Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this r... See more...

Aliases for DYNLL1 Gene

Aliases for DYNLL1 Gene

  • Dynein Light Chain LC8-Type 1 2 3 4 5
  • DLC1 2 3 4
  • DLC8 2 3 4
  • PIN 2 3 4
  • Protein Inhibitor Of Neuronal Nitric Oxide Synthase 3 4
  • Dynein, Cytoplasmic, Light Polypeptide 1 2 3
  • Dynein Light Chain 1, Cytoplasmic 3 4
  • 8 KDa Dynein Light Chain 3 4
  • DNCLC1 3 4
  • DNCL1 3 4
  • Hdlc1 2 3
  • LC8 2 3
  • Cytoplasmic Dynein Light Polypeptide 3
  • DYNLL1 5
  • HDLC1 4
  • LC8a 3

External Ids for DYNLL1 Gene

Previous HGNC Symbols for DYNLL1 Gene

  • DNCL1

Previous GeneCards Identifiers for DYNLL1 Gene

  • GC12P119397
  • GC12P120908
  • GC12P117917

Summaries for DYNLL1 Gene

Entrez Gene Summary for DYNLL1 Gene

  • Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYNLL1 Gene

DYNLL1 (Dynein Light Chain LC8-Type 1) is a Protein Coding gene. Diseases associated with DYNLL1 include Rabies and Prostate Carcinoma In Situ. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Intraflagellar transport. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein domain specific binding. An important paralog of this gene is DYNLL2.

UniProtKB/Swiss-Prot Summary for DYNLL1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
  • Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
  • Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
  • Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Gene Wiki entry for DYNLL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DYNLL1 Gene

Genomics for DYNLL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DYNLL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J120467 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 -0.4 -377 3.5 CHD2 TBP NR2C1 IKZF1 SMAD5 ETS1 IRF2 MBD2 ZNF217 POLR2A DYNLL1 HSALNG0094524 SRSF9 COQ5 GATC RPLP0 MSI1 RAB35 lnc-TRIAP1-2 HSALNG0094521
GH12J120494 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 261.9 +26.6 26559 4 TBP ZBTB10 SP1 MXD4 MNT IKZF1 SMAD5 IRF2 MBD2 POLR2A SRSF9 DYNLL1 NONHSAG012519.2 NRAV COQ5 GATC RPL29P24 RPL31P52 RNF10 TRIAP1
GH12J120580 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +111.8 111759 3.2 TBP SP1 MXD4 NR2C1 MNT DEK SMAD5 ZFP64 MBD2 ZNF217 POP5 lnc-COQ5-2 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569
GH12J120584 Promoter/Enhancer 1.2 Ensembl ENCODE 10.6 +114.8 114758 1.2 BCL11A CTCF ZIC2 REST SAP130 ZNF341 SMC3 SP2 ZFP91 ADNP COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ENSG00000256569 ACADS OASL DYNLL1
GH12J120549 Enhancer 1.1 Ensembl ENCODE 11.2 +81.6 81558 3.2 MXD4 CEBPA IKZF1 HOMEZ KDM6A THAP11 FOXA2 ZNF511 SMAD4 SAP130 COQ5 GATC COX6A1 RPL29P24 NRAV DYNLL1 SRSF9 RPL31P52 TRIAP1 ENSG00000111780
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYNLL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DYNLL1

Top Transcription factor binding sites by QIAGEN in the DYNLL1 gene promoter:
  • C/EBPalpha
  • Egr-4
  • GR
  • GR-alpha
  • GR-beta
  • Max

Genomic Locations for DYNLL1 Gene

Latest Assembly
chr12:120,469,842-120,498,493
(GRCh38/hg38)
Size:
28,652 bases
Orientation:
Plus strand

Previous Assembly
chr12:120,907,645-120,936,296
(GRCh37/hg19 by Entrez Gene)
Size:
28,652 bases
Orientation:
Plus strand

chr12:120,907,653-120,936,296
(GRCh37/hg19 by Ensembl)
Size:
28,644 bases
Orientation:
Plus strand

