This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modul... See more...

Aliases for DYNLT3 Gene

Aliases for DYNLT3 Gene

  • Dynein Light Chain Tctex-Type 3 2 3 4 5
  • Protein 91/23 3 4
  • TCTEX1L 2 3
  • TCTE1L 3 4
  • T-Complex-Associated-Testis-Expressed 1-Like 2
  • T-Complex-Associated Testis-Expressed 1-Like 4
  • TCTE1XL 4
  • DYNLT3 5
  • RP3 3

External Ids for DYNLT3 Gene

Previous HGNC Symbols for DYNLT3 Gene

  • TCTE1L

Previous GeneCards Identifiers for DYNLT3 Gene

  • GC0XM037455
  • GC0XM037580
  • GC0XM037696
  • GC0XM035443

Summaries for DYNLT3 Gene

Entrez Gene Summary for DYNLT3 Gene

  • This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

GeneCards Summary for DYNLT3 Gene

DYNLT3 (Dynein Light Chain Tctex-Type 3) is a Protein Coding gene. Diseases associated with DYNLT3 include Retinitis Pigmentosa 3 and Bardet-Biedl Syndrome 7. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Salmonella infection (KEGG). Gene Ontology (GO) annotations related to this gene include identical protein binding and motor activity. An important paralog of this gene is DYNLT1.

UniProtKB/Swiss-Prot Summary for DYNLT3 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).

Gene Wiki entry for DYNLT3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DYNLT3 Gene

Genomics for DYNLT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DYNLT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ037846 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.1 70 2.6 ZNF207 ZNF600 ATF2 CEBPA POLR2A ZIC2 ZBTB10 YY1 CEBPB FEZF1 DYNLT3 RNU6-49P HSALNG0137306 CYBB ENSG00000250349
GH0XJ037888 Promoter 0.4 EPDnew 262.4 -40.5 -40513 0.1 HNF4A DYNLT3 lnc-CYBB-1 SYTL5 RF00026-1111 RNU6-49P ENSG00000250349
GH0XJ037871 Enhancer 1 Ensembl ENCODE 12.3 -24.7 -24730 2.6 NCOR1 JUND NFIC MBD2 EP300 TAF9B TAL1 STAT3 ZNF316 USF2 DYNLT3 RNU6-49P RF00026-1111 lnc-CYBB-1 SYTL5 ENSG00000250349
GH0XJ038219 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 4.8 -372.6 -372630 2.8 ZNF600 ZIC2 ZNF341 CTCF SP2 RAD21 TAF1 GLIS1 ZNF398 ZNF561 SRPX ENSG00000226679 HSALNG0137312 DYNLT3 MK280607-170 H2AP ENSG00000250349
GH0XJ037780 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.2 +63.9 63892 9 BCLAF1 TRIM22 IRF4 EBF1 SPI1 SRF MAX POLR2A RAD51 ELF1 CYBB XK HSALNG0137300 lnc-CYBB-2 DYNLT3 ENSG00000250349
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYNLT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DYNLT3

Top Transcription factor binding sites by QIAGEN in the DYNLT3 gene promoter:
  • AP-1
  • C/EBPalpha
  • C/EBPbeta
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • Lmo2
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)

Genomic Locations for DYNLT3 Gene

Latest Assembly
chrX:37,836,757-37,847,571
(GRCh38/hg38)
Size:
10,815 bases
Orientation:
Minus strand

Previous Assembly
chrX:37,698,089-37,706,824
(GRCh37/hg19 by Entrez Gene)
Size:
8,736 bases
Orientation:
Minus strand

chrX:37,696,010-37,706,890
(GRCh37/hg19 by Ensembl)
Size:
10,881 bases
Orientation:
Minus strand

Genomic View for DYNLT3 Gene

Genes around DYNLT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLT3 Gene

Proteins for DYNLT3 Gene

  • Protein details for DYNLT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51808-DYLT3_HUMAN
    Recommended name:
    Dynein light chain Tctex-type 3
    Protein Accession:
    P51808
    Secondary Accessions:
    • Q6ICS3

    Protein attributes for DYNLT3 Gene

    Size:
    116 amino acids
    Molecular mass:
    13062 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.

neXtProt entry for DYNLT3 Gene

Post-translational modifications for DYNLT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYNLT3 Gene

No data available for DME Specific Peptides for DYNLT3 Gene

Domains & Families for DYNLT3 Gene

Protein Domains for DYNLT3 Gene

InterPro:
Blocks:
  • Tctex-1 family

Suggested Antigen Peptide Sequences for DYNLT3 Gene

GenScript: Design optimal peptide antigens:
  • T-complex-associated testis-expressed 1-like (DYLT3_HUMAN)
  • cDNA, FLJ92116, Homo sapiens t-complex-associated-testis-expressed 1-like (TCTE1L),mRNA (Q6ICS3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51808

UniProtKB/Swiss-Prot:

DYLT3_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with DYNLT3: view

Function for DYNLT3 Gene

Molecular function for DYNLT3 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).

