Aliases for DYNLL2 Gene

Aliases for DYNLL2 Gene

  • Dynein Light Chain LC8-Type 2 2 3 4 5
  • Dynein Light Chain 2, Cytoplasmic 3 4
  • 8 KDa Dynein Light Chain B 3 4
  • DNCL1B 2 3
  • RSPH22 2 3
  • DLC8b 3 4
  • Dlc2 2 3
  • Radial Spoke 22 Homolog (Chlamydomonas) 2
  • Radial Spoke 22 Homolog 3
  • MGC17810 2
  • DYNLL2 5
  • DLC2 4

External Ids for DYNLL2 Gene

Previous GeneCards Identifiers for DYNLL2 Gene

  • GC17P053516
  • GC17P056160
  • GC17P051521

Summaries for DYNLL2 Gene

GeneCards Summary for DYNLL2 Gene

DYNLL2 (Dynein Light Chain LC8-Type 2) is a Protein Coding gene. Diseases associated with DYNLL2 include Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly and Bardet-Biedl Syndrome 7. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include motor activity and cytoskeletal protein binding. An important paralog of this gene is DYNLL1.

UniProtKB/Swiss-Prot Summary for DYNLL2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

Gene Wiki entry for DYNLL2 Gene

Additional gene information for DYNLL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DYNLL2 Gene

Genomics for DYNLL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DYNLL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYNLL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DYNLL2

Top Transcription factor binding sites by QIAGEN in the DYNLL2 gene promoter:
  • AML1a
  • Lhx3a
  • LHX3b
  • Lmo2
  • MZF-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • STAT1

Genomic Locations for DYNLL2 Gene

Genomic Locations for DYNLL2 Gene
chr17:58,083,419-58,095,542
(GRCh38/hg38)
Size:
12,124 bases
Orientation:
Plus strand
chr17:56,160,776-56,172,897
(GRCh37/hg19)
Size:
12,122 bases
Orientation:
Plus strand

Genomic View for DYNLL2 Gene

Genes around DYNLL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLL2 Gene

Proteins for DYNLL2 Gene

  • Protein details for DYNLL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FJ2-DYL2_HUMAN
    Recommended name:
    Dynein light chain 2, cytoplasmic
    Protein Accession:
    Q96FJ2
    Secondary Accessions:
    • B2R5B4

    Protein attributes for DYNLL2 Gene

    Size:
    89 amino acids
    Molecular mass:
    10350 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with BCAS1. Interacts with Basson/BSN.

    Three dimensional structures from OCA and Proteopedia for DYNLL2 Gene

neXtProt entry for DYNLL2 Gene

Post-translational modifications for DYNLL2 Gene

  • Ubiquitination at Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for DYNLL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DYNLL2 Gene

Domains & Families for DYNLL2 Gene

Gene Families for DYNLL2 Gene

Protein Domains for DYNLL2 Gene

InterPro:
Blocks:
  • Dynein light chain, type 1
ProtoNet:

Suggested Antigen Peptide Sequences for DYNLL2 Gene

GenScript: Design optimal peptide antigens:
  • Dynein light chain LC8-type 2 (DYL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FJ2

UniProtKB/Swiss-Prot:

DYL2_HUMAN :
  • Belongs to the dynein light chain family.
Family:
  • Belongs to the dynein light chain family.
genes like me logo Genes that share domains with DYNLL2: view

Function for DYNLL2 Gene

Molecular function for DYNLL2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

Phenotypes From GWAS Catalog for DYNLL2 Gene

Gene Ontology (GO) - Molecular Function for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
GO:0044877 protein-containing complex binding IEA --
GO:0045505 dynein intermediate chain binding IBA 21873635
genes like me logo Genes that share ontologies with DYNLL2: view
genes like me logo Genes that share phenotypes with DYNLL2: view

Animal Model Products

CRISPR Products

miRNA for DYNLL2 Gene

miRTarBase miRNAs that target DYNLL2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNLL2 Gene