Genomic View for DYNLL1 Gene

Genes around DYNLL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLL1 Gene

Proteins for DYNLL1 Gene

  • Protein details for DYNLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63167-DYL1_HUMAN
    Recommended name:
    Dynein light chain 1, cytoplasmic
    Protein Accession:
    P63167
    Secondary Accessions:
    • Q15701

    Protein attributes for DYNLL1 Gene

    Size:
    89 amino acids
    Molecular mass:
    10366 Da
    Quaternary structure:
    • Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944'). Interacts with BICD2 (By similarity). Interacts with BCAS1 (By similarity). Interacts with Basson/BSN. Interacts with HDAC6 (PubMed:31505170). Interacts with TPPP (PubMed:31505170).
    • (Microbial infection) Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome.
    • (Microbial infection) Interacts with ebolavirus protein VP35; this interaction stabilizes VP35 N-terminal oligomerization domain and enhances viral RNA synthesis.

    Three dimensional structures from OCA and Proteopedia for DYNLL1 Gene

neXtProt entry for DYNLL1 Gene

Post-translational modifications for DYNLL1 Gene

  • Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
  • Ubiquitination at Lys9, Lys31, and Lys36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DYNLL1 Gene

Domains & Families for DYNLL1 Gene

Gene Families for DYNLL1 Gene

Protein Domains for DYNLL1 Gene

Suggested Antigen Peptide Sequences for DYNLL1 Gene

GenScript: Design optimal peptide antigens:
  • Protein inhibitor of neuronal nitric oxide synthase (DYL1_HUMAN)
  • cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA (Q6FGH9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63167

UniProtKB/Swiss-Prot:

DYL1_HUMAN :
  • Belongs to the dynein light chain family.
Family:
  • Belongs to the dynein light chain family.
genes like me logo Genes that share domains with DYNLL1: view

Function for DYNLL1 Gene

Molecular function for DYNLL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
UniProtKB/Swiss-Prot Function:
Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
UniProtKB/Swiss-Prot Function:
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
UniProtKB/Swiss-Prot Function:
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by ATMIN, PAK1 and estrogen.

Phenotypes From GWAS Catalog for DYNLL1 Gene

Gene Ontology (GO) - Molecular Function for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0004857 enzyme inhibitor activity IEA --
GO:0005515 protein binding IPI 14607844
GO:0008022 protein C-terminus binding IEA --
GO:0019899 enzyme binding IEA --
genes like me logo Genes that share ontologies with DYNLL1: view
genes like me logo Genes that share phenotypes with DYNLL1: view

Animal Models for DYNLL1 Gene

MGI Knock Outs for DYNLL1:
  • Dynll1 Dynll1<tm1(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYNLL1 Gene

Localization for DYNLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLL1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNLL1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2
endosome 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 20133940
GO:0005634 nucleus IEA,IDA 15891768
GO:0005737 cytoplasm IEA,IDA 8628263
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with DYNLL1: view

Pathways & Interactions for DYNLL1 Gene

genes like me logo Genes that share pathways with DYNLL1: view

Pathways by source for DYNLL1 Gene

2 GeneGo (Thomson Reuters) pathways for DYNLL1 Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Regulation of degradation of deltaF508 CFTR in CF

SIGNOR curated interactions for DYNLL1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006915 apoptotic process IEA --
GO:0007017 microtubule-based process IEA --
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with DYNLL1: view

Drugs & Compounds for DYNLL1 Gene

(2) Drugs for DYNLL1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 796
genes like me logo Genes that share compounds with DYNLL1: view

Transcripts for DYNLL1 Gene

mRNA/cDNA for DYNLL1 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNLL1

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL1 Gene

No ASD Table

Relevant External Links for DYNLL1 Gene

GeneLoc Exon Structure for
DYNLL1

Expression for DYNLL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYNLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DYNLL1 Gene