Phenotypes From GWAS Catalog for DYNLT3 Gene

Gene Ontology (GO) - Molecular Function for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with DYNLT3: view
genes like me logo Genes that share phenotypes with DYNLT3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNLT3 Gene

Localization for DYNLT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLT3 Gene

Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNLT3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 colocalizes_with kinetochore IEA,IDA 17289665
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with DYNLT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DYNLT3 Gene

Pathways & Interactions for DYNLT3 Gene

PathCards logo

SuperPathways for DYNLT3 Gene

SuperPathway Contained pathways
1 Salmonella infection (KEGG)
2 Cell cycle_Spindle assembly and chromosome separation
-
3 Regulation of degradation of deltaF508 CFTR in CF
.59
genes like me logo Genes that share pathways with DYNLT3: view

Pathways by source for DYNLT3 Gene

1 KEGG pathway for DYNLT3 Gene
2 GeneGo (Thomson Reuters) pathways for DYNLT3 Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Regulation of degradation of deltaF508 CFTR in CF

Gene Ontology (GO) - Biological Process for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle ISS --
GO:0045931 positive regulation of mitotic cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with DYNLT3: view

No data available for SIGNOR curated interactions for DYNLT3 Gene

Drugs & Compounds for DYNLT3 Gene

(1) Drugs for DYNLT3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DYNLT3: view

Transcripts for DYNLT3 Gene

mRNA/cDNA for DYNLT3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLT3

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLT3 Gene

No ASD Table

Relevant External Links for DYNLT3 Gene

GeneLoc Exon Structure for
DYNLT3

Expression for DYNLT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYNLT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DYNLT3 Gene

This gene is overexpressed in Colon (10.4), Retina (8.1), and Islet of Langerhans (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DYNLT3 Gene



Protein tissue co-expression partners for DYNLT3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DYNLT3

SOURCE GeneReport for Unigene cluster for DYNLT3 Gene:

Hs.446392

Evidence on tissue expression from TISSUES for DYNLT3 Gene

  • Nervous system(4.9)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with DYNLT3: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLT3 Gene

Orthologs for DYNLT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLT3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DYNLT3 29 30
  • 99.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DYNLT3 29 30
  • 93.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DYNLT3 29 30
  • 91.95 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dynlt3 29 16 30
  • 86.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dynlt3 29
  • 82.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia DYNLT3 30
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DYNLT3 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DYNLT3 29 30
  • 77.59 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DYNLT3 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dynlt3 29
  • 68.71 (n)
Zebrafish
(Danio rerio)
Actinopterygii dynlt3 29 30
  • 69.57 (n)
OneToOne
Dr.4843 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1114 29
Worm
(Caenorhabditis elegans)
Secernentea dylt-1 30
  • 29 (a)
OneToOne
Species where no ortholog for DYNLT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DYNLT3 Gene

ENSEMBL:
Gene Tree for DYNLT3 (if available)
TreeFam:
Gene Tree for DYNLT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYNLT3: view image
Alliance of Genome Resources:
Additional Orthologs for DYNLT3

Paralogs for DYNLT3 Gene

Paralogs for DYNLT3 Gene

(5) SIMAP similar genes for DYNLT3 Gene using alignment to 3 proteins:

  • DYLT3_HUMAN
  • A6NGJ0_HUMAN
  • F2Z328_HUMAN

Pseudogenes.org Pseudogenes for DYNLT3 Gene

genes like me logo Genes that share paralogs with DYNLT3: view

Variants for DYNLT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DYNLT3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs11771 Benign: not specified 37,841,795(-) G/A
NM_006520.3(DYNLT3):c.183C>T (p.Ala61=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DYNLT3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DYNLT3 Gene

Variant ID Type Subtype PubMed ID
nsv515194 CNV loss 21397061

Variation tolerance for DYNLT3 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYNLT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNLT3
Leiden Open Variation Database (LOVD)
DYNLT3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLT3 Gene

Disorders for DYNLT3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DYNLT3 Gene - From: COP

Disorder Aliases PubMed IDs
retinitis pigmentosa 3
  • rp3
bardet-biedl syndrome 7
  • bbs7
retinitis pigmentosa
  • rp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DYNLT3

genes like me logo Genes that share disorders with DYNLT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLT3 Gene

Publications for DYNLT3 Gene

  1. Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex. (PMID: 8004092) Roux AF … Musarella M (Human molecular genetics 1994) 2 3 4
  2. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. (PMID: 17289665) Lo KW … Pfister KK (The Journal of biological chemistry 2007) 3 4
  3. Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. (PMID: 16079286) Yeh TY … Sung CH (Journal of cell science 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for DYNLT3 Gene

Sources for DYNLT3 Gene