Aliases for DYNC1I1 Gene
External Ids for DYNC1I1 Gene
Previous HGNC Symbols for DYNC1I1 Gene
Previous GeneCards Identifiers for DYNC1I1 Gene
GeneCards Summary for DYNC1I1 Gene
DYNC1I1 (Dynein Cytoplasmic 1 Intermediate Chain 1) is a Protein Coding gene. Diseases associated with DYNC1I1 include Joubert Syndrome 31 and Paranoid Personality Disorder. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is DYNC1I2.
UniProtKB/Swiss-Prot Summary for DYNC1I1 Gene
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.