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Aliases for DYNLRB2 Gene

Aliases for DYNLRB2 Gene

  • Dynein Light Chain Roadblock-Type 2 2 3 3 5
  • Dynein, Cytoplasmic, Light Polypeptide 2B 2 3
  • Roadblock Domain-Containing Protein 2 3 4
  • Dynein Light Chain 2B, Cytoplasmic 3 4
  • DNCL2B 3 4
  • DNLC2B 3 4
  • ROBLD2 3 4
  • Testicular Tissue Protein Li 53 3
  • Roadblock Domain Containing 2 2
  • Bithoraxoid-Like Protein 3

External Ids for DYNLRB2 Gene

Previous HGNC Symbols for DYNLRB2 Gene

  • DNCL2B

Previous GeneCards Identifiers for DYNLRB2 Gene

  • GC16P079133
  • GC16P080574
  • GC16P066331

Summaries for DYNLRB2 Gene

GeneCards Summary for DYNLRB2 Gene

DYNLRB2 (Dynein Light Chain Roadblock-Type 2) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNLRB1.

UniProtKB/Swiss-Prot for DYNLRB2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Additional gene information for DYNLRB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLRB2 Gene

Genomics for DYNLRB2 Gene

GeneHancer (GH) Regulatory Elements for DYNLRB2 Gene

Promoters and enhancers for DYNLRB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J080540 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 665.6 +0.6 564 1.6 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SP3 DYNLRB2 LOC105371360 LOC102724084
GH16J080541 Enhancer 0.4 ENCODE 650.7 +1.5 1511 0 ZNF512 PRDM1 DYNLRB2 LOC105371360 LOC102724084
GH16J080542 Enhancer 0.4 ENCODE 650.7 +1.4 1371 0 ZNF512 PRDM1 DYNLRB2 LOC105371360 LOC102724084
GH16J080579 Enhancer 1 FANTOM5 ENCODE 19 +40.1 40109 1.3 CTCF STAT5A BATF KLF5 IRF4 RELA NFATC1 EED ZNF143 ATF7 DYNLRB2 CMC2 LINC01227 PIR62926
GH16J081431 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +892.1 892143 2.4 ATF1 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A IRF4 ZNF48 ETS1 ATF7 ENSG00000261141 DYNLRB2 CMIP PLCG2 ENSG00000272923
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYNLRB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYNLRB2 gene promoter:
  • GATA-3
  • GATA-2
  • GATA-1
  • AML1a
  • POU2F1
  • POU2F1a
  • aMEF-2
  • MEF-2A
  • Nkx3-1 v4

Genomic Locations for DYNLRB2 Gene

Genomic Locations for DYNLRB2 Gene
chr16:80,540,258-80,550,811
(GRCh38/hg38)
Size:
10,554 bases
Orientation:
Plus strand
chr16:80,574,631-80,584,657
(GRCh37/hg19)
Size:
10,027 bases
Orientation:
Plus strand

Genomic View for DYNLRB2 Gene

Genes around DYNLRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLRB2 Gene

Proteins for DYNLRB2 Gene

  • Protein details for DYNLRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF09-DLRB2_HUMAN
    Recommended name:
    Dynein light chain roadblock-type 2
    Protein Accession:
    Q8TF09

    Protein attributes for DYNLRB2 Gene

    Size:
    96 amino acids
    Molecular mass:
    10855 Da
    Quaternary structure:
    • Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1.
    Miscellaneous:
    • Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.

neXtProt entry for DYNLRB2 Gene

Post-translational modifications for DYNLRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYNLRB2 Gene

Domains & Families for DYNLRB2 Gene

Gene Families for DYNLRB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DYNLRB2 Gene

Suggested Antigen Peptide Sequences for DYNLRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF09

UniProtKB/Swiss-Prot:

DLRB2_HUMAN :
  • Belongs to the GAMAD family.
Family:
  • Belongs to the GAMAD family.
genes like me logo Genes that share domains with DYNLRB2: view

Function for DYNLRB2 Gene

Molecular function for DYNLRB2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Phenotypes From GWAS Catalog for DYNLRB2 Gene

Gene Ontology (GO) - Molecular Function for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 11750132
GO:0045505 dynein intermediate chain binding IBA --
genes like me logo Genes that share ontologies with DYNLRB2: view
genes like me logo Genes that share phenotypes with DYNLRB2: view

Animal Models for DYNLRB2 Gene

MGI Knock Outs for DYNLRB2:

Animal Model Products

CRISPR Products

miRNA for DYNLRB2 Gene

miRTarBase miRNAs that target DYNLRB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLRB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYNLRB2 Gene

