Aliases for DYNLRB1 Gene
External Ids for DYNLRB1 Gene
Previous HGNC Symbols for DYNLRB1 Gene
Previous GeneCards Identifiers for DYNLRB1 Gene
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
GeneCards Summary for DYNLRB1 Gene
DYNLRB1 (Dynein Light Chain Roadblock-Type 1) is a Protein Coding gene. Diseases associated with DYNLRB1 include Carrion's Disease and Hepatocellular Carcinoma. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNLRB2.
UniProtKB/Swiss-Prot Summary for DYNLRB1 Gene
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.