Aliases for DYNLL1 Gene
Aliases for DYNLL1 Gene
External Ids for DYNLL1 Gene
- HGNC: 15476
- Entrez Gene: 8655
- Ensembl: ENSG00000088986
- OMIM: 601562
- UniProtKB: P63167
Previous HGNC Symbols for DYNLL1 Gene
- DNCL1
Previous GeneCards Identifiers for DYNLL1 Gene
- GC12P119397
- GC12P120908
- GC12P117917
Summaries for DYNLL1 Gene
-
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for DYNLL1 Gene
DYNLL1 (Dynein Light Chain LC8-Type 1) is a Protein Coding gene. Diseases associated with DYNLL1 include Chronic Intestinal Vascular Insufficiency. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein domain specific binding. An important paralog of this gene is DYNLL2.
UniProtKB/Swiss-Prot for DYNLL1 Gene
-
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
-
Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
-
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
-
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Additional gene information for DYNLL1 Gene
- Monarch Initiative
- Search for DYNLL1 at DataMed
- Search for DYNLL1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLL1 Gene
Genomics for DYNLL1 Gene
GeneHancer (GH) Regulatory Elements for DYNLL1 Gene
Promoters and enhancers for DYNLL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DYNLL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DYNLL1 gene promoter:
-
- GR-alpha
- GR
- GR-beta
- Max
- C/EBPalpha
- Egr-4
Regulatory Element Products
Genomic Locations for DYNLL1 Gene
Genomic Locations for DYNLL1 Gene
- chr12:120,469,850-120,498,495
- (GRCh38/hg38)
- Size:
- 28,646 bases
- Orientation:
- Plus strand
- chr12:120,907,653-120,936,298
- (GRCh37/hg19)
- Size:
- 28,646 bases
- Orientation:
- Plus strand
Genomic View for DYNLL1 Gene
Genes around DYNLL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by Entrez Gene
- 12q24.31 by HGNC
- 12q24.31 by Ensembl
DYNLL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DYNLL1 Gene
Proteins for DYNLL1 Gene
-
Protein details for DYNLL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P63167-DYL1_HUMAN
- Recommended name:
- Dynein light chain 1, cytoplasmic
- Protein Accession:
- P63167
- Q15701
Protein attributes for DYNLL1 Gene
- Size:
- 89 amino acids
- Molecular mass:
- 10366 Da
- Quaternary structure:
-
- Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at Ser-944). Interacts with BICD2 (By similarity).
Protein Expression for DYNLL1 Gene
Post-translational modifications for DYNLL1 Gene
- Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
- Ubiquitination at Lys36, posLast=3131, and posLast=99
- Modification sites at PhosphoSitePlus
Other Protein References for DYNLL1 Gene
Antibody Products
- R&D Systems Antibodies for DYNLL1 (PIN)
- Novus Biologicals Antibodies for DYNLL1
- Invitrogen Antibodies for DYNLL1
- GeneTex DYNLL1 Antibody for DYNLL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for DYNLL1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DYNLL1
- Origene Custom Protein Services for DYNLL1
- ProSpec Recombinant Proteins for DYNLL1
- Search GeneTex for Proteins for DYNLL1
-
ProSci Proteins for DYNLL1
Assay Products
No data available for DME Specific Peptides for DYNLL1 Gene
Domains & Families for DYNLL1 Gene
Gene Families for DYNLL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DYNLL1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DYNLL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P63167- Family:
-
- Belongs to the dynein light chain family.
Function for DYNLL1 Gene
Molecular function for DYNLL1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
- UniProtKB/Swiss-Prot Function:
- Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
- UniProtKB/Swiss-Prot Function:
- Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
- UniProtKB/Swiss-Prot Function:
- Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by ATMIN, PAK1 and estrogen.
