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Aliases for DYDC2 Gene

Aliases for DYDC2 Gene

  • DPY30 Domain Containing 2 2 3 5
  • DPY30 Domain-Containing Protein 2 3 4

External Ids for DYDC2 Gene

Previous GeneCards Identifiers for DYDC2 Gene

  • GC10U900484
  • GC10P082095
  • GC10P075959

Summaries for DYDC2 Gene

Entrez Gene Summary for DYDC2 Gene

  • This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for DYDC2 Gene

DYDC2 (DPY30 Domain Containing 2) is a Protein Coding gene. Diseases associated with DYDC2 include Myofibrillar Myopathy and Arrhythmogenic Right Ventricular Cardiomyopathy. An important paralog of this gene is DYDC1.

Additional gene information for DYDC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYDC2 Gene

Genomics for DYDC2 Gene

GeneHancer (GH) Regulatory Elements for DYDC2 Gene

Promoters and enhancers for DYDC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J080344 Promoter 0.8 EPDnew 600.7 0.0 -31 0.1 ZNF652 KAT8 ARID4B TAF7 SP1 DYDC2 MBL1P ENSG00000235858 DYDC1
GH10J080406 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.4 +67.0 67001 10.7 ELF3 CBFA2T2 POLR2A CEBPG MAFK TFE3 TRIM24 SP7 ZNF174 SP1 PRXL2A DYDC2 LOC642361 DYDC1 MBL1P PLAC9 ANXA11 PIR57963
GH10J080356 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 17.5 +12.5 12456 1.6 RFX1 POLR2A NRF1 BMI1 USF1 SMAD5 SIN3A HNF4A USF2 DYDC1 PRXL2A DYDC2
GH10J080453 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 +119.6 119612 22.7 SP1 ZFX ZKSCAN8 ZNF148 NKRF MLLT1 ZNF121 GTF2F1 ZNF687 NFIB TSPAN14 PRXL2A LOC101929574 DYDC1 DYDC2 ANXA11 PLAC9 MBL1P SH2D4B PIR41876
GH10J080192 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.8 -143.5 -143468 16.8 ZFX CC2D1A SP1 CTCF ELF3 CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ANXA11 MBL1P LOC642361 ENSG00000235858 LINC00857 ENSG00000272489 MAT1A DYDC2 PLAC9 SH2D4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYDC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYDC2 gene promoter:
  • Chx10
  • FOXL1
  • HFH-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx5-1
  • POU3F2 (N-Oct-5b)

Genomic Locations for DYDC2 Gene

Genomic Locations for DYDC2 Gene
chr10:80,344,745-80,368,118
(GRCh38/hg38)
Size:
23,374 bases
Orientation:
Plus strand
chr10:82,104,501-82,127,829
(GRCh37/hg19)
Size:
23,329 bases
Orientation:
Plus strand

Genomic View for DYDC2 Gene

Genes around DYDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYDC2 Gene

Proteins for DYDC2 Gene

  • Protein details for DYDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IM9-DYDC2_HUMAN
    Recommended name:
    DPY30 domain-containing protein 2
    Protein Accession:
    Q96IM9
    Secondary Accessions:
    • D3DWD6
    • Q5QP07
    • Q5QP11

    Protein attributes for DYDC2 Gene

    Size:
    177 amino acids
    Molecular mass:
    20586 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DYDC2 Gene

Post-translational modifications for DYDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYDC2 Gene

Domains & Families for DYDC2 Gene

Gene Families for DYDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DYDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DYDC2 Gene

GenScript: Design optimal peptide antigens:
  • DPY30 domain-containing protein 2 (DYDC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96IM9

UniProtKB/Swiss-Prot:

DYDC2_HUMAN :
  • Belongs to the dpy-30 family.
Family:
  • Belongs to the dpy-30 family.
genes like me logo Genes that share domains with DYDC2: view

