Aliases for DYNLT3 Gene
External Ids for DYNLT3 Gene
Previous HGNC Symbols for DYNLT3 Gene
Previous GeneCards Identifiers for DYNLT3 Gene
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
GeneCards Summary for DYNLT3 Gene
DYNLT3 (Dynein Light Chain Tctex-Type 3) is a Protein Coding gene. Diseases associated with DYNLT3 include Retinitis Pigmentosa 3 and Bardet-Biedl Syndrome 7. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include identical protein binding and motor activity. An important paralog of this gene is DYNLT1.
UniProtKB/Swiss-Prot Summary for DYNLT3 Gene
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).