Mus musculus)
Mammalia Dyrk1b 17 31 30
  • 92.63 (n)
oppossum
(Monodelphis domestica)
Mammalia DYRK1B 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK1B 31
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYRK1B 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk1a.2 30
  • 70.15 (n)
zebrafish
(Danio rerio)
Actinopterygii dyrk1b 31 30
  • 73.95 (n)
OneToOne
psmb6 30
fruit fly
(Drosophila melanogaster)
Insecta mnb 31 32
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mbk-1 31 32
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 33 31
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1202 31
  • 73 (a)
OneToMany
Species where no ortholog for DYRK1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK1B Gene

ENSEMBL:
Gene Tree for DYRK1B (if available)
TreeFam:
Gene Tree for DYRK1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYRK1B: view image

Paralogs for DYRK1B Gene

(5) SIMAP similar genes for DYRK1B Gene using alignment to 3 proteins:

  • DYR1B_HUMAN
  • M0R131_HUMAN
  • M0R2X3_HUMAN
genes like me logo Genes that share paralogs with DYRK1B: view

Variants for DYRK1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DYRK1B Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
709099 Likely Benign: not provided 39,830,447(-) G/A SYNONYMOUS_VARIANT
721944 Likely Benign: not provided 39,826,835(-) G/A SYNONYMOUS_VARIANT
724408 Likely Benign: not provided 39,830,561(-) T/C SYNONYMOUS_VARIANT
725964 Likely Benign: not provided 39,826,195(-) C/T SYNONYMOUS_VARIANT
728555 Likely Benign: not provided 39,826,697(-) G/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for DYRK1B Gene

Structural Variations from Database of Genomic Variants (DGV) for DYRK1B Gene

Variant ID Type Subtype PubMed ID
esv2758760 CNV gain 17122850
nsv9725 CNV gain+loss 18304495

Variation tolerance for DYRK1B Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYRK1B Gene

Human Gene Mutation Database (HGMD)
DYRK1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK1B Gene

Disorders for DYRK1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for DYRK1B Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DYR1B_HUMAN
  • Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. {ECO:0000269 PubMed:24827035}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for DYRK1B

genes like me logo Genes that share disorders with DYRK1B: view

No data available for Genatlas for DYRK1B Gene

Publications for DYRK1B Gene

  1. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PMID: 9918863) Leder S … Becker W (Biochemical and biophysical research communications 1999) 2 3 4 23 54
  2. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PMID: 10910078) Lee K … Friedman E (Cancer research 2000) 3 4 23 54
  3. A form of the metabolic syndrome associated with mutations in DYRK1B. (PMID: 24827035) Keramati AR … Mani A (The New England journal of medicine 2014) 3 4 54
  4. The kinase Mirk is a potential therapeutic target in osteosarcoma. (PMID: 20042639) Yang C … Duan Z (Carcinogenesis 2010) 3 23 54
  5. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. (PMID: 19633423) Gao J … Haura EB (Cancer biology & therapy 2009) 3 23 54

Products for DYRK1B Gene

Sources for DYRK1B Gene