Localization for DYNLRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLRB2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNLRB2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005868 cytoplasmic dynein complex NAS,IBA 11750132
GO:0005874 microtubule IEA --
GO:0005929 cilium TAS --
genes like me logo Genes that share ontologies with DYNLRB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DYNLRB2 Gene

Pathways & Interactions for DYNLRB2 Gene

genes like me logo Genes that share pathways with DYNLRB2: view

Pathways by source for DYNLRB2 Gene

Gene Ontology (GO) - Biological Process for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA,NAS 11750132
GO:0035735 intraciliary transport involved in cilium assembly TAS --
genes like me logo Genes that share ontologies with DYNLRB2: view

No data available for SIGNOR curated interactions for DYNLRB2 Gene

Drugs & Compounds for DYNLRB2 Gene

No Compound Related Data Available

Transcripts for DYNLRB2 Gene

mRNA/cDNA for DYNLRB2 Gene

Unigene Clusters for DYNLRB2 Gene

Dynein, light chain, roadblock-type 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLRB2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for DYNLRB2 Gene

GeneLoc Exon Structure for
DYNLRB2
ECgene alternative splicing isoforms for
DYNLRB2

Expression for DYNLRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYNLRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYNLRB2 Gene

This gene is overexpressed in Testis (x29.2).

Protein differential expression in normal tissues from HIPED for DYNLRB2 Gene

This gene is overexpressed in Brain (22.4), Plasma (21.5), Heart (14.4), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DYNLRB2 Gene



Protein tissue co-expression partners for DYNLRB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYNLRB2 Gene:

DYNLRB2

SOURCE GeneReport for Unigene cluster for DYNLRB2 Gene:

Hs.98849

mRNA Expression by UniProt/SwissProt for DYNLRB2 Gene:

Q8TF09-DLRB2_HUMAN
Tissue specificity: High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte.

Evidence on tissue expression from TISSUES for DYNLRB2 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with DYNLRB2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLRB2 Gene

Orthologs for DYNLRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLRB2 34 33
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNLRB2 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNLRB2 34 33
  • 93.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLRB2 34 33
  • 92.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlrb2 16 34 33
  • 88.19 (n)
rat
(Rattus norvegicus)
Mammalia Dynlrb2 33
  • 85.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
chicken
(Gallus gallus)
Aves DYNLRB2 34 33
  • 81.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLRB2 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlrb2 33
  • 79.86 (n)
Str.10857 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6973 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-147k9.8 33
  • 77.08 (n)
DYNLRB2 34
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13879 33
fruit fly
(Drosophila melanogaster)
Insecta robl 33
  • 67.73 (n)
robl37BC 34
  • 25 (a)
OneToMany
CG16837 34
  • 23 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003360 33
  • 65.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 84 (a)
OneToOne
Cin.14206 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14206 33
Species where no ortholog for DYNLRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYNLRB2 Gene

ENSEMBL:
Gene Tree for DYNLRB2 (if available)
TreeFam:
Gene Tree for DYNLRB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYNLRB2: view image

Paralogs for DYNLRB2 Gene

Paralogs for DYNLRB2 Gene

(1) SIMAP similar genes for DYNLRB2 Gene using alignment to 5 proteins:

  • DLRB2_HUMAN
  • H3BNG9_HUMAN
  • H3BPA0_HUMAN
  • H3BQI1_HUMAN
  • Q7Z4M1_HUMAN
genes like me logo Genes that share paralogs with DYNLRB2: view

Variants for DYNLRB2 Gene

Sequence variations from dbSNP and Humsavar for DYNLRB2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs11866734 benign, not specified 80,549,600(+) C/A/G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1000109417 -- 80,542,529(+) A/G intron_variant
rs1000313694 -- 80,547,159(+) C/G intron_variant
rs1000508127 -- 80,539,152(+) C/T upstream_transcript_variant
rs1000703531 -- 80,549,982(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLRB2 Gene

Variant ID Type Subtype PubMed ID
esv3639274 CNV loss 21293372
nsv833300 CNV gain 17160897

Variation tolerance for DYNLRB2 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYNLRB2 Gene

Human Gene Mutation Database (HGMD)
DYNLRB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNLRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLRB2 Gene

Disorders for DYNLRB2 Gene

Additional Disease Information for DYNLRB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DYNLRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNLRB2 Gene

Publications for DYNLRB2 Gene

  1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PMID: 11750132) Jiang J … Zhao S (Gene 2001) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 44 58
  4. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister KK … Vallee RB (The Journal of cell biology 2005) 2 3 58
  5. The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. (PMID: 12077152) Susalka SJ … Pfister KK (The Journal of biological chemistry 2002) 3 4 58

Products for DYNLRB2 Gene

Sources for DYNLRB2 Gene

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