Protein tissue co-expression partners for DYNLL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DYNLL1

SOURCE GeneReport for Unigene cluster for DYNLL1 Gene:

Hs.5120

mRNA Expression by UniProt/SwissProt for DYNLL1 Gene:

P63167-DYL1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DYNLL1 Gene

  • Nervous system(4.9)
  • Liver(4.9)
  • Blood(4.5)
  • Pancreas(4.4)
  • Lung(3.9)
  • Kidney(3.9)
  • Skin(3.8)
  • Heart(3.7)
  • Intestine(3.6)
  • Muscle(2.7)
  • Eye(2.7)
  • Spleen(2.6)
  • Lymph node(2.5)
  • Adrenal gland(2.5)
  • Thyroid gland(2.3)
  • Stomach(2.2)
  • Gall bladder(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with DYNLL1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLL1 Gene

Orthologs for DYNLL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYNLL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DYNLL1 30 31
  • 100 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DYNLL1 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DYNLL1 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 99 (a)
OneToMany
-- 31
  • 98 (a)
OneToMany
-- 31
  • 97 (a)
OneToMany
DYNLL1 30 31 31 31
  • 93.26 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia DYNLL1 30 31
  • 94.76 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dynll1 30 17 31
  • 92.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dynll1 30
  • 92.51 (n)
Chicken
(Gallus gallus)
Aves DYNLL1 31
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DYNLL1 31
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8421 30
Zebrafish
(Danio rerio)
Actinopterygii dynll1 31
  • 97 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10095 30
Fruit Fly
(Drosophila melanogaster)
Insecta ctp 31
  • 94 (a)
OneToMany
Cdlc2 31
  • 94 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dlc-2 31
  • 38 (a)
ManyToMany
dlc-3 31
  • 22 (a)
ManyToMany
dlc-4 31
  • 22 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 31 33
  • 47 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.891 30
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5239 30
Species where no ortholog for DYNLL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for DYNLL1 Gene

ENSEMBL:
Gene Tree for DYNLL1 (if available)
TreeFam:
Gene Tree for DYNLL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYNLL1: view image

Paralogs for DYNLL1 Gene

Paralogs for DYNLL1 Gene

(4) SIMAP similar genes for DYNLL1 Gene using alignment to 4 proteins:

  • DYL1_HUMAN
  • F8VRV5_HUMAN
  • F8VXI7_HUMAN
  • F8VXL2_HUMAN
genes like me logo Genes that share paralogs with DYNLL1: view

Variants for DYNLL1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DYNLL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DYNLL1 Gene

Variant ID Type Subtype PubMed ID
esv3630925 CNV loss 21293372
nsv509482 CNV insertion 20534489
nsv973129 CNV duplication 23825009

Variation tolerance for DYNLL1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYNLL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNLL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DYNLL1 Gene

Disorders for DYNLL1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for DYNLL1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
rabies
  • lyssa
prostate carcinoma in situ
  • carcinoma in situ of prostate
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
retinitis pigmentosa 3
  • rp3
lissencephaly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DYNLL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DYNLL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLL1 Gene

Publications for DYNLL1 Gene

  1. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PMID: 18084006) Song C … Kumar R (The Journal of biological chemistry 2008) 3 4 23
  2. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PMID: 15193260) Vadlamudi RK … Kumar R (Cancer cell 2004) 3 4 23
  3. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (PMID: 10198631) Puthalakath H … Strasser A (Molecular cell 1999) 3 4 23
  4. Structure of the PIN/LC8 dimer with a bound peptide. (PMID: 10426949) Liang J … Clardy J (Nature structural biology 1999) 3 4 23
  5. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. (PMID: 8628263) Dick T … Chia W (Molecular and cellular biology 1996) 2 3 4

Products for DYNLL1 Gene

Sources for DYNLL1 Gene