Localization for DYNLL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLL2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNLL2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 4
extracellular 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear bodies (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DYNLL2: view

Pathways & Interactions for DYNLL2 Gene

genes like me logo Genes that share pathways with DYNLL2: view

Pathways by source for DYNLL2 Gene

2 GeneGo (Thomson Reuters) pathways for DYNLL2 Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Regulation of degradation of deltaF508 CFTR in CF
1 GeneTex pathway for DYNLL2 Gene

SIGNOR curated interactions for DYNLL2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007017 microtubule-based process IEA --
GO:0016236 macroautophagy TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0035735 intraciliary transport involved in cilium assembly TAS --
genes like me logo Genes that share ontologies with DYNLL2: view

Drugs & Compounds for DYNLL2 Gene

No Compound Related Data Available

Transcripts for DYNLL2 Gene

mRNA/cDNA for DYNLL2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLL2

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL2 Gene

No ASD Table

Relevant External Links for DYNLL2 Gene

GeneLoc Exon Structure for
DYNLL2

Expression for DYNLL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYNLL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DYNLL2 Gene



Protein tissue co-expression partners for DYNLL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DYNLL2

SOURCE GeneReport for Unigene cluster for DYNLL2 Gene:

Hs.720595

Evidence on tissue expression from TISSUES for DYNLL2 Gene

  • Lung(4.4)
  • Liver(4.4)
  • Nervous system(3.2)
  • Heart(2.8)
  • Kidney(2.6)
  • Muscle(2.4)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with DYNLL2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLL2 Gene

Orthologs for DYNLL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYNLL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DYNLL2 30 31
  • 100 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DYNLL2 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DYNLL2 31
  • 100 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dynll2 30
  • 98.5 (n)
Mouse
(Mus musculus)
Mammalia Dynll2 30 17 31
  • 97.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DYNLL2 30 31
  • 97.38 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DYNLL2 30 31
  • 96.63 (n)
OneToOne
Chicken
(Gallus gallus)
Aves DYNLL2 30 31
  • 88.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DYNLL2 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dynll2 30
  • 86.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8719 30
Zebrafish
(Danio rerio)
Actinopterygii dynll2a 31
  • 99 (a)
OneToMany
dynll2b 30 31
  • 83.52 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001335 30
  • 77.15 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta ctp 30
  • 76.03 (n)
Worm
(Caenorhabditis elegans)
Secernentea dlc-1 30 31
  • 82.4 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 31
  • 47 (a)
OneToMany
Rice
(Oryza sativa)
Liliopsida Os01g0256400 30
  • 70.73 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.14337 30
Corn
(Zea mays)
Liliopsida Zm.10206 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CS-DLC1 31
  • 96 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dlc2 30
  • 69.05 (n)
Species where no ortholog for DYNLL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DYNLL2 Gene

ENSEMBL:
Gene Tree for DYNLL2 (if available)
TreeFam:
Gene Tree for DYNLL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYNLL2: view image

Paralogs for DYNLL2 Gene

Paralogs for DYNLL2 Gene

(4) SIMAP similar genes for DYNLL2 Gene using alignment to 2 proteins:

  • DYL2_HUMAN
  • L8ECM3_HUMAN
genes like me logo Genes that share paralogs with DYNLL2: view

Variants for DYNLL2 Gene

Additional dbSNP identifiers (rs#s) for DYNLL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DYNLL2 Gene

Variant ID Type Subtype PubMed ID
nsv1127584 CNV deletion 24896259
nsv833497 CNV loss 17160897

Variation tolerance for DYNLL2 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYNLL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNLL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DYNLL2 Gene

Disorders for DYNLL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DYNLL2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DYNLL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLL2 Gene

Publications for DYNLL2 Gene

  1. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister KK … Vallee RB (The Journal of cell biology 2005) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. (PMID: 14561217) Day CL … Hinds MG (The Biochemical journal 2004) 3 23
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3

Products for DYNLL2 Gene

  • Signalway Proteins for DYNLL2

Sources for DYNLL2 Gene