Aliases for DYNAP Gene

Aliases for DYNAP Gene

  • Dynactin Associated Protein 2 3 5
  • Dynactin-Associated Protein 3 4
  • C18orf26 3 4
  • Chromosome 18 Open Reading Frame 26 2
  • FLJ39106 2
  • DYNAP 5
  • Full 4

External Ids for DYNAP Gene

Previous HGNC Symbols for DYNAP Gene

  • C18orf26

Previous GeneCards Identifiers for DYNAP Gene

  • GC18P052254
  • GC18P054587

Summaries for DYNAP Gene

GeneCards Summary for DYNAP Gene

DYNAP (Dynactin Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for DYNAP Gene

  • Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DYNAP Gene

Genomics for DYNAP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DYNAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J054530 Enhancer 0.3 ENCODE 250.7 -0.8 -843 1.7 NFIB NANOG DYNAP POLI ENSG00000264564 HSALNG0121650 STARD6
GH18J054528 Enhancer 0.7 Ensembl ENCODE 4.5 -3.3 -3323 2.4 YY1 TAF1 SP1 POU5F1 NANOG POLR2A USF2 USF1 POLI DYNAP ENSG00000264564 HSALNG0121650 STARD6
GH18J054567 Enhancer 0.2 Ensembl 11.9 +34.7 34688 0.4 lnc-DYNAP-3 DYNAP ENSG00000267428 MK280073-306 RAB27B
GH18J054480 Enhancer 0.2 Ensembl 5.5 -51.9 -51912 0.8 DYNAP POLI lnc-MBD2-1 lnc-C18orf54-2 STARD6
GH18J054357 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 -173.8 -173813 3.8 TBP ZBTB10 MXD4 CEBPA IKZF1 SMAD5 ETS1 ZFP64 MBD2 POLR2A C18orf54 STARD6 POLI lnc-C18orf54-1 piR-36955 lnc-MBD2-1 DYNAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYNAP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DYNAP

Genomic Locations for DYNAP Gene

Latest Assembly
chr18:54,532,713-54,599,544
(GRCh38/hg38)
Size:
66,832 bases
Orientation:
Plus strand

Previous Assembly
chr18:52,254,990-52,266,724
(GRCh37/hg19 by Entrez Gene)
Size:
11,735 bases
Orientation:
Plus strand

chr18:52,254,988-52,266,724
(GRCh37/hg19 by Ensembl)
Size:
11,737 bases
Orientation:
Plus strand

Genomic View for DYNAP Gene

Genes around DYNAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNAP Gene

Proteins for DYNAP Gene

  • Protein details for DYNAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1N2-DYNAP_HUMAN
    Recommended name:
    Dynactin-associated protein
    Protein Accession:
    Q8N1N2

    Protein attributes for DYNAP Gene

    Size:
    210 amino acids
    Molecular mass:
    22529 Da
    Quaternary structure:
    • Interacts with DCTN1 and DCTN2.

neXtProt entry for DYNAP Gene

Post-translational modifications for DYNAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYNAP Gene

Domains & Families for DYNAP Gene

Gene Families for DYNAP Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DYNAP Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with DYNAP: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DYNAP Gene

Function for DYNAP Gene

Molecular function for DYNAP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.

Phenotypes From GWAS Catalog for DYNAP Gene

Gene Ontology (GO) - Molecular Function for DYNAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20978158
genes like me logo Genes that share ontologies with DYNAP: view
genes like me logo Genes that share phenotypes with DYNAP: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNAP Gene

Localization for DYNAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNAP Gene

Golgi apparatus membrane. Single-pass membrane protein. Cell membrane. Single-pass membrane protein. Note=Concentrated at cell-cell borders. Localizes at membranes in a microtubule-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNAP gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
cytoskeleton 1
cytosol 1
mitochondrion 0
nucleus 0

Gene Ontology (GO) - Cellular Components for DYNAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IBA,IDA 20978158
GO:0005886 plasma membrane IBA,IDA 20978158
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DYNAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DYNAP Gene

Pathways & Interactions for DYNAP Gene

PathCards logo

SuperPathways for DYNAP Gene

No Data Available

Interacting Proteins for DYNAP Gene

Gene Ontology (GO) - Biological Process for DYNAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 20978158
GO:0032148 activation of protein kinase B activity IBA,IDA 20978158
GO:0042981 regulation of apoptotic process IDA 20978158
GO:1901625 cellular response to ergosterol IDA 20978158
genes like me logo Genes that share ontologies with DYNAP: view

No data available for Pathways by source and SIGNOR curated interactions for DYNAP Gene

Drugs & Compounds for DYNAP Gene

No Compound Related Data Available

Transcripts for DYNAP Gene

mRNA/cDNA for DYNAP Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNAP

Alternative Splicing Database (ASD) splice patterns (SP) for DYNAP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DYNAP Gene

GeneLoc Exon Structure for
DYNAP

Expression for DYNAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYNAP Gene

mRNA differential expression in normal tissues according to GTEx for DYNAP Gene

This gene is overexpressed in Esophagus - Mucosa (x41.9) and Minor Salivary Gland (x6.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DYNAP

SOURCE GeneReport for Unigene cluster for DYNAP Gene:

Hs.376146

mRNA Expression by UniProt/SwissProt for DYNAP Gene:

Q8N1N2-DYNAP_HUMAN
Tissue specificity: Expressed in fibroblast and numerous cancer cell lines (at protein level).
genes like me logo Genes that share expression patterns with DYNAP: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNAP Gene

Orthologs for DYNAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for DYNAP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DYNAP 30 31
  • 96.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 33 (a)
OneToMany
-- 31
  • 31 (a)
OneToMany
Species where no ortholog for DYNAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for DYNAP Gene

ENSEMBL:
Gene Tree for DYNAP (if available)
TreeFam:
Gene Tree for DYNAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYNAP: view image

Paralogs for DYNAP Gene

Pseudogenes.org Pseudogenes for DYNAP Gene

genes like me logo Genes that share paralogs with DYNAP: view

No data available for Paralogs for DYNAP Gene

Variants for DYNAP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DYNAP Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs35428499 - p.Val38Ala
rs9947055 - p.Thr189Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DYNAP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DYNAP Gene

Variant ID Type Subtype PubMed ID
dgv188n21 CNV loss 19592680
nsv833660 CNV gain 17160897

Variation tolerance for DYNAP Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYNAP Gene

Human Gene Mutation Database (HGMD)
DYNAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNAP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNAP Gene

Disorders for DYNAP Gene

Additional Disease Information for DYNAP

No disorders were found for DYNAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNAP Gene

Publications for DYNAP Gene

  1. A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. (PMID: 20978158) Kunoh T … Mizukami T (Molecular cancer therapeutics 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4

Products for DYNAP Gene

Sources for DYNAP Gene