Aliases for DYRK1B Gene
External Ids for DYRK1B Gene
Previous GeneCards Identifiers for DYRK1B Gene
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for DYRK1B Gene
DYRK1B (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B) is a Protein Coding gene. Diseases associated with DYRK1B include Abdominal Obesity-Metabolic Syndrome 3 and Mental Retardation, Autosomal Dominant 7. Among its related pathways are Glucose / Energy Metabolism and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK1A.
UniProtKB/Swiss-Prot Summary for DYRK1B Gene
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.