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DYNLRB2 (Dynein Light Chain Roadblock-Type 2) is a Protein Coding gene. Diseases associated with DYNLRB2 include Deafness, Autosomal Recessive 77 and Hepatocellular Carcinoma. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Intraflagellar transport. Gene Ontology (GO) annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNLRB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003774 | motor activity | IEA | -- |
GO:0003777 | microtubule motor activity | NAS | 11750132 |
GO:0045505 | dynein intermediate chain binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005813 | centrosome | IBA | 21873635 |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005868 | cytoplasmic dynein complex | IBA,NAS | 11750132 |
GO:0005874 | microtubule | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Organelle biogenesis and maintenance |
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2 | Salmonella infection (KEGG) | ||
3 | Intraflagellar transport | ||
4 | Cell cycle_Spindle assembly and chromosome separation |
Cell cycle_Spindle assembly and chromosome separation
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5 | Regulation of degradation of deltaF508 CFTR in CF |
Regulation of degradation of deltaF508 CFTR in CF
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007018 | microtubule-based movement | IBA,NAS | 11750132 |
GO:0035735 | intraciliary transport involved in cilium assembly | TAS | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | - | - | - | - | |||||||||||||
SP3: | - | - | |||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DYNLRB2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DYNLRB2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DYNLRB2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DYNLRB2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dynlrb2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dynlrb2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | DYNLRB2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DYNLRB2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dynlrb2 30 |
|
||
Str.10857 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6973 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-147k9.8 30 |
|
||
DYNLRB2 31 |
|
OneToOne | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13879 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | robl 30 |
|
||
robl37BC 31 |
|
OneToMany | |||
CG16837 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003360 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14206 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11866734 | Benign: not specified | 80,549,600(+) |
C/T NM_130897.3(DYNLRB2):c.196C>T (p.Leu66=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
rs13332289 | - |
p.His14Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3639274 | CNV | loss | 21293372 |
nsv833300 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
deafness, autosomal recessive 77 |
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hepatocellular carcinoma |
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retinitis pigmentosa 3 |
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