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Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
DYNLL1 (Dynein Light Chain LC8-Type 1) is a Protein Coding gene. Diseases associated with DYNLL1 include Rabies and Prostate Carcinoma In Situ. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein domain specific binding. An important paralog of this gene is DYNLL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003774 | motor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 14607844 |
GO:0045505 | dynein intermediate chain binding | IBA | 21873635 |
GO:0051959 | dynein light intermediate chain binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000776 | kinetochore | IDA | 20133940 |
GO:0005634 | nucleus | IEA,IDA | 15891768 |
GO:0005737 | cytoplasm | IEA,IDA | 8628263 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005813 | centrosome | IDA | 21399614 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
2 | Transport to the Golgi and subsequent modification | ||
3 | Activation of BH3-only proteins | ||
4 | Innate Immune System |
.61
|
|
5 | Apoptotic execution phase |
.31
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007017 | microtubule-based process | IEA | -- |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Nitric Oxide | Approved | Pharma | 771 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DYNLL1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DYNLL1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DYNLL1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
DYNLL1 30 31 31 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | DYNLL1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dynll1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dynll1 30 |
|
||
Chicken (Gallus gallus) |
Aves | DYNLL1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DYNLL1 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8421 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dynll1 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10095 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ctp 31 |
|
OneToMany | |
Cdlc2 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | dlc-2 31 |
|
ManyToMany | |
dlc-3 31 |
|
ManyToMany | |||
dlc-4 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DYN2 31 33 |
|
OneToMany | |
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.891 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5239 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
rabies |
|
|
prostate carcinoma in situ |
|
|
retinitis pigmentosa 3 |
|
|
retinitis pigmentosa 18 |
|
|
chronic intestinal vascular insufficiency |
|
|