Phenotypes From GWAS Catalog for DYNLL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003774 | motor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 14607844 |
| GO:0008092 | cytoskeletal protein binding | IBA | -- |
| GO:0008574 | contributes_to ATP-dependent microtubule motor activity, plus-end-directed | IBA | -- |
| GO:0019899 | enzyme binding | IEA | -- |
Phenotypes for DYNLL1 Gene
- MGI mutant phenotypes for DYNLL1:
-
inferred from 3 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- neoplasm
- mortality/aging
- cellular phenotype
- embryo phenotype
- normal phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for DYNLL1:
Animal Models for DYNLL1 Gene
- MGI Knock Outs for DYNLL1:
-
- Dynll1 Dynll1<tm1(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DYNLL1
-
CRISPR Products
-
OriGene CRISPR knockouts for DYNLL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DYNLL1
- genomics-online: gRNA clones - Search results for available DYNLL1 gene related products
- Applied Biological Materials CRISPR for DYNLL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYNLL1
- GenScript: Design CRISPR guide RNA sequences for DYNLL1
miRNA for DYNLL1 Gene
- miRTarBase miRNAs that target DYNLL1
-
- hsa-mir-92a-3p (MIRT049381)
- hsa-mir-659-3p (MIRT482714)
- hsa-mir-29b-2-5p (MIRT482715)
- hsa-mir-328-3p (MIRT482716)
- hsa-mir-573 (MIRT482717)
- hsa-mir-3616-5p (MIRT482718)
- hsa-mir-6740-5p (MIRT482719)
- hsa-mir-4650-3p (MIRT482720)
- hsa-mir-7155-3p (MIRT482721)
- hsa-mir-3136-3p (MIRT482722)
- hsa-mir-4795-5p (MIRT482723)
- hsa-mir-6831-5p (MIRT482724)
- hsa-mir-4726-3p (MIRT482725)
- hsa-mir-3927-3p (MIRT482726)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DYNLL1
- Browse OriGene Inhibitory RNA Products For DYNLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLL1
- genomics-online: shRNA clones - Search results for available DYNLL1 gene related products
Clone Products
-
OriGene ORF clones in human for DYNLL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DYNLL1
- VectorBuilder custom plasmid, inducible vectors for DYNLL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYNLL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYNLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DYNLL1
- genomics-online: cdna clones - Search results for available DYNLL1 gene related products
- orf clones - Search results for available DYNLL1 gene related products
- Applied Biological Materials Clones for DYNLL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYNLL1 Gene
Localization for DYNLL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DYNLL1 Gene
- Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
- Cytosol (2)
- Nuclear bodies (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IDA | 20133940 |
| GO:0005634 | nucleus | IDA,IEA | 15891768 |
| GO:0005737 | cytoplasm | IDA,IEA | 8628263 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005813 | centrosome | IDA | 21399614 |
Pathways & Interactions for DYNLL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Transport to the Golgi and subsequent modification | ||
| 3 | Activation of BH3-only proteins | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
Pathways by source for DYNLL1 Gene
37 Reactome pathways for DYNLL1 Gene
1 KEGG pathway for DYNLL1 Gene
2 GeneGo (Thomson Reuters) pathways for DYNLL1 Gene
Interacting Proteins for DYNLL1 Gene
Selected Interacting proteins:
P63167-DYL1_HUMAN
ENSP00000242577
for DYNLL1 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for DYNLL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
Drugs & Compounds for DYNLL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Nitric Oxide | Approved | Pharma | 643 |
Transcripts for DYNLL1 Gene
mRNA/cDNA for DYNLL1 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (951) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000242577 720 bps (uc001tyl.4)
- ENST00000392508 697 bps (uc001tym.4)
- ENST00000392509 814 bps (uc001tyj.4)
- ENST00000548214 616 bps (uc058ubs.1)
- ENST00000548342 662 bps (uc058ubr.1)
Unigene Clusters for DYNLL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DYNLL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DYNLL1
- genomics-online: gRNA clones - Search results for available DYNLL1 gene related products
- Applied Biological Materials CRISPR for DYNLL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYNLL1
- GenScript: Design CRISPR guide RNA sequences for DYNLL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DYNLL1
- Browse OriGene Inhibitory RNA Products For DYNLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLL1
- genomics-online: shRNA clones - Search results for available DYNLL1 gene related products
Clone Products
-
OriGene ORF clones in human for DYNLL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DYNLL1
- VectorBuilder custom plasmid, inducible vectors for DYNLL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYNLL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYNLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DYNLL1
- genomics-online: cdna clones - Search results for available DYNLL1 gene related products
- orf clones - Search results for available DYNLL1 gene related products
- Applied Biological Materials Clones for DYNLL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DYNLL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DYNLL1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DYNLL1 Gene:
DYNLL1SOURCE GeneReport for Unigene cluster for DYNLL1 Gene:
Hs.5120mRNA Expression by UniProt/SwissProt for DYNLL1 Gene:
P63167-DYL1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for DYNLL1 Gene
- Nervous system(4.9)
- Liver(4.8)
- Pancreas(4.3)
- Kidney(3.7)
- Lung(3.7)
- Heart(3.4)
- Skin(3.4)
- Intestine(3.3)
- Blood(2.4)
- Gall bladder(2.2)
- Spleen(2.2)
- Stomach(2.2)
- Adrenal gland(2.1)
- Eye(2.1)
- Lymph node(2.1)
- Muscle(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DYNLL1
-
OriGene qPCR primer pairs for DYNLL1