Function for DYDC2 Gene

Phenotypes From GWAS Catalog for DYDC2 Gene

genes like me logo Genes that share phenotypes with DYDC2: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DYDC2 - Now 50% OFF >
  • * DYDC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DYDC2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DYDC2 Gene

Localization for DYDC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYDC2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 0
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for DYDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044666 MLL3/4 complex IEA --
GO:0048188 Set1C/COMPASS complex IBA 21873635
genes like me logo Genes that share ontologies with DYDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DYDC2 Gene

Pathways & Interactions for DYDC2 Gene

PathCards logo

SuperPathways for DYDC2 Gene

No Data Available

Interacting Proteins for DYDC2 Gene

Gene Ontology (GO) - Biological Process for DYDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051568 histone H3-K4 methylation IBA 21873635
genes like me logo Genes that share ontologies with DYDC2: view

No data available for Pathways by source and SIGNOR curated interactions for DYDC2 Gene

Drugs & Compounds for DYDC2 Gene

No Compound Related Data Available

Transcripts for DYDC2 Gene

mRNA/cDNA for DYDC2 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for DYDC2 Gene

DPY30 domain containing 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DYDC2 - Now 50% OFF >
  • * DYDC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DYDC2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DYDC2 Gene

No ASD Table

Relevant External Links for DYDC2 Gene

GeneLoc Exon Structure for
DYDC2
ECgene alternative splicing isoforms for
DYDC2

Expression for DYDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYDC2 Gene

This gene is overexpressed in Fallopian Tube (x7.2), Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Caudate (basal ganglia) (x6.3), Brain - Hypothalamus (x5.2), Testis (x4.4), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for DYDC2 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DYDC2 Gene



Protein tissue co-expression partners for DYDC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYDC2 Gene:

DYDC2

SOURCE GeneReport for Unigene cluster for DYDC2 Gene:

Hs.741500

Evidence on tissue expression from TISSUES for DYDC2 Gene

  • Lung(2.5)
genes like me logo Genes that share expression patterns with DYDC2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYDC2 Gene

Orthologs for DYDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DYDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYDC2 35 34
  • 99.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYDC2 35 34
  • 82.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DYDC2 35 34
  • 80.19 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dydc2 17 35 34
  • 74.34 (n)
rat
(Rattus norvegicus)
Mammalia Dydc2 34
  • 70.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DYDC2 35
  • 37 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYDC2 35
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYDC2 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DYDC2 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for DYDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYDC2 Gene

ENSEMBL:
Gene Tree for DYDC2 (if available)
TreeFam:
Gene Tree for DYDC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYDC2: view image

Paralogs for DYDC2 Gene

Paralogs for DYDC2 Gene

(1) SIMAP similar genes for DYDC2 Gene using alignment to 1 proteins:

  • DYDC2_HUMAN
genes like me logo Genes that share paralogs with DYDC2: view

Variants for DYDC2 Gene

Sequence variations from dbSNP and Humsavar for DYDC2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000073229 -- 80,356,223(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000183720 -- 80,363,233(+) A/T intron_variant
rs1000255872 -- 80,362,917(+) G/T intron_variant
rs1000399455 -- 80,363,405(+) A/G intron_variant
rs1000448044 -- 80,345,037(+) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DYDC2 Gene

Variant ID Type Subtype PubMed ID
esv3623951 CNV gain 21293372
nsv1141879 OTHER inversion 24896259
nsv520763 CNV gain 19592680
nsv551637 CNV gain 21841781
nsv825479 CNV gain 20364138
nsv831923 CNV loss 17160897

Variation tolerance for DYDC2 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYDC2
Human Gene Mutation Database (HGMD)
DYDC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYDC2 Gene

Disorders for DYDC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DYDC2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myofibrillar myopathy
  • myopathy, myofibrillar, desmin-related
arrhythmogenic right ventricular cardiomyopathy
  • arrhythmogenic right ventricular dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search DYDC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DYDC2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DYDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYDC2 Gene

Publications for DYDC2 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for DYDC2 Gene

Sources for DYDC2 Gene

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