- genomics-online: primer clones - Search results for available DYNLL1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLL1 Gene
Orthologs for DYNLL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DYNLL1 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DYNLL1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | DYNLL1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| DYNLL1 34 34 34 33 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | DYNLL1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dynll1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dynll1 33 |
|
||
| chicken (Gallus gallus) |
Aves | DYNLL1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DYNLL1 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8421 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dynll1 34 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10095 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ctp 34 |
|
OneToMany | |
| Cdlc2 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | dlc-2 34 |
|
ManyToMany | |
| dlc-3 34 |
|
ManyToMany | |||
| dlc-4 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DYN2 36 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.891 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | Cin.5239 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5239 33 |
|
- Species where no ortholog for DYNLL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for DYNLL1 Gene
- ENSEMBL:
- Gene Tree for DYNLL1 (if available)
- TreeFam:
- Gene Tree for DYNLL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DYNLL1: view image
Paralogs for DYNLL1 Gene
(4) SIMAP similar genes for DYNLL1 Gene using alignment to 4 proteins:
- DYL1_HUMAN
- F8VRV5_HUMAN
- F8VXI7_HUMAN
- F8VXL2_HUMAN
Pseudogenes.org Pseudogenes for DYNLL1 Gene
Variants for DYNLL1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000168021 | -- | 120,473,566(+) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000172043 | -- | 120,471,504(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000204532 | -- | 120,471,138(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000217439 | -- | 120,482,131(+) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000386945 | -- | 120,477,953(+) | A/C | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
54.8% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DYNLL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DYNLL1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLL1 Gene
Disorders for DYNLL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic intestinal vascular insufficiency |
|
|
Search DYNLL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DYNLL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLL1 Gene
Publications for DYNLL1 Gene
- Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PMID: 18084006) Song C … Kumar R (The Journal of biological chemistry 2008) 3 4 22 58
- Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PMID: 15193260) Vadlamudi RK … Kumar R (Cancer cell 2004) 3 4 22 58
- The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (PMID: 10198631) Puthalakath H … Strasser A (Molecular cell 1999) 3 4 22 58
- Structure of the PIN/LC8 dimer with a bound peptide. (PMID: 10426949) Liang J … Clardy J (Nature structural biology 1999) 3 4 22 58
- Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. (PMID: 8628263) Dick T … Chia W (Molecular and cellular biology 1996) 2 3 4 58
Products for DYNLL1 Gene
- R&D Systems Antibodies for DYNLL1 (PIN)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for DYNLL1
- Origene Custom Protein Services for DYNLL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DYNLL1
- Browse OriGene Inhibitory RNA Products For DYNLL1
- OriGene qPCR primer pairs and template standards for DYNLL1
- OriGene qPCR primer pairs for DYNLL1
- OriGene CRISPR knockouts for DYNLL1
- OriGene ORF clones in human for DYNLL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DYNLL1
- GenScript: Next-day shipping of latest version cDNA ORF clones for DYNLL1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DYNLL1
- GenScript Custom Assay Services for DYNLL1
- GenScript Custom overexpressing Cell Line Services for DYNLL1
- GenScript: Design CRISPR guide RNA sequences for DYNLL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DYNLL1
- Sino Biological Human cDNA Clone for DYNLL1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DYNLL1
- Novus Biologicals lysates and proteins for DYNLL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for DYNLL1
- VectorBuilder custom plasmid, inducible vectors for DYNLL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYNLL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYNLL1
- antibodies-online: Search results for available DYNLL1 related products ranked by validation data
- antibodies-online: Search results for available DYNLL1 related products ranked by validation data
- antibodies-online: Search results for available DYNLL1 related products ranked by validation data
- GeneTex DYNLL1 Antibody for DYNLL1
- Search GeneTex for Proteins for DYNLL1
- Santa Cruz Biotechnology (SCBT) Antibodies for DYNLL1
- Search Santa Cruz Biotechnology (SCBT) for DYNLL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DYNLL1
- Search for DYNLL1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for DYNLL1
- genomics-online: cdna clones - Search results for available DYNLL1 gene related products
- orf clones - Search results for available DYNLL1 gene related products
- genomics-online: gRNA clones - Search results for available DYNLL1 gene related products
- genomics-online: primer clones - Search results for available DYNLL1 gene related products
- genomics-online: shRNA clones - Search results for available DYNLL1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DYNLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DYNLL1
- GeneCopoeia miRNA 3'UTR Target clone products for DYNLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLL1
Sources for DYNLL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt